Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Chronic decreased circulating total IgG

MedGen UID:: 1685230
•Concept ID:: C5139153
•: Finding

Synonym:	Chronic decreased total IgG in blood

HPO:	HP:0032134

Definition

A lasting reduction beneath the normal level of total immunoglobulin G (IgG) in the blood. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVChronic decreased circulating total IgG

Abnormal lymphocyte physiology
- Abnormality of B cell physiology
  - Abnormal circulating immunoglobulin concentration
    - Abnormal circulating IgG concentration
      - Decreased circulating IgG concentration
        Decreased circulating total IgG concentration
        Chronic decreased circulating total IgG

Conditions with this feature

Immunodeficiency, common variable, 3

MedGen UID:: 462088
•Concept ID:: C3150738
•: Disease or Syndrome

See: Condition Record

Immunodeficiency, common variable, 5

MedGen UID:: 462090
•Concept ID:: C3150740
•: Disease or Syndrome

Any common variable immunodeficiency in which the cause of the disease is a mutation in the MS4A1 gene.

See: Condition Record

Immunodeficiency, common variable, 6

MedGen UID:: 462091
•Concept ID:: C3150741
•: Disease or Syndrome

Any common variable immunodeficiency in which the cause of the disease is a mutation in the CD81 gene.

See: Condition Record

Immunodeficiency 47

MedGen UID:: 934786
•Concept ID:: C4310819
•: Disease or Syndrome

Immunodeficiency-47 (IMD47) is an X-linked recessive complex syndrome characterized by liver dysfunction, recurrent bacterial infections, hypogammaglobulinemia, and defective glycosylation of serum proteins. Some patients also have neurologic abnormalities (summary by Jansen et al., 2016).

See: Condition Record

Immunodeficiency 47

Immunodeficiency, common variable, 3

Immunodeficiency, common variable, 5

Immunodeficiency, common variable, 6

Recent clinical studies

Etiology

High serum immunoglobulin D levels in systemic lupus erythematosus: more to be found?

Liang P, Huang Q, Xu Y, Chen L, Li J, Xu A, Yang Q
Clin Rheumatol 2023 Apr;42(4):1069-1076. Epub 2022 Dec 30 doi: 10.1007/s10067-022-06457-9. PMID: 36585530

Role of CD36 expression on circulating monocytes subsets in children on regular hemodialysis.

Mansour N, Abdel-Salam M, Hammad R, Moustafa S, Maghraby H
Egypt J Immunol 2021 Oct;28(4):224-232. PMID: 34882371

Altered levels of circulating natural antibodies against VEGFR1-derived peptide in atherosclerosis.

Wang P, Liu S, Wang Z, Zhao H, Zhang X
J Int Med Res 2020 Aug;48(8):300060520948750. doi: 10.1177/0300060520948750. PMID: 32811267 Free PMC Article

Antenatal corticosteroids impact the inflammatory rather than the antiangiogenic profile of women with preeclampsia.

Nayeri UA, Buhimschi IA, Laky CA, Cross SN, Duzyj CM, Ramma W, Sibai BM, Funai EF, Ahmed A, Buhimschi CS
Hypertension 2014 Jun;63(6):1285-92. Epub 2014 Mar 24 doi: 10.1161/HYPERTENSIONAHA.114.03173. PMID: 24664292

Chronic alcohol consumption is associated with changes in the distribution, immunophenotype, and the inflammatory cytokine secretion profile of circulating dendritic cells.

Laso FJ, Vaquero JM, Almeida J, Marcos M, Orfao A
Alcohol Clin Exp Res 2007 May;31(5):846-54. Epub 2007 Mar 26 doi: 10.1111/j.1530-0277.2007.00377.x. PMID: 17386065

See all (14)

Diagnosis

Importance of circulating monocyte subpopulations and Fcγ receptors in immune thrombocytopenia.

Abou-Elalla AA, Yacoub MF, Abdelfattah W, Abdelhameed AM, Khereba BS, Hanna MOF
Blood Coagul Fibrinolysis 2023 Jul 1;34(5):281-288. Epub 2023 May 11 doi: 10.1097/MBC.0000000000001223. PMID: 37395214

Altered levels of circulating natural antibodies against VEGFR1-derived peptide in atherosclerosis.

Wang P, Liu S, Wang Z, Zhao H, Zhang X
J Int Med Res 2020 Aug;48(8):300060520948750. doi: 10.1177/0300060520948750. PMID: 32811267 Free PMC Article

Effects of Repeated Complement Activation Associated with Chronic Treatment of Cynomolgus Monkeys with 2'-O-Methoxyethyl Modified Antisense Oligonucleotide.

