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Locally Advanced Colorectal Carcinoma

MedGen UID:
1704242
•Concept ID:
C5206809
•
Neoplastic Process

Definition

A colorectal carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Professional guidelines

PubMed

Role of extended resection in the initial treatment of locally advanced colorectal carcinoma.
Lopez MJ, Monafo WW
Surgery 1993 Apr;113(4):365-72. PMID: 7681222
Treatment of metastatic colorectal cancer by means of specific monoclonal antibodies conjugated with iodine-131: a phase II study.
Riva P, Marangolo M, Tison V, Armaroli L, Moscatelli G, Franceschi G, Spinelli A, Vecchietti G, Morigi P, Tassini R
Int J Rad Appl Instrum B 1991;18(1):109-19. doi: 10.1016/0883-2897(91)90057-r. PMID: 2010295

Recent clinical studies

Etiology

HIPECT4: multicentre, randomized clinical trial to evaluate safety and efficacy of Hyperthermic intra-peritoneal chemotherapy (HIPEC) with Mitomycin C used during surgery for treatment of locally advanced colorectal carcinoma.
Arjona-Sánchez A, Barrios P, Boldo-Roda E, Camps B, Carrasco-Campos J, Concepción Martín V, García-Fadrique A, Gutiérrez-Calvo A, Morales R, Ortega-Pérez G, Pérez-Viejo E, Prada-Villaverde A, Torres-Melero J, Vicente E, Villarejo-Campos P, Sánchez-Hidalgo JM, Casado-Adam A, García-Martin R, Medina M, Caro T, Villar C, Aranda E, Cano-Osuna MT, Díaz-López C, Torres-Tordera E, Briceño-Delgado FJ, Rufián-Peña S
BMC Cancer 2018 Feb 13;18(1):183. doi: 10.1186/s12885-018-4096-0. PMID: 29439668Free PMC Article
Rationale for bladder-sparing surgery in patients with locally advanced colorectal carcinoma.
Balbay MD, Slaton JW, Trane N, Skibber J, Dinney CP
Cancer 1999 Dec 1;86(11):2212-6. doi: 10.1002/(sici)1097-0142(19991201)86:11<2212::aid-cncr6>3.0.co;2-2. PMID: 10590359
Extended resection for locally advanced colorectal carcinoma.
Curley SA, Carlson GW, Shumate CR, Wishnow KI, Ames FC
Am J Surg 1992 Jun;163(6):553-9. doi: 10.1016/0002-9610(92)90554-5. PMID: 1595834
Sphincter-preserving extended resection for locally advanced rectosigmoid carcinoma involving the urinary bladder.
Fuhrman GM, Talamonti MS, Curley SA
J Surg Oncol 1992 Jun;50(2):77-80. doi: 10.1002/jso.2930500204. PMID: 1593889
Pelvic exenteration for locally advanced colorectal carcinoma.
Boey J, Wong J, Ong GB
Ann Surg 1982 Apr;195(4):513-8. doi: 10.1097/00000658-198204000-00022. PMID: 6175286Free PMC Article

Diagnosis

Distinguishing prostatic from colorectal adenocarcinoma on biopsy samples: the role of morphology and immunohistochemistry.
Owens CL, Epstein JI, Netto GJ
Arch Pathol Lab Med 2007 Apr;131(4):599-603. doi: 10.5858/2007-131-599-DPFCAO. PMID: 17425391
Rationale for bladder-sparing surgery in patients with locally advanced colorectal carcinoma.
Balbay MD, Slaton JW, Trane N, Skibber J, Dinney CP
Cancer 1999 Dec 1;86(11):2212-6. doi: 10.1002/(sici)1097-0142(19991201)86:11<2212::aid-cncr6>3.0.co;2-2. PMID: 10590359
Role of extended resection in the initial treatment of locally advanced colorectal carcinoma.
Lopez MJ, Monafo WW
Surgery 1993 Apr;113(4):365-72. PMID: 7681222

