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Cutaneous Indeterminate Dendritic Cell Histiocytosis

MedGen UID:
1709305
•Concept ID:
C5239288
•
Neoplastic Process
Synonyms: Cutaneous Indeterminate Cell Histiocytosis; Cutaneous Indeterminate Dendritic Cell Tumor

Definition

A very rare dendritic cell tumor affecting the skin. It is composed of spindle to ovoid cells with a phenotype that is similar to the Langerhans cells. It manifests with cutaneous papules, nodules, and plaques. The clinical course is variable. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous Indeterminate Dendritic Cell Histiocytosis

Recent clinical studies

Etiology

Cutaneous histiocytoses in children.
Fraitag S, Emile JF
Histopathology 2022 Jan;80(1):196-215. doi: 10.1111/his.14569. PMID: 34958507
Cutaneous Indeterminate Cell Histiocytosis of Donor Origin After Allogeneic Hematopoietic Stem-Cell Transplantation.
Santos-Briz A, Román C, Corral R, de Dios A, Vázquez L, Ludeña MD
Am J Dermatopathol 2017 Sep;39(9):696-699. doi: 10.1097/DAD.0000000000000935. PMID: 28825606

Diagnosis

Indeterminate DC histiocytosis is distinct from LCH and often associated with other hematopoietic neoplasms.
Ozkaya N, Melloul Benizri S, Venkataraman G, Karai LJ, Fraitag S, Razanamahery J, Pittaluga S, Battistella M, Pack S, Le Pelletier F, Xi L, Moreau A, Lee I, Hélias-Rodzewicz Z, Donadieu J, Haroche J, Raffeld M, Jaffe ES, Emile JF
Blood Adv 2024 Nov 26;8(22):5796-5805. doi: 10.1182/bloodadvances.2024013545. PMID: 39361706Free PMC Article
A Case of Indeterminate Cutaneous Dendritic Cell Tumors in the Setting of Chronic Myelomonocytic Leukemia.
Nyckowski T, Vance P, Marks E
Am J Dermatopathol 2022 Jun 1;44(6):449-453. Epub 2022 Apr 6 doi: 10.1097/DAD.0000000000002195. PMID: 35385851
Indeterminate Dendritic Cell Tumor: A Report of Two New Cases Lacking the ETV3-NCOA2 Translocation and a Literature Review.
Davick JJ, Kim J, Wick MR, Gru AA
Am J Dermatopathol 2018 Oct;40(10):736-748. doi: 10.1097/DAD.0000000000001191. PMID: 29877893
Indeterminate cell tumor: a rare dendritic neoplasm.
Rezk SA, Spagnolo DV, Brynes RK, Weiss LM
Am J Surg Pathol 2008 Dec;32(12):1868-76. doi: 10.1097/PAS.0b013e31818593d6. PMID: 18813122
Cutaneous indeterminate cell histiocytosis: a new spindle cell variant resembling dendritic cell sarcoma.
Rosenberg AS, Morgan MB
J Cutan Pathol 2001 Nov;28(10):531-7. doi: 10.1034/j.1600-0560.2001.281007.x. PMID: 11737523

Therapy

Indeterminate cell histiocytosis in a patient with systemic lupus erythematosus and antiphospholipid antibody syndrome: an unusual association.
Akdogan N, Demircan C, Bolek EC, Gokoz O, Karaduman A
Lupus 2020 Jan;29(1):74-78. Epub 2019 Dec 1 doi: 10.1177/0961203319890675. PMID: 31789127
Cutaneous Indeterminate Cell Histiocytosis of Donor Origin After Allogeneic Hematopoietic Stem-Cell Transplantation.
Santos-Briz A, Román C, Corral R, de Dios A, Vázquez L, Ludeña MD
Am J Dermatopathol 2017 Sep;39(9):696-699. doi: 10.1097/DAD.0000000000000935. PMID: 28825606

Prognosis

Indeterminate DC histiocytosis is distinct from LCH and often associated with other hematopoietic neoplasms.
Ozkaya N, Melloul Benizri S, Venkataraman G, Karai LJ, Fraitag S, Razanamahery J, Pittaluga S, Battistella M, Pack S, Le Pelletier F, Xi L, Moreau A, Lee I, Hélias-Rodzewicz Z, Donadieu J, Haroche J, Raffeld M, Jaffe ES, Emile JF
Blood Adv 2024 Nov 26;8(22):5796-5805. doi: 10.1182/bloodadvances.2024013545. PMID: 39361706Free PMC Article
Indeterminate Dendritic Cell Tumor: A Report of Two New Cases Lacking the ETV3-NCOA2 Translocation and a Literature Review.
Davick JJ, Kim J, Wick MR, Gru AA
Am J Dermatopathol 2018 Oct;40(10):736-748. doi: 10.1097/DAD.0000000000001191. PMID: 29877893

Clinical prediction guides

Indeterminate DC histiocytosis is distinct from LCH and often associated with other hematopoietic neoplasms.
Ozkaya N, Melloul Benizri S, Venkataraman G, Karai LJ, Fraitag S, Razanamahery J, Pittaluga S, Battistella M, Pack S, Le Pelletier F, Xi L, Moreau A, Lee I, Hélias-Rodzewicz Z, Donadieu J, Haroche J, Raffeld M, Jaffe ES, Emile JF
Blood Adv 2024 Nov 26;8(22):5796-5805. doi: 10.1182/bloodadvances.2024013545. PMID: 39361706Free PMC Article
Indeterminate Dendritic Cell Tumor: A Report of Two New Cases Lacking the ETV3-NCOA2 Translocation and a Literature Review.
Davick JJ, Kim J, Wick MR, Gru AA
Am J Dermatopathol 2018 Oct;40(10):736-748. doi: 10.1097/DAD.0000000000001191. PMID: 29877893
Self-regressing S100-negative CD1a-positive cutaneous histiocytosis.
Tardío JC, Aguado M, Borbujo J
Am J Dermatopathol 2013 Jun;35(4):e57-9. doi: 10.1097/DAD.0b013e31827adc72. PMID: 23334517
Indeterminate cell histiocytosis. Clinical and pathologic study in a pediatric patient.
Rodríguez-Jurado R, Vidaurri-de la Cruz H, Durán-Mckinster C, Ruíz-Maldonado R
Arch Pathol Lab Med 2003 Jun;127(6):748-51. doi: 10.5858/2003-127-748-ICH. PMID: 12741905

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