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Mantle cell lymphoma

MedGen UID:
1668377
•Concept ID:
C4721414
•
Neoplastic Process
Synonyms: Centrocytic Small-Cell Lymphoma; Centrocytic Small-Cell Lymphomas; Diffuse Lymphocytic Lymphoma, Poorly Differentiated; Diffuse Lymphocytic Lymphoma, Poorly-Differentiated; Lymphocytic Lymphoma, Diffuse, Poorly Differentiated; Lymphocytic Lymphoma, Diffuse, Poorly-Differentiated; Lymphoma, Centrocytic Small Cell; Lymphoma, Centrocytic Small-Cell; Lymphoma, Lymphocytic, Diffuse, Intermediate Differentiated; Lymphoma, Lymphocytic, Diffuse, Poorly-Differentiated; Lymphoma, Mantle Cell; Lymphoma, Mantle-Cell; Lymphoma, Mantle-Zone; Lymphoma, Small-Cell, Centrocytic; Lymphomas, Centrocytic Small-Cell; Lymphomas, Mantle-Cell; Lymphomas, Mantle-Zone; Mantle Cell Lymphoma; Mantle Zone Lymphoma; Mantle-Cell Lymphoma; Mantle-Cell Lymphomas; Mantle-Zone Lymphoma; Mantle-Zone Lymphomas; Small-Cell Lymphoma, Centrocytic; Small-Cell Lymphomas, Centrocytic
SNOMED CT: Mantle cell lymphoma (74654000); Mantle cell lymphoma (443487006)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Non-Mendelian inheritance (Orphanet)
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018876
OMIM®: 607585
Orphanet: ORPHA52416

Definition

Mantle cell lymphoma is a rare form of malignant non-Hodgkin lymphoma (see this term) affecting B lymphocytes in the lymph nodes in a region called the ``mantle zone''. [from ORDO]

Professional guidelines

PubMed

Mantle cell lymphoma-Update on molecular biology, prognostication and treatment approaches.
Silkenstedt E, Dreyling M
Hematol Oncol 2023 Jun;41 Suppl 1:36-42. doi: 10.1002/hon.3149. PMID: 37294961
Treatment approaches for patients with TP53-mutated mantle cell lymphoma.
Lew TE, Minson A, Dickinson M, Handunnetti SM, Blombery P, Khot A, Anderson MA, Ritchie D, Tam CS, Seymour JF
Lancet Haematol 2023 Feb;10(2):e142-e154. doi: 10.1016/S2352-3026(22)00355-6. PMID: 36725119
Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA).
Hayden PJ, Roddie C, Bader P, Basak GW, Bonig H, Bonini C, Chabannon C, Ciceri F, Corbacioglu S, Ellard R, Sanchez-Guijo F, Jäger U, Hildebrandt M, Hudecek M, Kersten MJ, Köhl U, Kuball J, Mielke S, Mohty M, Murray J, Nagler A, Rees J, Rioufol C, Saccardi R, Snowden JA, Styczynski J, Subklewe M, Thieblemont C, Topp M, Ispizua ÁU, Chen D, Vrhovac R, Gribben JG, Kröger N, Einsele H, Yakoub-Agha I
Ann Oncol 2022 Mar;33(3):259-275. Epub 2021 Dec 16 doi: 10.1016/j.annonc.2021.12.003. PMID: 34923107

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) B-Cell Lymphomas, 2024

Recent clinical studies

Etiology

Mantle cell lymphoma-Update on molecular biology, prognostication and treatment approaches.
Silkenstedt E, Dreyling M
Hematol Oncol 2023 Jun;41 Suppl 1:36-42. doi: 10.1002/hon.3149. PMID: 37294961
Treatment approaches for patients with TP53-mutated mantle cell lymphoma.
Lew TE, Minson A, Dickinson M, Handunnetti SM, Blombery P, Khot A, Anderson MA, Ritchie D, Tam CS, Seymour JF
Lancet Haematol 2023 Feb;10(2):e142-e154. doi: 10.1016/S2352-3026(22)00355-6. PMID: 36725119
New Directions for Mantle Cell Lymphoma in 2022.
Kumar A, Eyre TA, Lewis KL, Thompson MC, Cheah CY
Am Soc Clin Oncol Educ Book 2022 Apr;42:1-15. doi: 10.1200/EDBK_349509. PMID: 35561299
Mantle cell lymphoma in 2022-A comprehensive update on molecular pathogenesis, risk stratification, clinical approach, and current and novel treatments.
Jain P, Wang ML
Am J Hematol 2022 May;97(5):638-656. doi: 10.1002/ajh.26523. PMID: 35266562
Update on mantle cell lymphoma.
Maddocks K
Blood 2018 Oct 18;132(16):1647-1656. Epub 2018 Aug 28 doi: 10.1182/blood-2018-03-791392. PMID: 30154113

