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Anal Canal Small Cell Neuroendocrine Carcinoma

MedGen UID:
1707941
•Concept ID:
C2064241
•
Neoplastic Process
Synonyms: Anal Canal Small Cell Carcinoma; Anal Canal Small Cell NEC; Anal Small Cell NEC; Anal Small Cell Neuroendocrine Carcinoma

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the anal canal. It is characterized by the presence of malignant small cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnal Canal Small Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

The Management and Prevention of Anal Squamous Cell Carcinoma.
Eng C, Messick C, Glynne-Jones R
Am Soc Clin Oncol Educ Book 2019 Jan;39:216-225. Epub 2019 May 17 doi: 10.1200/EDBK_237433. PMID: 31099616
Surgical management of anal cancer.
Gilshtein H, Khoury W
Minerva Chir 2015 Apr;70(2):141-5. Epub 2015 Feb 18 PMID: 25690347
Carcinoma of the anal canal: small steps in treatment advances.
Eng C
Clin Adv Hematol Oncol 2011 Sep;9(9):662-9. PMID: 22402509

Recent clinical studies

Etiology

Characteristics of anal canal squamous cell carcinoma as an HPV-associated cancer in Japan.
Yamada K, Shiraishi K, Takashima A, Takayanagi D, Saiki Y, Takano S, Tanaka M, Fukunaga M, Sugimoto K, Iwasaki Y, Nakamura Y, Kuwahara D, Tsuji Y, Takano M, Sugihara K, Ajioka Y
Int J Clin Oncol 2023 Aug;28(8):990-998. Epub 2023 Apr 28 doi: 10.1007/s10147-023-02339-5. PMID: 37115427
Clinical Analysis of Extrapulmonary Neuroendocrine Carcinoma: A Retrospective and Single Institution Experience.
Okumura T, Noguchi T, Sekiguchi N, Kobayashi T, Kanda S, Ida K, Minagawa T, Tokumaru S, Umemura T, Koizumi T
Chemotherapy 2023;68(2):87-94. Epub 2022 Nov 3 doi: 10.1159/000527377. PMID: 36327945
The Management and Prevention of Anal Squamous Cell Carcinoma.
Eng C, Messick C, Glynne-Jones R
Am Soc Clin Oncol Educ Book 2019 Jan;39:216-225. Epub 2019 May 17 doi: 10.1200/EDBK_237433. PMID: 31099616
Anal gland carcinoma.
Hobbs CM, Lowry MA, Owen D, Sobin LH
Cancer 2001 Oct 15;92(8):2045-9. doi: 10.1002/1097-0142(20011015)92:8<2045::aid-cncr1543>3.0.co;2-v. PMID: 11596018
Anal carcinoma.
Leichman LP, Cummings BJ
Curr Probl Cancer 1990 May-Jun;14(3):117-59. doi: 10.1016/0147-0272(90)90014-h. PMID: 2202554

Diagnosis

Characteristics of anal canal squamous cell carcinoma as an HPV-associated cancer in Japan.
Yamada K, Shiraishi K, Takashima A, Takayanagi D, Saiki Y, Takano S, Tanaka M, Fukunaga M, Sugimoto K, Iwasaki Y, Nakamura Y, Kuwahara D, Tsuji Y, Takano M, Sugihara K, Ajioka Y
Int J Clin Oncol 2023 Aug;28(8):990-998. Epub 2023 Apr 28 doi: 10.1007/s10147-023-02339-5. PMID: 37115427
Clinical Analysis of Extrapulmonary Neuroendocrine Carcinoma: A Retrospective and Single Institution Experience.
Okumura T, Noguchi T, Sekiguchi N, Kobayashi T, Kanda S, Ida K, Minagawa T, Tokumaru S, Umemura T, Koizumi T
Chemotherapy 2023;68(2):87-94. Epub 2022 Nov 3 doi: 10.1159/000527377. PMID: 36327945
Small cell neuroendocrine carcinoma disguised as an external hemorrhoid.
Allmark A, Brubaker ML
JAAPA 2021 Aug 1;34(8):35-39. doi: 10.1097/01.JAA.0000742960.70174.8d. PMID: 34320538
The Management and Prevention of Anal Squamous Cell Carcinoma.
Eng C, Messick C, Glynne-Jones R
Am Soc Clin Oncol Educ Book 2019 Jan;39:216-225. Epub 2019 May 17 doi: 10.1200/EDBK_237433. PMID: 31099616
Tumors and Tumorlike Conditions of the Anal Canal and Perianal Region: MR Imaging Findings.
Surabhi VR, Menias CO, Amer AM, Elshikh M, Katabathina VS, Hara AK, Baughman WC, Kielar A, Elsayes KM, Siegel CL
Radiographics 2016 Sep-Oct;36(5):1339-53. doi: 10.1148/rg.2016150209. PMID: 27618320

