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Immediate-type hypersensitivity drug reaction

MedGen UID:
1688804
•Concept ID:
C5139307
•
Pathologic Function
HPO: HP:0032378

Definition

Hypersensitivity that is observed within 1 hr of exposures. A variety of adverse reactions can occur within minutes to hours of exposure to a drug. Some can be related to the pharmacological action of the drug (WHO Adverse Reaction Terminology type A for augmented) and usually have a low mortality. Others are not readily predictable based on the structure and pharmacological action of the drug and have a relatively high mortality risk (Type B for bizarre). The most serious form of immediate onset drug hypersensitivity reaction, anaphylaxis. Other reactions including itching, dizziness/light-headedness, nausea, chest discomfort but without any objective skin features, physical signs or physiological compromise. Skin only reactions include generalized erythema, urticaria or angioedema without any sentinel features (see below) of other organ involvement. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImmediate-type hypersensitivity drug reaction

Professional guidelines

PubMed

Management of adverse reactions to biologic agents.
Isabwe GAC, de Las Vecillas Sanchez L, Castells M
Allergy Asthma Proc 2017 Nov 1;38(6):409-418. doi: 10.2500/aap.2017.38.4085. PMID: 29046192
Penicillin skin testing in the evaluation and management of penicillin allergy.
Fox S, Park MA
Ann Allergy Asthma Immunol 2011 Jan;106(1):1-7. Epub 2010 Jul 3 doi: 10.1016/j.anai.2010.05.010. PMID: 21195938
Antimicrobial treatment guidelines for acute bacterial rhinosinusitis.
Anon JB, Jacobs MR, Poole MD, Ambrose PG, Benninger MS, Hadley JA, Craig WA; Sinus And Allergy Health Partnership
Otolaryngol Head Neck Surg 2004 Jan;130(1 Suppl):1-45. doi: 10.1016/j.otohns.2003.12.003. PMID: 14726904Free PMC Article

Recent clinical studies

Etiology

Drug Hypersensitivity Reactions.
Dykewicz MS, Lam JK
Med Clin North Am 2020 Jan;104(1):109-128. doi: 10.1016/j.mcna.2019.09.003. PMID: 31757230
Cutaneous drug hypersensitivity: developments and controversies.
Brockow K, Pfützner W
Curr Opin Allergy Clin Immunol 2019 Aug;19(4):308-318. doi: 10.1097/ACI.0000000000000548. PMID: 31135396
Immediate-type hypersensitivity drug reactions.
Stone SF, Phillips EJ, Wiese MD, Heddle RJ, Brown SG
Br J Clin Pharmacol 2014 Jul;78(1):1-13. doi: 10.1111/bcp.12297. PMID: 24286446Free PMC Article
Gentamicin-induced anaphylaxis.
Connolly M, McAdoo J, Bourke JF
Ir J Med Sci 2007 Dec;176(4):317-8. Epub 2007 Aug 28 doi: 10.1007/s11845-007-0077-z. PMID: 17724569
Antimicrobial treatment guidelines for acute bacterial rhinosinusitis.
Anon JB, Jacobs MR, Poole MD, Ambrose PG, Benninger MS, Hadley JA, Craig WA; Sinus And Allergy Health Partnership
Otolaryngol Head Neck Surg 2004 Jan;130(1 Suppl):1-45. doi: 10.1016/j.otohns.2003.12.003. PMID: 14726904Free PMC Article

Diagnosis

Drug Hypersensitivity Reactions.
Dykewicz MS, Lam JK
Med Clin North Am 2020 Jan;104(1):109-128. doi: 10.1016/j.mcna.2019.09.003. PMID: 31757230
Cutaneous drug hypersensitivity: developments and controversies.
Brockow K, Pfützner W
Curr Opin Allergy Clin Immunol 2019 Aug;19(4):308-318. doi: 10.1097/ACI.0000000000000548. PMID: 31135396
Immediate-type hypersensitivity drug reactions.
Stone SF, Phillips EJ, Wiese MD, Heddle RJ, Brown SG
Br J Clin Pharmacol 2014 Jul;78(1):1-13. doi: 10.1111/bcp.12297. PMID: 24286446Free PMC Article
Carboplatin hypersensitivity.
Sliesoraitis S, Chikhale PJ
Int J Gynecol Cancer 2005 Jan-Feb;15(1):13-8. doi: 10.1111/j.1048-891x.2005.14401.x. PMID: 15670291
Antimicrobial treatment guidelines for acute bacterial rhinosinusitis.
Anon JB, Jacobs MR, Poole MD, Ambrose PG, Benninger MS, Hadley JA, Craig WA; Sinus And Allergy Health Partnership
Otolaryngol Head Neck Surg 2004 Jan;130(1 Suppl):1-45. doi: 10.1016/j.otohns.2003.12.003. PMID: 14726904Free PMC Article

