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Decreased specific antibody response to infection

MedGen UID:
1693873
•Concept ID:
C5139471
•
Finding
HPO: HP:0410308

Definition

A reduced ability to synthesize antibodies against antigens from an infectious agent or pathogen (such as bacteria, viruses, parasites, etc.), as measured by antibody titer determination following infection. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased specific antibody response to infection

Professional guidelines

PubMed

Down-regulation of TNF-α via macrophage-targeted RNAi system for the treatment of acute inflammatory sepsis.
Lee J, Son W, Hong J, Song Y, Yang CS, Kim YH
J Control Release 2021 Aug 10;336:344-353. Epub 2021 Jun 18 doi: 10.1016/j.jconrel.2021.06.022. PMID: 34147573
Acquired antibody responses against Plasmodium vivax infection vary with host genotype for duffy antigen receptor for chemokines (DARC).
Maestre A, Muskus C, Duque V, Agudelo O, Liu P, Takagi A, Ntumngia FB, Adams JH, Sim KL, Hoffman SL, Corradin G, Velez ID, Wang R
PLoS One 2010 Jul 15;5(7):e11437. doi: 10.1371/journal.pone.0011437. PMID: 20664684Free PMC Article
The management of coronavirus infections with particular reference to SARS.
Wong SS, Yuen KY
J Antimicrob Chemother 2008 Sep;62(3):437-41. Epub 2008 Jun 18 doi: 10.1093/jac/dkn243. PMID: 18565970Free PMC Article

Recent clinical studies

Etiology

Cellular immune response to SARS-CoV-2 in patients with primary antibody deficiencies.
Mizera D, Dziedzic R, Drynda A, Gradzikiewicz A, Jakieła B, Celińska-Löwenhoff M, Padjas A, Matyja-Bednarczyk A, Zaręba L, Bazan-Socha S
Front Immunol 2023;14:1275892. Epub 2023 Oct 12 doi: 10.3389/fimmu.2023.1275892. PMID: 37901210Free PMC Article
ADCC-activating antibodies correlate with decreased risk of congenital human cytomegalovirus transmission.
Semmes EC, Miller IG, Rodgers N, Phan CT, Hurst JH, Walsh KM, Stanton RJ, Pollara J, Permar SR
JCI Insight 2023 Jul 10;8(13) doi: 10.1172/jci.insight.167768. PMID: 37427588Free PMC Article
COVID-19 and the role of cytokines in this disease.
Hasanvand A
Inflammopharmacology 2022 Jun;30(3):789-798. Epub 2022 May 4 doi: 10.1007/s10787-022-00992-2. PMID: 35505267Free PMC Article
Evolution of antibody immunity to SARS-CoV-2.
Gaebler C, Wang Z, Lorenzi JCC, Muecksch F, Finkin S, Tokuyama M, Cho A, Jankovic M, Schaefer-Babajew D, Oliveira TY, Cipolla M, Viant C, Barnes CO, Bram Y, Breton G, Hägglöf T, Mendoza P, Hurley A, Turroja M, Gordon K, Millard KG, Ramos V, Schmidt F, Weisblum Y, Jha D, Tankelevich M, Martinez-Delgado G, Yee J, Patel R, Dizon J, Unson-O'Brien C, Shimeliovich I, Robbiani DF, Zhao Z, Gazumyan A, Schwartz RE, Hatziioannou T, Bjorkman PJ, Mehandru S, Bieniasz PD, Caskey M, Nussenzweig MC
Nature 2021 Mar;591(7851):639-644. Epub 2021 Jan 18 doi: 10.1038/s41586-021-03207-w. PMID: 33461210Free PMC Article
Social ties and susceptibility to the common cold.
Cohen S, Doyle WJ, Skoner DP, Rabin BS, Gwaltney JM Jr
JAMA 1997 Jun 25;277(24):1940-4. PMID: 9200634

