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Unusual protozoan infection

MedGen UID:
1686599
•Concept ID:
C5139080
•
Disease or Syndrome
HPO: HP:0020104

Definition

An unusual protozoan infection that is regarded as a sign of a pathological susceptibility to infection by a protozoal agent. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnusual protozoan infection

Professional guidelines

PubMed

Unusual Cryptosporidium genotypes in human cases of diarrhea.
Robinson G, Elwin K, Chalmers RM
Emerg Infect Dis 2008 Nov;14(11):1800-2. doi: 10.3201/eid1411.080239. PMID: 18976577Free PMC Article
The identification and characterisation of an unusual genotype of Cryptosporidium from human faeces as Cryptosporidium meleagridis.
Pedraza-Díaz S, Amar C, McLauchlin J
FEMS Microbiol Lett 2000 Aug 15;189(2):189-94. doi: 10.1111/j.1574-6968.2000.tb09228.x. PMID: 10930736
Clinical pharmacokinetics in the treatment of tropical diseases. Some applications and limitations.
Edwards G, Winstanley PA, Ward SA
Clin Pharmacokinet 1994 Aug;27(2):150-65. doi: 10.2165/00003088-199427020-00006. PMID: 7955777

Recent clinical studies

Etiology

Malaria parasite plasmepsins: More than just plain old degradative pepsins.
Nasamu AS, Polino AJ, Istvan ES, Goldberg DE
J Biol Chem 2020 Jun 19;295(25):8425-8441. Epub 2020 May 4 doi: 10.1074/jbc.REV120.009309. PMID: 32366462Free PMC Article
DNA Topoisomerases of Kinetoplastid Parasites: Brief Overview and Recent Perspectives.
Saha S, Chowdhury SR, Majumder HK
Curr Issues Mol Biol 2019;31:45-62. Epub 2019 Jun 5 doi: 10.21775/cimb.031.045. PMID: 31165719
A Brief History of APOL1: A Gene Evolving.
Friedman DJ
Semin Nephrol 2017 Nov;37(6):508-513. doi: 10.1016/j.semnephrol.2017.07.003. PMID: 29110757
Uptake and mode of action of drugs used against sleeping sickness.
Denise H, Barrett MP
Biochem Pharmacol 2001 Jan 1;61(1):1-5. doi: 10.1016/s0006-2952(00)00477-9. PMID: 11137702
The parasitophorous vacuole membrane surrounding Plasmodium and Toxoplasma: an unusual compartment in infected cells.
Lingelbach K, Joiner KA
J Cell Sci 1998 Jun;111 ( Pt 11):1467-75. doi: 10.1242/jcs.111.11.1467. PMID: 9580555

Diagnosis

Fever with perinasal and tongue lesions: A diagnostic challenge.
Pipitò L, Catania B, Trizzino M, Rodolico V, Cascio A
Travel Med Infect Dis 2023 May-Jun;53:102566. Epub 2023 Mar 11 doi: 10.1016/j.tmaid.2023.102566. PMID: 36913993
Malarial hepatopathy.
Bhalla A, Suri V, Singh V
J Postgrad Med 2006 Oct-Dec;52(4):315-20. PMID: 17102560
Nasal leishmaniasis.
Vernham GA, Sadiq H, Mallon EA
J Laryngol Otol 1993 Sep;107(9):834-6. doi: 10.1017/s0022215100124569. PMID: 8228603
Amoebic pericarditis.
Blackett K
Int J Cardiol 1988 Nov;21(2):183-7. doi: 10.1016/0167-5273(88)90222-7. PMID: 3225071
American cutaneous leishmaniasis.
White SW, Hendricks LD
Int J Dermatol 1982 Mar;21(2):86-8. doi: 10.1111/j.1365-4362.1982.tb00507.x. PMID: 7068308

Therapy

Malaria parasite plasmepsins: More than just plain old degradative pepsins.
Nasamu AS, Polino AJ, Istvan ES, Goldberg DE
J Biol Chem 2020 Jun 19;295(25):8425-8441. Epub 2020 May 4 doi: 10.1074/jbc.REV120.009309. PMID: 32366462Free PMC Article
Neonatal fever: A puzzling case.
Bonnet Ducrot S, Plantaz D, Mathieu N, Debillon T, Bost Bru C, Brenier-Pinchart MP, Fricker-Hidalgo H, Chevallier M
Arch Pediatr 2018 Oct;25(7):435-438. Epub 2018 Sep 21 doi: 10.1016/j.arcped.2018.08.004. PMID: 30249489
Severe hydroxychloroquine myopathy.
Abdel-Hamid H, Oddis CV, Lacomis D
Muscle Nerve 2008 Sep;38(3):1206-10. doi: 10.1002/mus.21091. PMID: 18720511
Toxoplasmosis.
Dodds EM
Curr Opin Ophthalmol 2006 Dec;17(6):557-61. doi: 10.1097/ICU.0b013e32801094ca. PMID: 17065925
Uptake and mode of action of drugs used against sleeping sickness.
Denise H, Barrett MP
Biochem Pharmacol 2001 Jan 1;61(1):1-5. doi: 10.1016/s0006-2952(00)00477-9. PMID: 11137702

