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Thyroid Gland Spindle Cell Follicular Adenoma

MedGen UID:
1666446
•Concept ID:
C4744475
•
Neoplastic Process

Definition

A rare thyroid gland follicular adenoma composed predominantly of spindle cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid Gland Spindle Cell Follicular Adenoma

Professional guidelines

PubMed

Comprehensive guidance on the diagnosis and management of primary mesenchymal tumours of the thyroid gland.
Gubbi S, Thakur S, Avadhanula S, Araque KA, Filie AC, Raffeld M, Welch J, Del Rivero J, Kebebew E, Burman KD, Wartofsky L, Klubo-Gwiezdzinska J
Lancet Oncol 2020 Nov;21(11):e528-e537. doi: 10.1016/S1470-2045(20)30332-6. PMID: 33152312Free PMC Article
Pitfalls in Challenging Thyroid Tumors: Emphasis on Differential Diagnosis and Ancillary Biomarkers.
Cameselle-Teijeiro JM, Eloy C, Sobrinho-Simões M
Endocr Pathol 2020 Sep;31(3):197-217. Epub 2020 Jul 6 doi: 10.1007/s12022-020-09638-x. PMID: 32632840Free PMC Article
Anaplastic thyroid cancer: prevalence, diagnosis and treatment.
Chiacchio S, Lorenzoni A, Boni G, Rubello D, Elisei R, Mariani G
Minerva Endocrinol 2008 Dec;33(4):341-57. PMID: 18923370

Recent clinical studies

Etiology

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Pitfalls in Challenging Thyroid Tumors: Emphasis on Differential Diagnosis and Ancillary Biomarkers.
Cameselle-Teijeiro JM, Eloy C, Sobrinho-Simões M
Endocr Pathol 2020 Sep;31(3):197-217. Epub 2020 Jul 6 doi: 10.1007/s12022-020-09638-x. PMID: 32632840Free PMC Article
Spindle cell oncocytoma of the pituitary gland.
Giantini Larsen AM, Cote DJ, Zaidi HA, Bi WL, Schmitt PJ, Iorgulescu JB, Miller MB, Smith TR, Lopes MB, Jane JA, Laws ER
J Neurosurg 2019 Aug 1;131(2):517-525. Epub 2018 Oct 19 doi: 10.3171/2018.4.JNS18211. PMID: 30485213Free PMC Article
Overview of the 2017 WHO Classification of Pituitary Tumors.
Mete O, Lopes MB
Endocr Pathol 2017 Sep;28(3):228-243. doi: 10.1007/s12022-017-9498-z. PMID: 28766057
Epithelioid pituicytoma.
Ellis JA, Tsankova NM, D'Amico R, Ausiello JC, Canoll P, Rosenblum MK, Bruce JN
World Neurosurg 2012 Jul;78(1-2):191.E1-7. Epub 2011 Nov 7 doi: 10.1016/j.wneu.2011.09.011. PMID: 22120271Free PMC Article

Diagnosis

Inflammatory myofibroblastic tumor of the thyroid gland.
Zhang Y, Liu J
Front Endocrinol (Lausanne) 2023;14:1156117. Epub 2023 May 15 doi: 10.3389/fendo.2023.1156117. PMID: 37255972Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Pitfalls in Challenging Thyroid Tumors: Emphasis on Differential Diagnosis and Ancillary Biomarkers.
Cameselle-Teijeiro JM, Eloy C, Sobrinho-Simões M
Endocr Pathol 2020 Sep;31(3):197-217. Epub 2020 Jul 6 doi: 10.1007/s12022-020-09638-x. PMID: 32632840Free PMC Article
Spindle cell oncocytoma of the pituitary gland.
Giantini Larsen AM, Cote DJ, Zaidi HA, Bi WL, Schmitt PJ, Iorgulescu JB, Miller MB, Smith TR, Lopes MB, Jane JA, Laws ER
J Neurosurg 2019 Aug 1;131(2):517-525. Epub 2018 Oct 19 doi: 10.3171/2018.4.JNS18211. PMID: 30485213Free PMC Article
Epithelioid pituicytoma.
Ellis JA, Tsankova NM, D'Amico R, Ausiello JC, Canoll P, Rosenblum MK, Bruce JN
World Neurosurg 2012 Jul;78(1-2):191.E1-7. Epub 2011 Nov 7 doi: 10.1016/j.wneu.2011.09.011. PMID: 22120271Free PMC Article

Therapy

Papillary thyroid carcinoma with desmoid-type fibromatosis: the clinicopathological features with characteristic imaging and molecular correlation requiring comprehensive treatment.
Huang H, Li L, Liu X, Zhao L, Cui Z, Zhang R, Chen S
Hum Pathol 2023 Jun;136:84-95. Epub 2023 Apr 3 doi: 10.1016/j.humpath.2023.03.019. PMID: 37019411
Posterior pituitary tumours: the spectrum of a unique entity. A clinical and histological study of a large case series.
Guerrero-Pérez F, Vidal N, Marengo AP, Pozo CD, Blanco C, Rivero-Celada D, Díez JJ, Iglesias P, Picó A, Villabona C
Endocrine 2019 Jan;63(1):36-43. Epub 2018 Oct 1 doi: 10.1007/s12020-018-1774-2. PMID: 30276594
Simultaneous cytomegalovirus infection and Kaposi's sarcoma of the thyroid diagnosed by fine needle aspiration in an AIDS patient. A case report and first cytologic description of the two entities occurring together.
Zhang X, el-Sahrigy D, Elhosseiny A, Melamed MR
Acta Cytol 2003 Jul-Aug;47(4):645-8. doi: 10.1159/000326582. PMID: 12920760
Treatment of anaplastic giant and spindle cell carcinoma of the thyroid gland with combination Adriamycin and radiation therapy. A new approach.
Kim JH, Leeper RD
Cancer 1983 Sep 15;52(6):954-7. doi: 10.1002/1097-0142(19830915)52:6<954::aid-cncr2820520603>3.0.co;2-d. PMID: 6883279
Anaplastic spindle-cell and giant-cell tumors of the thyroid gland.
Nishiyama RH, Dunn EL, Thompson NW
Cancer 1972 Jul;30(1):113-27. doi: 10.1002/1097-0142(197207)30:1<113::aid-cncr2820300118>3.0.co;2-e. PMID: 5040735

