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Unresectable Epithelioid Hemangioendothelioma

MedGen UID:
1710197
•Concept ID:
C5239076
•
Neoplastic Process

Definition

An epithelioid hemangioendothelioma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Epithelioid Hemangioendothelioma

Professional guidelines

PubMed

Hepatic epithelioid haemangioendothelioma: is transplantation the only treatment option?
Grotz TE, Nagorney D, Donohue J, Que F, Kendrick M, Farnell M, Harmsen S, Mulligan D, Nguyen J, Rosen C, Reid-Lombardo KM
HPB (Oxford) 2010 Oct;12(8):546-53. Epub 2010 Sep 2 doi: 10.1111/j.1477-2574.2010.00213.x. PMID: 20887322Free PMC Article
Vascular endothelial growth factor expression in hepatic epithelioid hemangioendothelioma: Implications for treatment and surgical management.
Emamaullee JA, Edgar R, Toso C, Thiesen A, Bain V, Bigam D, Kneteman N, Shapiro AM
Liver Transpl 2010 Feb;16(2):191-7. doi: 10.1002/lt.21964. PMID: 20104492

Recent clinical studies

Etiology

Liver Transplantation for Non-hepatocellular Carcinoma Malignancy: A Single-Center Experience.
Mont Alverne Pierre AM, Veras CM, Esmeraldo TM, Schwermann MP, Studart E Neves MS, Bastos Pinho JE, Canito Brasil IR
Transplant Proc 2019 Dec;51(10):3355-3359. Epub 2019 Oct 25 doi: 10.1016/j.transproceed.2019.09.001. PMID: 31669072
Clinical characteristics of epithelioid hemangioendothelioma: a single-center retrospective study.
Wu X, Li B, Zheng C, Hong T, He X
Eur J Med Res 2019 Feb 28;24(1):16. doi: 10.1186/s40001-019-0375-8. PMID: 30819247Free PMC Article
Liver Transplant for Nonhepatocellular Carcinoma Malignancy.
Haberal Reyhan N
Exp Clin Transplant 2017 Mar;15(Suppl 2):69-73. doi: 10.6002/ect.TOND16.L18. PMID: 28302003
Epithelioid hemangioendothelioma of the liver as a rare indication for liver transplantation.
Remiszewski P, Szczerba E, Kalinowski P, Gierej B, Dudek K, Grodzicki M, Kotulski M, Paluszkiewicz R, Patkowski W, Zieniewicz K, Krawczyk M
World J Gastroenterol 2014 Aug 28;20(32):11333-9. doi: 10.3748/wjg.v20.i32.11333. PMID: 25170219Free PMC Article
Liver transplantation for malignancies.
Eghtesad B, Aucejo F
J Gastrointest Cancer 2014 Sep;45(3):353-62. doi: 10.1007/s12029-014-9590-2. PMID: 24604263

Diagnosis

Clinical characteristics of epithelioid hemangioendothelioma: a single-center retrospective study.
Wu X, Li B, Zheng C, Hong T, He X
Eur J Med Res 2019 Feb 28;24(1):16. doi: 10.1186/s40001-019-0375-8. PMID: 30819247Free PMC Article
Telatinib Is an Effective Targeted Therapy for Pseudomyogenic Hemangioendothelioma.
van IJzendoorn DGP, Sleijfer S, Gelderblom H, Eskens FALM, van Leenders GJLH, Szuhai K, Bovée JVMG
Clin Cancer Res 2018 Jun 1;24(11):2678-2687. Epub 2018 Mar 6 doi: 10.1158/1078-0432.CCR-17-3512. PMID: 29511030
Epithelioid hemangioendothelioma of the liver as a rare indication for liver transplantation.
Remiszewski P, Szczerba E, Kalinowski P, Gierej B, Dudek K, Grodzicki M, Kotulski M, Paluszkiewicz R, Patkowski W, Zieniewicz K, Krawczyk M
World J Gastroenterol 2014 Aug 28;20(32):11333-9. doi: 10.3748/wjg.v20.i32.11333. PMID: 25170219Free PMC Article
Hepatic malignant epithelioid hemangioendothelioma: a case report and review of the literature.
Woodall CE, Scoggins CR, Lewis AM, McMasters KM, Martin RC
Am Surg 2008 Jan;74(1):64-8. PMID: 18274433
Tumor diagnosis in the adult liver transplant candidate.
Mahfouz A, Vogl T, Hamm B
Eur Radiol 1999;9(5):841-52. doi: 10.1007/s003300050754. PMID: 10369978

