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Acute Myeloid Leukemia with Trisomy 8

MedGen UID:
1696774
•Concept ID:
C5206816
•
Neoplastic Process

Definition

An acute myeloid leukemia with trisomy 8. Trisomy 8 is one of the most frequent occurring cytogenetic abnormalities in acute myeloid leukemia. It is grouped as intermediate risk in cytogenetic classifications of acute myeloid leukemia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute Myeloid Leukemia with Trisomy 8

Professional guidelines

PubMed

Clinical Features of Clonal Cytogenetic Abnormalities in Philadelphia-negative Cells Developed During Tyrosine Kinase Inhibitor Treatment.
Oiwa K, Lee S, Fujita K, Ueda T, Yamauchi T
Intern Med 2024 Mar 1;63(5):729-732. Epub 2023 Jul 19 doi: 10.2169/internalmedicine.2182-23. PMID: 37468240Free PMC Article
Circular RNA SPI1 expression before and after induction therapy and its correlation with clinical features, treatment response, and survival of acute myeloid leukemia patients.
Xiong T, Xia L, Song Q
J Clin Lab Anal 2023 Feb;37(3):e24835. Epub 2023 Jan 16 doi: 10.1002/jcla.24835. PMID: 36644997Free PMC Article
Genotype-outcome correlations in pediatric AML: the impact of a monosomal karyotype in trial AML-BFM 2004.
Rasche M, von Neuhoff C, Dworzak M, Bourquin JP, Bradtke J, Göhring G, Escherich G, Fleischhack G, Graf N, Gruhn B, Haas OA, Klingebiel T, Kremens B, Lehrnbecher T, von Stackelberg A, Tchinda J, Zemanova Z, Thiede C, von Neuhoff N, Zimmermann M, Creutzig U, Reinhardt D
Leukemia 2017 Dec;31(12):2807-2814. Epub 2017 Apr 25 doi: 10.1038/leu.2017.121. PMID: 28443606Free PMC Article

Recent clinical studies

Etiology

Prognosis influence of additional chromosome abnormalities in newly diagnosed acute promyelocytic leukemia with t(15;17)(q24;q21).
Liu L, Wang J, Xu H, Zhao S, Wang L, Huang J, Wang H, Tong H, Jin J
Hematology 2024 Dec;29(1):2293513. Epub 2023 Dec 27 doi: 10.1080/16078454.2023.2293513. PMID: 38149662
Molecular genetic and clinical characterization of acute myeloid leukemia with trisomy 8 as the sole chromosome abnormality.
Liu J, Han W, Cai X, Wang Z, Cao L, Hua H, Jia Z, Chao H, Lu X, Shen H
Hematology 2022 Dec;27(1):565-574. doi: 10.1080/16078454.2022.2071799. PMID: 35549661
Trisomy 8 in acute myeloid leukemia.
Hemsing AL, Hovland R, Tsykunova G, Reikvam H
Expert Rev Hematol 2019 Nov;12(11):947-958. Epub 2019 Sep 26 doi: 10.1080/17474086.2019.1657400. PMID: 31422708
Genetic abnormalities and pathophysiology of MDS.
Hosono N
Int J Clin Oncol 2019 Aug;24(8):885-892. Epub 2019 May 15 doi: 10.1007/s10147-019-01462-6. PMID: 31093808
Childhood myelodysplastic syndrome.
Chatterjee T, Choudhry VP
Indian J Pediatr 2013 Sep;80(9):764-71. Epub 2013 Aug 3 doi: 10.1007/s12098-013-1130-8. PMID: 23912822

Diagnosis

Prognosis influence of additional chromosome abnormalities in newly diagnosed acute promyelocytic leukemia with t(15;17)(q24;q21).
Liu L, Wang J, Xu H, Zhao S, Wang L, Huang J, Wang H, Tong H, Jin J
Hematology 2024 Dec;29(1):2293513. Epub 2023 Dec 27 doi: 10.1080/16078454.2023.2293513. PMID: 38149662
Autoimmune and inflammatory manifestations associated with acute myeloid leukemia with Trisomy 8-Case series and review of the literature.
Buchrits S, Kozlovoski D, Gafter-Gvili A, Raanani P, Hayman L, Revyako I, Bernstine H, Wolach O, Shimony S
Eur J Haematol 2022 Mar;108(3):199-203. Epub 2021 Dec 21 doi: 10.1111/ejh.13725. PMID: 34748235
Trisomy 8 in acute myeloid leukemia.
Hemsing AL, Hovland R, Tsykunova G, Reikvam H
Expert Rev Hematol 2019 Nov;12(11):947-958. Epub 2019 Sep 26 doi: 10.1080/17474086.2019.1657400. PMID: 31422708
Myeloid Sarcoma.
Magdy M, Abdel Karim N, Eldessouki I, Gaber O, Rahouma M, Ghareeb M
Oncol Res Treat 2019;42(4):224-229. Epub 2019 Mar 6 doi: 10.1159/000497210. PMID: 30840960
Childhood myelodysplastic syndrome.
Chatterjee T, Choudhry VP
Indian J Pediatr 2013 Sep;80(9):764-71. Epub 2013 Aug 3 doi: 10.1007/s12098-013-1130-8. PMID: 23912822

