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Increased urinary transitional epithelial cell count

MedGen UID:
1703159
•Concept ID:
C5139199
•
Finding
HPO: HP:0032214

Definition

An increased number of transitional epithelial cells per high-power field in urinanalysis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased urinary transitional epithelial cell count

Professional guidelines

PubMed

Improving clinical performance of urine sediment analysis by implementation of intelligent verification criteria.
Oyaert M, Maghari S, Speeckaert M, Delanghe J
Clin Chem Lab Med 2022 Oct 26;60(11):1772-1779. Epub 2022 Sep 8 doi: 10.1515/cclm-2022-0617. PMID: 36069776
Cross-over data supporting long-term antibiotic treatment in patients with painful lower urinary tract symptoms, pyuria and negative urinalysis.
Swamy S, Kupelian AS, Khasriya R, Dharmasena D, Toteva H, Dehpour T, Collins L, Rohn JL, Malone-Lee J
Int Urogynecol J 2019 Mar;30(3):409-414. Epub 2018 Dec 18 doi: 10.1007/s00192-018-3846-5. PMID: 30564872Free PMC Article
Reduction in chromosomal damage in schistosomiasis patients after treatment with praziquantel.
Anwar WA, Rosin MP
Mutat Res 1993 Jan;298(3):179-85. doi: 10.1016/0165-1218(93)90039-g. PMID: 7678152

Recent clinical studies

Etiology

Intraoperative cell salvage: The impact on immune cell numbers.
Roets M, Sturgess D, Tran T, Obeysekera M, Perros A, Tung JP, Flower R, van Zundert A, Dean M
PLoS One 2023;18(8):e0289177. Epub 2023 Aug 1 doi: 10.1371/journal.pone.0289177. PMID: 37527263Free PMC Article
Enhanced SHP-1 Expression in Podocyturia Is Associated with Kidney Dysfunction in Patients with Diabetes.
Lizotte F, Robillard S, Lavoie N, Rousseau M, Denhez B, Moreau J, Higgins S, Sabbagh R, Côté AM, Geraldes P
Kidney360 2022 Oct 27;3(10):1710-1719. Epub 2022 Aug 31 doi: 10.34067/KID.0002152022. PMID: 36514736Free PMC Article
Role of aggregate-forming pilus (AFP) in adherence and colonization of both intestinal and urinary tracts.
Schüroff PA, Abe CM, Silva JW, de Paula Coelho C, Andrade FB, Hernandes RT, Dobrindt U, Gomes TAT, Elias WP
Virulence 2022 Dec;13(1):1423-1433. doi: 10.1080/21505594.2022.2112818. PMID: 35982607Free PMC Article
Effects of Electronic Cigarette Constituents on the Human Lung: A Pilot Clinical Trial.
Song MA, Reisinger SA, Freudenheim JL, Brasky TM, Mathé EA, McElroy JP, Nickerson QA, Weng DY, Wewers MD, Shields PG
Cancer Prev Res (Phila) 2020 Feb;13(2):145-152. Epub 2019 Oct 16 doi: 10.1158/1940-6207.CAPR-19-0400. PMID: 31619441Free PMC Article
Glomerular epithelial CD44 expression and segmental sclerosis in IgA nephropathy.
Kim S, Kim YH, Choi KH, Jeong HJ
Clin Exp Nephrol 2016 Dec;20(6):871-877. Epub 2015 Dec 28 doi: 10.1007/s10157-015-1222-z. PMID: 26711244

Diagnosis

Rapid Screening of Urinary Tract Infection Using Microfluidic Inertial-Impedance Cytometry.
Petchakup C, Chen YYC, Tay HM, Ong HB, Hon PY, De PP, Yeo TW, Li KHH, Vasoo S, Hou HW
ACS Sens 2023 Aug 25;8(8):3136-3145. Epub 2023 Jul 21 doi: 10.1021/acssensors.3c00819. PMID: 37477562
Focal Segmental Glomerulosclerosis Associated with Essential Thrombocythemia.
Sugimoto H, Sawa N, Yamagiwa H, Kawada M, Ikuma D, Oba Y, Mizuno H, Sekine A, Yamanouchi M, Hasegawa E, Suwabe T, Nishida A, Kono K, Kinowaki K, Ohashi K, Yamaguchi Y, Ubara Y
Intern Med 2023 Jun 15;62(12):1789-1794. Epub 2022 Oct 26 doi: 10.2169/internalmedicine.0767-22. PMID: 36288989Free PMC Article
Improving clinical performance of urine sediment analysis by implementation of intelligent verification criteria.
Oyaert M, Maghari S, Speeckaert M, Delanghe J
Clin Chem Lab Med 2022 Oct 26;60(11):1772-1779. Epub 2022 Sep 8 doi: 10.1515/cclm-2022-0617. PMID: 36069776
Complement fragments are biomarkers of antibody-mediated endothelial injury.
Stites E, Renner B, Laskowski J, Le Quintrec M, You Z, Freed B, Cooper J, Jalal D, Thurman JM
Mol Immunol 2020 Feb;118:142-152. Epub 2019 Dec 26 doi: 10.1016/j.molimm.2019.12.011. PMID: 31884386Free PMC Article
Tumor Cell-Derived Microvesicles Induced Not Epithelial-Mesenchymal Transition but Apoptosis in Human Proximal Tubular (HK-2) Cells: Implications for Renal Impairment in Multiple Myeloma.
Zhao A, Kong F, Liu CJ, Yan G, Gao F, Guo H, Guo AY, Chen Z, Li Q
Int J Mol Sci 2017 Feb 27;18(3) doi: 10.3390/ijms18030513. PMID: 28264449Free PMC Article

