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Metastatic Prostate Adenocarcinoma

MedGen UID:
167835
•Concept ID:
C0862636
•
Neoplastic Process
Synonym: Metastatic Prostatic Adenocarcinoma

Definition

An adenocarcinoma that arises from the prostate gland and has spread to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Prostate Adenocarcinoma

Professional guidelines

PubMed

Novel therapeutic compounds for prostate adenocarcinoma treatment: An analysis using bioinformatic approaches and the CMap database.
Li K, Fan J, Qin X, Wei Q
Medicine (Baltimore) 2020 Dec 18;99(51):e23768. doi: 10.1097/MD.0000000000023768. PMID: 33371142Free PMC Article
Roles of Alternative RNA Splicing of the Bif-1 Gene by SRRM4 During the Development of Treatment-induced Neuroendocrine Prostate Cancer.
Gan Y, Li Y, Long Z, Lee AR, Xie N, Lovnicki JM, Tang Y, Chen X, Huang J, Dong X
EBioMedicine 2018 May;31:267-275. Epub 2018 May 16 doi: 10.1016/j.ebiom.2018.05.002. PMID: 29759485Free PMC Article

Recent clinical studies

Etiology

Metastatic prostate adenocarcinoma to the brain - a clinicopathologic analysis of 21 cases.
Ajmal N, Deng Y, Kenyon LC, Curtis MT, Dispagna M, Izes J, Li L
Diagn Pathol 2024 Oct 1;19(1):132. doi: 10.1186/s13000-024-01554-6. PMID: 39354583Free PMC Article
Immunogenomic Landscape of Neuroendocrine Prostate Cancer.
Bhinder B, Ferguson A, Sigouros M, Uppal M, Elsaeed AG, Bareja R, Alnajar H, Eng KW, Conteduca V, Sboner A, Mosquera JM, Elemento O, Beltran H
Clin Cancer Res 2023 Aug 1;29(15):2933-2943. doi: 10.1158/1078-0432.CCR-22-3743. PMID: 37223924Free PMC Article
Abiraterone plus prednisone added to androgen deprivation therapy and docetaxel in de novo metastatic castration-sensitive prostate cancer (PEACE-1): a multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design.
Fizazi K, Foulon S, Carles J, Roubaud G, McDermott R, Fléchon A, Tombal B, Supiot S, Berthold D, Ronchin P, Kacso G, Gravis G, Calabro F, Berdah JF, Hasbini A, Silva M, Thiery-Vuillemin A, Latorzeff I, Mourey L, Laguerre B, Abadie-Lacourtoisie S, Martin E, El Kouri C, Escande A, Rosello A, Magne N, Schlurmann F, Priou F, Chand-Fouche ME, Freixa SV, Jamaluddin M, Rieger I, Bossi A; PEACE-1 investigators
Lancet 2022 Apr 30;399(10336):1695-1707. Epub 2022 Apr 8 doi: 10.1016/S0140-6736(22)00367-1. PMID: 35405085
Metastatic prostate adenocarcinoma to cervical lymph nodes: an unusual diagnosis on fine-needle aspiration biopsy.
Albadri ST, Salomão D
J Am Soc Cytopathol 2021 Mar-Apr;10(2):231-238. Epub 2020 Aug 25 doi: 10.1016/j.jasc.2020.08.009. PMID: 32950433
The U Shape of Prostate-specific Antigen and Prostate Cancer-specific Mortality in High-grade Metastatic Prostate Adenocarcinoma.
Wang J, Abudurexiti M, Shao N, Wei Y, Zhu Y, Ye DW
Eur Urol Focus 2020 Jan 15;6(1):53-62. Epub 2018 Sep 11 doi: 10.1016/j.euf.2018.08.024. PMID: 30217630

