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Nodular Leptomeningeal Disease Finding

MedGen UID:
1700211
•Concept ID:
C5206873
•
Finding
Synonym: Nodular Leptomeningeal Disease

Definition

A finding of diffuse spread of neoplastic cells to the leptomeninges that may be characterized by focal nodular enhancement on the dural, pial, or meningeal surface on MRI. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNodular Leptomeningeal Disease Finding

Professional guidelines

PubMed

Medulloblastoma in adults: an analysis of clinico-pathological, molecular and treatment factors.
Franchino F, Morra I, Forni M, Bertero L, Zanini C, Roveta F, Ricardi U, Mantovani C, Carpaneto A, Migliore E, Pellerino A, Ferrio F, Cassoni P, Garbossa D, Soffietti R, Rudà R
J Neurosurg Sci 2024 Jun;68(3):260-269. Epub 2021 Nov 11 doi: 10.23736/S0390-5616.21.05548-X. PMID: 34763393
Pachymeningitis in Biopsy-Proven Sarcoidosis: Clinical Course, Radiographic Findings, Response to Treatment, and Long-term Outcomes.
Chakales PA, Herman MC, Chien LC, Hutto SK
Neurol Neuroimmunol Neuroinflamm 2022 Nov;9(6) Epub 2022 Sep 26 doi: 10.1212/NXI.0000000000200028. PMID: 36163175Free PMC Article
Neurosarcoidosis of the Cauda Equina: Clinical Course, Radiographic and Electrodiagnostic Findings, Response to Treatment, and Outcomes.
Bou GA, Garcia-Santibanez R, Castilho AJ, Hutto SK
Neurol Neuroimmunol Neuroinflamm 2022 Jul;9(4) Epub 2022 Apr 29 doi: 10.1212/NXI.0000000000001170. PMID: 35487693Free PMC Article

Recent clinical studies

Etiology

Genomic alterations associated with postoperative nodular leptomeningeal disease after resection of brain metastases.
Morshed RA, Cummins DD, Nguyen MP, Saggi S, Vasudevan HN, Braunstein SE, Goldschmidt E, Chang EF, McDermott MW, Berger MS, Theodosopoulos PV, Daras M, Hervey-Jumper SL, Aghi MK
J Neurosurg 2024 Feb 1;140(2):328-337. Epub 2023 Jul 28 doi: 10.3171/2023.5.JNS23460. PMID: 37548547Free PMC Article
Identification of risk factors associated with leptomeningeal disease after resection of brain metastases.
Morshed RA, Saggi S, Cummins DD, Molinaro AM, Young JS, Viner JA, Villanueva-Meyer JE, Goldschmidt E, Boreta L, Braunstein SE, Chang EF, McDermott MW, Berger MS, Theodosopoulos PV, Hervey-Jumper SL, Aghi MK, Daras M
J Neurosurg 2023 Aug 1;139(2):402-413. Epub 2023 Jan 13 doi: 10.3171/2022.12.JNS221490. PMID: 36640095Free PMC Article
A Case of Neurosarcoidosis Mimicking Brain Tumor.
Sari L, Peker AA, Cesme DH, Alkan A
Curr Med Imaging 2021;17(5):657-659. doi: 10.2174/1573405616666201118114152. PMID: 33213326
Stereotactic Radiosurgery for Resected Brain Metastases: Single-Institutional Experience of Over 500 Cavities.
Shi S, Sandhu N, Jin MC, Wang E, Jaoude JA, Schofield K, Zhang C, Liu E, Gibbs IC, Hancock SL, Chang SD, Li G, Hayden-Gephart M, Adler JR, Soltys SG, Pollom EL
Int J Radiat Oncol Biol Phys 2020 Mar 15;106(4):764-771. Epub 2019 Nov 27 doi: 10.1016/j.ijrobp.2019.11.022. PMID: 31785338
Predictors of leptomeningeal disease following hypofractionated stereotactic radiotherapy for intact and resected brain metastases.
Nguyen TK, Sahgal A, Detsky J, Atenafu EG, Myrehaug S, Tseng CL, Husain Z, Heyn C, Maralani P, Ruschin M, Perry J, Soliman H
Neuro Oncol 2020 Jan 11;22(1):84-93. doi: 10.1093/neuonc/noz144. PMID: 31412120Free PMC Article

