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Blasts 0.1 Percent or More of Bone Marrow Nucleated Cells

MedGen UID:
1676927
•Concept ID:
C4763526
•
Finding
Synonym: Blasts Greater than or Equal to 0.1 Percent of Bone Marrow Nucleated Cells

Definition

A semi-quantitative microscopic finding indicating that at least 0.1 percent of the nucleated cells in a bone marrow sample are immature mononuclear cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBlasts 0.1 Percent or More of Bone Marrow Nucleated Cells

Professional guidelines

PubMed

Bone Marrow Nucleated Cells and Bone Marrow-Derived CD271+ Mesenchymal Stem Cell in Treatment of Encephalopathy and Drug-Resistant Epilepsy.
Milczarek O, Jarocha D, Starowicz-Filip A, Kasprzycki M, Kijowski J, Mordel A, Kwiatkowski S, Majka M
Stem Cell Rev Rep 2024 May;20(4):1015-1025. Epub 2024 Mar 14 doi: 10.1007/s12015-023-10673-4. PMID: 38483743
A Review of Commercially Available Point-of-Care Devices to Concentrate Bone Marrow for the Treatment of Osteoarthritis and Focal Cartilage Lesions.
Gaul F, Bugbee WD, Hoenecke HR Jr, D'Lima DD
Cartilage 2019 Oct;10(4):387-394. Epub 2018 Apr 13 doi: 10.1177/1947603518768080. PMID: 29652173Free PMC Article
Diagnostic criteria for hypocellular acute leukemia: a clinical entity distinct from overt acute leukemia and myelodysplastic syndrome.
Nagai K, Kohno T, Chen YX, Tsushima H, Mori H, Nakamura H, Jinnai I, Matsuo T, Kuriyama K, Tomonaga M, Bennett JM
Leuk Res 1996 Jul;20(7):563-74. doi: 10.1016/0145-2126(95)00136-0. PMID: 8795690

Recent clinical studies

Etiology

Alterations of the expression of TET2 and DNA 5-hmC predict poor prognosis in Myelodysplastic Neoplasms.
Seethy AA, Pethusamy K, Kushwaha T, Kumar G, Talukdar J, Chaubey R, Sundaram UD, Mahapatra M, Saxena R, Dhar R, Inampudi KK, Karmakar S
BMC Cancer 2023 Oct 26;23(1):1035. doi: 10.1186/s12885-023-11449-2. PMID: 37884893Free PMC Article
Can velmanase alfa be the next widespread potential therapy for alpha-mannosidosis?
Abdul Ghani S, Burney S, Ul Hussain H, Abdul Wahid M, Mumtaz H
Int J Surg 2023 Sep 1;109(9):2882-2885. doi: 10.1097/JS9.0000000000000528. PMID: 37352513Free PMC Article
Haploidentical bone marrow transplantation in patients with relapsed or refractory severe aplastic anaemia in the USA (BMT CTN 1502): a multicentre, single-arm, phase 2 trial.
DeZern AE, Eapen M, Wu J, Talano JA, Solh M, Dávila Saldaña BJ, Karanes C, Horwitz ME, Mallhi K, Arai S, Farhadfar N, Hexner E, Westervelt P, Antin JH, Deeg HJ, Leifer E, Brodsky RA, Logan BR, Horowitz MM, Jones RJ, Pulsipher MA
Lancet Haematol 2022 Sep;9(9):e660-e669. Epub 2022 Jul 27 doi: 10.1016/S2352-3026(22)00206-X. PMID: 35907408Free PMC Article
In vitro-derived platelets: the challenges we will have to face to assess quality and safety.
Mookerjee S, Foster HR, Waller AK, Ghevaert CJ
Platelets 2020 Aug 17;31(6):724-730. Epub 2020 Jun 2 doi: 10.1080/09537104.2020.1769051. PMID: 32486997
Acute megakaryoblastic leukemia.
Gassmann W, Löffler H
Leuk Lymphoma 1995;18 Suppl 1:69-73. doi: 10.3109/10428199509075307. PMID: 7496359

