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Renal interstitial deposits

MedGen UID:
1709193
•Concept ID:
C5397661
•
Finding
HPO: HP:0032644

Definition

Abnormal accumulation of a metabolite, protein, or protein-derived substance in the interstitial region of the kidney. [from HPO]

Professional guidelines

PubMed

Rituximab for the Treatment of IgG4-Related Tubulointerstitial Nephritis: Case Report and Review of the Literature.
McMahon BA, Novick T, Scheel PJ, Bagnasco S, Atta MG
Medicine (Baltimore) 2015 Aug;94(32):e1366. doi: 10.1097/MD.0000000000001366. PMID: 26266393Free PMC Article
Diagnosis and management of gout.
Pittman JR, Bross MH
Am Fam Physician 1999 Apr 1;59(7):1799-806, 1810. PMID: 10208700
Pulmonary capillaritis and alveolar hemorrhage. Update on diagnosis and management.
Green RJ, Ruoss SJ, Kraft SA, Duncan SR, Berry GJ, Raffin TA
Chest 1996 Nov;110(5):1305-16. doi: 10.1378/chest.110.5.1305. PMID: 8915239

Recent clinical studies

Etiology

Scleromyxedema.
Hoffmann JHO, Enk AH
J Dtsch Dermatol Ges 2020 Dec;18(12):1449-1467. doi: 10.1111/ddg.14319. PMID: 33373143
Nephrotoxicity of Antimicrobials and Antibiotics.
Morales-Alvarez MC
Adv Chronic Kidney Dis 2020 Jan;27(1):31-37. doi: 10.1053/j.ackd.2019.08.001. PMID: 32146999
Idiopathic hypercalciuria and formation of calcium renal stones.
Coe FL, Worcester EM, Evan AP
Nat Rev Nephrol 2016 Sep;12(9):519-33. Epub 2016 Jul 25 doi: 10.1038/nrneph.2016.101. PMID: 27452364Free PMC Article
IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects.
Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B
Autoimmun Rev 2015 Jul;14(7):579-85. Epub 2015 Feb 14 doi: 10.1016/j.autrev.2015.02.003. PMID: 25688001
C3 glomerulopathy: clinicopathologic features and predictors of outcome.
Medjeral-Thomas NR, O'Shaughnessy MM, O'Regan JA, Traynor C, Flanagan M, Wong L, Teoh CW, Awan A, Waldron M, Cairns T, O'Kelly P, Dorman AM, Pickering MC, Conlon PJ, Cook HT
Clin J Am Soc Nephrol 2014 Jan;9(1):46-53. Epub 2013 Oct 31 doi: 10.2215/CJN.04700513. PMID: 24178974Free PMC Article

Diagnosis

Snake bite associated with acute kidney injury.
Sarkar S, Sinha R, Chaudhury AR, Maduwage K, Abeyagunawardena A, Bose N, Pradhan S, Bresolin NL, Garcia BA, McCulloch M
Pediatr Nephrol 2021 Dec;36(12):3829-3840. Epub 2021 Feb 9 doi: 10.1007/s00467-020-04911-x. PMID: 33559706
Nephrotoxicity of Antimicrobials and Antibiotics.
Morales-Alvarez MC
Adv Chronic Kidney Dis 2020 Jan;27(1):31-37. doi: 10.1053/j.ackd.2019.08.001. PMID: 32146999
IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects.
Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B
Autoimmun Rev 2015 Jul;14(7):579-85. Epub 2015 Feb 14 doi: 10.1016/j.autrev.2015.02.003. PMID: 25688001
Pathology of IgA nephropathy.
Roberts IS
Nat Rev Nephrol 2014 Aug;10(8):445-54. Epub 2014 May 27 doi: 10.1038/nrneph.2014.92. PMID: 24861083
C3 glomerulopathy: clinicopathologic features and predictors of outcome.
Medjeral-Thomas NR, O'Shaughnessy MM, O'Regan JA, Traynor C, Flanagan M, Wong L, Teoh CW, Awan A, Waldron M, Cairns T, O'Kelly P, Dorman AM, Pickering MC, Conlon PJ, Cook HT
Clin J Am Soc Nephrol 2014 Jan;9(1):46-53. Epub 2013 Oct 31 doi: 10.2215/CJN.04700513. PMID: 24178974Free PMC Article

Therapy

Nephrotoxicity of Antimicrobials and Antibiotics.
Morales-Alvarez MC
Adv Chronic Kidney Dis 2020 Jan;27(1):31-37. doi: 10.1053/j.ackd.2019.08.001. PMID: 32146999
Salidroside Ameliorates Renal Interstitial Fibrosis by Inhibiting the TLR4/NF-κB and MAPK Signaling Pathways.
Li R, Guo Y, Zhang Y, Zhang X, Zhu L, Yan T
Int J Mol Sci 2019 Mar 4;20(5) doi: 10.3390/ijms20051103. PMID: 30836660Free PMC Article
IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects.
Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B
Autoimmun Rev 2015 Jul;14(7):579-85. Epub 2015 Feb 14 doi: 10.1016/j.autrev.2015.02.003. PMID: 25688001
Pathology of IgA nephropathy.
Roberts IS
Nat Rev Nephrol 2014 Aug;10(8):445-54. Epub 2014 May 27 doi: 10.1038/nrneph.2014.92. PMID: 24861083
Acute phosphate nephropathy.
Markowitz GS, Perazella MA
Kidney Int 2009 Nov;76(10):1027-34. Epub 2009 Aug 12 doi: 10.1038/ki.2009.308. PMID: 19675530

