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Myoglobin casts

MedGen UID:: 1704472
•Concept ID:: C4285597
•: Finding

HPO:	HP:0032593

Definition

A type of acelluar casts with positive myoglobin staining A that have a surface composed of granules, which can vary in size. The granules can be rather heterogeneous, ranging from fine (finely granular cast) up to coarse (coarsely granular cast), dark, clear, and pigmented. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMyoglobin casts

Abnormality of the urinary system
- Abnormality of the urinary system physiology
  - Abnormality of urine homeostasis
    - Abnormal urine cytology
      - Cylindruria
        Acellular urinary casts
        Myoglobin casts

Professional guidelines

PubMed

Primary treatment of 50 patients with high-tension electrical injuries. I. Fluid resuscitation.

Arturson G, Hedlund A
Scand J Plast Reconstr Surg 1984;18(1):111-8. doi: 10.3109/02844318409057412. PMID: 6740254

See all (1)

Recent clinical studies

Etiology

Kidney transplantation from donors with rhabdomyolysis and acute renal failure.

Chen CB, Zheng YT, Zhou J, Han M, Wang XP, Yuan XP, Wang CX, He XS
Clin Transplant 2017 Aug;31(8) Epub 2017 Jun 22 doi: 10.1111/ctr.13021. PMID: 28564273

Myoglobin casts in renal biopsies: immunohistochemistry and morphologic spectrum.

Liapis H, Boils C, Hennigar R, Silva F
Hum Pathol 2016 Aug;54:25-30. Epub 2016 Mar 30 doi: 10.1016/j.humpath.2016.02.026. PMID: 27038680

Acute renal failure following kidney transplantation associated with myoglobinuria in patients treated with rapamycin.

Pelletier R, Nadasdy T, Nadasdy G, Satoskar A, Tewari AK, Cotrill J, Henry M, Rajab A, Ferguson R
Transplantation 2006 Sep 15;82(5):645-50. doi: 10.1097/01.tp.0000230310.27913.01. PMID: 16969287

An adolescent girl with Meyer-Betz syndrome.

Kasap B, Soylu A, Türkmen M, Kavukcu S
Clin Rheumatol 2006 Nov;25(6):904-6. Epub 2005 Nov 19 doi: 10.1007/s10067-005-0091-3. PMID: 16328090

Acute renal failure following physical torture.

Malik GH, Sirwal IA, Reshi AR, Najar MS, Tanvir M, Altaf M
Nephron 1993;63(4):434-7. doi: 10.1159/000187248. PMID: 8459879

See all (5)

Diagnosis

A Case of Kidney Transplantation from a Deceased Donor with Acute Kidney Injury due to Rhabdomyolysis.

Takada Y, Hotta K, Moriya K, Sasaki H, Takamoto D, Higuchi H, Tanabe T, Minami K, Iwasaki S, Tsuji T, Tanaka H
Nephron 2023;147 Suppl 1:101-105. Epub 2023 Mar 24 doi: 10.1159/000530340. PMID: 36966535

Myoglobin cast nephropathy following multiple bee stings.

Madireddy N, Swain M, Yalamarty R
Indian J Pathol Microbiol 2023 Jan-Mar;66(1):177-179. doi: 10.4103/ijpm.ijpm_981_21. PMID: 36656236

Oxidative stress and inflammasome activation in human rhabdomyolysis-induced acute kidney injury.

Grivei A, Giuliani KTK, Wang X, Ungerer J, Francis L, Hepburn K, John GT, Gois PFH, Kassianos AJ, Healy H
Free Radic Biol Med 2020 Nov 20;160:690-695. Epub 2020 Sep 14 doi: 10.1016/j.freeradbiomed.2020.09.011. PMID: 32942024

Myoglobin casts in renal biopsies: immunohistochemistry and morphologic spectrum.

Liapis H, Boils C, Hennigar R, Silva F
Hum Pathol 2016 Aug;54:25-30. Epub 2016 Mar 30 doi: 10.1016/j.humpath.2016.02.026. PMID: 27038680

Pathological evidence of rhabdomyolysis-induced acute tubulointerstitial nephritis accompanying Legionella pneumophila pneumonia.

Shimura C, Saraya T, Wada H, Takata S, Mikura S, Yasutake T, Kato J, Kato A, Yamamoto M, Watanabe M, Yokoyama T, Kurai D, Ishii H, Aoshima M, Yamada A, Goto H
J Clin Pathol 2008 Sep;61(9):1062-3. Epub 2008 Jun 13 doi: 10.1136/jcp.2008.057000. PMID: 18552170

See all (13)

Therapy

A Case of Kidney Transplantation from a Deceased Donor with Acute Kidney Injury due to Rhabdomyolysis.

