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Abnormal cord blood measurement

MedGen UID:
1671013
•Concept ID:
C4732848
•
Finding
HPO: HP:0410210

Definition

An abnormality in any umbilical cord measurement performed after birth, such as the blood gas level. [from HPO]

Professional guidelines

PubMed

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Guidelines-similarities and dissimilarities: a systematic review of international clinical practice guidelines for pregnancy hypertension.
Scott G, Gillon TE, Pels A, von Dadelszen P, Magee LA
Am J Obstet Gynecol 2022 Feb;226(2S):S1222-S1236. Epub 2020 Aug 20 doi: 10.1016/j.ajog.2020.08.018. PMID: 32828743
Society for Maternal-Fetal Medicine Consult Series #53: Intrahepatic cholestasis of pregnancy: Replaces Consult #13, April 2011.
Society for Maternal-Fetal Medicine (SMFM). Electronic address: pubs@smfm.org, Lee RH, Mara Greenberg, Metz TD, Pettker CM
Am J Obstet Gynecol 2021 Feb;224(2):B2-B9. Epub 2020 Nov 13 doi: 10.1016/j.ajog.2020.11.002. PMID: 33197417

Recent clinical studies

Etiology

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Diagnosis of major heart defects by routine first-trimester ultrasound examination: association with increased nuchal translucency, tricuspid regurgitation and abnormal flow in ductus venosus.
Minnella GP, Crupano FM, Syngelaki A, Zidere V, Akolekar R, Nicolaides KH
Ultrasound Obstet Gynecol 2020 May;55(5):637-644. doi: 10.1002/uog.21956. PMID: 31875326
Methodological Approaches to Evaluate Fetal Drug Exposure.
Bouazza N, Foissac F, Hirt D, Urien S, Benaboud S, Lui G, Treluyer JM
Curr Pharm Des 2019;25(5):496-504. doi: 10.2174/1381612825666190319102812. PMID: 30892158
Amniotic fluid and umbilical cord serum erythropoietin in term and prolonged pregnancies.
Seikku L, Stefanovic V, Rahkonen P, Teramo K, Paavonen J, Tikkanen M, Rahkonen L
Eur J Obstet Gynecol Reprod Biol 2019 Feb;233:1-5. Epub 2018 Dec 3 doi: 10.1016/j.ejogrb.2018.11.022. PMID: 30529256
Genetic Screening and the Obese Gravida.
Rose NC
Clin Obstet Gynecol 2016 Mar;59(1):140-7. doi: 10.1097/GRF.0000000000000172. PMID: 26670835

Diagnosis

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Diagnosis of major heart defects by routine first-trimester ultrasound examination: association with increased nuchal translucency, tricuspid regurgitation and abnormal flow in ductus venosus.
Minnella GP, Crupano FM, Syngelaki A, Zidere V, Akolekar R, Nicolaides KH
Ultrasound Obstet Gynecol 2020 May;55(5):637-644. doi: 10.1002/uog.21956. PMID: 31875326
Amniotic fluid and umbilical cord serum erythropoietin in term and prolonged pregnancies.
Seikku L, Stefanovic V, Rahkonen P, Teramo K, Paavonen J, Tikkanen M, Rahkonen L
Eur J Obstet Gynecol Reprod Biol 2019 Feb;233:1-5. Epub 2018 Dec 3 doi: 10.1016/j.ejogrb.2018.11.022. PMID: 30529256
Women should decide which conditions matter.
Norton ME, Kuppermann M
Am J Obstet Gynecol 2016 Nov;215(5):583-587.e1. doi: 10.1016/j.ajog.2016.06.045. PMID: 27793311
Genetic Screening and the Obese Gravida.
Rose NC
Clin Obstet Gynecol 2016 Mar;59(1):140-7. doi: 10.1097/GRF.0000000000000172. PMID: 26670835