Diagnosis

Can velmanase alfa be the next widespread potential therapy for alpha-mannosidosis?
Abdul Ghani S, Burney S, Ul Hussain H, Abdul Wahid M, Mumtaz H
Int J Surg 2023 Sep 1;109(9):2882-2885. doi: 10.1097/JS9.0000000000000528. PMID: 37352513Free PMC Article
Bioengineered Exosomal Extracellular Vesicles in Cancer Therapeutics.
Miles J, Andre M, Caobi A, Ruiz M, Nair M, Raymond AD
Crit Rev Biomed Eng 2020;48(3):177-187. doi: 10.1615/CritRevBiomedEng.2020034847. PMID: 33389895Free PMC Article
The challenging task of enumerating blasts in the bone marrow.
Hodes A, Calvo KR, Dulau A, Maric I, Sun J, Braylan R
Semin Hematol 2019 Jan;56(1):58-64. Epub 2018 Aug 16 doi: 10.1053/j.seminhematol.2018.07.001. PMID: 30573046
Fat Embolism Syndrome Secondary to Bone Marrow Necrosis in Patients with Hemoglobinopathies.
Gangaraju R, Reddy VV, Marques MB
South Med J 2016 Sep;109(9):549-53. doi: 10.14423/SMJ.0000000000000520. PMID: 27598359
Acute megakaryoblastic leukemia.
Gassmann W, Löffler H
Leuk Lymphoma 1995;18 Suppl 1:69-73. doi: 10.3109/10428199509075307. PMID: 7496359

Therapy

Can velmanase alfa be the next widespread potential therapy for alpha-mannosidosis?
Abdul Ghani S, Burney S, Ul Hussain H, Abdul Wahid M, Mumtaz H
Int J Surg 2023 Sep 1;109(9):2882-2885. doi: 10.1097/JS9.0000000000000528. PMID: 37352513Free PMC Article
Haploidentical bone marrow transplantation in patients with relapsed or refractory severe aplastic anaemia in the USA (BMT CTN 1502): a multicentre, single-arm, phase 2 trial.
DeZern AE, Eapen M, Wu J, Talano JA, Solh M, Dávila Saldaña BJ, Karanes C, Horwitz ME, Mallhi K, Arai S, Farhadfar N, Hexner E, Westervelt P, Antin JH, Deeg HJ, Leifer E, Brodsky RA, Logan BR, Horowitz MM, Jones RJ, Pulsipher MA
Lancet Haematol 2022 Sep;9(9):e660-e669. Epub 2022 Jul 27 doi: 10.1016/S2352-3026(22)00206-X. PMID: 35907408Free PMC Article
Expansion of immature, nucleated red blood cells by transient low-dose methotrexate immune tolerance induction in mice.
Tran JQ, Grover D, Zhang M, Stapels M, Brennan R, Bangari DS, Piepenhagen PA, Roberts E, Oliva P, Zubair F, Vela JL, Richards SM, Joseph AM
Clin Exp Immunol 2021 Mar;203(3):409-423. Epub 2020 Dec 16 doi: 10.1111/cei.13552. PMID: 33205401Free PMC Article
The Concentration of Total Nucleated Cells in Harvested Bone Marrow for Transplantation Has Decreased over Time.
Prokopishyn NL, Logan BR, Kiefer DM, Sees JA, Chitphakdithai P, Ahmed IA, Anderlini PN, Beitinjaneh AM, Bredeson C, Cerny J, Chhabra S, Daly A, Diaz MA, Farhadfar N, Frangoul HA, Ganguly S, Gastineau DA, Gergis U, Hale GA, Hematti P, Kamble RT, Kasow KA, Lazarus HM, Liesveld JL, Murthy HS, Norkin M, Olsson RF, Papari M, Savani BN, Szer J, Waller EK, Wirk B, Yared JA, Pulsipher MA, Shah NN, Switzer GE, O'Donnell PV, Confer DL, Shaw BE
Biol Blood Marrow Transplant 2019 Jul;25(7):1325-1330. Epub 2019 Feb 2 doi: 10.1016/j.bbmt.2019.01.034. PMID: 30716454Free PMC Article
Bone marrow harvest from unrelated donors-up-to-date methodology.
Pruszczyk K, Skwierawska K, Król M, Moskowicz A, Jabłoński D, Torosian T, Piotrowska I, Urbanowska E, Wiktor-Jędrzejczak W, Snarski E
Eur J Haematol 2017 Oct;99(4):357-365. doi: 10.1111/ejh.12929. PMID: 28719093