Prognosis

Snake bite associated with acute kidney injury.
Sarkar S, Sinha R, Chaudhury AR, Maduwage K, Abeyagunawardena A, Bose N, Pradhan S, Bresolin NL, Garcia BA, McCulloch M
Pediatr Nephrol 2021 Dec;36(12):3829-3840. Epub 2021 Feb 9 doi: 10.1007/s00467-020-04911-x. PMID: 33559706
Scleromyxedema.
Hoffmann JHO, Enk AH
J Dtsch Dermatol Ges 2020 Dec;18(12):1449-1467. doi: 10.1111/ddg.14319. PMID: 33373143
IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects.
Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B
Autoimmun Rev 2015 Jul;14(7):579-85. Epub 2015 Feb 14 doi: 10.1016/j.autrev.2015.02.003. PMID: 25688001
Pathology of IgA nephropathy.
Roberts IS
Nat Rev Nephrol 2014 Aug;10(8):445-54. Epub 2014 May 27 doi: 10.1038/nrneph.2014.92. PMID: 24861083
C3 glomerulopathy: clinicopathologic features and predictors of outcome.
Medjeral-Thomas NR, O'Shaughnessy MM, O'Regan JA, Traynor C, Flanagan M, Wong L, Teoh CW, Awan A, Waldron M, Cairns T, O'Kelly P, Dorman AM, Pickering MC, Conlon PJ, Cook HT
Clin J Am Soc Nephrol 2014 Jan;9(1):46-53. Epub 2013 Oct 31 doi: 10.2215/CJN.04700513. PMID: 24178974Free PMC Article

Clinical prediction guides

Snake bite associated with acute kidney injury.
Sarkar S, Sinha R, Chaudhury AR, Maduwage K, Abeyagunawardena A, Bose N, Pradhan S, Bresolin NL, Garcia BA, McCulloch M
Pediatr Nephrol 2021 Dec;36(12):3829-3840. Epub 2021 Feb 9 doi: 10.1007/s00467-020-04911-x. PMID: 33559706
C3 glomerulonephritis and dense deposit disease share a similar disease course in a large United States cohort of patients with C3 glomerulopathy.
Bomback AS, Santoriello D, Avasare RS, Regunathan-Shenk R, Canetta PA, Ahn W, Radhakrishnan J, Marasa M, Rosenstiel PE, Herlitz LC, Markowitz GS, D'Agati VD, Appel GB
Kidney Int 2018 Apr;93(4):977-985. Epub 2018 Jan 6 doi: 10.1016/j.kint.2017.10.022. PMID: 29310824
Pathology of IgA nephropathy.
Roberts IS
Nat Rev Nephrol 2014 Aug;10(8):445-54. Epub 2014 May 27 doi: 10.1038/nrneph.2014.92. PMID: 24861083
C3 glomerulopathy: clinicopathologic features and predictors of outcome.
Medjeral-Thomas NR, O'Shaughnessy MM, O'Regan JA, Traynor C, Flanagan M, Wong L, Teoh CW, Awan A, Waldron M, Cairns T, O'Kelly P, Dorman AM, Pickering MC, Conlon PJ, Cook HT
Clin J Am Soc Nephrol 2014 Jan;9(1):46-53. Epub 2013 Oct 31 doi: 10.2215/CJN.04700513. PMID: 24178974Free PMC Article
Lyme nephritis.
Littman MP
J Vet Emerg Crit Care (San Antonio) 2013 Mar-Apr;23(2):163-73. Epub 2013 Mar 5 doi: 10.1111/vec.12026. PMID: 23461642

Recent systematic reviews

Biopsy-proven kidney involvement in hypocomplementemic urticarial vasculitis.
Corthier A, Jachiet M, Bertin D, Servais A, Barbet C, Bigot A, Doutre MS, Bessis D, Bouffandeau A, Moranne O, Jarrot PA, Bardin N, Terrier B, Burtey S, Puéchal X, Daniel L, Jourde-Chiche N
BMC Nephrol 2022 Feb 16;23(1):67. doi: 10.1186/s12882-022-02689-8. PMID: 35172758Free PMC Article
Renal lithiasis and inflammatory bowel diseases, an update on pediatric population.
Bianchi L, Gaiani F, Bizzarri B, Minelli R, Cortegoso Valdivia P, Leandro G, Di Mario F, De' Angelis GL, Ruberto C
Acta Biomed 2018 Dec 17;89(9-S):76-80. doi: 10.23750/abm.v89i9-S.7908. PMID: 30561398Free PMC Article

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