Therapy

Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Polycystic ovary syndrome: a "risk-enhancing" factor for cardiovascular disease.
Guan C, Zahid S, Minhas AS, Ouyang P, Vaught A, Baker VL, Michos ED
Fertil Steril 2022 May;117(5):924-935. doi: 10.1016/j.fertnstert.2022.03.009. PMID: 35512976
Effectiveness of breathing exercises, foot reflexology and back massage (BRM) on labour pain, anxiety, duration, satisfaction, stress hormones and newborn outcomes among primigravidae during the first stage of labour in Saudi Arabia: a study protocol for a randomised controlled trial.
Baljon KJ, Romli MH, Ismail AH, Khuan L, Chew BH
BMJ Open 2020 Jun 15;10(6):e033844. doi: 10.1136/bmjopen-2019-033844. PMID: 32540887Free PMC Article
Cell-free DNA analysis for noninvasive examination of trisomy.
Norton ME, Jacobsson B, Swamy GK, Laurent LC, Ranzini AC, Brar H, Tomlinson MW, Pereira L, Spitz JL, Hollemon D, Cuckle H, Musci TJ, Wapner RJ
N Engl J Med 2015 Apr 23;372(17):1589-97. Epub 2015 Apr 1 doi: 10.1056/NEJMoa1407349. PMID: 25830321
Pesticide exposure in children.
Roberts JR, Karr CJ; Council On Environmental Health
Pediatrics 2012 Dec;130(6):e1765-88. Epub 2012 Nov 26 doi: 10.1542/peds.2012-2758. PMID: 23184105Free PMC Article

Prognosis

Diagnosis of major heart defects by routine first-trimester ultrasound examination: association with increased nuchal translucency, tricuspid regurgitation and abnormal flow in ductus venosus.
Minnella GP, Crupano FM, Syngelaki A, Zidere V, Akolekar R, Nicolaides KH
Ultrasound Obstet Gynecol 2020 May;55(5):637-644. doi: 10.1002/uog.21956. PMID: 31875326
Methodological Approaches to Evaluate Fetal Drug Exposure.
Bouazza N, Foissac F, Hirt D, Urien S, Benaboud S, Lui G, Treluyer JM
Curr Pharm Des 2019;25(5):496-504. doi: 10.2174/1381612825666190319102812. PMID: 30892158
Cell-free DNA analysis for noninvasive examination of trisomy.
Norton ME, Jacobsson B, Swamy GK, Laurent LC, Ranzini AC, Brar H, Tomlinson MW, Pereira L, Spitz JL, Hollemon D, Cuckle H, Musci TJ, Wapner RJ
N Engl J Med 2015 Apr 23;372(17):1589-97. Epub 2015 Apr 1 doi: 10.1056/NEJMoa1407349. PMID: 25830321
Interpretation of clotting tests in the neonate.
Pal S, Curley A, Stanworth SJ
Arch Dis Child Fetal Neonatal Ed 2015 May;100(3):F270-4. Epub 2014 Nov 20 doi: 10.1136/archdischild-2014-306196. PMID: 25414486
SURUSS in perspective.
Wald NJ, Rodeck C, Hackshaw AK, Rudnicka A
Semin Perinatol 2005 Aug;29(4):225-35. doi: 10.1053/j.semperi.2005.05.006. PMID: 16104673

Clinical prediction guides

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Diagnosis of major heart defects by routine first-trimester ultrasound examination: association with increased nuchal translucency, tricuspid regurgitation and abnormal flow in ductus venosus.
Minnella GP, Crupano FM, Syngelaki A, Zidere V, Akolekar R, Nicolaides KH
Ultrasound Obstet Gynecol 2020 May;55(5):637-644. doi: 10.1002/uog.21956. PMID: 31875326
Methodological Approaches to Evaluate Fetal Drug Exposure.
Bouazza N, Foissac F, Hirt D, Urien S, Benaboud S, Lui G, Treluyer JM
Curr Pharm Des 2019;25(5):496-504. doi: 10.2174/1381612825666190319102812. PMID: 30892158
Amniotic fluid and umbilical cord serum erythropoietin in term and prolonged pregnancies.
Seikku L, Stefanovic V, Rahkonen P, Teramo K, Paavonen J, Tikkanen M, Rahkonen L
Eur J Obstet Gynecol Reprod Biol 2019 Feb;233:1-5. Epub 2018 Dec 3 doi: 10.1016/j.ejogrb.2018.11.022. PMID: 30529256
Clinical significance of cerebroplacental ratio.
Kalafat E, Khalil A
Curr Opin Obstet Gynecol 2018 Dec;30(6):344-354. doi: 10.1097/GCO.0000000000000490. PMID: 30299319

