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Spitzoid melanoma

MedGen UID:
1713307
•Concept ID:
C3495721
•
Neoplastic Process
Synonyms: Malignant Spitz Tumor; Spitz Melanoma; Spitzoid Melanoma; spitzoid melanoma
 
Monarch Initiative: MONDO:0850101

Definition

A cutaneous melanoma that is associated with genomic alterations observed in Spitz nevus and Spitz melanocytoma. It shares histopathological and clinical features with Spitz melanocytoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpitzoid melanoma

Professional guidelines

PubMed

Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society.
Lallas A, Apalla Z, Ioannides D, Lazaridou E, Kyrgidis A, Broganelli P, Alfano R, Zalaudek I, Argenziano G; International Dermoscopy Society
Br J Dermatol 2017 Sep;177(3):645-655. Epub 2017 Jul 19 doi: 10.1111/bjd.15339. PMID: 28118479
Differential diagnosis of Spitzoid melanocytic neoplasms.
Stefanaki C, Stefanaki K, Chardalias L, Soura E, Stratigos A
J Eur Acad Dermatol Venereol 2016 Aug;30(8):1269-77. Epub 2016 May 13 doi: 10.1111/jdv.13665. PMID: 27173829
Characteristics of spitzoid melanoma and clues for differential diagnosis with spitz nevus.
Requena C, Botella R, Nagore E, Sanmartín O, Llombart B, Serra-Guillén C, Guillén C, Requena L, Traves V
Am J Dermatopathol 2012 Jul;34(5):478-86. doi: 10.1097/DAD.0b013e318234e780. PMID: 22257900

Recent clinical studies

Etiology

Melanoma in children: A systematic review and individual patient meta-analysis.
Pampena R, Piccolo V, Muscianese M, Kyrgidis A, Lai M, Russo T, Briatico G, Di Brizzi EV, Cascone G, Pellerone S, Longo C, Moscarella E, Argenziano G
J Eur Acad Dermatol Venereol 2023 Sep;37(9):1758-1776. Epub 2023 Jun 2 doi: 10.1111/jdv.19220. PMID: 37210654
Spitz Tumors of the Skin.
Menezes FD, Mooi WJ
Surg Pathol Clin 2017 Jun;10(2):281-298. Epub 2017 Mar 31 doi: 10.1016/j.path.2017.01.004. PMID: 28477881
Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society.
Lallas A, Apalla Z, Ioannides D, Lazaridou E, Kyrgidis A, Broganelli P, Alfano R, Zalaudek I, Argenziano G; International Dermoscopy Society
Br J Dermatol 2017 Sep;177(3):645-655. Epub 2017 Jul 19 doi: 10.1111/bjd.15339. PMID: 28118479
Paediatric melanoma.
Wood BA
Pathology 2016 Feb;48(2):155-65. Epub 2016 Jan 16 doi: 10.1016/j.pathol.2015.12.001. PMID: 27020388
Spitzoid melanoma.
Kamino H
Clin Dermatol 2009 Nov-Dec;27(6):545-55. doi: 10.1016/j.clindermatol.2008.09.013. PMID: 19880042

Diagnosis

Melanoma in children: A systematic review and individual patient meta-analysis.
Pampena R, Piccolo V, Muscianese M, Kyrgidis A, Lai M, Russo T, Briatico G, Di Brizzi EV, Cascone G, Pellerone S, Longo C, Moscarella E, Argenziano G
J Eur Acad Dermatol Venereol 2023 Sep;37(9):1758-1776. Epub 2023 Jun 2 doi: 10.1111/jdv.19220. PMID: 37210654
Spitz Nevus: Review and Update.
Brown A, Sawyer JD, Neumeister MW
Clin Plast Surg 2021 Oct;48(4):677-686. Epub 2021 Aug 18 doi: 10.1016/j.cps.2021.06.002. PMID: 34503728
Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society.
Lallas A, Apalla Z, Ioannides D, Lazaridou E, Kyrgidis A, Broganelli P, Alfano R, Zalaudek I, Argenziano G; International Dermoscopy Society
Br J Dermatol 2017 Sep;177(3):645-655. Epub 2017 Jul 19 doi: 10.1111/bjd.15339. PMID: 28118479
Paediatric melanoma.
Wood BA
Pathology 2016 Feb;48(2):155-65. Epub 2016 Jan 16 doi: 10.1016/j.pathol.2015.12.001. PMID: 27020388
Spitzoid melanoma.
Kamino H
Clin Dermatol 2009 Nov-Dec;27(6):545-55. doi: 10.1016/j.clindermatol.2008.09.013. PMID: 19880042