Prognosis

Inflammatory myofibroblastic tumor of the thyroid gland.
Zhang Y, Liu J
Front Endocrinol (Lausanne) 2023;14:1156117. Epub 2023 May 15 doi: 10.3389/fendo.2023.1156117. PMID: 37255972Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Comprehensive guidance on the diagnosis and management of primary mesenchymal tumours of the thyroid gland.
Gubbi S, Thakur S, Avadhanula S, Araque KA, Filie AC, Raffeld M, Welch J, Del Rivero J, Kebebew E, Burman KD, Wartofsky L, Klubo-Gwiezdzinska J
Lancet Oncol 2020 Nov;21(11):e528-e537. doi: 10.1016/S1470-2045(20)30332-6. PMID: 33152312Free PMC Article
Epithelioid pituicytoma.
Ellis JA, Tsankova NM, D'Amico R, Ausiello JC, Canoll P, Rosenblum MK, Bruce JN
World Neurosurg 2012 Jul;78(1-2):191.E1-7. Epub 2011 Nov 7 doi: 10.1016/j.wneu.2011.09.011. PMID: 22120271Free PMC Article
Primary spindle cell lesions of the thyroid gland; an overview.
Papi G, Corrado S, LiVolsi VA
Am J Clin Pathol 2006 Jun;125 Suppl:S95-123. doi: 10.1309/4DQW6RQX3C6KRX1J. PMID: 16830961

Clinical prediction guides

Expanding the Spectrum of NR4A3 Fusion-Positive Gynecologic Leiomyosarcomas.
Momeni-Boroujeni A, Mullaney K, DiNapoli SE, Leitao MM Jr, Hensley ML, Katabi N, Allison DHR, Park KJ, Antonescu CR, Chiang S
Mod Pathol 2024 May;37(5):100474. Epub 2024 Mar 18 doi: 10.1016/j.modpat.2024.100474. PMID: 38508521
Comprehensive guidance on the diagnosis and management of primary mesenchymal tumours of the thyroid gland.
Gubbi S, Thakur S, Avadhanula S, Araque KA, Filie AC, Raffeld M, Welch J, Del Rivero J, Kebebew E, Burman KD, Wartofsky L, Klubo-Gwiezdzinska J
Lancet Oncol 2020 Nov;21(11):e528-e537. doi: 10.1016/S1470-2045(20)30332-6. PMID: 33152312Free PMC Article
Rare Thyroid Transcription Factor 1-Positive Tumors of the Sellar Region: Barrow Neurological Institute Retrospective Case Series.
Cole TS, Potla S, Sarris CE, Przybylowski CJ, Baranoski JF, Mooney MA, Barranco FD, White WL, Eschbacher JM, Little AS
World Neurosurg 2019 Sep;129:e294-e302. Epub 2019 May 24 doi: 10.1016/j.wneu.2019.05.132. PMID: 31132506
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: case report and literature review.
Oishi N, Kondo T, Nakazawa T, Mochizuki K, Kasai K, Inoue T, Yamamoto T, Watanabe H, Hatsushika K, Masuyama K, Katoh R
Pathol Res Pract 2014 Dec;210(12):1142-5. Epub 2014 May 9 doi: 10.1016/j.prp.2014.04.020. PMID: 24893893
Thymomas.
LeGolvan DP, Abell MR
Cancer 1977 May;39(5):2142-57. doi: 10.1002/1097-0142(197705)39:5<2142::aid-cncr2820390531>3.0.co;2-q. PMID: 558046

Recent systematic reviews

Primary schwannoma of the thyroid gland: analysis of case characteristics and review of the literature.
Ren H, Cui X, Zhang L
BMC Surg 2024 Aug 17;24(1):234. doi: 10.1186/s12893-024-02523-y. PMID: 39154012Free PMC Article
Case Report and Systematic Review: Sarcomatoid Parathyroid Carcinoma-A Rare, Highly Malignant Subtype.
Yu Y, Wang Y, Wu Q, Zhao X, Liu D, Zhao Y, Li Y, Wang G, Xu J, Chen J, Zhang N, Tian X
Front Endocrinol (Lausanne) 2021;12:793718. Epub 2021 Dec 15 doi: 10.3389/fendo.2021.793718. PMID: 34975762Free PMC Article
Primary Tumors of the Posterior Pituitary Gland: A Systematic Review of the Literature in Light of the New 2017 World Health Organization Classification of Pituitary Tumors.
Whipple SG, Savardekar AR, Rao S, Mahadevan A, Guthikonda B, Kosty JA
World Neurosurg 2021 Jan;145:148-158. Epub 2020 Sep 8 doi: 10.1016/j.wneu.2020.09.023. PMID: 32916355

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