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Chemotherapy-related Cognitive Impairment

MedGen UID:
1709769
•Concept ID:
C5392105
•
Mental or Behavioral Dysfunction
Synonyms: Chemo Fog; Chemo-Fog; Chemobrain; Chemotherapy Induced Cognitive Dysfunction; Chemotherapy Induced Cognitive Impairment; Chemotherapy Induced Cognitive Impairments; Chemotherapy Related Cognitive Dysfunction; Chemotherapy Related Cognitive Impairment; Chemotherapy-Induced Cognitive Dysfunction; Chemotherapy-Induced Cognitive Impairment; Chemotherapy-Induced Cognitive Impairments; Chemotherapy-Related Cognitive Dysfunction; Chemotherapy-Related Cognitive Dysfunctions; Chemotherapy-Related Cognitive Impairment; Chemotherapy-Related Cognitive Impairments; Cognitive Dysfunction, Chemotherapy-Induced; Cognitive Dysfunction, Chemotherapy-Related; Cognitive Impairment, Chemotherapy-Induced; Cognitive Impairment, Chemotherapy-Related; Cognitive Impairments, Chemotherapy-Induced; Cognitive Impairments, Chemotherapy-Related

Definition

Diminished mental function after chemotherapy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChemotherapy-related Cognitive Impairment

Professional guidelines

PubMed

Mechanisms and Treatment for Cancer- and Chemotherapy-Related Cognitive Impairment in Survivors of Non-CNS Malignancies.
Chung NC, Walker AK, Dhillon HM, Vardy JL
Oncology (Williston Park) 2018 Dec 17;32(12):591-8. PMID: 30632128
Is there a relationship between objectively measured cognitive changes in patients with solid tumours undergoing chemotherapy treatment and their health-related quality of life outcomes? A systematic review.
Dwek MR, Rixon L, Hurt C, Simon A, Newman S
Psychooncology 2017 Oct;26(10):1422-1432. Epub 2017 Feb 20 doi: 10.1002/pon.4331. PMID: 27893174
Cognitive impairment in gynecologic cancers: a systematic review of current approaches to diagnosis and treatment.
Craig CD, Monk BJ, Farley JH, Chase DM
Support Care Cancer 2014 Jan;22(1):279-87. Epub 2013 Nov 10 doi: 10.1007/s00520-013-2029-7. PMID: 24212261

Recent clinical studies

Etiology

Chemobrain: A review on mechanistic insight, targets and treatments.
Rao V, Bhushan R, Kumari P, Cheruku SP, Ravichandiran V, Kumar N
Adv Cancer Res 2022;155:29-76. Epub 2022 May 11 doi: 10.1016/bs.acr.2022.04.001. PMID: 35779876
Probiotic supplement attenuates chemotherapy-related cognitive impairment in patients with breast cancer: a randomised, double-blind, and placebo-controlled trial.
Juan Z, Chen J, Ding B, Yongping L, Liu K, Wang L, Le Y, Liao Q, Shi J, Huang J, Wu Y, Ma D, Ouyang W, Tong J
Eur J Cancer 2022 Jan;161:10-22. Epub 2021 Dec 9 doi: 10.1016/j.ejca.2021.11.006. PMID: 34896904
Study of Chemotherapy-Induced Cognitive Impairment in Women with Breast Cancer.
Rodríguez Martín B, Fernández Rodríguez EJ, Rihuete Galve MI, Cruz Hernández JJ
Int J Environ Res Public Health 2020 Nov 30;17(23) doi: 10.3390/ijerph17238896. PMID: 33265966Free PMC Article
Chemotherapy-related cognitive impairment in older patients with cancer.
Loh KP, Janelsins MC, Mohile SG, Holmes HM, Hsu T, Inouye SK, Karuturi MS, Kimmick GG, Lichtman SM, Magnuson A, Whitehead MI, Wong ML, Ahles TA
J Geriatr Oncol 2016 Jul;7(4):270-80. Epub 2016 Jul 5 doi: 10.1016/j.jgo.2016.04.008. PMID: 27197918Free PMC Article
Chemotherapy-related cognitive impairment.
Myers JS
Clin J Oncol Nurs 2009 Aug;13(4):413-21. doi: 10.1188/09.CJON.413-421. PMID: 19648097

