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Persistent Pulmonary Hypertension of the Newborn, AE

MedGen UID:
1665907
Concept ID:
C4723747
Finding
Synonym: Persistent Pulmonary Hypertension of the Newborn, Adverse Event

Definition

An adverse event in a newborn characterized by elevated pulmonary vascular pressure in a neonate. [from NCI]

Professional guidelines

PubMed

Siefkes HM, Lakshminrusimha S
Arch Dis Child Fetal Neonatal Ed 2021 Jul;106(4):446-455. Epub 2021 Jan 21 doi: 10.1136/archdischild-2020-319705. PMID: 33478959Free PMC Article
Kalish BT
Neonatal Netw 2017 Jan 1;36(1):40-47. doi: 10.1891/0730-0832.36.1.40. PMID: 28137353
Abman SH, Hansmann G, Archer SL, Ivy DD, Adatia I, Chung WK, Hanna BD, Rosenzweig EB, Raj JU, Cornfield D, Stenmark KR, Steinhorn R, Thébaud B, Fineman JR, Kuehne T, Feinstein JA, Friedberg MK, Earing M, Barst RJ, Keller RL, Kinsella JP, Mullen M, Deterding R, Kulik T, Mallory G, Humpl T, Wessel DL; American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Clinical Cardiology; Council on Cardiovascular Disease in the Young; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Surgery and Anesthesia; and the American Thoracic Society
Circulation 2015 Nov 24;132(21):2037-99. Epub 2015 Nov 3 doi: 10.1161/CIR.0000000000000329. PMID: 26534956

Recent clinical studies

Etiology

Desaunay P, Eude LG, Dreyfus M, Alexandre C, Fedrizzi S, Alexandre J, Uguz F, Guénolé F
Paediatr Drugs 2023 May;25(3):247-265. Epub 2023 Feb 28 doi: 10.1007/s40272-023-00561-2. PMID: 36853497
Lebin LG, Novick AM
Curr Psychiatry Rep 2022 Nov;24(11):687-695. Epub 2022 Oct 1 doi: 10.1007/s11920-022-01372-x. PMID: 36181572Free PMC Article
Imam SS, El-Farrash RA, Taha AS, Saleh GA
J Cardiovasc Pharmacol 2022 Nov 1;80(5):746-752. doi: 10.1097/FJC.0000000000001332. PMID: 35881893
Bałkowiec-Iskra E, Mirowska-Guzel DM, Wielgoś M
Ginekol Pol 2017;88(1):36-42. doi: 10.5603/GP.a2017.0007. PMID: 28157249
Pearlstein T
Best Pract Res Clin Obstet Gynaecol 2015 Jul;29(5):754-64. Epub 2015 Apr 17 doi: 10.1016/j.bpobgyn.2015.04.004. PMID: 25976080

Diagnosis

Imam SS, El-Farrash RA, Taha AS, Saleh GA
J Cardiovasc Pharmacol 2022 Nov 1;80(5):746-752. doi: 10.1097/FJC.0000000000001332. PMID: 35881893
Luecke C, McPherson C
Neonatal Netw 2017 May 1;36(3):160-168. doi: 10.1891/0730-0832.36.3.160. PMID: 28494828
Abman SH, Hansmann G, Archer SL, Ivy DD, Adatia I, Chung WK, Hanna BD, Rosenzweig EB, Raj JU, Cornfield D, Stenmark KR, Steinhorn R, Thébaud B, Fineman JR, Kuehne T, Feinstein JA, Friedberg MK, Earing M, Barst RJ, Keller RL, Kinsella JP, Mullen M, Deterding R, Kulik T, Mallory G, Humpl T, Wessel DL; American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Clinical Cardiology; Council on Cardiovascular Disease in the Young; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Surgery and Anesthesia; and the American Thoracic Society
Circulation 2015 Nov 24;132(21):2037-99. Epub 2015 Nov 3 doi: 10.1161/CIR.0000000000000329. PMID: 26534956
Pearlstein T
Best Pract Res Clin Obstet Gynaecol 2015 Jul;29(5):754-64. Epub 2015 Apr 17 doi: 10.1016/j.bpobgyn.2015.04.004. PMID: 25976080
Grigoriadis S
J Popul Ther Clin Pharmacol 2014;21(3):e533-41. Epub 2014 Dec 11 PMID: 25594738

