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Trabecular Meshwork Proliferation

MedGen UID:
1691400
•Concept ID:
C5205891
•
Finding

Definition

Activation of abnormal cell growth within the trabecular meshwork of the eye, usually due to injury. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrabecular Meshwork Proliferation

Professional guidelines

PubMed

Future directions of glaucoma treatment: emerging gene, neuroprotection, nanomedicine, stem cell, and vascular therapies.
Ciociola EC, Fernandez E, Kaufmann M, Klifto MR
Curr Opin Ophthalmol 2024 Mar 1;35(2):89-96. Epub 2023 Nov 1 doi: 10.1097/ICU.0000000000001016. PMID: 37910173
The Potential Role of Small-Molecule PERK Inhibitor LDN-0060609 in Primary Open-Angle Glaucoma Treatment.
Rozpędek-Kamińska W, Galita G, Siwecka N, Carroll SL, Diehl JA, Kucharska E, Pytel D, Majsterek I
Int J Mol Sci 2021 Apr 26;22(9) doi: 10.3390/ijms22094494. PMID: 33925820Free PMC Article
Impact of the clinical use of ROCK inhibitor on the pathogenesis and treatment of glaucoma.
Honjo M, Tanihara H
Jpn J Ophthalmol 2018 Mar;62(2):109-126. Epub 2018 Feb 14 doi: 10.1007/s10384-018-0566-9. PMID: 29445943

Recent clinical studies

Etiology

Sigma-1 Receptor Agonist Fluvoxamine Ameliorates Fibrotic Response of Trabecular Meshwork Cells.
Hodrea J, Tran MN, Besztercei B, Medveczki T, Szabo AJ, Őrfi L, Kovacs I, Fekete A
Int J Mol Sci 2023 Jul 19;24(14) doi: 10.3390/ijms241411646. PMID: 37511406Free PMC Article
Non-canonical Wnt signaling in the eye.
Shah R, Amador C, Chun ST, Ghiam S, Saghizadeh M, Kramerov AA, Ljubimov AV
Prog Retin Eye Res 2023 Jul;95:101149. Epub 2022 Nov 25 doi: 10.1016/j.preteyeres.2022.101149. PMID: 36443219Free PMC Article
Matrix Metalloproteinases and Glaucoma.
Kim MH, Lim SH
Biomolecules 2022 Sep 25;12(10) doi: 10.3390/biom12101368. PMID: 36291577Free PMC Article
A tissue-engineered human trabecular meshwork hydrogel for advanced glaucoma disease modeling.
Li H, Bagué T, Kirschner A, Strat AN, Roberts H, Weisenthal RW, Patteson AE, Annabi N, Stamer WD, Ganapathy PS, Herberg S
Exp Eye Res 2021 Apr;205:108472. Epub 2021 Jan 29 doi: 10.1016/j.exer.2021.108472. PMID: 33516765Free PMC Article
Human trabecular meshwork cell behavior is influenced by collagen scaffold pore architecture and glycosaminoglycan composition.
Osmond MJ, Krebs MD, Pantcheva MB
Biotechnol Bioeng 2020 Oct;117(10):3150-3159. Epub 2020 Jul 9 doi: 10.1002/bit.27477. PMID: 32589791Free PMC Article

Diagnosis

Dexamethasone Downregulates Autophagy through Accelerated Turn-Over of the Ulk-1 Complex in a Trabecular Meshwork Cells Strain: Insights on Steroid-Induced Glaucoma Pathogenesis.
Sbardella D, Tundo GR, Coletta M, Manni G, Oddone F
Int J Mol Sci 2021 May 31;22(11) doi: 10.3390/ijms22115891. PMID: 34072647Free PMC Article
Isolation and Characterization of primary human trabecular meshwork cells from segmental flow regions: New tools for understanding segmental flow.
Staverosky J, Dhamodaran K, Acott T, Raghunathan V, Vranka J
Exp Eye Res 2020 Aug;197:108046. Epub 2020 May 4 doi: 10.1016/j.exer.2020.108046. PMID: 32376472Free PMC Article
Ex-PRESS mini-shunt implanted in a pregnant patient with iridocorneal endothelial syndrome.
Colás-Tomás T, López Tizón E
Eur J Ophthalmol 2020 Jan;30(1):NP25-NP28. Epub 2019 Jan 8 doi: 10.1177/1120672118820508. PMID: 30618278
Effects of thailanstatins on glucocorticoid response in trabecular meshwork and steroid-induced glaucoma.
Jain A, Liu X, Wordinger RJ, Yorio T, Cheng YQ, Clark AF
Invest Ophthalmol Vis Sci 2013 May 3;54(5):3137-42. doi: 10.1167/iovs.12-11480. PMID: 23548621Free PMC Article
Detection of differentially expressed glycogenes in trabecular meshwork of eyes with primary open-angle glaucoma.
Diskin S, Kumar J, Cao Z, Schuman JS, Gilmartin T, Head SR, Panjwani N
Invest Ophthalmol Vis Sci 2006 Apr;47(4):1491-9. doi: 10.1167/iovs.05-0736. PMID: 16565384Free PMC Article