Recent systematic reviews

Genetic Variation and Sickle Cell Disease Severity: A Systematic Review and Meta-Analysis.
Kirkham JK, Estepp JH, Weiss MJ, Rashkin SR
JAMA Netw Open 2023 Oct 2;6(10):e2337484. doi: 10.1001/jamanetworkopen.2023.37484. PMID: 37851445Free PMC Article
Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia: a systematic review and individual-participant data meta-analysis.
Toloza FJK, Derakhshan A, Männistö T, Bliddal S, Popova PV, Carty DM, Chen L, Taylor P, Mosso L, Oken E, Suvanto E, Itoh S, Kishi R, Bassols J, Auvinen J, López-Bermejo A, Brown SJ, Boucai L, Hisada A, Yoshinaga J, Shilova E, Grineva EN, Vrijkotte TGM, Sunyer J, Jiménez-Zabala A, Riaño-Galan I, Lopez-Espinosa MJ, Prokop LJ, Singh Ospina N, Brito JP, Rodriguez-Gutierrez R, Alexander EK, Chaker L, Pearce EN, Peeters RP, Feldt-Rasmussen U, Guxens M, Chatzi L, Delles C, Roeters van Lennep JE, Pop VJM, Lu X, Walsh JP, Nelson SM, Korevaar TIM, Maraka S
Lancet Diabetes Endocrinol 2022 Apr;10(4):243-252. Epub 2022 Mar 4 doi: 10.1016/S2213-8587(22)00007-9. PMID: 35255260Free PMC Article
Guidelines-similarities and dissimilarities: a systematic review of international clinical practice guidelines for pregnancy hypertension.
Scott G, Gillon TE, Pels A, von Dadelszen P, Magee LA
Am J Obstet Gynecol 2022 Feb;226(2S):S1222-S1236. Epub 2020 Aug 20 doi: 10.1016/j.ajog.2020.08.018. PMID: 32828743
Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity With Preterm Birth: A Systematic Review and Meta-analysis.
Consortium on Thyroid and Pregnancy—Study Group on Preterm Birth, Korevaar TIM, Derakhshan A, Taylor PN, Meima M, Chen L, Bliddal S, Carty DM, Meems M, Vaidya B, Shields B, Ghafoor F, Popova PV, Mosso L, Oken E, Suvanto E, Hisada A, Yoshinaga J, Brown SJ, Bassols J, Auvinen J, Bramer WM, López-Bermejo A, Dayan C, Boucai L, Vafeiadi M, Grineva EN, Tkachuck AS, Pop VJM, Vrijkotte TG, Guxens M, Chatzi L, Sunyer J, Jiménez-Zabala A, Riaño I, Murcia M, Lu X, Mukhtar S, Delles C, Feldt-Rasmussen U, Nelson SM, Alexander EK, Chaker L, Männistö T, Walsh JP, Pearce EN, Steegers EAP, Peeters RP
JAMA 2019 Aug 20;322(7):632-641. doi: 10.1001/jama.2019.10931. PMID: 31429897Free PMC Article
Accuracy of non-invasive prenatal testing using cell-free DNA for detection of Down, Edwards and Patau syndromes: a systematic review and meta-analysis.
Taylor-Phillips S, Freeman K, Geppert J, Agbebiyi A, Uthman OA, Madan J, Clarke A, Quenby S, Clarke A
BMJ Open 2016 Jan 18;6(1):e010002. doi: 10.1136/bmjopen-2015-010002. PMID: 26781507Free PMC Article

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