Diagnosis

Mantle cell lymphoma-Update on molecular biology, prognostication and treatment approaches.
Silkenstedt E, Dreyling M
Hematol Oncol 2023 Jun;41 Suppl 1:36-42. doi: 10.1002/hon.3149. PMID: 37294961
New Directions for Mantle Cell Lymphoma in 2022.
Kumar A, Eyre TA, Lewis KL, Thompson MC, Cheah CY
Am Soc Clin Oncol Educ Book 2022 Apr;42:1-15. doi: 10.1200/EDBK_349509. PMID: 35561299
Molecular Pathogenesis of Mantle Cell Lymphoma.
Navarro A, Beà S, Jares P, Campo E
Hematol Oncol Clin North Am 2020 Oct;34(5):795-807. Epub 2020 Jul 22 doi: 10.1016/j.hoc.2020.05.002. PMID: 32861278Free PMC Article
Differential diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma and other indolent lymphomas, including mantle cell lymphoma.
Yoshino T, Tanaka T, Sato Y
J Clin Exp Hematop 2020 Dec 15;60(4):124-129. Epub 2020 Apr 3 doi: 10.3960/jslrt.19041. PMID: 32249238Free PMC Article
Update on mantle cell lymphoma.
Maddocks K
Blood 2018 Oct 18;132(16):1647-1656. Epub 2018 Aug 28 doi: 10.1182/blood-2018-03-791392. PMID: 30154113

Therapy

The shifting therapeutic paradigm for relapsed/refractory mantle cell lymphoma.
Arun Kumar S, Gao J, Patel SA
Leuk Res 2023 Nov;134:107385. Epub 2023 Sep 1 doi: 10.1016/j.leukres.2023.107385. PMID: 37672954Free PMC Article
CAR T-Cell therapy for the management of mantle cell lymphoma.
Huang Z, Chavda VP, Bezbaruah R, Dhamne H, Yang DH, Zhao HB
Mol Cancer 2023 Mar 31;22(1):67. doi: 10.1186/s12943-023-01755-5. PMID: 37004047Free PMC Article
New Directions for Mantle Cell Lymphoma in 2022.
Kumar A, Eyre TA, Lewis KL, Thompson MC, Cheah CY
Am Soc Clin Oncol Educ Book 2022 Apr;42:1-15. doi: 10.1200/EDBK_349509. PMID: 35561299
Bruton Tyrosine Kinase Inhibitors: Present and Future.
Burger JA
Cancer J 2019 Nov/Dec;25(6):386-393. doi: 10.1097/PPO.0000000000000412. PMID: 31764119Free PMC Article
The hyper-CVAD regimen in adult acute lymphocytic leukemia.
Garcia-Manero G, Kantarjian HM
Hematol Oncol Clin North Am 2000 Dec;14(6):1381-96, x-xi. doi: 10.1016/s0889-8588(05)70192-1. PMID: 11147229

Prognosis

Three-Year Follow-Up of KTE-X19 in Patients With Relapsed/Refractory Mantle Cell Lymphoma, Including High-Risk Subgroups, in the ZUMA-2 Study.
Wang M, Munoz J, Goy A, Locke FL, Jacobson CA, Hill BT, Timmerman JM, Holmes H, Jaglowski S, Flinn IW, McSweeney PA, Miklos DB, Pagel JM, Kersten MJ, Bouabdallah K, Khanal R, Topp MS, Houot R, Beitinjaneh A, Peng W, Fang X, Shen RR, Siddiqi R, Kloos I, Reagan PM
J Clin Oncol 2023 Jan 20;41(3):555-567. Epub 2022 Jun 4 doi: 10.1200/JCO.21.02370. PMID: 35658525Free PMC Article
Mantle cell lymphoma: 2019 update on the diagnosis, pathogenesis, prognostication, and management.
Jain P, Wang M
Am J Hematol 2019 Jun;94(6):710-725. Epub 2019 Apr 19 doi: 10.1002/ajh.25487. PMID: 30963600
Management of adverse effects/toxicity of ibrutinib.
Paydas S
Crit Rev Oncol Hematol 2019 Apr;136:56-63. Epub 2019 Feb 10 doi: 10.1016/j.critrevonc.2019.02.001. PMID: 30878129
Orbital lymphoma.
Olsen TG, Heegaard S
Surv Ophthalmol 2019 Jan-Feb;64(1):45-66. Epub 2018 Aug 23 doi: 10.1016/j.survophthal.2018.08.002. PMID: 30144455
Update on mantle cell lymphoma.
Maddocks K
Blood 2018 Oct 18;132(16):1647-1656. Epub 2018 Aug 28 doi: 10.1182/blood-2018-03-791392. PMID: 30154113