Diagnosis

Genomic alterations associated with postoperative nodular leptomeningeal disease after resection of brain metastases.
Morshed RA, Cummins DD, Nguyen MP, Saggi S, Vasudevan HN, Braunstein SE, Goldschmidt E, Chang EF, McDermott MW, Berger MS, Theodosopoulos PV, Daras M, Hervey-Jumper SL, Aghi MK
J Neurosurg 2024 Feb 1;140(2):328-337. Epub 2023 Jul 28 doi: 10.3171/2023.5.JNS23460. PMID: 37548547Free PMC Article
Neurological Involvement in Malignant Atrophic Papulosis: A Comprehensive Review of Literature.
Yousefi S, Borhani-Haghighi A, Safari A, Shapiro L
Neurol India 2022 Jan-Feb;70(1):5-10. doi: 10.4103/0028-3886.338719. PMID: 35263846
Intradural Extramedullary Spinal Neoplasms: Radiologic-Pathologic Correlation.
Koeller KK, Shih RY
Radiographics 2019 Mar-Apr;39(2):468-490. doi: 10.1148/rg.2019180200. PMID: 30844353
Therapy of leptomeningeal metastasis in solid tumors.
Mack F, Baumert BG, Schäfer N, Hattingen E, Scheffler B, Herrlinger U, Glas M
Cancer Treat Rev 2016 Feb;43:83-91. Epub 2015 Dec 24 doi: 10.1016/j.ctrv.2015.12.004. PMID: 26827696
Patterns of contrast enhancement in the brain and meninges.
Smirniotopoulos JG, Murphy FM, Rushing EJ, Rees JH, Schroeder JW
Radiographics 2007 Mar-Apr;27(2):525-51. doi: 10.1148/rg.272065155. PMID: 17374867

Therapy

Identification of risk factors associated with leptomeningeal disease after resection of brain metastases.
Morshed RA, Saggi S, Cummins DD, Molinaro AM, Young JS, Viner JA, Villanueva-Meyer JE, Goldschmidt E, Boreta L, Braunstein SE, Chang EF, McDermott MW, Berger MS, Theodosopoulos PV, Hervey-Jumper SL, Aghi MK, Daras M
J Neurosurg 2023 Aug 1;139(2):402-413. Epub 2023 Jan 13 doi: 10.3171/2022.12.JNS221490. PMID: 36640095Free PMC Article
Stereotactic Radiosurgery for Resected Brain Metastases: Single-Institutional Experience of Over 500 Cavities.
Shi S, Sandhu N, Jin MC, Wang E, Jaoude JA, Schofield K, Zhang C, Liu E, Gibbs IC, Hancock SL, Chang SD, Li G, Hayden-Gephart M, Adler JR, Soltys SG, Pollom EL
Int J Radiat Oncol Biol Phys 2020 Mar 15;106(4):764-771. Epub 2019 Nov 27 doi: 10.1016/j.ijrobp.2019.11.022. PMID: 31785338
Therapy of leptomeningeal metastasis in solid tumors.
Mack F, Baumert BG, Schäfer N, Hattingen E, Scheffler B, Herrlinger U, Glas M
Cancer Treat Rev 2016 Feb;43:83-91. Epub 2015 Dec 24 doi: 10.1016/j.ctrv.2015.12.004. PMID: 26827696
Diagnosis and individualized therapy of neoplastic meningitis.
Strik H, Prömmel P
Expert Rev Anticancer Ther 2010 Jul;10(7):1137-48. doi: 10.1586/era.10.86. PMID: 20645702
Neurosarcoidosis: a review of its intracranial manifestation.
Nowak DA, Widenka DC
J Neurol 2001 May;248(5):363-72. doi: 10.1007/s004150170175. PMID: 11437156