Therapy

Telatinib Is an Effective Targeted Therapy for Pseudomyogenic Hemangioendothelioma.
van IJzendoorn DGP, Sleijfer S, Gelderblom H, Eskens FALM, van Leenders GJLH, Szuhai K, Bovée JVMG
Clin Cancer Res 2018 Jun 1;24(11):2678-2687. Epub 2018 Mar 6 doi: 10.1158/1078-0432.CCR-17-3512. PMID: 29511030
Liver Transplant for Nonhepatocellular Carcinoma Malignancy.
Haberal Reyhan N
Exp Clin Transplant 2017 Mar;15(Suppl 2):69-73. doi: 10.6002/ect.TOND16.L18. PMID: 28302003
Liver transplantation for hepatobiliary malignancies: a new era of "Transplant Oncology" has begun.
Hibi T, Itano O, Shinoda M, Kitagawa Y
Surg Today 2017 Apr;47(4):403-415. Epub 2016 Apr 29 doi: 10.1007/s00595-016-1337-1. PMID: 27130463
Liver transplantation for malignancies.
Eghtesad B, Aucejo F
J Gastrointest Cancer 2014 Sep;45(3):353-62. doi: 10.1007/s12029-014-9590-2. PMID: 24604263
Liver transplantation for non-hepatocellular carcinoma malignancy: Indications, limitations, and analysis of the current literature.
Grossman EJ, Millis JM
Liver Transpl 2010 Aug;16(8):930-42. doi: 10.1002/lt.22106. PMID: 20677284

Prognosis

Epithelioid hemangioendothelioma-its history, clinical features, molecular biology and current therapy.
Tsuchihashi K, Baba E
Jpn J Clin Oncol 2024 Jul 7;54(7):739-747. doi: 10.1093/jjco/hyae037. PMID: 38555494
Clinical characteristics of epithelioid hemangioendothelioma: a single-center retrospective study.
Wu X, Li B, Zheng C, Hong T, He X
Eur J Med Res 2019 Feb 28;24(1):16. doi: 10.1186/s40001-019-0375-8. PMID: 30819247Free PMC Article
Liver transplantation for non-hepatocellular carcinoma malignancy: Indications, limitations, and analysis of the current literature.
Grossman EJ, Millis JM
Liver Transpl 2010 Aug;16(8):930-42. doi: 10.1002/lt.22106. PMID: 20677284
Liver transplantation for malignancy.
Hertl M, Cosimi AB
Oncologist 2005 Apr;10(4):269-81. doi: 10.1634/theoncologist.10-4-269. PMID: 15821247
Tumor diagnosis in the adult liver transplant candidate.
Mahfouz A, Vogl T, Hamm B
Eur Radiol 1999;9(5):841-52. doi: 10.1007/s003300050754. PMID: 10369978

Clinical prediction guides

Epithelioid hemangioendothelioma-its history, clinical features, molecular biology and current therapy.
Tsuchihashi K, Baba E
Jpn J Clin Oncol 2024 Jul 7;54(7):739-747. doi: 10.1093/jjco/hyae037. PMID: 38555494
Epithelioid hemangioendothelioma of the liver as a rare indication for liver transplantation.
Remiszewski P, Szczerba E, Kalinowski P, Gierej B, Dudek K, Grodzicki M, Kotulski M, Paluszkiewicz R, Patkowski W, Zieniewicz K, Krawczyk M
World J Gastroenterol 2014 Aug 28;20(32):11333-9. doi: 10.3748/wjg.v20.i32.11333. PMID: 25170219Free PMC Article
Liver transplantation for non-hepatocellular carcinoma malignancy: Indications, limitations, and analysis of the current literature.
Grossman EJ, Millis JM
Liver Transpl 2010 Aug;16(8):930-42. doi: 10.1002/lt.22106. PMID: 20677284
Vascular endothelial growth factor expression in hepatic epithelioid hemangioendothelioma: Implications for treatment and surgical management.
Emamaullee JA, Edgar R, Toso C, Thiesen A, Bain V, Bigam D, Kneteman N, Shapiro AM
Liver Transpl 2010 Feb;16(2):191-7. doi: 10.1002/lt.21964. PMID: 20104492
Tumor diagnosis in the adult liver transplant candidate.
Mahfouz A, Vogl T, Hamm B
Eur Radiol 1999;9(5):841-52. doi: 10.1007/s003300050754. PMID: 10369978

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