Therapy

Drug Hypersensitivity Reactions.
Dykewicz MS, Lam JK
Med Clin North Am 2020 Jan;104(1):109-128. doi: 10.1016/j.mcna.2019.09.003. PMID: 31757230
Tolerance of Fondaparinux in Immediate-type Hypersensitivity to Heparins.
Trog LM, Kahle B, Schindewolf M, Jappe U, Ludwig RJ
Am J Med 2015 Nov;128(11):e21-2. Epub 2015 Jul 11 doi: 10.1016/j.amjmed.2015.06.024. PMID: 26169891
Carboplatin hypersensitivity.
Sliesoraitis S, Chikhale PJ
Int J Gynecol Cancer 2005 Jan-Feb;15(1):13-8. doi: 10.1111/j.1048-891x.2005.14401.x. PMID: 15670291
Antimicrobial treatment guidelines for acute bacterial rhinosinusitis.
Anon JB, Jacobs MR, Poole MD, Ambrose PG, Benninger MS, Hadley JA, Craig WA; Sinus And Allergy Health Partnership
Otolaryngol Head Neck Surg 2004 Jan;130(1 Suppl):1-45. doi: 10.1016/j.otohns.2003.12.003. PMID: 14726904Free PMC Article
Quinolone hypersensitivity.
Campi P, Pichler WJ
Curr Opin Allergy Clin Immunol 2003 Aug;3(4):275-81. doi: 10.1097/00130832-200308000-00007. PMID: 12865771

Prognosis

Drug Hypersensitivity Reactions.
Dykewicz MS, Lam JK
Med Clin North Am 2020 Jan;104(1):109-128. doi: 10.1016/j.mcna.2019.09.003. PMID: 31757230
Immediate-type hypersensitivity drug reactions.
Stone SF, Phillips EJ, Wiese MD, Heddle RJ, Brown SG
Br J Clin Pharmacol 2014 Jul;78(1):1-13. doi: 10.1111/bcp.12297. PMID: 24286446Free PMC Article
Gentamicin-induced anaphylaxis.
Connolly M, McAdoo J, Bourke JF
Ir J Med Sci 2007 Dec;176(4):317-8. Epub 2007 Aug 28 doi: 10.1007/s11845-007-0077-z. PMID: 17724569
Carboplatin hypersensitivity.
Sliesoraitis S, Chikhale PJ
Int J Gynecol Cancer 2005 Jan-Feb;15(1):13-8. doi: 10.1111/j.1048-891x.2005.14401.x. PMID: 15670291
Antimicrobial treatment guidelines for acute bacterial rhinosinusitis.
Anon JB, Jacobs MR, Poole MD, Ambrose PG, Benninger MS, Hadley JA, Craig WA; Sinus And Allergy Health Partnership
Otolaryngol Head Neck Surg 2004 Jan;130(1 Suppl):1-45. doi: 10.1016/j.otohns.2003.12.003. PMID: 14726904Free PMC Article

Clinical prediction guides

Drug Hypersensitivity Reactions.
Dykewicz MS, Lam JK
Med Clin North Am 2020 Jan;104(1):109-128. doi: 10.1016/j.mcna.2019.09.003. PMID: 31757230
Immediate-type hypersensitivity drug reactions.
Stone SF, Phillips EJ, Wiese MD, Heddle RJ, Brown SG
Br J Clin Pharmacol 2014 Jul;78(1):1-13. doi: 10.1111/bcp.12297. PMID: 24286446Free PMC Article
Carboplatin hypersensitivity.
Sliesoraitis S, Chikhale PJ
Int J Gynecol Cancer 2005 Jan-Feb;15(1):13-8. doi: 10.1111/j.1048-891x.2005.14401.x. PMID: 15670291
Antimicrobial treatment guidelines for acute bacterial rhinosinusitis.
Anon JB, Jacobs MR, Poole MD, Ambrose PG, Benninger MS, Hadley JA, Craig WA; Sinus And Allergy Health Partnership
Otolaryngol Head Neck Surg 2004 Jan;130(1 Suppl):1-45. doi: 10.1016/j.otohns.2003.12.003. PMID: 14726904Free PMC Article
Budesonide and nasal histamine challenge.
Pipkorn U
Allergy 1982 Jul;37(5):359-63. doi: 10.1111/j.1398-9995.1982.tb01922.x. PMID: 7125153

Recent systematic reviews

Systematic review on skin adverse effects of important hazardous hair cosmetic ingredients with a focus on hairdressers.
Uter W, Strahwald J, Hallmann S, Johansen JD, Havmose MS, Kezic S, van der Molen HF, Macan J, Babić Ž, Franić Z, Macan M, Turk R, Symanzik C, Weinert P, John SM
Contact Dermatitis 2023 Feb;88(2):93-108. Epub 2022 Oct 28 doi: 10.1111/cod.14236. PMID: 36254351
Skin Allergy to Azole Antifungal Agents for Systemic Use: A Review of the Literature.
Calogiuri G, Garvey LH, Nettis E, Romita P, Di Leo E, Caruso R, Butani L, Foti C
Recent Pat Inflamm Allergy Drug Discov 2019;13(2):144-157. doi: 10.2174/1872213X13666190919162414. PMID: 31538908
Immediate-Type Hypersensitivity Cross-Reactions to Proton Pump Inhibitors: A Descriptive Study of Data from the French National Pharmacovigilance Database.
Tourillon C, Mahe J, Baron A, Lambert A, Yélehé-Okouma M, Veyrac G, Jolliet P
Int Arch Allergy Immunol 2019;178(2):159-166. Epub 2018 Nov 28 doi: 10.1159/000493581. PMID: 30485850

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