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Unresectable Meningioma

MedGen UID:
1705535
•Concept ID:
C5206878
•
Neoplastic Process

Definition

A meningioma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Meningioma

Professional guidelines

PubMed

The role of chemotherapy and targeted therapy in the treatment of intracranial meningioma.
Chamberlain MC
Curr Opin Oncol 2012 Nov;24(6):666-71. doi: 10.1097/CCO.0b013e328356364d. PMID: 22759739
Alterations in the pituitary-thyroid and pituitary-adrenal axes--consequences of long-term mifepristone treatment.
Heikinheimo O, Ranta S, Grunberg S, Lähteenmäki P, Spitz IM
Metabolism 1997 Mar;46(3):292-6. doi: 10.1016/s0026-0495(97)90256-0. PMID: 9054472
Lack of efficacy of megestrol acetate in the treatment of unresectable meningioma.
Grunberg SM, Weiss MH
J Neurooncol 1990 Feb;8(1):61-5. doi: 10.1007/BF00182088. PMID: 2319292

Recent clinical studies

Etiology

Double-Blind Phase III Randomized Trial of the Antiprogestin Agent Mifepristone in the Treatment of Unresectable Meningioma: SWOG S9005.
Ji Y, Rankin C, Grunberg S, Sherrod AE, Ahmadi J, Townsend JJ, Feun LG, Fredericks RK, Russell CA, Kabbinavar FF, Stelzer KJ, Schott A, Verschraegen C
J Clin Oncol 2015 Dec 1;33(34):4093-8. Epub 2015 Nov 2 doi: 10.1200/JCO.2015.61.6490. PMID: 26527781Free PMC Article
Somatostatin receptor-targeted radiopeptide therapy with 90Y-DOTATOC and 177Lu-DOTATOC in progressive meningioma: long-term results of a phase II clinical trial.
Marincek N, Radojewski P, Dumont RA, Brunner P, Müller-Brand J, Maecke HR, Briel M, Walter MA
J Nucl Med 2015 Feb;56(2):171-6. Epub 2015 Jan 15 doi: 10.2967/jnumed.114.147256. PMID: 25593116
French abortion drug RU 486: U.S. research battles heat up.
Fintor L
J Natl Cancer Inst 1991 Mar 6;83(5):316-8. doi: 10.1093/jnci/83.5.316-a. PMID: 1823559

Diagnosis

The role of chemotherapy and targeted therapy in the treatment of intracranial meningioma.
Chamberlain MC
Curr Opin Oncol 2012 Nov;24(6):666-71. doi: 10.1097/CCO.0b013e328356364d. PMID: 22759739
Clinical use of octreotide in unresectable meningiomas. A report of three cases.
García-Luna PP, Relimpio F, Pumar A, Pereira JL, Leal-Cerro A, Trujillo F, Cortés A, Astorga R
J Neurosurg Sci 1993 Dec;37(4):237-41. PMID: 7931648

Therapy

Long-term outcomes of patients with unresectable benign meningioma treated with proton beam therapy.
Sato H, Mizumoto M, Okumura T, Sakurai H, Sakamoto N, Akutsu H, Ishikawa E, Tsuboi K
J Radiat Res 2021 May 12;62(3):427-437. doi: 10.1093/jrr/rrab017. PMID: 33855438Free PMC Article
Pharmacotherapeutic options for atypical meningiomas.
Ahsan SA, Chendeb K, Profyris C, Teo C, Sughrue ME
Expert Opin Pharmacother 2019 Oct;20(15):1831-1836. Epub 2019 Jul 19 doi: 10.1080/14656566.2019.1643840. PMID: 31322413
The role of chemotherapy and targeted therapy in the treatment of intracranial meningioma.
Chamberlain MC
Curr Opin Oncol 2012 Nov;24(6):666-71. doi: 10.1097/CCO.0b013e328356364d. PMID: 22759739
Mifepristone. Auxiliary therapeutic use in cancer and related disorders.
Koide SS
J Reprod Med 1998 Jul;43(7):551-60. PMID: 9693404
Role of antiprogestational therapy for meningiomas.
Grunberg SM
Hum Reprod 1994 Jun;9 Suppl 1:202-7. doi: 10.1093/humrep/9.suppl_1.202. PMID: 7962466

