U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic Clear Cell Sarcoma of Soft Tissue

MedGen UID:
1695380
•Concept ID:
C5205915
•
Neoplastic Process

Definition

A clear cell sarcoma of soft tissue that has spread from the original site of growth to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Clear Cell Sarcoma of Soft Tissue

Professional guidelines

PubMed

Management of the Hand Tumors.
Datta NK, Das KP, Aish PK, Datta M, Banik SK, Sen SK, Chowdhury RM
Mymensingh Med J 2023 Jan;32(1):135-143. PMID: 36594313
Metastatic nonclear renal cell carcinoma current review in evolving treatment strategies.
Suárez C, Díaz-Mejía N, Morales-Barrera R, González M, Mateo J, Carles J
Curr Opin Urol 2021 May 1;31(3):242-248. doi: 10.1097/MOU.0000000000000869. PMID: 33742977
Biology and management of clear cell sarcoma: state of the art and future perspectives.
Cornillie J, van Cann T, Wozniak A, Hompes D, Schöffski P
Expert Rev Anticancer Ther 2016 Aug;16(8):839-45. Epub 2016 Jun 20 doi: 10.1080/14737140.2016.1197122. PMID: 27253849

Recent clinical studies

Etiology

Cutaneous Melanocytic Tumor With CRTC1::TRIM11 Translocation : An Emerging Entity Analyzed in a Series of 41 Cases.
Hanna J, Ko JS, Billings SD, Boivin F, Beaudoux O, Pissaloux D, Tirode F, Laga A, Fletcher CDM, de la Fouchardiere A
Am J Surg Pathol 2022 Nov 1;46(11):1457-1466. Epub 2022 Aug 23 doi: 10.1097/PAS.0000000000001952. PMID: 35993578
Clear cell sarcoma of the kidney in Austrian children: Long-term survival after relapse.
Friesenbichler W, Lüftinger R, Kropshofer G, Henkel M, Amann G, Furtwängler R, Graf N, Kager L
Pediatr Blood Cancer 2021 May;68(5):e28860. Epub 2021 Jan 12 doi: 10.1002/pbc.28860. PMID: 33438324
Cancer and mTOR Inhibitors in Transplant Recipients.
de Fijter JW
Transplantation 2017 Jan;101(1):45-55. doi: 10.1097/TP.0000000000001447. PMID: 27547865
Cutaneous clear cell neoplasms: a histopathological reappraisal.
Biswas A, Mahalingam M
Am J Dermatopathol 2012 May;34(3):237-54. doi: 10.1097/DAD.0b013e3182106d28. PMID: 22513804
Clear cell tumors of bone.
Swanson PE
Semin Diagn Pathol 1997 Nov;14(4):281-91. PMID: 9383827

Diagnosis

The many faces of Atypical fibroxanthoma.
Agaimy A
Semin Diagn Pathol 2023 Jul;40(4):306-312. Epub 2023 Jun 23 doi: 10.1053/j.semdp.2023.06.001. PMID: 37438163
PRAME Expression in Cancer. A Systematic Immunohistochemical Study of >5800 Epithelial and Nonepithelial Tumors.
Kaczorowski M, Chłopek M, Kruczak A, Ryś J, Lasota J, Miettinen M
Am J Surg Pathol 2022 Nov 1;46(11):1467-1476. Epub 2022 Aug 16 doi: 10.1097/PAS.0000000000001944. PMID: 35973038Free PMC Article
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Non-mesenchymal Mimics of Sarcoma.
Doyle LA
Surg Pathol Clin 2015 Sep;8(3):493-513. doi: 10.1016/j.path.2015.05.010. PMID: 26297067
Clear cell sarcoma of the kidney: a review.
Gooskens SL, Furtwängler R, Vujanic GM, Dome JS, Graf N, van den Heuvel-Eibrink MM
Eur J Cancer 2012 Sep;48(14):2219-26. Epub 2012 May 12 doi: 10.1016/j.ejca.2012.04.009. PMID: 22579455

Therapy

Metastatic nonclear renal cell carcinoma current review in evolving treatment strategies.
Suárez C, Díaz-Mejía N, Morales-Barrera R, González M, Mateo J, Carles J
Curr Opin Urol 2021 May 1;31(3):242-248. doi: 10.1097/MOU.0000000000000869. PMID: 33742977
Cancer and mTOR Inhibitors in Transplant Recipients.
de Fijter JW
Transplantation 2017 Jan;101(1):45-55. doi: 10.1097/TP.0000000000001447. PMID: 27547865
Biology and management of clear cell sarcoma: state of the art and future perspectives.
Cornillie J, van Cann T, Wozniak A, Hompes D, Schöffski P
Expert Rev Anticancer Ther 2016 Aug;16(8):839-45. Epub 2016 Jun 20 doi: 10.1080/14737140.2016.1197122. PMID: 27253849
Vemurafenib in Multiple Nonmelanoma Cancers with BRAF V600 Mutations.
Hyman DM, Puzanov I, Subbiah V, Faris JE, Chau I, Blay JY, Wolf J, Raje NS, Diamond EL, Hollebecque A, Gervais R, Elez-Fernandez ME, Italiano A, Hofheinz RD, Hidalgo M, Chan E, Schuler M, Lasserre SF, Makrutzki M, Sirzen F, Veronese ML, Tabernero J, Baselga J
N Engl J Med 2015 Aug 20;373(8):726-36. doi: 10.1056/NEJMoa1502309. PMID: 26287849Free PMC Article
Clear cell sarcoma of the ileum: report of a case and review of the literature.
D'Amico FE, Ruffolo C, Romeo S, Massani M, Dei Tos AP, Bassi N
Int J Surg Pathol 2012 Aug;20(4):401-6. Epub 2011 Dec 28 doi: 10.1177/1066896911428073. PMID: 22207412