Diagnosis

A Drosophila model relevant to chemotherapy-related cognitive impairment.
Torre M, Bukhari H, Nithianandam V, Zanella CA, Mata DA, Feany MB
Sci Rep 2023 Nov 7;13(1):19290. doi: 10.1038/s41598-023-46616-9. PMID: 37935827Free PMC Article
Study of Chemotherapy-Induced Cognitive Impairment in Women with Breast Cancer.
Rodríguez Martín B, Fernández Rodríguez EJ, Rihuete Galve MI, Cruz Hernández JJ
Int J Environ Res Public Health 2020 Nov 30;17(23) doi: 10.3390/ijerph17238896. PMID: 33265966Free PMC Article
Chemotherapy-related cognitive impairment: mechanisms, clinical features and research perspectives.
Cascella M, Di Napoli R, Carbone D, Cuomo GF, Bimonte S, Muzio MR
Recenti Prog Med 2018 Nov;109(11):523-530. doi: 10.1701/3031.30289. PMID: 30565571
Chemotherapy-related cognitive impairment in older patients with cancer.
Loh KP, Janelsins MC, Mohile SG, Holmes HM, Hsu T, Inouye SK, Karuturi MS, Kimmick GG, Lichtman SM, Magnuson A, Whitehead MI, Wong ML, Ahles TA
J Geriatr Oncol 2016 Jul;7(4):270-80. Epub 2016 Jul 5 doi: 10.1016/j.jgo.2016.04.008. PMID: 27197918Free PMC Article
Chemotherapy-related cognitive impairment.
Myers JS
Clin J Oncol Nurs 2009 Aug;13(4):413-21. doi: 10.1188/09.CJON.413-421. PMID: 19648097

Therapy

Nasal administration of mitochondria reverses chemotherapy-induced cognitive deficits.
Alexander JF, Seua AV, Arroyo LD, Ray PR, Wangzhou A, Heiβ-Lückemann L, Schedlowski M, Price TJ, Kavelaars A, Heijnen CJ
Theranostics 2021;11(7):3109-3130. Epub 2021 Jan 1 doi: 10.7150/thno.53474. PMID: 33537077Free PMC Article
Study of Chemotherapy-Induced Cognitive Impairment in Women with Breast Cancer.
Rodríguez Martín B, Fernández Rodríguez EJ, Rihuete Galve MI, Cruz Hernández JJ
Int J Environ Res Public Health 2020 Nov 30;17(23) doi: 10.3390/ijerph17238896. PMID: 33265966Free PMC Article
Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment.
Geraghty AC, Gibson EM, Ghanem RA, Greene JJ, Ocampo A, Goldstein AK, Ni L, Yang T, Marton RM, Paşca SP, Greenberg ME, Longo FM, Monje M
Neuron 2019 Jul 17;103(2):250-265.e8. Epub 2019 May 20 doi: 10.1016/j.neuron.2019.04.032. PMID: 31122677Free PMC Article
Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment.
Gibson EM, Nagaraja S, Ocampo A, Tam LT, Wood LS, Pallegar PN, Greene JJ, Geraghty AC, Goldstein AK, Ni L, Woo PJ, Barres BA, Liddelow S, Vogel H, Monje M
Cell 2019 Jan 10;176(1-2):43-55.e13. Epub 2018 Dec 6 doi: 10.1016/j.cell.2018.10.049. PMID: 30528430Free PMC Article
Chemotherapy-related cognitive impairment: mechanisms, clinical features and research perspectives.
Cascella M, Di Napoli R, Carbone D, Cuomo GF, Bimonte S, Muzio MR
Recenti Prog Med 2018 Nov;109(11):523-530. doi: 10.1701/3031.30289. PMID: 30565571

Prognosis

Behavioral and biologic characteristics of cancer-related cognitive impairment biotypes.
Mulholland MM, Prinsloo S, Kvale E, Dula AN, Palesh O, Kesler SR
Brain Imaging Behav 2023 Jun;17(3):320-328. Epub 2023 May 2 doi: 10.1007/s11682-023-00774-6. PMID: 37127832Free PMC Article
Subjective cognition and mood in persistent chemotherapy-related cognitive impairment.
Vega JN, Albert KM, Mayer IA, Taylor WD, Newhouse PA
J Cancer Surviv 2022 Jun;16(3):614-623. Epub 2021 May 11 doi: 10.1007/s11764-021-01055-1. PMID: 33973154Free PMC Article
Functional connectome biotypes of chemotherapy-related cognitive impairment.
Kesler SR, Petersen ML, Rao V, Harrison RA, Palesh O
J Cancer Surviv 2020 Aug;14(4):483-493. Epub 2020 Mar 10 doi: 10.1007/s11764-020-00863-1. PMID: 32157609Free PMC Article
Post-chemotherapy cognitive impairment in hematological patients: current understanding of chemobrain in hematology.
Allegra A, Innao V, Basile G, Pugliese M, Allegra AG, Pulvirenti N, Musolino C
Expert Rev Hematol 2020 Apr;13(4):393-404. Epub 2020 Mar 10 doi: 10.1080/17474086.2020.1738213. PMID: 32129131
Objective and subjective cognitive impairment following chemotherapy for cancer: a systematic review.
Hutchinson AD, Hosking JR, Kichenadasse G, Mattiske JK, Wilson C
Cancer Treat Rev 2012 Nov;38(7):926-34. Epub 2012 Jun 2 doi: 10.1016/j.ctrv.2012.05.002. PMID: 22658913