Therapy

The role of routine imaging in pediatric cutaneous melanoma.
Halalsheh H, Kaste SC, Navid F, Bahrami A, Shulkin BL, Rao B, Kunkel M, Artz N, Pappo A
Pediatr Blood Cancer 2018 Dec;65(12):e27412. Epub 2018 Aug 19 doi: 10.1002/pbc.27412. PMID: 30124237Free PMC Article
Evolving Childhood Melanoma Monitored by Parental Photodocumentation.
Bartenstein DW, Song JS, Nazarian RM, Hawryluk EB
J Pediatr 2017 Jul;186:205-205.e1. Epub 2017 Mar 24 doi: 10.1016/j.jpeds.2017.02.075. PMID: 28347477
The distribution of BRAF gene fusions in solid tumors and response to targeted therapy.
Ross JS, Wang K, Chmielecki J, Gay L, Johnson A, Chudnovsky J, Yelensky R, Lipson D, Ali SM, Elvin JA, Vergilio JA, Roels S, Miller VA, Nakamura BN, Gray A, Wong MK, Stephens PJ
Int J Cancer 2016 Feb 15;138(4):881-90. Epub 2015 Sep 8 doi: 10.1002/ijc.29825. PMID: 26314551Free PMC Article
Multiple Spitz nevi: a clinicopathologic study of 9 patients.
Zayour M, Bolognia JL, Lazova R
J Am Acad Dermatol 2012 Sep;67(3):451-8, 458.e1-2. Epub 2012 Jan 31 doi: 10.1016/j.jaad.2011.11.941. PMID: 22300833
Statistical analysis of the concordance of immunohistochemical stains with the final diagnosis in spitzoid neoplasms.
Puri PK, Ferringer TC, Tyler WB, Wilson ML, Kirchner HL, Elston DM
Am J Dermatopathol 2011 Feb;33(1):72-7. doi: 10.1097/DAD.0b013e3181da3841. PMID: 20700039

Prognosis

Melanoma in children: A systematic review and individual patient meta-analysis.
Pampena R, Piccolo V, Muscianese M, Kyrgidis A, Lai M, Russo T, Briatico G, Di Brizzi EV, Cascone G, Pellerone S, Longo C, Moscarella E, Argenziano G
J Eur Acad Dermatol Venereol 2023 Sep;37(9):1758-1776. Epub 2023 Jun 2 doi: 10.1111/jdv.19220. PMID: 37210654
Spitz Nevus: Review and Update.
Brown A, Sawyer JD, Neumeister MW
Clin Plast Surg 2021 Oct;48(4):677-686. Epub 2021 Aug 18 doi: 10.1016/j.cps.2021.06.002. PMID: 34503728
Spitz Nevus and Other Spitzoid Tumors in Children. Part 2: Cytogenetic and Molecular Features. Prognosis and Treatment.
Sainz-Gaspar L, Sánchez-Bernal J, Noguera-Morel L, Hernández-Martín A, Colmenero I, Torrelo A
Actas Dermosifiliogr (Engl Ed) 2020 Jan 2;111(1):20-25. Epub 2019 Nov 15 doi: 10.1016/j.ad.2019.02.010. PMID: 31739993
Pathology and genomics of pediatric melanoma: A critical reexamination and new insights.
Bahrami A, Barnhill RL
Pediatr Blood Cancer 2018 Feb;65(2) Epub 2017 Sep 12 doi: 10.1002/pbc.26792. PMID: 28895292Free PMC Article
Spitzoid melanoma.
Kamino H
Clin Dermatol 2009 Nov-Dec;27(6):545-55. doi: 10.1016/j.clindermatol.2008.09.013. PMID: 19880042

Clinical prediction guides

PRAME immunohistochemistry of spitzoid neoplasms.
Koh SS, Lau SK, Scapa JV, Cassarino DS
J Cutan Pathol 2022 Aug;49(8):709-716. Epub 2022 May 24 doi: 10.1111/cup.14245. PMID: 35488519
Spitz Nevus: Review and Update.
Brown A, Sawyer JD, Neumeister MW
Clin Plast Surg 2021 Oct;48(4):677-686. Epub 2021 Aug 18 doi: 10.1016/j.cps.2021.06.002. PMID: 34503728
Spitz Nevus and Other Spitzoid Tumors in Children. Part 2: Cytogenetic and Molecular Features. Prognosis and Treatment.
Sainz-Gaspar L, Sánchez-Bernal J, Noguera-Morel L, Hernández-Martín A, Colmenero I, Torrelo A
Actas Dermosifiliogr (Engl Ed) 2020 Jan 2;111(1):20-25. Epub 2019 Nov 15 doi: 10.1016/j.ad.2019.02.010. PMID: 31739993
Differential diagnosis of Spitzoid melanocytic neoplasms.
Stefanaki C, Stefanaki K, Chardalias L, Soura E, Stratigos A
J Eur Acad Dermatol Venereol 2016 Aug;30(8):1269-77. Epub 2016 May 13 doi: 10.1111/jdv.13665. PMID: 27173829
The distribution of BRAF gene fusions in solid tumors and response to targeted therapy.
Ross JS, Wang K, Chmielecki J, Gay L, Johnson A, Chudnovsky J, Yelensky R, Lipson D, Ali SM, Elvin JA, Vergilio JA, Roels S, Miller VA, Nakamura BN, Gray A, Wong MK, Stephens PJ
Int J Cancer 2016 Feb 15;138(4):881-90. Epub 2015 Sep 8 doi: 10.1002/ijc.29825. PMID: 26314551Free PMC Article

Recent systematic reviews

Melanoma in children: A systematic review and individual patient meta-analysis.
Pampena R, Piccolo V, Muscianese M, Kyrgidis A, Lai M, Russo T, Briatico G, Di Brizzi EV, Cascone G, Pellerone S, Longo C, Moscarella E, Argenziano G
J Eur Acad Dermatol Venereol 2023 Sep;37(9):1758-1776. Epub 2023 Jun 2 doi: 10.1111/jdv.19220. PMID: 37210654
Clinical and Dermoscopic Features Associated With Difficult-to-Recognize Variants of Cutaneous Melanoma: A Systematic Review.
Pampena R, Lai M, Lombardi M, Mirra M, Raucci M, Lallas A, Apalla Z, Argenziano G, Pellacani G, Longo C
JAMA Dermatol 2020 Apr 1;156(4):430-439. doi: 10.1001/jamadermatol.2019.4912. PMID: 32101255

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