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Decreased specific antibody response to protein vaccine

MedGen UID:
1707869
•Concept ID:
C5139457
•
Finding
HPO: HP:0410294

Definition

A reduced ability to synthesize postvaccination antibodies against proteins in vaccines, as measured by antibody titer determination following vaccination. [from HPO]

Professional guidelines

PubMed

Clinical, Virologic, and Immunologic Evaluation of Symptomatic Coronavirus Disease 2019 Rebound Following Nirmatrelvir/Ritonavir Treatment.
Epling BP, Rocco JM, Boswell KL, Laidlaw E, Galindo F, Kellogg A, Das S, Roder A, Ghedin E, Kreitman A, Dewar RL, Kelly SEM, Kalish H, Rehman T, Highbarger J, Rupert A, Kocher G, Holbrook MR, Lisco A, Manion M, Koup RA, Sereti I
Clin Infect Dis 2023 Feb 18;76(4):573-581. doi: 10.1093/cid/ciac663. PMID: 36200701Free PMC Article
Early human B cell signatures of the primary antibody response to mRNA vaccination.
Kardava L, Rachmaninoff N, Lau WW, Buckner CM, Trihemasava K, Blazkova J, Lopes de Assis F, Wang W, Zhang X, Wang Y, Chiang CI, Narpala S, McCormack GE, Liu C, Seamon CA, Sneller MC, O'Connell S, Li Y, McDermott AB, Chun TW, Fauci AS, Tsang JS, Moir S
Proc Natl Acad Sci U S A 2022 Jul 12;119(28):e2204607119. Epub 2022 Jun 27 doi: 10.1073/pnas.2204607119. PMID: 35759653Free PMC Article
Comparison of management options for specific antibody deficiency.
Pandya A, Burgen E, Chen GJ, Hobson J, Nguyen M, Pirzad A, Hayat Khan S
Allergy Asthma Proc 2021 Jan 1;42(1):87-92. doi: 10.2500/aap.2021.42.200086. PMID: 33404392

Recent clinical studies

Therapy

Limosilactobacillus reuteri DSM 17938 supplementation and SARS-CoV-2 specific antibody response in healthy adults: a randomized, triple-blinded, placebo-controlled trial.
Forsgård RA, Rode J, Lobenius-Palmér K, Kamm A, Patil S, Tacken MGJ, Lentjes MAH, Axelsson J, Grompone G, Montgomery S, Brummer RJ
Gut Microbes 2023 Jan-Dec;15(1):2229938. doi: 10.1080/19490976.2023.2229938. PMID: 37401761Free PMC Article
Gliadin Nanoparticles Induce Immune Tolerance to Gliadin in Mouse Models of Celiac Disease.
Freitag TL, Podojil JR, Pearson RM, Fokta FJ, Sahl C, Messing M, Andersson LC, Leskinen K, Saavalainen P, Hoover LI, Huang K, Phippard D, Maleki S, King NJC, Shea LD, Miller SD, Meri SK, Getts DR
Gastroenterology 2020 May;158(6):1667-1681.e12. Epub 2020 Feb 4 doi: 10.1053/j.gastro.2020.01.045. PMID: 32032584Free PMC Article
Immune Therapy for Sarcomas.
Anderson PM
Adv Exp Med Biol 2017;995:127-140. doi: 10.1007/978-3-319-53156-4_6. PMID: 28321815
Pneumococcal Vaccination Strategies. An Update and Perspective.
Berical AC, Harris D, Dela Cruz CS, Possick JD
Ann Am Thorac Soc 2016 Jun;13(6):933-44. doi: 10.1513/AnnalsATS.201511-778FR. PMID: 27088424Free PMC Article
Vaccine strategies against schistosomiasis.
Capron A, Dessaint JP, Capron M, Pierce RJ
Mem Inst Oswaldo Cruz 1992;87 Suppl 4:19-27. doi: 10.1590/s0074-02761992000800003. PMID: 1343894

Prognosis

Predicted serotype-specific effectiveness of pneumococcal conjugate vaccines V114 and PCV20 against invasive pneumococcal disease in children.
Ryman J, Sachs JR, Yee KL, Banniettis N, Weaver J, Weiss T
Expert Rev Vaccines 2024 Jan-Dec;23(1):60-68. Epub 2023 Dec 14 doi: 10.1080/14760584.2023.2292773. PMID: 38073483
Defending against SARS-CoV-2: The T cell perspective.
Almendro-Vázquez P, Laguna-Goya R, Paz-Artal E
Front Immunol 2023;14:1107803. Epub 2023 Jan 27 doi: 10.3389/fimmu.2023.1107803. PMID: 36776863Free PMC Article
Chronic Lymphocytic Leukemia in the SARS-CoV-2 Pandemic.
Arellano-Llamas AA, Vela-Ojeda J, Hernandez-Caballero A
Curr Oncol Rep 2022 Feb;24(2):209-213. Epub 2022 Jan 21 doi: 10.1007/s11912-022-01198-z. PMID: 35061199Free PMC Article
Immune response to SARS-CoV-2 and mechanisms of immunopathological changes in COVID-19.
Azkur AK, Akdis M, Azkur D, Sokolowska M, van de Veen W, Brüggen MC, O'Mahony L, Gao Y, Nadeau K, Akdis CA
Allergy 2020 Jul;75(7):1564-1581. doi: 10.1111/all.14364. PMID: 32396996Free PMC Article
Immune Therapy for Sarcomas.
Anderson PM
Adv Exp Med Biol 2017;995:127-140. doi: 10.1007/978-3-319-53156-4_6. PMID: 28321815