Clinical prediction guides

A Drosophila model relevant to chemotherapy-related cognitive impairment.
Torre M, Bukhari H, Nithianandam V, Zanella CA, Mata DA, Feany MB
Sci Rep 2023 Nov 7;13(1):19290. doi: 10.1038/s41598-023-46616-9. PMID: 37935827Free PMC Article
Subjective cognition and mood in persistent chemotherapy-related cognitive impairment.
Vega JN, Albert KM, Mayer IA, Taylor WD, Newhouse PA
J Cancer Surviv 2022 Jun;16(3):614-623. Epub 2021 May 11 doi: 10.1007/s11764-021-01055-1. PMID: 33973154Free PMC Article
Chemotherapy-Induced Cognitive Impairment and Hippocampal Neurogenesis: A Review of Physiological Mechanisms and Interventions.
Sekeres MJ, Bradley-Garcia M, Martinez-Canabal A, Winocur G
Int J Mol Sci 2021 Nov 24;22(23) doi: 10.3390/ijms222312697. PMID: 34884513Free PMC Article
Study of Chemotherapy-Induced Cognitive Impairment in Women with Breast Cancer.
Rodríguez Martín B, Fernández Rodríguez EJ, Rihuete Galve MI, Cruz Hernández JJ
Int J Environ Res Public Health 2020 Nov 30;17(23) doi: 10.3390/ijerph17238896. PMID: 33265966Free PMC Article
Neural correlates of chemotherapy-related cognitive impairment.
Kaiser J, Bledowski C, Dietrich J
Cortex 2014 May;54:33-50. Epub 2014 Jan 30 doi: 10.1016/j.cortex.2014.01.010. PMID: 24632463

Recent systematic reviews

Chemotherapy-induced cognitive impairment in breast cancer survivors: A systematic review of studies from 2000 to 2021.
Amani O, Mazaheri MA, Moghani MM, Zarani F, Choolabi RH
Cancer Rep (Hoboken) 2024 Feb;7(2):e1989. doi: 10.1002/cnr2.1989. PMID: 38351543Free PMC Article
Prevalence and associated factors of chemotherapy-related cognitive impairment in older breast cancer survivors.
Zhou X, Zhang X, Zhong T, Zhou M, Gao L, Chen L
J Adv Nurs 2024 Feb;80(2):484-499. Epub 2023 Sep 7 doi: 10.1111/jan.15842. PMID: 37675947
Effectiveness of Nonpharmacologic Interventions for Chemotherapy-Related Cognitive Impairment in Breast Cancer Patients: A Systematic Review and Network Meta-analysis.
Liu Y, Liu JE, Chen S, Zhao F, Chen L, Li R
Cancer Nurs 2023 Sep-Oct 01;46(5):E305-E319. Epub 2022 Dec 11 doi: 10.1097/NCC.0000000000001152. PMID: 37607381
Role of Cytokines in Chemotherapy-related Cognitive Impairment of Breast Cancer Patients: A Systematic Review.
Tyagi K, Masoom M, Majid H, Garg A, Bhurani D, Agarwal NB, Khan MA
Curr Rev Clin Exp Pharmacol 2023;18(2):110-119. doi: 10.2174/2772432817666220304212456. PMID: 35249524
Objective and subjective cognitive impairment following chemotherapy for cancer: a systematic review.
Hutchinson AD, Hosking JR, Kichenadasse G, Mattiske JK, Wilson C
Cancer Treat Rev 2012 Nov;38(7):926-34. Epub 2012 Jun 2 doi: 10.1016/j.ctrv.2012.05.002. PMID: 22658913

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