Shen L, Engelhardt JA, Hung G, Yee J, Kikkawa R, Matson J, Tayefeh B, Machemer T, Giclas PC, Henry SP
Nucleic Acid Ther 2016 Aug;26(4):236-49. Epub 2016 May 3 doi: 10.1089/nat.2015.0584. PMID: 27140858

The role of HLA A2 and Cw2 in the pathogenesis of human demodicosis.

Mumcuoglu KY, Akilov OE
Dermatology 2005;210(2):109-14. doi: 10.1159/000082565. PMID: 15724092

HIV-1 antigen-specific and -nonspecific B cell responses are sensitive to combination antiretroviral therapy.

Morris L, Binley JM, Clas BA, Bonhoeffer S, Astill TP, Kost R, Hurley A, Cao Y, Markowitz M, Ho DD, Moore JP
J Exp Med 1998 Jul 20;188(2):233-45. doi: 10.1084/jem.188.2.233. PMID: 9670036 Free PMC Article

See all (7)

Therapy

Effects of Repeated Complement Activation Associated with Chronic Treatment of Cynomolgus Monkeys with 2'-O-Methoxyethyl Modified Antisense Oligonucleotide.

Antenatal corticosteroids impact the inflammatory rather than the antiangiogenic profile of women with preeclampsia.

B-lymphocyte dysfunction in chronic HIV-1 infection does not prevent cross-clade neutralization breadth.

Boliar S, Murphy MK, Tran TC, Carnathan DG, Armstrong WS, Silvestri G, Derdeyn CA
J Virol 2012 Aug;86(15):8031-40. Epub 2012 May 23 doi: 10.1128/JVI.00771-12. PMID: 22623771 Free PMC Article

In vivo binding of mouse IgG via polyreactive surface IgM abrogates progressive lymphocytosis in prolymphocytic leukemia.

Weston KM, Mulligan SP, Raison RL
Leuk Lymphoma 1998 Apr;29(3-4):361-73. doi: 10.3109/10428199809068572. PMID: 9684933

HIV-1 antigen-specific and -nonspecific B cell responses are sensitive to combination antiretroviral therapy.

See all (10)

Prognosis

High serum immunoglobulin D levels in systemic lupus erythematosus: more to be found?

Liang P, Huang Q, Xu Y, Chen L, Li J, Xu A, Yang Q
Clin Rheumatol 2023 Apr;42(4):1069-1076. Epub 2022 Dec 30 doi: 10.1007/s10067-022-06457-9. PMID: 36585530

Altered Circulating Immune Cell Distribution in Traumatic Spinal Cord Injury Patients in Relation to Clinical Parameters.

Fraussen J, Beckers L, van Laake-Geelen CCM, Depreitere B, Deckers J, Cornips EMJ, Peuskens D, Somers V
Front Immunol 2022;13:873315. Epub 2022 Jun 28 doi: 10.3389/fimmu.2022.873315. PMID: 35837411 Free PMC Article

Pathologic natural killer cell subset redistribution in HIV-1 infection: new insights in pathophysiology and clinical outcomes.

Brunetta E, Hudspeth KL, Mavilio D
J Leukoc Biol 2010 Dec;88(6):1119-30. Epub 2010 Jul 22 doi: 10.1189/jlb.0410225. PMID: 20651298

The role of HLA A2 and Cw2 in the pathogenesis of human demodicosis.

Mumcuoglu KY, Akilov OE
Dermatology 2005;210(2):109-14. doi: 10.1159/000082565. PMID: 15724092

See all (4)

Clinical prediction guides

High serum immunoglobulin D levels in systemic lupus erythematosus: more to be found?

Liang P, Huang Q, Xu Y, Chen L, Li J, Xu A, Yang Q
Clin Rheumatol 2023 Apr;42(4):1069-1076. Epub 2022 Dec 30 doi: 10.1007/s10067-022-06457-9. PMID: 36585530

Altered Circulating Immune Cell Distribution in Traumatic Spinal Cord Injury Patients in Relation to Clinical Parameters.

Antenatal corticosteroids impact the inflammatory rather than the antiangiogenic profile of women with preeclampsia.

In vivo binding of mouse IgG via polyreactive surface IgM abrogates progressive lymphocytosis in prolymphocytic leukemia.

Weston KM, Mulligan SP, Raison RL
Leuk Lymphoma 1998 Apr;29(3-4):361-73. doi: 10.3109/10428199809068572. PMID: 9684933

The effects of acute and chronic exercise of immunoglobulins.

Nieman DC, Nehlsen-Cannarella SL
Sports Med 1991 Mar;11(3):183-201. doi: 10.2165/00007256-199111030-00003. PMID: 2047622

See all (13)