Therapy

Nanoencapsulated hybrid compound SA-2 with long-lasting intraocular pressure-lowering activity in rodent eyes.
Stankowska DL, Millar JC, Kodati B, Behera S, Chaphalkar RM, Nguyen T, Nguyen KT, Krishnamoorthy RR, Ellis DZ, Acharya S
Mol Vis 2021;27:37-49. Epub 2021 Jan 16 PMID: 33633438Free PMC Article
Human trabecular meshwork cell behavior is influenced by collagen scaffold pore architecture and glycosaminoglycan composition.
Osmond MJ, Krebs MD, Pantcheva MB
Biotechnol Bioeng 2020 Oct;117(10):3150-3159. Epub 2020 Jul 9 doi: 10.1002/bit.27477. PMID: 32589791Free PMC Article
Impact of the clinical use of ROCK inhibitor on the pathogenesis and treatment of glaucoma.
Honjo M, Tanihara H
Jpn J Ophthalmol 2018 Mar;62(2):109-126. Epub 2018 Feb 14 doi: 10.1007/s10384-018-0566-9. PMID: 29445943
Hsp70 protects human trabecular meshwork cells injury induced by UVB through Smad pathway.
Cao Y, Gao L, Tang R, Zhang W
Pharmazie 2017 Jun 1;72(6):334-337. doi: 10.1691/ph.2017.7432. PMID: 29442021
Nonpenetrating glaucoma surgery: a critical evaluation.
Sarodia U, Shaarawy T, Barton K
Curr Opin Ophthalmol 2007 Mar;18(2):152-8. doi: 10.1097/ICU.0b013e328091c1ae. PMID: 17301618

Prognosis

miR‑200c‑3p regulates the proliferation and apoptosis of human trabecular meshwork cells by targeting PTEN.
Shen Y, Zhu Y, Rong F
Mol Med Rep 2020 Aug;22(2):1605-1612. Epub 2020 Jun 1 doi: 10.3892/mmr.2020.11198. PMID: 32626945
MicroRNA-483-3p Inhibits Extracellular Matrix Production by Targeting Smad4 in Human Trabecular Meshwork Cells.
Shen W, Han Y, Huang B, Qi Y, Xu L, Guo R, Wang X, Wang J
Invest Ophthalmol Vis Sci 2015 Dec;56(13):8419-27. doi: 10.1167/iovs.15-18036. PMID: 26747772
Aging of trabecular meshwork cells of the human eye in vitro.
Schachtschabel DO, Binninger E
Z Gerontol 1990 May-Jun;23(3):133-5. PMID: 2392868

Clinical prediction guides

iPSC-derived cells stimulate ABCG2(+)/NES(+) endogenous trabecular meshwork cell proliferation and tissue regeneration.
Xi G, Feng P, Zhang X, Wu S, Zhang J, Wang X, Xiang A, Xu W, Wang N, Zhu W
Cell Prolif 2024 Jul;57(7):e13611. Epub 2024 Feb 14 doi: 10.1111/cpr.13611. PMID: 38356373Free PMC Article
miR‑200c‑3p regulates the proliferation and apoptosis of human trabecular meshwork cells by targeting PTEN.
Shen Y, Zhu Y, Rong F
Mol Med Rep 2020 Aug;22(2):1605-1612. Epub 2020 Jun 1 doi: 10.3892/mmr.2020.11198. PMID: 32626945
Stem Cells from Human Trabecular Meshwork Hold the Potential to Develop into Ocular and Non-Ocular Lineages After Long-Term Storage.
Kumar A, Xu Y, Du Y
Stem Cells Dev 2020 Jan 1;29(1):49-61. Epub 2019 Dec 9 doi: 10.1089/scd.2019.0169. PMID: 31680626Free PMC Article
YAP and TAZ mediate steroid-induced alterations in the trabecular meshwork cytoskeleton in human trabecular meshwork cells.
Peng J, Wang H, Wang X, Sun M, Deng S, Wang Y
Int J Mol Med 2018 Jan;41(1):164-172. Epub 2017 Oct 23 doi: 10.3892/ijmm.2017.3207. PMID: 29115373Free PMC Article
Clinicopathologic features of Chandler's syndrome.
Patel A, Kenyon KR, Hirst LW, Quigley HA, Stark WJ, Meyer RF, Green WR
Surv Ophthalmol 1983 Mar-Apr;27(5):327-44. doi: 10.1016/0039-6257(83)90234-5. PMID: 6344293

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