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Monoclonal elevation of circulating IgA

MedGen UID:
1697825
•Concept ID:
C5139277
•
Finding
HPO: HP:0032335

Definition

An increase in circulating IgA characterized by one predominant band in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase in circulating immunoglobulins. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMonoclonal elevation of circulating IgA

Professional guidelines

PubMed

Circulating levels of B lymphocyte stimulator in patients with rheumatoid arthritis following rituximab treatment: relationships with B cell depletion, circulating antibodies, and clinical relapse.
Cambridge G, Stohl W, Leandro MJ, Migone TS, Hilbert DM, Edwards JC
Arthritis Rheum 2006 Mar;54(3):723-32. doi: 10.1002/art.21650. PMID: 16508933

Recent clinical studies

Etiology

Circulating immunoglobulins and transient lymphocytopenia in a sub-study of CAPRISA 012B, testing HIV monoclonal antibodies in a phase 1 trial.
Sobia P, Mahomed S, Sivro A, Paul S, Osman F, Harkoo I, Garrett N, Karim QA, Karim SSA, Archary D
Sci Rep 2024 Jun 12;14(1):13499. doi: 10.1038/s41598-024-63902-2. PMID: 38866888Free PMC Article
Rituximab in patients with acute ST-elevation myocardial infarction: an experimental medicine safety study.
Zhao TX, Aetesam-Ur-Rahman M, Sage AP, Victor S, Kurian R, Fielding S, Ait-Oufella H, Chiu YD, Binder CJ, Mckie M, Hoole SP, Mallat Z
Cardiovasc Res 2022 Feb 21;118(3):872-882. doi: 10.1093/cvr/cvab113. PMID: 33783498Free PMC Article
Clinical significance of autoantibodies in a large cohort of patients with chronic graft-versus-host disease defined by NIH criteria.
Kuzmina Z, Gounden V, Curtis L, Avila D, Rnp TT, Baruffaldi J, Cowen EW, Naik HB, Hasni SA, Mays JW, Mitchell S, Baird K, Steinberg SM, Pavletic SZ
Am J Hematol 2015 Feb;90(2):114-9. Epub 2014 Nov 24 doi: 10.1002/ajh.23885. PMID: 25363867Free PMC Article
Circulating serum free light chains as predictive markers of AIDS-related lymphoma.
Landgren O, Goedert JJ, Rabkin CS, Wilson WH, Dunleavy K, Kyle RA, Katzmann JA, Rajkumar SV, Engels EA
J Clin Oncol 2010 Feb 10;28(5):773-9. Epub 2010 Jan 4 doi: 10.1200/JCO.2009.25.1322. PMID: 20048176Free PMC Article
Experimental murine IgA nephropathy following passive administration of vomitoxin-induced IgA monoclonal antibodies.
Yan D, Rumbeiha WK, Pestka JJ
Food Chem Toxicol 1998 Dec;36(12):1095-106. doi: 10.1016/s0278-6915(98)00072-6. PMID: 9862652

Diagnosis

Investigating the utility of saliva immunoglobulins for the detection of myeloma and using myeloma proteins to clarify partition between oral and systemic immunity.
Heaney JLJ, Faustini S, Evans L, Rapson A, Collman E, Emery A, Campbell JP, Moore S, Goodall M, Afzal Z, Chapple IL, Pratt G, Drayson MT
Eur J Haematol 2022 Jun;108(6):493-502. Epub 2022 Feb 28 doi: 10.1111/ejh.13758. PMID: 35184331Free PMC Article
Rituximab in patients with acute ST-elevation myocardial infarction: an experimental medicine safety study.
Zhao TX, Aetesam-Ur-Rahman M, Sage AP, Victor S, Kurian R, Fielding S, Ait-Oufella H, Chiu YD, Binder CJ, Mckie M, Hoole SP, Mallat Z
Cardiovasc Res 2022 Feb 21;118(3):872-882. doi: 10.1093/cvr/cvab113. PMID: 33783498Free PMC Article
Clinical significance of autoantibodies in a large cohort of patients with chronic graft-versus-host disease defined by NIH criteria.
Kuzmina Z, Gounden V, Curtis L, Avila D, Rnp TT, Baruffaldi J, Cowen EW, Naik HB, Hasni SA, Mays JW, Mitchell S, Baird K, Steinberg SM, Pavletic SZ
Am J Hematol 2015 Feb;90(2):114-9. Epub 2014 Nov 24 doi: 10.1002/ajh.23885. PMID: 25363867Free PMC Article
Circulating serum free light chains as predictive markers of AIDS-related lymphoma.
Landgren O, Goedert JJ, Rabkin CS, Wilson WH, Dunleavy K, Kyle RA, Katzmann JA, Rajkumar SV, Engels EA
J Clin Oncol 2010 Feb 10;28(5):773-9. Epub 2010 Jan 4 doi: 10.1200/JCO.2009.25.1322. PMID: 20048176Free PMC Article
Chronic idiopathic ataxic neuropathy.
Dalakas MC
Ann Neurol 1986 Jun;19(6):545-54. doi: 10.1002/ana.410190605. PMID: 3014995