Successful Transplantation of "Black Kidneys" Due to Myoglobin Nephropathy.

Chen X, Huang G, Yang S, Li J, Fu Q, Yuan X, Chen W, Wang C
Transplant Proc 2018 Oct;50(8):2436-2438. Epub 2018 Mar 19 doi: 10.1016/j.transproceed.2018.02.205. PMID: 30316373

Rhabdomyolysis-Associated Acute Kidney Injury With Normal Creatine Phosphokinase.

Kamal F, Snook L, Saikumar JH
Am J Med Sci 2018 Jan;355(1):84-87. Epub 2017 Apr 24 doi: 10.1016/j.amjms.2017.04.014. PMID: 29289268

Paraphenylenediamine Containing Hair Dye: An Emerging Household Poisoning.

Patra AP, Shaha KK, Rayamane AP, Dash SK, Mohanty MK, Mohanty S
Am J Forensic Med Pathol 2015 Sep;36(3):167-71. doi: 10.1097/PAF.0000000000000165. PMID: 26056768

Pathological evidence of rhabdomyolysis-induced acute tubulointerstitial nephritis accompanying Legionella pneumophila pneumonia.

See all (10)

Prognosis

Rhabdomyolysis associated acute renal failure - Report of two fatal cases and a brief review of literature.

Das S, Hanuman SB, Mylapalli JL
J Forensic Leg Med 2020 Apr;71:101941. Epub 2020 Mar 12 doi: 10.1016/j.jflm.2020.101941. PMID: 32342911

Myoglobin casts in renal biopsies: immunohistochemistry and morphologic spectrum.

Liapis H, Boils C, Hennigar R, Silva F
Hum Pathol 2016 Aug;54:25-30. Epub 2016 Mar 30 doi: 10.1016/j.humpath.2016.02.026. PMID: 27038680

Acute renal failure following kidney transplantation associated with myoglobinuria in patients treated with rapamycin.

Pelletier R, Nadasdy T, Nadasdy G, Satoskar A, Tewari AK, Cotrill J, Henry M, Rajab A, Ferguson R
Transplantation 2006 Sep 15;82(5):645-50. doi: 10.1097/01.tp.0000230310.27913.01. PMID: 16969287

An adolescent girl with Meyer-Betz syndrome.

Kasap B, Soylu A, Türkmen M, Kavukcu S
Clin Rheumatol 2006 Nov;25(6):904-6. Epub 2005 Nov 19 doi: 10.1007/s10067-005-0091-3. PMID: 16328090

See all (4)

Clinical prediction guides

COVID-19-Associated Kidney Injury: A Case Series of Kidney Biopsy Findings.

Sharma P, Uppal NN, Wanchoo R, Shah HH, Yang Y, Parikh R, Khanin Y, Madireddy V, Larsen CP, Jhaveri KD, Bijol V; Northwell Nephrology COVID-19 Research Consortium
J Am Soc Nephrol 2020 Sep;31(9):1948-1958. Epub 2020 Jul 13 doi: 10.1681/ASN.2020050699. PMID: 32660970 Free PMC Article

Sudden death due to malignant hyperthermia with a mutation of RYR1: autopsy, morphology and genetic analysis.

Li W, Zhang L, Liang Y, Tong F, Zhou Y
Forensic Sci Med Pathol 2017 Dec;13(4):444-449. Epub 2017 Nov 4 doi: 10.1007/s12024-017-9925-y. PMID: 29101530

Myoglobin casts in renal biopsies: immunohistochemistry and morphologic spectrum.

Liapis H, Boils C, Hennigar R, Silva F
Hum Pathol 2016 Aug;54:25-30. Epub 2016 Mar 30 doi: 10.1016/j.humpath.2016.02.026. PMID: 27038680

Bile cast nephropathy is a common pathologic finding for kidney injury associated with severe liver dysfunction.

van Slambrouck CM, Salem F, Meehan SM, Chang A
Kidney Int 2013 Jul;84(1):192-7. Epub 2013 Mar 13 doi: 10.1038/ki.2013.78. PMID: 23486516

Confluent muscle pallor: a macroscopic marker of cocaine-induced rhabdomyolysis.

Byard RW, Summersides G, Thompson A
Forensic Sci Med Pathol 2011 Dec;7(4):364-6. Epub 2011 Mar 6 doi: 10.1007/s12024-011-9229-6. PMID: 21380787

See all (6)