Clinical prediction guides

Recent advances in genomics and therapeutics in mantle cell lymphoma.
Lu T, Zhang J, McCracken JM, Young KH
Cancer Treat Rev 2024 Jan;122:102651. Epub 2023 Nov 4 doi: 10.1016/j.ctrv.2023.102651. PMID: 37976759
Update on mantle cell lymphoma.
Maddocks K
Blood 2018 Oct 18;132(16):1647-1656. Epub 2018 Aug 28 doi: 10.1182/blood-2018-03-791392. PMID: 30154113
Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification.
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; Italian Lymphoma Foundation; European Organisation for Research; Treatment of Cancer/Dutch Hemato-Oncology Group; Grupo Español de Médula Ósea; German High-Grade Lymphoma Study Group; German Hodgkin's Study Group; Japanese Lymphorra Study Group; Lymphoma Study Association; NCIC Clinical Trials Group; Nordic Lymphoma Study Group; Southwest Oncology Group; United Kingdom National Cancer Research Institute
J Clin Oncol 2014 Sep 20;32(27):3059-68. doi: 10.1200/JCO.2013.54.8800. PMID: 25113753Free PMC Article
Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma.
Wang ML, Rule S, Martin P, Goy A, Auer R, Kahl BS, Jurczak W, Advani RH, Romaguera JE, Williams ME, Barrientos JC, Chmielowska E, Radford J, Stilgenbauer S, Dreyling M, Jedrzejczak WW, Johnson P, Spurgeon SE, Li L, Zhang L, Newberry K, Ou Z, Cheng N, Fang B, McGreivy J, Clow F, Buggy JJ, Chang BY, Beaupre DM, Kunkel LA, Blum KA
N Engl J Med 2013 Aug 8;369(6):507-16. Epub 2013 Jun 19 doi: 10.1056/NEJMoa1306220. PMID: 23782157Free PMC Article
A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma.
Hoster E, Dreyling M, Klapper W, Gisselbrecht C, van Hoof A, Kluin-Nelemans HC, Pfreundschuh M, Reiser M, Metzner B, Einsele H, Peter N, Jung W, Wörmann B, Ludwig WD, Dührsen U, Eimermacher H, Wandt H, Hasford J, Hiddemann W, Unterhalt M; German Low Grade Lymphoma Study Group (GLSG); European Mantle Cell Lymphoma Network
Blood 2008 Jan 15;111(2):558-65. Epub 2007 Oct 25 doi: 10.1182/blood-2007-06-095331. PMID: 17962512

Recent systematic reviews

A systematic review and meta-analysis of nonrelapse mortality after CAR T cell therapy.
Cordas Dos Santos DM, Tix T, Shouval R, Gafter-Gvili A, Alberge JB, Cliff ERS, Theurich S, von Bergwelt-Baildon M, Ghobrial IM, Subklewe M, Perales MA, Rejeski K
Nat Med 2024 Sep;30(9):2667-2678. Epub 2024 Jul 8 doi: 10.1038/s41591-024-03084-6. PMID: 38977912
Late relapse after CAR-T cell therapy for adult patients with hematologic malignancies: A definite evidence from systematic review and meta-analysis on individual data.
Zinzi A, Gaio M, Liguori V, Cagnotta C, Paolino D, Paolisso G, Castaldo G, Nicoletti GF, Rossi F, Capuano A, Rafaniello C
Pharmacol Res 2023 Apr;190:106742. Epub 2023 Mar 22 doi: 10.1016/j.phrs.2023.106742. PMID: 36963592
Efficacy and safety of ibrutinib in mantle cell lymphoma: A systematic review and meta-analysis.
Roufarshbaf M, Javeri M, Akbari V, Matin PH, Farrokhi P, Sadeghi E, Heidari Z, Moghaddas A
Daru 2022 Dec;30(2):367-378. Epub 2022 Sep 3 doi: 10.1007/s40199-022-00444-w. PMID: 36057010Free PMC Article
Genetic mutations and features of mantle cell lymphoma: a systematic review and meta-analysis.
Hill HA, Qi X, Jain P, Nomie K, Wang Y, Zhou S, Wang ML
Blood Adv 2020 Jul 14;4(13):2927-2938. doi: 10.1182/bloodadvances.2019001350. PMID: 32598477Free PMC Article
Clinical efficacy and safety in relapsed/refractory mantle cell lymphoma: a systematic literature review.
Njue A, Colosia A, Trask PC, Olivares R, Khan S, Abbe A, Police R, Wang J, Ruiz-Soto R, Kaye JA, Awan F
Clin Lymphoma Myeloma Leuk 2015 Jan;15(1):1-12.e7. Epub 2014 Jun 11 doi: 10.1016/j.clml.2014.03.006. PMID: 25052050

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    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) B-Cell Lymphomas, 2024

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