Diagnosis

Carbon Nanostructured Immunosensing of Anti-SARS-CoV-2 S-Protein Antibodies.
du Plooy J, Kock B, Jahed N, Iwuoha E, Pokpas K
Molecules 2023 Dec 9;28(24) doi: 10.3390/molecules28248022. PMID: 38138513Free PMC Article
Cellular immune response to SARS-CoV-2 in patients with primary antibody deficiencies.
Mizera D, Dziedzic R, Drynda A, Gradzikiewicz A, Jakieła B, Celińska-Löwenhoff M, Padjas A, Matyja-Bednarczyk A, Zaręba L, Bazan-Socha S
Front Immunol 2023;14:1275892. Epub 2023 Oct 12 doi: 10.3389/fimmu.2023.1275892. PMID: 37901210Free PMC Article
SARS-CoV-2-specific CD8+ T cell responses in convalescent COVID-19 individuals.
Kared H, Redd AD, Bloch EM, Bonny TS, Sumatoh H, Kairi F, Carbajo D, Abel B, Newell EW, Bettinotti MP, Benner SE, Patel EU, Littlefield K, Laeyendecker O, Shoham S, Sullivan D, Casadevall A, Pekosz A, Nardin A, Fehlings M, Tobian AA, Quinn TC
J Clin Invest 2021 Mar 1;131(5) doi: 10.1172/JCI145476. PMID: 33427749Free PMC Article
Phase IA/IB study of single-agent tislelizumab, an investigational anti-PD-1 antibody, in solid tumors.
Desai J, Deva S, Lee JS, Lin CC, Yen CJ, Chao Y, Keam B, Jameson M, Hou MM, Kang YK, Markman B, Lu CH, Rau KM, Lee KH, Horvath L, Friedlander M, Hill A, Sandhu S, Barlow P, Wu CY, Zhang Y, Liang L, Wu J, Paton V, Millward M
J Immunother Cancer 2020 Jun;8(1) doi: 10.1136/jitc-2019-000453. PMID: 32540858Free PMC Article
Neuraminidase inhibitors for preventing and treating influenza in adults and children.
Jefferson T, Jones MA, Doshi P, Del Mar CB, Hama R, Thompson MJ, Spencer EA, Onakpoya I, Mahtani KR, Nunan D, Howick J, Heneghan CJ
Cochrane Database Syst Rev 2014 Apr 10;2014(4):CD008965. doi: 10.1002/14651858.CD008965.pub4. PMID: 24718923Free PMC Article

Therapy

Phase IA/IB study of single-agent tislelizumab, an investigational anti-PD-1 antibody, in solid tumors.
Desai J, Deva S, Lee JS, Lin CC, Yen CJ, Chao Y, Keam B, Jameson M, Hou MM, Kang YK, Markman B, Lu CH, Rau KM, Lee KH, Horvath L, Friedlander M, Hill A, Sandhu S, Barlow P, Wu CY, Zhang Y, Liang L, Wu J, Paton V, Millward M
J Immunother Cancer 2020 Jun;8(1) doi: 10.1136/jitc-2019-000453. PMID: 32540858Free PMC Article
Infections and vasculitis.
Thomas K, Vassilopoulos D
Curr Opin Rheumatol 2017 Jan;29(1):17-23. doi: 10.1097/BOR.0000000000000348. PMID: 27662570
Neuraminidase inhibitors for preventing and treating influenza in adults and children.
Jefferson T, Jones MA, Doshi P, Del Mar CB, Hama R, Thompson MJ, Spencer EA, Onakpoya I, Mahtani KR, Nunan D, Howick J, Heneghan CJ
Cochrane Database Syst Rev 2014 Apr 10;2014(4):CD008965. doi: 10.1002/14651858.CD008965.pub4. PMID: 24718923Free PMC Article
Inhibition of human cytomegalovirus replication via peptide aptamers directed against the nonconventional nuclear localization signal of the essential viral replication factor pUL84.
Kaiser N, Lischka P, Wagenknecht N, Stamminger T
J Virol 2009 Nov;83(22):11902-13. Epub 2009 Sep 9 doi: 10.1128/JVI.01378-09. PMID: 19740994Free PMC Article
Effects of antiviral therapy on the production of anti-human immunodeficiency virus-specific immunoglobulin in infants and children.
Pollack H, Zhan MX, Moore T, Tao PZ, Krasinski K, Borkowsky W
J Infect Dis 1994 Oct;170(4):1003-6. doi: 10.1093/infdis/170.4.1003. PMID: 7930694

Prognosis

Phase IA/IB study of single-agent tislelizumab, an investigational anti-PD-1 antibody, in solid tumors.
Desai J, Deva S, Lee JS, Lin CC, Yen CJ, Chao Y, Keam B, Jameson M, Hou MM, Kang YK, Markman B, Lu CH, Rau KM, Lee KH, Horvath L, Friedlander M, Hill A, Sandhu S, Barlow P, Wu CY, Zhang Y, Liang L, Wu J, Paton V, Millward M
J Immunother Cancer 2020 Jun;8(1) doi: 10.1136/jitc-2019-000453. PMID: 32540858Free PMC Article
Immune response to SARS-CoV-2 and mechanisms of immunopathological changes in COVID-19.
Azkur AK, Akdis M, Azkur D, Sokolowska M, van de Veen W, Brüggen MC, O'Mahony L, Gao Y, Nadeau K, Akdis CA
Allergy 2020 Jul;75(7):1564-1581. doi: 10.1111/all.14364. PMID: 32396996Free PMC Article
Neutralizing Antibody-Mediated Response and Risk of BK Virus-Associated Nephropathy.
Solis M, Velay A, Porcher R, Domingo-Calap P, Soulier E, Joly M, Meddeb M, Kack-Kack W, Moulin B, Bahram S, Stoll-Keller F, Barth H, Caillard S, Fafi-Kremer S
J Am Soc Nephrol 2018 Jan;29(1):326-334. Epub 2017 Oct 17 doi: 10.1681/ASN.2017050532. PMID: 29042457Free PMC Article
Infections and vasculitis.
Thomas K, Vassilopoulos D
Curr Opin Rheumatol 2017 Jan;29(1):17-23. doi: 10.1097/BOR.0000000000000348. PMID: 27662570
Characteristics of asymptomatic secondary immune responses to measles virus in late convalescent donors.
Huiss S, Damien B, Schneider F, Muller CP
Clin Exp Immunol 1997 Sep;109(3):416-20. doi: 10.1046/j.1365-2249.1997.00137.x. PMID: 9328115Free PMC Article