Therapy

HIPECT4: multicentre, randomized clinical trial to evaluate safety and efficacy of Hyperthermic intra-peritoneal chemotherapy (HIPEC) with Mitomycin C used during surgery for treatment of locally advanced colorectal carcinoma.
Arjona-Sánchez A, Barrios P, Boldo-Roda E, Camps B, Carrasco-Campos J, Concepción Martín V, García-Fadrique A, Gutiérrez-Calvo A, Morales R, Ortega-Pérez G, Pérez-Viejo E, Prada-Villaverde A, Torres-Melero J, Vicente E, Villarejo-Campos P, Sánchez-Hidalgo JM, Casado-Adam A, García-Martin R, Medina M, Caro T, Villar C, Aranda E, Cano-Osuna MT, Díaz-López C, Torres-Tordera E, Briceño-Delgado FJ, Rufián-Peña S
BMC Cancer 2018 Feb 13;18(1):183. doi: 10.1186/s12885-018-4096-0. PMID: 29439668Free PMC Article
Total pelvic exenteration for locally advanced colorectal carcinoma--postoperative complications.
Shirouzu K, Isomoto H, Morodomi T, Ogata Y, Akagi Y, Kakegawa T
Kurume Med J 1995;42(1):33-7. doi: 10.2739/kurumemedj.42.33. PMID: 7596089
Treatment of metastatic colorectal cancer by means of specific monoclonal antibodies conjugated with iodine-131: a phase II study.
Riva P, Marangolo M, Tison V, Armaroli L, Moscatelli G, Franceschi G, Spinelli A, Vecchietti G, Morigi P, Tassini R
Int J Rad Appl Instrum B 1991;18(1):109-19. doi: 10.1016/0883-2897(91)90057-r. PMID: 2010295
Clinical trials in colorectal cancer: experience of the Gastrointestinal Tumor Study Group and the Southwest Oncology Group.
Bukowski RM
Int J Colorectal Dis 1987 Jun;2(2):100-6. doi: 10.1007/BF01647701. PMID: 3305744

Prognosis

Histopathology of locally advanced colorectal carcinoma, with emphasis on tumor invasion of adherent peritoneal membranes.
Chen JH
Pathol Res Pract 2018 Jun;214(6):902-906. Epub 2018 Apr 3 doi: 10.1016/j.prp.2018.03.024. PMID: 29631918
Rationale for bladder-sparing surgery in patients with locally advanced colorectal carcinoma.
Balbay MD, Slaton JW, Trane N, Skibber J, Dinney CP
Cancer 1999 Dec 1;86(11):2212-6. doi: 10.1002/(sici)1097-0142(19991201)86:11<2212::aid-cncr6>3.0.co;2-2. PMID: 10590359
Role of extended resection in the initial treatment of locally advanced colorectal carcinoma.
Lopez MJ, Monafo WW
Surgery 1993 Apr;113(4):365-72. PMID: 7681222
Extended resection for locally advanced colorectal carcinoma.
Curley SA, Carlson GW, Shumate CR, Wishnow KI, Ames FC
Am J Surg 1992 Jun;163(6):553-9. doi: 10.1016/0002-9610(92)90554-5. PMID: 1595834
Pelvic exenteration for locally advanced colorectal carcinoma.
Boey J, Wong J, Ong GB
Ann Surg 1982 Apr;195(4):513-8. doi: 10.1097/00000658-198204000-00022. PMID: 6175286Free PMC Article

Clinical prediction guides

Association of pre-surgery to pre-radiotherapy lymphocyte counts ratio with disease-free survival in rectal cancer patients receiving neoadjuvant concurrent chemoradiotherapy.
Xu H, You G, Zhang M, Song T, Zhang H, Yang J, Jia Y, Tang J, Liang X
World J Surg Oncol 2019 Nov 30;17(1):199. doi: 10.1186/s12957-019-1747-9. PMID: 31785609Free PMC Article
Rationale for bladder-sparing surgery in patients with locally advanced colorectal carcinoma.
Balbay MD, Slaton JW, Trane N, Skibber J, Dinney CP
Cancer 1999 Dec 1;86(11):2212-6. doi: 10.1002/(sici)1097-0142(19991201)86:11<2212::aid-cncr6>3.0.co;2-2. PMID: 10590359
Extended resection for locally advanced colorectal carcinoma.
Curley SA, Carlson GW, Shumate CR, Wishnow KI, Ames FC
Am J Surg 1992 Jun;163(6):553-9. doi: 10.1016/0002-9610(92)90554-5. PMID: 1595834

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