Prognosis

Double-Blind Phase III Randomized Trial of the Antiprogestin Agent Mifepristone in the Treatment of Unresectable Meningioma: SWOG S9005.
Ji Y, Rankin C, Grunberg S, Sherrod AE, Ahmadi J, Townsend JJ, Feun LG, Fredericks RK, Russell CA, Kabbinavar FF, Stelzer KJ, Schott A, Verschraegen C
J Clin Oncol 2015 Dec 1;33(34):4093-8. Epub 2015 Nov 2 doi: 10.1200/JCO.2015.61.6490. PMID: 26527781Free PMC Article
Somatostatin receptor-targeted radiopeptide therapy with 90Y-DOTATOC and 177Lu-DOTATOC in progressive meningioma: long-term results of a phase II clinical trial.
Marincek N, Radojewski P, Dumont RA, Brunner P, Müller-Brand J, Maecke HR, Briel M, Walter MA
J Nucl Med 2015 Feb;56(2):171-6. Epub 2015 Jan 15 doi: 10.2967/jnumed.114.147256. PMID: 25593116
Mifepristone. Auxiliary therapeutic use in cancer and related disorders.
Koide SS
J Reprod Med 1998 Jul;43(7):551-60. PMID: 9693404
Helium charged particle radiotherapy for meningioma: experience at UCLBL. University of California Lawrence Berkeley Laboratory.
Kaplan ID, Castro JR, Phillips TL
Int J Radiat Oncol Biol Phys 1994 Jan 1;28(1):257-61. doi: 10.1016/0360-3016(94)90165-1. PMID: 8270449
Clinical use of octreotide in unresectable meningiomas. A report of three cases.
García-Luna PP, Relimpio F, Pumar A, Pereira JL, Leal-Cerro A, Trujillo F, Cortés A, Astorga R
J Neurosurg Sci 1993 Dec;37(4):237-41. PMID: 7931648

Clinical prediction guides

Long-term outcomes of patients with unresectable benign meningioma treated with proton beam therapy.
Sato H, Mizumoto M, Okumura T, Sakurai H, Sakamoto N, Akutsu H, Ishikawa E, Tsuboi K
J Radiat Res 2021 May 12;62(3):427-437. doi: 10.1093/jrr/rrab017. PMID: 33855438Free PMC Article
Somatostatin receptor-targeted radiopeptide therapy with 90Y-DOTATOC and 177Lu-DOTATOC in progressive meningioma: long-term results of a phase II clinical trial.
Marincek N, Radojewski P, Dumont RA, Brunner P, Müller-Brand J, Maecke HR, Briel M, Walter MA
J Nucl Med 2015 Feb;56(2):171-6. Epub 2015 Jan 15 doi: 10.2967/jnumed.114.147256. PMID: 25593116
Long-term administration of mifepristone (RU486): clinical tolerance during extended treatment of meningioma.
Grunberg SM, Weiss MH, Russell CA, Spitz IM, Ahmadi J, Sadun A, Sitruk-Ware R
Cancer Invest 2006 Dec;24(8):727-33. doi: 10.1080/07357900601062339. PMID: 17162554
The treatment of recurrent unresectable and malignant meningiomas with interferon alpha-2B.
Kaba SE, DeMonte F, Bruner JM, Kyritsis AP, Jaeckle KA, Levin V, Yung WK
Neurosurgery 1997 Feb;40(2):271-5. doi: 10.1097/00006123-199702000-00007. PMID: 9007858
Clinical use of octreotide in unresectable meningiomas. A report of three cases.
García-Luna PP, Relimpio F, Pumar A, Pereira JL, Leal-Cerro A, Trujillo F, Cortés A, Astorga R
J Neurosurg Sci 1993 Dec;37(4):237-41. PMID: 7931648

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