Therapy

Circulating immunoglobulins and transient lymphocytopenia in a sub-study of CAPRISA 012B, testing HIV monoclonal antibodies in a phase 1 trial.
Sobia P, Mahomed S, Sivro A, Paul S, Osman F, Harkoo I, Garrett N, Karim QA, Karim SSA, Archary D
Sci Rep 2024 Jun 12;14(1):13499. doi: 10.1038/s41598-024-63902-2. PMID: 38866888Free PMC Article
Rituximab in patients with acute ST-elevation myocardial infarction: an experimental medicine safety study.
Zhao TX, Aetesam-Ur-Rahman M, Sage AP, Victor S, Kurian R, Fielding S, Ait-Oufella H, Chiu YD, Binder CJ, Mckie M, Hoole SP, Mallat Z
Cardiovasc Res 2022 Feb 21;118(3):872-882. doi: 10.1093/cvr/cvab113. PMID: 33783498Free PMC Article
Targeting BAFF and APRIL in systemic lupus erythematosus and other antibody-associated diseases.
Samy E, Wax S, Huard B, Hess H, Schneider P
Int Rev Immunol 2017 Jan 2;36(1):3-19. doi: 10.1080/08830185.2016.1276903. PMID: 28215100
Clinical significance of autoantibodies in a large cohort of patients with chronic graft-versus-host disease defined by NIH criteria.
Kuzmina Z, Gounden V, Curtis L, Avila D, Rnp TT, Baruffaldi J, Cowen EW, Naik HB, Hasni SA, Mays JW, Mitchell S, Baird K, Steinberg SM, Pavletic SZ
Am J Hematol 2015 Feb;90(2):114-9. Epub 2014 Nov 24 doi: 10.1002/ajh.23885. PMID: 25363867Free PMC Article
The effects of immunomodulation on peripheral T cell subsets.
Chatenoud L, Berrih S, Bene MC, Kreis H, Bach JF
J Clin Immunol 1982 Jul;2(3 Suppl):61S-66S. PMID: 6290529

Prognosis

Targeting BAFF and APRIL in systemic lupus erythematosus and other antibody-associated diseases.
Samy E, Wax S, Huard B, Hess H, Schneider P
Int Rev Immunol 2017 Jan 2;36(1):3-19. doi: 10.1080/08830185.2016.1276903. PMID: 28215100
Circulating serum free light chains as predictive markers of AIDS-related lymphoma.
Landgren O, Goedert JJ, Rabkin CS, Wilson WH, Dunleavy K, Kyle RA, Katzmann JA, Rajkumar SV, Engels EA
J Clin Oncol 2010 Feb 10;28(5):773-9. Epub 2010 Jan 4 doi: 10.1200/JCO.2009.25.1322. PMID: 20048176Free PMC Article
Chronic idiopathic ataxic neuropathy.
Dalakas MC
Ann Neurol 1986 Jun;19(6):545-54. doi: 10.1002/ana.410190605. PMID: 3014995
The effects of immunomodulation on peripheral T cell subsets.
Chatenoud L, Berrih S, Bene MC, Kreis H, Bach JF
J Clin Immunol 1982 Jul;2(3 Suppl):61S-66S. PMID: 6290529

Clinical prediction guides

Circulating immunoglobulins and transient lymphocytopenia in a sub-study of CAPRISA 012B, testing HIV monoclonal antibodies in a phase 1 trial.
Sobia P, Mahomed S, Sivro A, Paul S, Osman F, Harkoo I, Garrett N, Karim QA, Karim SSA, Archary D
Sci Rep 2024 Jun 12;14(1):13499. doi: 10.1038/s41598-024-63902-2. PMID: 38866888Free PMC Article
Targeting BAFF and APRIL in systemic lupus erythematosus and other antibody-associated diseases.
Samy E, Wax S, Huard B, Hess H, Schneider P
Int Rev Immunol 2017 Jan 2;36(1):3-19. doi: 10.1080/08830185.2016.1276903. PMID: 28215100
Circulating serum free light chains as predictive markers of AIDS-related lymphoma.
Landgren O, Goedert JJ, Rabkin CS, Wilson WH, Dunleavy K, Kyle RA, Katzmann JA, Rajkumar SV, Engels EA
J Clin Oncol 2010 Feb 10;28(5):773-9. Epub 2010 Jan 4 doi: 10.1200/JCO.2009.25.1322. PMID: 20048176Free PMC Article
Experimental murine IgA nephropathy following passive administration of vomitoxin-induced IgA monoclonal antibodies.
Yan D, Rumbeiha WK, Pestka JJ
Food Chem Toxicol 1998 Dec;36(12):1095-106. doi: 10.1016/s0278-6915(98)00072-6. PMID: 9862652
The effects of immunomodulation on peripheral T cell subsets.
Chatenoud L, Berrih S, Bene MC, Kreis H, Bach JF
J Clin Immunol 1982 Jul;2(3 Suppl):61S-66S. PMID: 6290529

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