Therapy

Osman A, Halling C, Crume M, Al Tabosh H, Odackal N, Ball MK
J Perinatol 2023 Oct;43(10):1211-1221. Epub 2023 Aug 5 doi: 10.1038/s41372-023-01708-2. PMID: 37543651
Desaunay P, Eude LG, Dreyfus M, Alexandre C, Fedrizzi S, Alexandre J, Uguz F, Guénolé F
Paediatr Drugs 2023 May;25(3):247-265. Epub 2023 Feb 28 doi: 10.1007/s40272-023-00561-2. PMID: 36853497
Sankaran D, Lakshminrusimha S
Semin Fetal Neonatal Med 2022 Aug;27(4):101381. Epub 2022 Aug 7 doi: 10.1016/j.siny.2022.101381. PMID: 35963740
Abman SH, Hansmann G, Archer SL, Ivy DD, Adatia I, Chung WK, Hanna BD, Rosenzweig EB, Raj JU, Cornfield D, Stenmark KR, Steinhorn R, Thébaud B, Fineman JR, Kuehne T, Feinstein JA, Friedberg MK, Earing M, Barst RJ, Keller RL, Kinsella JP, Mullen M, Deterding R, Kulik T, Mallory G, Humpl T, Wessel DL; American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Clinical Cardiology; Council on Cardiovascular Disease in the Young; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Surgery and Anesthesia; and the American Thoracic Society
Circulation 2015 Nov 24;132(21):2037-99. Epub 2015 Nov 3 doi: 10.1161/CIR.0000000000000329. PMID: 26534956
Pearlstein T
Best Pract Res Clin Obstet Gynaecol 2015 Jul;29(5):754-64. Epub 2015 Apr 17 doi: 10.1016/j.bpobgyn.2015.04.004. PMID: 25976080

Prognosis

He Z, Zhu S, Zhou K, Jin Y, He L, Xu W, Lao C, Liu G, Han S
Pediatr Pulmonol 2021 Aug;56(8):2399-2412. Epub 2021 May 13 doi: 10.1002/ppul.25444. PMID: 33983650
van Laere D, van Overmeire B, Gupta S, El-Khuffash A, Savoia M, McNamara PJ, Schwarz CE, de Boode WP; European Special Interest Group ‘Neonatologist Performed Echocardiography’ (NPE)
Pediatr Res 2018 Jul;84(Suppl 1):46-56. doi: 10.1038/s41390-018-0077-x. PMID: 30072803Free PMC Article
Babooa N, Shi WJ, Chen C
World J Pediatr 2017 Dec;13(6):517-527. Epub 2017 Oct 20 doi: 10.1007/s12519-017-0056-z. PMID: 29058246
Sallaam S, Natarajan G, Aggarwal S
Congenit Heart Dis 2016 May;11(3):239-44. Epub 2015 Nov 11 doi: 10.1111/chd.12304. PMID: 26554402
Occhiogrosso M, Omran SS, Altemus M
Am J Psychiatry 2012 Feb;169(2):134-40. doi: 10.1176/appi.ajp.2011.11040553. PMID: 22420034

Clinical prediction guides

Zhong B, Tan K, Razak A, Sackett V, Machipisa C, Zhou L, Samiee-Zafarghandy S, Sehgal A, Hunt RW, Pharande P, Malhotra A
Pediatr Res 2023 Nov;94(5):1714-1719. Epub 2023 May 17 doi: 10.1038/s41390-023-02649-4. PMID: 37198403Free PMC Article
Desaunay P, Eude LG, Dreyfus M, Alexandre C, Fedrizzi S, Alexandre J, Uguz F, Guénolé F
Paediatr Drugs 2023 May;25(3):247-265. Epub 2023 Feb 28 doi: 10.1007/s40272-023-00561-2. PMID: 36853497
He Z, Zhu S, Zhou K, Jin Y, He L, Xu W, Lao C, Liu G, Han S
Pediatr Pulmonol 2021 Aug;56(8):2399-2412. Epub 2021 May 13 doi: 10.1002/ppul.25444. PMID: 33983650
Shu LP, Zhang RH, Cai YH, Zhou JB, Yang JK, Qi L
Can J Diabetes 2020 Jun;44(4):327-334.e3. Epub 2019 Oct 31 doi: 10.1016/j.jcjd.2019.10.002. PMID: 31902718
Fenger-Grøn J, Thomsen M, Andersen KS, Nielsen RG
Dan Med Bull 2011 Sep;58(9):A4303. PMID: 21893008

Recent systematic reviews

Desaunay P, Eude LG, Dreyfus M, Alexandre C, Fedrizzi S, Alexandre J, Uguz F, Guénolé F
Paediatr Drugs 2023 May;25(3):247-265. Epub 2023 Feb 28 doi: 10.1007/s40272-023-00561-2. PMID: 36853497
He Z, Zhu S, Zhou K, Jin Y, He L, Xu W, Lao C, Liu G, Han S
Pediatr Pulmonol 2021 Aug;56(8):2399-2412. Epub 2021 May 13 doi: 10.1002/ppul.25444. PMID: 33983650
More K, Athalye-Jape GK, Rao SC, Patole SK
Cochrane Database Syst Rev 2016 Aug 18;2016(8):CD010531. doi: 10.1002/14651858.CD010531.pub2. PMID: 27535894Free PMC Article
Grigoriadis S, Vonderporten EH, Mamisashvili L, Tomlinson G, Dennis CL, Koren G, Steiner M, Mousmanis P, Cheung A, Ross LE
BMJ 2014 Jan 14;348:f6932. doi: 10.1136/bmj.f6932. PMID: 24429387Free PMC Article
't Jong GW, Einarson T, Koren G, Einarson A
Reprod Toxicol 2012 Nov;34(3):293-7. Epub 2012 May 5 doi: 10.1016/j.reprotox.2012.04.015. PMID: 22564982

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