Therapy

ADAM12 promotes gemcitabine resistance by activating EGFR signaling pathway and induces EMT in bladder cancer.
Wang R, Gao D, Chen C, Fan G, Cheng H, Tao Y, Lu J, Tian J, Wang Y, Wang Z
Clin Transl Oncol 2023 May;25(5):1425-1435. Epub 2022 Dec 13 doi: 10.1007/s12094-022-03044-x. PMID: 36512304
Calcium dobesilate mediates renal interstitial fibrosis and delay renal peritubular capillary loss through Sirt1/p53 signaling pathway.
Wang Y, Zuo B, Wang N, Li S, Liu C, Sun D
Biomed Pharmacother 2020 Dec;132:110798. Epub 2020 Oct 1 doi: 10.1016/j.biopha.2020.110798. PMID: 33011612
Effects of Electronic Cigarette Constituents on the Human Lung: A Pilot Clinical Trial.
Song MA, Reisinger SA, Freudenheim JL, Brasky TM, Mathé EA, McElroy JP, Nickerson QA, Weng DY, Wewers MD, Shields PG
Cancer Prev Res (Phila) 2020 Feb;13(2):145-152. Epub 2019 Oct 16 doi: 10.1158/1940-6207.CAPR-19-0400. PMID: 31619441Free PMC Article
Protective effects of gliclazide on high glucose and AGEs-induced damage of glomerular mesangial cells and renal tubular epithelial cells via inhibiting RAGE-p22phox-NF-kB pathway.
Yang PY, Li PC, Feng B
Eur Rev Med Pharmacol Sci 2019 Oct;23(20):9099-9107. doi: 10.26355/eurrev_201910_19313. PMID: 31696501
CD16+CD56+ cells are a potential culprit for hematuria in IgA nephropathy.
Iwatani H, Nagasawa Y, Yamamoto R, Iio K, Mizui M, Horii A, Kitahara T, Inohara H, Kumanogoh A, Imai E, Rakugi H, Isaka Y
Clin Exp Nephrol 2015 Apr;19(2):216-24. Epub 2014 May 6 doi: 10.1007/s10157-014-0968-z. PMID: 24798970

Prognosis

Enhanced SHP-1 Expression in Podocyturia Is Associated with Kidney Dysfunction in Patients with Diabetes.
Lizotte F, Robillard S, Lavoie N, Rousseau M, Denhez B, Moreau J, Higgins S, Sabbagh R, Côté AM, Geraldes P
Kidney360 2022 Oct 27;3(10):1710-1719. Epub 2022 Aug 31 doi: 10.34067/KID.0002152022. PMID: 36514736Free PMC Article
Peritubular Capillary Rarefaction: An Underappreciated Regulator of CKD Progression.
Kida Y
Int J Mol Sci 2020 Nov 4;21(21) doi: 10.3390/ijms21218255. PMID: 33158122Free PMC Article
miR-325-3p Overexpression Inhibits Proliferation and Metastasis of Bladder Cancer Cells by Regulating MT3.
Sun S, Liu F, Xian S, Cai D
Med Sci Monit 2020 Jun 8;26:e920331. doi: 10.12659/MSM.920331. PMID: 32512576Free PMC Article
Tumor Cell-Derived Microvesicles Induced Not Epithelial-Mesenchymal Transition but Apoptosis in Human Proximal Tubular (HK-2) Cells: Implications for Renal Impairment in Multiple Myeloma.
Zhao A, Kong F, Liu CJ, Yan G, Gao F, Guo H, Guo AY, Chen Z, Li Q
Int J Mol Sci 2017 Feb 27;18(3) doi: 10.3390/ijms18030513. PMID: 28264449Free PMC Article
A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro.
Adler M, Ramm S, Hafner M, Muhlich JL, Gottwald EM, Weber E, Jaklic A, Ajay AK, Svoboda D, Auerbach S, Kelly EJ, Himmelfarb J, Vaidya VS
J Am Soc Nephrol 2016 Apr;27(4):1015-28. Epub 2015 Aug 10 doi: 10.1681/ASN.2015010060. PMID: 26260164Free PMC Article

Clinical prediction guides

Integrated single-cell and spatial transcriptomic profiling reveals higher intratumour heterogeneity and epithelial-fibroblast interactions in recurrent bladder cancer.
Shi ZD, Sun Z, Zhu ZB, Liu X, Chen JZ, Hao L, Zhu JF, Pang K, Wu D, Dong Y, Liu YF, Chen WH, Liang Q, Zhuo SC, Han CH
Clin Transl Med 2023 Jul;13(7):e1338. doi: 10.1002/ctm2.1338. PMID: 37488671Free PMC Article
Rapid Screening of Urinary Tract Infection Using Microfluidic Inertial-Impedance Cytometry.
Petchakup C, Chen YYC, Tay HM, Ong HB, Hon PY, De PP, Yeo TW, Li KHH, Vasoo S, Hou HW
ACS Sens 2023 Aug 25;8(8):3136-3145. Epub 2023 Jul 21 doi: 10.1021/acssensors.3c00819. PMID: 37477562
Peritubular Capillary Rarefaction: An Underappreciated Regulator of CKD Progression.
Kida Y
Int J Mol Sci 2020 Nov 4;21(21) doi: 10.3390/ijms21218255. PMID: 33158122Free PMC Article
Downregulated LINC00460 inhibits cell proliferation and promotes cell apoptosis in prostate cancer.
Dong Y, Quan HY
Eur Rev Med Pharmacol Sci 2019 Jul;23(14):6070-6078. doi: 10.26355/eurrev_201907_18420. PMID: 31364108
Growth hormone and chronic kidney disease.
Pasupulati AK, Menon RK
Curr Opin Nephrol Hypertens 2019 Jan;28(1):10-15. doi: 10.1097/MNH.0000000000000468. PMID: 30394899

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