Diagnosis

Metastatic prostate adenocarcinoma to the brain - a clinicopathologic analysis of 21 cases.
Ajmal N, Deng Y, Kenyon LC, Curtis MT, Dispagna M, Izes J, Li L
Diagn Pathol 2024 Oct 1;19(1):132. doi: 10.1186/s13000-024-01554-6. PMID: 39354583Free PMC Article
Abiraterone plus prednisone added to androgen deprivation therapy and docetaxel in de novo metastatic castration-sensitive prostate cancer (PEACE-1): a multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design.
Fizazi K, Foulon S, Carles J, Roubaud G, McDermott R, Fléchon A, Tombal B, Supiot S, Berthold D, Ronchin P, Kacso G, Gravis G, Calabro F, Berdah JF, Hasbini A, Silva M, Thiery-Vuillemin A, Latorzeff I, Mourey L, Laguerre B, Abadie-Lacourtoisie S, Martin E, El Kouri C, Escande A, Rosello A, Magne N, Schlurmann F, Priou F, Chand-Fouche ME, Freixa SV, Jamaluddin M, Rieger I, Bossi A; PEACE-1 investigators
Lancet 2022 Apr 30;399(10336):1695-1707. Epub 2022 Apr 8 doi: 10.1016/S0140-6736(22)00367-1. PMID: 35405085
Metastatic prostate adenocarcinoma to cervical lymph nodes: an unusual diagnosis on fine-needle aspiration biopsy.
Albadri ST, Salomão D
J Am Soc Cytopathol 2021 Mar-Apr;10(2):231-238. Epub 2020 Aug 25 doi: 10.1016/j.jasc.2020.08.009. PMID: 32950433
The U Shape of Prostate-specific Antigen and Prostate Cancer-specific Mortality in High-grade Metastatic Prostate Adenocarcinoma.
Wang J, Abudurexiti M, Shao N, Wei Y, Zhu Y, Ye DW
Eur Urol Focus 2020 Jan 15;6(1):53-62. Epub 2018 Sep 11 doi: 10.1016/j.euf.2018.08.024. PMID: 30217630
Performance of different prostate specific antibodies in the cytological diagnosis of metastatic prostate adenocarcinoma.
Jia L, Jiang Y, Michael CW
Diagn Cytopathol 2017 Nov;45(11):998-1004. Epub 2017 Sep 9 doi: 10.1002/dc.23809. PMID: 28888085

Therapy

Eruptive Papules as a Cutaneous Manifestation of Metastatic Prostate Adenocarcinoma.
Onalaja-Underwood AA, Sokumbi O
Am J Dermatopathol 2023 Dec 1;45(12):828-830. doi: 10.1097/DAD.0000000000002559. PMID: 37883967
Abiraterone plus prednisone added to androgen deprivation therapy and docetaxel in de novo metastatic castration-sensitive prostate cancer (PEACE-1): a multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design.
Fizazi K, Foulon S, Carles J, Roubaud G, McDermott R, Fléchon A, Tombal B, Supiot S, Berthold D, Ronchin P, Kacso G, Gravis G, Calabro F, Berdah JF, Hasbini A, Silva M, Thiery-Vuillemin A, Latorzeff I, Mourey L, Laguerre B, Abadie-Lacourtoisie S, Martin E, El Kouri C, Escande A, Rosello A, Magne N, Schlurmann F, Priou F, Chand-Fouche ME, Freixa SV, Jamaluddin M, Rieger I, Bossi A; PEACE-1 investigators
Lancet 2022 Apr 30;399(10336):1695-1707. Epub 2022 Apr 8 doi: 10.1016/S0140-6736(22)00367-1. PMID: 35405085
Circulating tumor DNA profile recognizes transformation to castration-resistant neuroendocrine prostate cancer.
Beltran H, Romanel A, Conteduca V, Casiraghi N, Sigouros M, Franceschini GM, Orlando F, Fedrizzi T, Ku SY, Dann E, Alonso A, Mosquera JM, Sboner A, Xiang J, Elemento O, Nanus DM, Tagawa ST, Benelli M, Demichelis F
J Clin Invest 2020 Apr 1;130(4):1653-1668. doi: 10.1172/JCI131041. PMID: 32091413Free PMC Article
Quantitative Test-Retest Measurement of (68)Ga-PSMA-HBED-CC in Tumor and Normal Tissue.
Pollard JH, Raman C, Zakharia Y, Tracy CR, Nepple KG, Ginader T, Breheny P, Sunderland JJ
J Nucl Med 2020 Aug;61(8):1145-1152. Epub 2019 Dec 5 doi: 10.2967/jnumed.119.236083. PMID: 31806776
P450-dependent enzymes as targets for prostate cancer therapy.
De Coster R, Wouters W, Bruynseels J
J Steroid Biochem Mol Biol 1996 Jan;56(1-6 Spec No):133-43. doi: 10.1016/0960-0760(95)00230-8. PMID: 8603034