Prognosis

Genomic alterations associated with postoperative nodular leptomeningeal disease after resection of brain metastases.
Morshed RA, Cummins DD, Nguyen MP, Saggi S, Vasudevan HN, Braunstein SE, Goldschmidt E, Chang EF, McDermott MW, Berger MS, Theodosopoulos PV, Daras M, Hervey-Jumper SL, Aghi MK
J Neurosurg 2024 Feb 1;140(2):328-337. Epub 2023 Jul 28 doi: 10.3171/2023.5.JNS23460. PMID: 37548547Free PMC Article
Identification of risk factors associated with leptomeningeal disease after resection of brain metastases.
Morshed RA, Saggi S, Cummins DD, Molinaro AM, Young JS, Viner JA, Villanueva-Meyer JE, Goldschmidt E, Boreta L, Braunstein SE, Chang EF, McDermott MW, Berger MS, Theodosopoulos PV, Hervey-Jumper SL, Aghi MK, Daras M
J Neurosurg 2023 Aug 1;139(2):402-413. Epub 2023 Jan 13 doi: 10.3171/2022.12.JNS221490. PMID: 36640095Free PMC Article
Neurological Involvement in Malignant Atrophic Papulosis: A Comprehensive Review of Literature.
Yousefi S, Borhani-Haghighi A, Safari A, Shapiro L
Neurol India 2022 Jan-Feb;70(1):5-10. doi: 10.4103/0028-3886.338719. PMID: 35263846
Predictors of leptomeningeal disease following hypofractionated stereotactic radiotherapy for intact and resected brain metastases.
Nguyen TK, Sahgal A, Detsky J, Atenafu EG, Myrehaug S, Tseng CL, Husain Z, Heyn C, Maralani P, Ruschin M, Perry J, Soliman H
Neuro Oncol 2020 Jan 11;22(1):84-93. doi: 10.1093/neuonc/noz144. PMID: 31412120Free PMC Article
Late radiation injury to peripheral nerves.
Pradat PF, Delanian S
Handb Clin Neurol 2013;115:743-58. doi: 10.1016/B978-0-444-52902-2.00043-6. PMID: 23931813

Clinical prediction guides

Genomic alterations associated with postoperative nodular leptomeningeal disease after resection of brain metastases.
Morshed RA, Cummins DD, Nguyen MP, Saggi S, Vasudevan HN, Braunstein SE, Goldschmidt E, Chang EF, McDermott MW, Berger MS, Theodosopoulos PV, Daras M, Hervey-Jumper SL, Aghi MK
J Neurosurg 2024 Feb 1;140(2):328-337. Epub 2023 Jul 28 doi: 10.3171/2023.5.JNS23460. PMID: 37548547Free PMC Article
Neurosarcoidosis of the Cauda Equina: Clinical Course, Radiographic and Electrodiagnostic Findings, Response to Treatment, and Outcomes.
Bou GA, Garcia-Santibanez R, Castilho AJ, Hutto SK
Neurol Neuroimmunol Neuroinflamm 2022 Jul;9(4) Epub 2022 Apr 29 doi: 10.1212/NXI.0000000000001170. PMID: 35487693Free PMC Article
Prognostic validation and clinical implications of the EANO ESMO classification of leptomeningeal metastasis from solid tumors.
Le Rhun E, Devos P, Weller J, Seystahl K, Mo F, Compter A, Berghoff AS, Jongen JLM, Wolpert F, Rudà R, Brandsma D, van den Bent M, Preusser M, Herrlinger U, Weller M
Neuro Oncol 2021 Jul 1;23(7):1100-1112. doi: 10.1093/neuonc/noaa298. PMID: 33367859Free PMC Article
Nodular Leptomeningeal Disease-A Distinct Pattern of Recurrence After Postresection Stereotactic Radiosurgery for Brain Metastases: A Multi-institutional Study of Interobserver Reliability.
Turner BE, Prabhu RS, Burri SH, Brown PD, Pollom EL, Milano MT, Weiss SE, Iv M, Fischbein N, Soliman H, Lo SS, Chao ST, Cox BW, Murphy JD, Li G, Gephart MH, Nagpal S, Atalar B, Azoulay M, Thomas R, Tillman G, Durkee BY, Shah JL, Soltys SG
Int J Radiat Oncol Biol Phys 2020 Mar 1;106(3):579-586. Epub 2019 Oct 10 doi: 10.1016/j.ijrobp.2019.10.002. PMID: 31605786Free PMC Article
Late radiation injury to peripheral nerves.
Pradat PF, Delanian S
Handb Clin Neurol 2013;115:743-58. doi: 10.1016/B978-0-444-52902-2.00043-6. PMID: 23931813

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