Prognosis

Unusual Gastric Nodules.
Shi J
Gastroenterology 2016 Sep;151(3):e13-4. Epub 2016 Aug 1 doi: 10.1053/j.gastro.2016.04.044. PMID: 27490229
Cutaneous leishmaniasis caused by Leishmania major in morocco: still a topical question.
Riyad M, Chiheb S, Soussi-Abdallaoui M
East Mediterr Health J 2013 May;19(5):495-501. PMID: 24617131
What is responsible for a large and unusual outbreak of leishmaniasis in Madrid?
Carrillo E, Moreno J, Cruz I
Trends Parasitol 2013 Dec;29(12):579-80. doi: 10.1016/j.pt.2013.10.007. PMID: 24275160
Ion and nutrient uptake by malaria parasite-infected erythrocytes.
Desai SA
Cell Microbiol 2012 Jul;14(7):1003-9. Epub 2012 Apr 19 doi: 10.1111/j.1462-5822.2012.01790.x. PMID: 22432505Free PMC Article
Toxoplasmosis.
Dodds EM
Curr Opin Ophthalmol 2006 Dec;17(6):557-61. doi: 10.1097/ICU.0b013e32801094ca. PMID: 17065925

Clinical prediction guides

Depolymerization of SUMO chains induces slender to stumpy differentiation in T. brucei bloodstream parasites.
Iribarren PA, Di Marzio LA, Berazategui MA, Saura A, Coria L, Cassataro J, Rojas F, Navarro M, Alvarez VE
PLoS Pathog 2024 Apr;20(4):e1012166. Epub 2024 Apr 18 doi: 10.1371/journal.ppat.1012166. PMID: 38635823Free PMC Article
Annulate lamellae and intracellular pathogens.
Eymieux S, Blanchard E, Uzbekov R, Hourioux C, Roingeard P
Cell Microbiol 2021 Aug;23(8):e13328. Epub 2021 Mar 25 doi: 10.1111/cmi.13328. PMID: 33740320
Ca(2+)-binding protein from Entamoeba histolytica (EhCaBP6) is a novel GTPase.
Verma D, Agarwal S, Keerthi V, Murmu A, Gourinath S, Bhattacharya A, Chary KR
Biochem Biophys Res Commun 2020 Jun 30;527(3):631-637. Epub 2020 May 16 doi: 10.1016/j.bbrc.2020.04.141. PMID: 32423808
Ion and nutrient uptake by malaria parasite-infected erythrocytes.
Desai SA
Cell Microbiol 2012 Jul;14(7):1003-9. Epub 2012 Apr 19 doi: 10.1111/j.1462-5822.2012.01790.x. PMID: 22432505Free PMC Article
Plasmodium falciparum signal sequences: simply sequences or special signals?
Nacer A, Berry L, Slomianny C, Mattei D
Int J Parasitol 2001 Oct;31(12):1371-9. doi: 10.1016/s0020-7519(01)00253-3. PMID: 11566304

Recent systematic reviews

Prevalence of ocular toxoplasmosis among people living with HIV: a systematic review and meta-analysis.
Kantzanou M, Kostares E, Kostare G, Boufidou F, Tzanai A, Kostares M, Tsakris A
Future Microbiol 2024;19(6):525-534. Epub 2024 Mar 20 doi: 10.2217/fmb-2023-0215. PMID: 38507297Free PMC Article
Focal spleen lesions in visceral leishmaniasis, a neglected manifestation of a neglected disease: report of three cases and systematic review of literature.
Rinaldi F, Giachè S, Spinicci M, Corsi P, Ambu S, Gianfaldoni G, Rigacci L, Arena U, Bartoloni A, Zammarchi L
Infection 2019 Aug;47(4):507-518. Epub 2019 Feb 15 doi: 10.1007/s15010-019-01279-5. PMID: 30771194
Malaria in Meghalaya: a systematic literature review and analysis of data from the National Vector-Borne Disease Control Programme.
Kessler A, van Eijk AM, Jamir L, Walton C, Carlton JM, Albert S
Malar J 2018 Nov 6;17(1):411. doi: 10.1186/s12936-018-2563-3. PMID: 30400879Free PMC Article
Atypical presentations of cutaneous leishmaniasis: A systematic review.
Meireles CB, Maia LC, Soares GC, Teodoro IPP, Gadelha MDSV, da Silva CGL, de Lima MAP
Acta Trop 2017 Aug;172:240-254. Epub 2017 May 17 doi: 10.1016/j.actatropica.2017.05.022. PMID: 28526427

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