Clinical prediction guides

Predicted serotype-specific effectiveness of pneumococcal conjugate vaccines V114 and PCV20 against invasive pneumococcal disease in children.
Ryman J, Sachs JR, Yee KL, Banniettis N, Weaver J, Weiss T
Expert Rev Vaccines 2024 Jan-Dec;23(1):60-68. Epub 2023 Dec 14 doi: 10.1080/14760584.2023.2292773. PMID: 38073483
Immune cell kinetics and antibody response in COVID-19 patients with low-count monoclonal B-cell lymphocytosis.
Oliva-Ariza G, Fuentes-Herrero B, Lecrevisse Q, Carbonell C, Pérez-Pons A, Torres-Valle A, Pozo J, Martín-Oterino JÁ, González-López Ó, López-Bernús A, Bernal-Ribes M, Belhassen-García M, Pérez-Escurza O, Pérez-Andrés M, Vazquez L, Hernández-Pérez G, García Palomo FJ, Leoz P, Costa-Alba P, Pérez-Losada E, Yeguas A, Santos Sánchez M, García-Blázquez M, Morán-Plata FJ, Damasceno D, Botafogo V, Muñoz-García N, Fluxa R, van Dongen JJM, Marcos M, Almeida J, Orfao A; ECRIN-M3 Consortium
Am J Hematol 2023 Dec;98(12):1909-1922. Epub 2023 Oct 4 doi: 10.1002/ajh.27119. PMID: 37792579
Clinical Outcomes, Immunogenicity, and Safety of BNT162b2 Vaccine in Primary Antibody Deficiency.
Milota T, Smetanova J, Skotnicova A, Rataj M, Lastovicka J, Zelena H, Parackova Z, Fejtkova M, Kanderova V, Fronkova E, Rejlova K, Sediva A, Kalina T
J Allergy Clin Immunol Pract 2023 Jan;11(1):306-314.e2. Epub 2022 Nov 13 doi: 10.1016/j.jaip.2022.10.046. PMID: 36379409
Population differences in antibody response to SARS-CoV-2 infection and BNT162b2 vaccination.
Shapira G, Abu Hamad R, Weiner C, Rainy N, Sorek-Abramovich R, Benveniste-Levkovitz P, Rock R, Avnat E, Levtzion-Korach O, Bar Chaim A, Shomron N
FASEB J 2022 Apr;36(4):e22223. doi: 10.1096/fj.202101492R. PMID: 35239233Free PMC Article
Immune response to SARS-CoV-2 and mechanisms of immunopathological changes in COVID-19.
Azkur AK, Akdis M, Azkur D, Sokolowska M, van de Veen W, Brüggen MC, O'Mahony L, Gao Y, Nadeau K, Akdis CA
Allergy 2020 Jul;75(7):1564-1581. doi: 10.1111/all.14364. PMID: 32396996Free PMC Article

Recent systematic reviews

Efficacy of SARS-CoV-2 vaccines and the dose-response relationship with three major antibodies: a systematic review and meta-analysis of randomised controlled trials.
Yang ZR, Jiang YW, Li FX, Liu D, Lin TF, Zhao ZY, Wei C, Jin QY, Li XM, Jia YX, Zhu FC, Yang ZY, Sha F, Feng ZJ, Tang JL
Lancet Microbe 2023 Apr;4(4):e236-e246. Epub 2023 Feb 28 doi: 10.1016/S2666-5247(22)00390-1. PMID: 36868258Free PMC Article
Efficacy and safety of tixagevimab-cilgavimab as pre-exposure prophylaxis for COVID-19: A systematic review and meta-analysis.
Soeroto AY, Yanto TA, Kurniawan A, Hariyanto TI
Rev Med Virol 2023 Mar;33(2):e2420. Epub 2023 Jan 8 doi: 10.1002/rmv.2420. PMID: 36617704
Impaired serological response to COVID-19 vaccination following anticancer therapy: A systematic review and meta-analysis.
Tang K, Wei Z, Wu X
J Med Virol 2022 Oct;94(10):4860-4868. Epub 2022 Jul 6 doi: 10.1002/jmv.27956. PMID: 35750492Free PMC Article
Antibody response to SARS-CoV-2 infection in humans: A systematic review.
Post N, Eddy D, Huntley C, van Schalkwyk MCI, Shrotri M, Leeman D, Rigby S, Williams SV, Bermingham WH, Kellam P, Maher J, Shields AM, Amirthalingam G, Peacock SJ, Ismail SA
PLoS One 2020;15(12):e0244126. Epub 2020 Dec 31 doi: 10.1371/journal.pone.0244126. PMID: 33382764Free PMC Article
The effect of HLA on immunological response to hepatitis B vaccine in healthy people: a meta-analysis.
Li ZK, Nie JJ, Li J, Zhuang H
Vaccine 2013 Sep 13;31(40):4355-61. Epub 2013 Jul 23 doi: 10.1016/j.vaccine.2013.06.108. PMID: 23887040

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