Therapy

CD74 is expressed in a subset of pediatric acute myeloid leukemia patients and is a promising target for therapy: a report from the Children's Oncology Group.
Menssen AJ, Hudson CA, Alonzo T, Gerbing R, Pardo L, Leonti A, Cook JA, Hsu FC, Lott LL, Dai F, Fearing C, Ghirardelli K, Hylkema T, Tarlock K, Loeb KR, Kolb EA, Cooper T, Pollard J, Wells DA, Loken MR, Aplenc R, Meshinchi S, Brodersen LE
Haematologica 2024 Oct 1;109(10):3182-3193. doi: 10.3324/haematol.2023.283757. PMID: 38299667Free PMC Article
Prognosis influence of additional chromosome abnormalities in newly diagnosed acute promyelocytic leukemia with t(15;17)(q24;q21).
Liu L, Wang J, Xu H, Zhao S, Wang L, Huang J, Wang H, Tong H, Jin J
Hematology 2024 Dec;29(1):2293513. Epub 2023 Dec 27 doi: 10.1080/16078454.2023.2293513. PMID: 38149662
Establishment and validation of prognostic nomogram in acute leukemia with trisomy 8.
Deng T, Wang S, Ran Z, Liu Q, Wang M
Hematology 2023 Dec;28(1):2240131. doi: 10.1080/16078454.2023.2240131. PMID: 37545412
Myeloid Sarcoma.
Magdy M, Abdel Karim N, Eldessouki I, Gaber O, Rahouma M, Ghareeb M
Oncol Res Treat 2019;42(4):224-229. Epub 2019 Mar 6 doi: 10.1159/000497210. PMID: 30840960
Relapse and cytogenetic evolution in myeloid neoplasms.
Ertz-Archambault N, Kelemen K
Panminerva Med 2017 Dec;59(4):308-319. doi: 10.23736/S0031-0808.17.03380-8. PMID: 29144072

Prognosis

Prognosis influence of additional chromosome abnormalities in newly diagnosed acute promyelocytic leukemia with t(15;17)(q24;q21).
Liu L, Wang J, Xu H, Zhao S, Wang L, Huang J, Wang H, Tong H, Jin J
Hematology 2024 Dec;29(1):2293513. Epub 2023 Dec 27 doi: 10.1080/16078454.2023.2293513. PMID: 38149662
Establishment and validation of prognostic nomogram in acute leukemia with trisomy 8.
Deng T, Wang S, Ran Z, Liu Q, Wang M
Hematology 2023 Dec;28(1):2240131. doi: 10.1080/16078454.2023.2240131. PMID: 37545412
Molecular genetic and clinical characterization of acute myeloid leukemia with trisomy 8 as the sole chromosome abnormality.
Liu J, Han W, Cai X, Wang Z, Cao L, Hua H, Jia Z, Chao H, Lu X, Shen H
Hematology 2022 Dec;27(1):565-574. doi: 10.1080/16078454.2022.2071799. PMID: 35549661
Trisomy 8 in acute myeloid leukemia.
Hemsing AL, Hovland R, Tsykunova G, Reikvam H
Expert Rev Hematol 2019 Nov;12(11):947-958. Epub 2019 Sep 26 doi: 10.1080/17474086.2019.1657400. PMID: 31422708
Childhood myelodysplastic syndrome.
Chatterjee T, Choudhry VP
Indian J Pediatr 2013 Sep;80(9):764-71. Epub 2013 Aug 3 doi: 10.1007/s12098-013-1130-8. PMID: 23912822

Clinical prediction guides

Prognosis influence of additional chromosome abnormalities in newly diagnosed acute promyelocytic leukemia with t(15;17)(q24;q21).
Liu L, Wang J, Xu H, Zhao S, Wang L, Huang J, Wang H, Tong H, Jin J
Hematology 2024 Dec;29(1):2293513. Epub 2023 Dec 27 doi: 10.1080/16078454.2023.2293513. PMID: 38149662
Establishment and validation of prognostic nomogram in acute leukemia with trisomy 8.
Deng T, Wang S, Ran Z, Liu Q, Wang M
Hematology 2023 Dec;28(1):2240131. doi: 10.1080/16078454.2023.2240131. PMID: 37545412
ASXL1 mutations in AML are associated with specific clinical and cytogenetic characteristics.
Kakosaiou K, Panitsas F, Daraki A, Pagoni M, Apostolou P, Ioannidou A, Vlachadami I, Marinakis T, Giatra C, Vasilatou D, Sambani C, Pappa V, Manola KN
Leuk Lymphoma 2018 Oct;59(10):2439-2446. Epub 2018 Feb 7 doi: 10.1080/10428194.2018.1433298. PMID: 29411666
Relapse and cytogenetic evolution in myeloid neoplasms.
Ertz-Archambault N, Kelemen K
Panminerva Med 2017 Dec;59(4):308-319. doi: 10.23736/S0031-0808.17.03380-8. PMID: 29144072
Childhood myelodysplastic syndrome.
Chatterjee T, Choudhry VP
Indian J Pediatr 2013 Sep;80(9):764-71. Epub 2013 Aug 3 doi: 10.1007/s12098-013-1130-8. PMID: 23912822

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