Therapy

The Management and Prevention of Anal Squamous Cell Carcinoma.
Eng C, Messick C, Glynne-Jones R
Am Soc Clin Oncol Educ Book 2019 Jan;39:216-225. Epub 2019 May 17 doi: 10.1200/EDBK_237433. PMID: 31099616
Carcinoma of the anal canal: small steps in treatment advances.
Eng C
Clin Adv Hematol Oncol 2011 Sep;9(9):662-9. PMID: 22402509
Anal cancer: current and future methodology.
Eng C
Cancer Invest 2006 Aug-Sep;24(5):535-44. doi: 10.1080/07357900600815208. PMID: 16939964
Malignant tumors of the anal canal: the spectrum of disease, treatment, and outcomes.
Klas JV, Rothenberger DA, Wong WD, Madoff RD
Cancer 1999 Apr 15;85(8):1686-93. doi: 10.1002/(sici)1097-0142(19990415)85:8<1686::aid-cncr7>3.0.co;2-7. PMID: 10223561
Anal carcinoma--a histological review.
Williams GR, Talbot IC
Histopathology 1994 Dec;25(6):507-16. doi: 10.1111/j.1365-2559.1994.tb01370.x. PMID: 7698728

Prognosis

Characteristics of anal canal squamous cell carcinoma as an HPV-associated cancer in Japan.
Yamada K, Shiraishi K, Takashima A, Takayanagi D, Saiki Y, Takano S, Tanaka M, Fukunaga M, Sugimoto K, Iwasaki Y, Nakamura Y, Kuwahara D, Tsuji Y, Takano M, Sugihara K, Ajioka Y
Int J Clin Oncol 2023 Aug;28(8):990-998. Epub 2023 Apr 28 doi: 10.1007/s10147-023-02339-5. PMID: 37115427
Clinical Analysis of Extrapulmonary Neuroendocrine Carcinoma: A Retrospective and Single Institution Experience.
Okumura T, Noguchi T, Sekiguchi N, Kobayashi T, Kanda S, Ida K, Minagawa T, Tokumaru S, Umemura T, Koizumi T
Chemotherapy 2023;68(2):87-94. Epub 2022 Nov 3 doi: 10.1159/000527377. PMID: 36327945
Surgical management of anal cancer.
Gilshtein H, Khoury W
Minerva Chir 2015 Apr;70(2):141-5. Epub 2015 Feb 18 PMID: 25690347
Anal carcinoma--a histological review.
Williams GR, Talbot IC
Histopathology 1994 Dec;25(6):507-16. doi: 10.1111/j.1365-2559.1994.tb01370.x. PMID: 7698728
Anal carcinoma.
Leichman LP, Cummings BJ
Curr Probl Cancer 1990 May-Jun;14(3):117-59. doi: 10.1016/0147-0272(90)90014-h. PMID: 2202554

Clinical prediction guides

Assessing the Reliability and Positive Predictive Value of p16 as a Surrogate for Human Papillomavirus-Mediated E6/7 mRNA Expression in Squamous Cell Carcinoma of the Anal Canal.
Frankart AJ, Criss BE, Dillehay McKillip K, Wise-Draper T, Takiar V, Kharofa J
Dis Colon Rectum 2021 Apr 1;64(4):459-465. doi: 10.1097/DCR.0000000000001836. PMID: 33394778
Establishment and Characterization of a Novel Cell Line Derived from a Small Cell Neuroendocrine Carcinoma of the Anal Canal.
Dizdar L, Drusenheimer J, Werner TA, Möhlendick B, Schütte SC, Esposito I, Filler TJ, Knoefel WT, Krieg A
Neuroendocrinology 2018;107(3):246-256. Epub 2018 Jul 19 doi: 10.1159/000492222. PMID: 30025411
Surgery and high-dose-rate intraoperative radiation therapy for recurrent squamous-cell carcinoma of the anal canal.
Wright JL, Gollub MJ, Weiser MR, Saltz LB, Wong WD, Paty PB, Temple LK, Guillem JG, Minsky BD, Goodman KA
Dis Colon Rectum 2011 Sep;54(9):1090-7. doi: 10.1097/DCR.0b013e318220c0a1. PMID: 21825888
Anal gland carcinoma.
Hobbs CM, Lowry MA, Owen D, Sobin LH
Cancer 2001 Oct 15;92(8):2045-9. doi: 10.1002/1097-0142(20011015)92:8<2045::aid-cncr1543>3.0.co;2-v. PMID: 11596018
Carcinoma of the anal canal. A clinical and pathologic study of 188 cases.
Boman BM, Moertel CG, O'Connell MJ, Scott M, Weiland LH, Beart RW, Gunderson LL, Spencer RJ
Cancer 1984 Jul 1;54(1):114-25. doi: 10.1002/1097-0142(19840701)54:1<114::aid-cncr2820540124>3.0.co;2-p. PMID: 6326995

Recent systematic reviews

Outcome following local excision of T1 anal cancers-a systematic review.
Pedersen TB, Kildsig J, Serup-Hansen E, Gocht-Jensen P, Klein MF
Int J Colorectal Dis 2020 Sep;35(9):1663-1671. Epub 2020 Jul 15 doi: 10.1007/s00384-020-03687-8. PMID: 32671458
Executive Summary of the American Radium Society Appropriate Use Criteria for Treatment of Anal Cancer.
Russo S, Anker CJ, Abdel-Wahab M, Azad N, Bianchi N, Das P, Dragovic J, Goodman KA, Jones W 3rd, Kennedy T, Kumar R, Lee P, Sharma N, Small W, Suh WW, Jabbour SK
Int J Radiat Oncol Biol Phys 2019 Nov 1;105(3):591-605. Epub 2019 Jul 6 doi: 10.1016/j.ijrobp.2019.06.2544. PMID: 31288054Free PMC Article

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