Prognosis

Alterations of the expression of TET2 and DNA 5-hmC predict poor prognosis in Myelodysplastic Neoplasms.
Seethy AA, Pethusamy K, Kushwaha T, Kumar G, Talukdar J, Chaubey R, Sundaram UD, Mahapatra M, Saxena R, Dhar R, Inampudi KK, Karmakar S
BMC Cancer 2023 Oct 26;23(1):1035. doi: 10.1186/s12885-023-11449-2. PMID: 37884893Free PMC Article
Minimal/Measurable Disease Analysis in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma by Flow Cytometry.
Gao Q, Roshal M
Curr Protoc 2022 Aug;2(8):e503. doi: 10.1002/cpz1.503. PMID: 35980134Free PMC Article
Bioengineered Exosomal Extracellular Vesicles in Cancer Therapeutics.
Miles J, Andre M, Caobi A, Ruiz M, Nair M, Raymond AD
Crit Rev Biomed Eng 2020;48(3):177-187. doi: 10.1615/CritRevBiomedEng.2020034847. PMID: 33389895Free PMC Article
The challenging task of enumerating blasts in the bone marrow.
Hodes A, Calvo KR, Dulau A, Maric I, Sun J, Braylan R
Semin Hematol 2019 Jan;56(1):58-64. Epub 2018 Aug 16 doi: 10.1053/j.seminhematol.2018.07.001. PMID: 30573046
Human leukocyte antigen matching in cord blood transplantation.
Gluckman E, Koegler G, Rocha V
Semin Hematol 2005 Apr;42(2):85-90. doi: 10.1053/j.seminhematol.2005.01.006. PMID: 15846574

Clinical prediction guides

Determining hemodilution in diagnostic bone marrow aspirated samples in plasma cell disorders by next-generation flow cytometry: Proposal for a bone marrow quality index.
Óskarsson JÞ, Rögnvaldsson S, Thorsteinsdottir S, Aspelund T, Gunnarsson SB, Hákonardóttir GK, Sigurðardóttir GÁ, Þórðardóttir ÁR, Gíslason GK, Ólafsson A, Sigurðsson JK, Eyþórsson E, Jónsson Á, Viðarsson B, Önundarson PT, Agnarsson BA, Pálmason R, Sigurðardóttir M, Þorsteinsdóttir I, Ólafsson Í, Harding S, Flores-Montero J, Orfao A, Durie BGM, Love TJ, Kristinsson SY
Blood Cancer J 2023 Dec 1;13(1):177. doi: 10.1038/s41408-023-00951-2. PMID: 38040702Free PMC Article
Alterations of the expression of TET2 and DNA 5-hmC predict poor prognosis in Myelodysplastic Neoplasms.
Seethy AA, Pethusamy K, Kushwaha T, Kumar G, Talukdar J, Chaubey R, Sundaram UD, Mahapatra M, Saxena R, Dhar R, Inampudi KK, Karmakar S
BMC Cancer 2023 Oct 26;23(1):1035. doi: 10.1186/s12885-023-11449-2. PMID: 37884893Free PMC Article
Biofabrication of anin-vitrobone model for Gaucher disease.
Banerjee D, Ivanova MM, Celik N, Kim MH, Derman ID, Limgala RP, Ozbolat IT, Goker-Alpan O
Biofabrication 2023 Sep 22;15(4) doi: 10.1088/1758-5090/acf95a. PMID: 37703870Free PMC Article
Haploidentical bone marrow transplantation in patients with relapsed or refractory severe aplastic anaemia in the USA (BMT CTN 1502): a multicentre, single-arm, phase 2 trial.
DeZern AE, Eapen M, Wu J, Talano JA, Solh M, Dávila Saldaña BJ, Karanes C, Horwitz ME, Mallhi K, Arai S, Farhadfar N, Hexner E, Westervelt P, Antin JH, Deeg HJ, Leifer E, Brodsky RA, Logan BR, Horowitz MM, Jones RJ, Pulsipher MA
Lancet Haematol 2022 Sep;9(9):e660-e669. Epub 2022 Jul 27 doi: 10.1016/S2352-3026(22)00206-X. PMID: 35907408Free PMC Article
The challenging task of enumerating blasts in the bone marrow.
Hodes A, Calvo KR, Dulau A, Maric I, Sun J, Braylan R
Semin Hematol 2019 Jan;56(1):58-64. Epub 2018 Aug 16 doi: 10.1053/j.seminhematol.2018.07.001. PMID: 30573046

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