Prognosis

Metastatic prostate adenocarcinoma to the brain - a clinicopathologic analysis of 21 cases.
Ajmal N, Deng Y, Kenyon LC, Curtis MT, Dispagna M, Izes J, Li L
Diagn Pathol 2024 Oct 1;19(1):132. doi: 10.1186/s13000-024-01554-6. PMID: 39354583Free PMC Article
Identification of Novel Diagnosis Biomarkers for Therapy-Related Neuroendocrine Prostate Cancer.
Zhang C, Qian J, Wu Y, Zhu Z, Yu W, Gong Y, Li X, He Z, Zhou L
Pathol Oncol Res 2021;27:1609968. Epub 2021 Sep 27 doi: 10.3389/pore.2021.1609968. PMID: 34646089Free PMC Article
Metastatic Prostate Adenocarcinoma of the Mandible Diagnosed With Oral Manifestations.
Ayranci F, Omezli MM, Torul D, Ay M
J Craniofac Surg 2020 May/Jun;31(3):e220-e222. doi: 10.1097/SCS.0000000000006025. PMID: 31688259
The U Shape of Prostate-specific Antigen and Prostate Cancer-specific Mortality in High-grade Metastatic Prostate Adenocarcinoma.
Wang J, Abudurexiti M, Shao N, Wei Y, Zhu Y, Ye DW
Eur Urol Focus 2020 Jan 15;6(1):53-62. Epub 2018 Sep 11 doi: 10.1016/j.euf.2018.08.024. PMID: 30217630
Metastatic prostate adenocarcinoma to the penis: a series of 29 cases with predilection for ductal adenocarcinoma.
Ellis CL, Epstein JI
Am J Surg Pathol 2015 Jan;39(1):67-74. doi: 10.1097/PAS.0000000000000289. PMID: 25025445

Clinical prediction guides

Identification of Novel Diagnosis Biomarkers for Therapy-Related Neuroendocrine Prostate Cancer.
Zhang C, Qian J, Wu Y, Zhu Z, Yu W, Gong Y, Li X, He Z, Zhou L
Pathol Oncol Res 2021;27:1609968. Epub 2021 Sep 27 doi: 10.3389/pore.2021.1609968. PMID: 34646089Free PMC Article
Circulating tumor DNA profile recognizes transformation to castration-resistant neuroendocrine prostate cancer.
Beltran H, Romanel A, Conteduca V, Casiraghi N, Sigouros M, Franceschini GM, Orlando F, Fedrizzi T, Ku SY, Dann E, Alonso A, Mosquera JM, Sboner A, Xiang J, Elemento O, Nanus DM, Tagawa ST, Benelli M, Demichelis F
J Clin Invest 2020 Apr 1;130(4):1653-1668. doi: 10.1172/JCI131041. PMID: 32091413Free PMC Article
The U Shape of Prostate-specific Antigen and Prostate Cancer-specific Mortality in High-grade Metastatic Prostate Adenocarcinoma.
Wang J, Abudurexiti M, Shao N, Wei Y, Zhu Y, Ye DW
Eur Urol Focus 2020 Jan 15;6(1):53-62. Epub 2018 Sep 11 doi: 10.1016/j.euf.2018.08.024. PMID: 30217630
Metastatic prostate adenocarcinoma to the penis: a series of 29 cases with predilection for ductal adenocarcinoma.
Ellis CL, Epstein JI
Am J Surg Pathol 2015 Jan;39(1):67-74. doi: 10.1097/PAS.0000000000000289. PMID: 25025445
Clinical outcome of Taiwanese men with metastatic prostate cancer compared with other ethnic groups.
Chen CH, Tzai TS, Huang SP, Wu HC, Tai HC, Chang YH, Pu YS
Urology 2008 Dec;72(6):1287-92. Epub 2008 Apr 18 doi: 10.1016/j.urology.2008.01.026. PMID: 18372020

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