Clinical prediction guides

Duration of SARS-CoV-2 Serum-Neutralizing Antibodies Against SARS-CoV-2 Dependent on the Individual.
Li J, Zou L, Li S, Zou R, Fang Z, Zhang P, Li H, Wang S, Ke D, Gao P, Jin C, Fang C, Zhou J, He E, Skog S
Viral Immunol 2023 Apr;36(3):153-162. Epub 2023 Mar 21 doi: 10.1089/vim.2022.0094. PMID: 36944125
COVID-19 and the role of cytokines in this disease.
Hasanvand A
Inflammopharmacology 2022 Jun;30(3):789-798. Epub 2022 May 4 doi: 10.1007/s10787-022-00992-2. PMID: 35505267Free PMC Article
Immune response to SARS-CoV-2 and mechanisms of immunopathological changes in COVID-19.
Azkur AK, Akdis M, Azkur D, Sokolowska M, van de Veen W, Brüggen MC, O'Mahony L, Gao Y, Nadeau K, Akdis CA
Allergy 2020 Jul;75(7):1564-1581. doi: 10.1111/all.14364. PMID: 32396996Free PMC Article
Neutralizing Antibody-Mediated Response and Risk of BK Virus-Associated Nephropathy.
Solis M, Velay A, Porcher R, Domingo-Calap P, Soulier E, Joly M, Meddeb M, Kack-Kack W, Moulin B, Bahram S, Stoll-Keller F, Barth H, Caillard S, Fafi-Kremer S
J Am Soc Nephrol 2018 Jan;29(1):326-334. Epub 2017 Oct 17 doi: 10.1681/ASN.2017050532. PMID: 29042457Free PMC Article
Characteristics of asymptomatic secondary immune responses to measles virus in late convalescent donors.
Huiss S, Damien B, Schneider F, Muller CP
Clin Exp Immunol 1997 Sep;109(3):416-20. doi: 10.1046/j.1365-2249.1997.00137.x. PMID: 9328115Free PMC Article

Recent systematic reviews

Impaired serological response to COVID-19 vaccination following anticancer therapy: A systematic review and meta-analysis.
Tang K, Wei Z, Wu X
J Med Virol 2022 Oct;94(10):4860-4868. Epub 2022 Jul 6 doi: 10.1002/jmv.27956. PMID: 35750492Free PMC Article
Antibody response to SARS-CoV-2 infection in humans: A systematic review.
Post N, Eddy D, Huntley C, van Schalkwyk MCI, Shrotri M, Leeman D, Rigby S, Williams SV, Bermingham WH, Kellam P, Maher J, Shields AM, Amirthalingam G, Peacock SJ, Ismail SA
PLoS One 2020;15(12):e0244126. Epub 2020 Dec 31 doi: 10.1371/journal.pone.0244126. PMID: 33382764Free PMC Article
Rapid diagnostic tests for plague.
Jullien S, Dissanayake HA, Chaplin M
Cochrane Database Syst Rev 2020 Jun 26;6(6):CD013459. doi: 10.1002/14651858.CD013459.pub2. PMID: 32597510Free PMC Article
Screening for Syphilis Infection in Pregnant Women: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.
Lin JS, Eder ML, Bean SI
JAMA 2018 Sep 4;320(9):918-925. doi: 10.1001/jama.2018.7769. PMID: 30193282
Neuraminidase inhibitors for preventing and treating influenza in adults and children.
Jefferson T, Jones MA, Doshi P, Del Mar CB, Hama R, Thompson MJ, Spencer EA, Onakpoya I, Mahtani KR, Nunan D, Howick J, Heneghan CJ
Cochrane Database Syst Rev 2014 Apr 10;2014(4):CD008965. doi: 10.1002/14651858.CD008965.pub4. PMID: 24718923Free PMC Article

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