Oligoclonal elevation of circulating IgM

MedGen UID:: 1694510
•Concept ID:: C5139274
•: Finding

HPO:	HP:0032332

Definition

An increase in circulating IgM characterized by two or more bands in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVOligoclonal elevation of circulating IgM

Abnormal leukocyte physiology
- Abnormal lymphocyte physiology
  - Abnormality of B cell physiology
    - Abnormal circulating immunoglobulin concentration
      - Abnormal circulating IgM concentration
        Increased circulating IgM level
        Oligoclonal elevation of circulating IgM

Recent clinical studies

Diagnosis

Tumor cell dissemination triggers an intrathecal immune response in neoplastic meningitis.

Weller M, Stevens A, Sommer N, Schabet M, Wiethölter H
Cancer 1992 Mar 15;69(6):1475-80. doi: 10.1002/1097-0142(19920315)69:6<1475::aid-cncr2820690627>3.0.co;2-d. PMID: 1371713

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Oligoclonal elevation of circulating IgM

Definition

Term Hierarchy

Recent clinical studies

Diagnosis

Supplemental Content

Table of contents

Clinical resources

Consumer resources

Reviews

Recent activity