Prognosis

Cutaneous Melanocytic Tumor With CRTC1::TRIM11 Translocation : An Emerging Entity Analyzed in a Series of 41 Cases.
Hanna J, Ko JS, Billings SD, Boivin F, Beaudoux O, Pissaloux D, Tirode F, Laga A, Fletcher CDM, de la Fouchardiere A
Am J Surg Pathol 2022 Nov 1;46(11):1457-1466. Epub 2022 Aug 23 doi: 10.1097/PAS.0000000000001952. PMID: 35993578
Metastatic Clear-Cell Sarcoma.
Huang X, Liao X
N Engl J Med 2020 Jul 23;383(4):379. doi: 10.1056/NEJMicm1913435. PMID: 32706536
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Biology and management of clear cell sarcoma: state of the art and future perspectives.
Cornillie J, van Cann T, Wozniak A, Hompes D, Schöffski P
Expert Rev Anticancer Ther 2016 Aug;16(8):839-45. Epub 2016 Jun 20 doi: 10.1080/14737140.2016.1197122. PMID: 27253849
Significance of circulating tumor cells in soft tissue sarcoma.
Nicolazzo C, Gradilone A
Anal Cell Pathol (Amst) 2015;2015:697395. Epub 2015 Jun 18 doi: 10.1155/2015/697395. PMID: 26167450Free PMC Article

Clinical prediction guides

STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma.
Adane B, Alexe G, Seong BKA, Lu D, Hwang EE, Hnisz D, Lareau CA, Ross L, Lin S, Dela Cruz FS, Richardson M, Weintraub AS, Wang S, Iniguez AB, Dharia NV, Conway AS, Robichaud AL, Tanenbaum B, Krill-Burger JM, Vazquez F, Schenone M, Berman JN, Kung AL, Carr SA, Aryee MJ, Young RA, Crompton BD, Stegmaier K
Cancer Cell 2021 Jun 14;39(6):827-844.e10. doi: 10.1016/j.ccell.2021.05.007. PMID: 34129824Free PMC Article
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Cancer and mTOR Inhibitors in Transplant Recipients.
de Fijter JW
Transplantation 2017 Jan;101(1):45-55. doi: 10.1097/TP.0000000000001447. PMID: 27547865
Vemurafenib in Multiple Nonmelanoma Cancers with BRAF V600 Mutations.
Hyman DM, Puzanov I, Subbiah V, Faris JE, Chau I, Blay JY, Wolf J, Raje NS, Diamond EL, Hollebecque A, Gervais R, Elez-Fernandez ME, Italiano A, Hofheinz RD, Hidalgo M, Chan E, Schuler M, Lasserre SF, Makrutzki M, Sirzen F, Veronese ML, Tabernero J, Baselga J
N Engl J Med 2015 Aug 20;373(8):726-36. doi: 10.1056/NEJMoa1502309. PMID: 26287849Free PMC Article
Clear cell sarcoma of the kidney: a review.
Gooskens SL, Furtwängler R, Vujanic GM, Dome JS, Graf N, van den Heuvel-Eibrink MM
Eur J Cancer 2012 Sep;48(14):2219-26. Epub 2012 May 12 doi: 10.1016/j.ejca.2012.04.009. PMID: 22579455

Recent systematic reviews

Epidermal growth factor receptor (EGFR) inhibitors for metastatic colorectal cancer.
Chan DLH, Segelov E, Wong RS, Smith A, Herbertson RA, Li BT, Tebbutt N, Price T, Pavlakis N
Cochrane Database Syst Rev 2017 Jun 27;6(6):CD007047. doi: 10.1002/14651858.CD007047.pub2. PMID: 28654140Free PMC Article
Autologous haematopoietic stem cell transplantation following high-dose chemotherapy for non-rhabdomyosarcoma soft tissue sarcomas: a Cochrane systematic review*.
Peinemann F, Labeit AM
BMJ Open 2014 Jul 29;4(7):e005033. doi: 10.1136/bmjopen-2014-005033. PMID: 25079925Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...