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Focal aware non-motor seizure

MedGen UID:
1718117
•Concept ID:
C5397692
•
Disease or Syndrome
Synonym: Focal non-motor aware seizure
 
HPO: HP:0032682

Definition

A focal non-motor seizure in which awareness is retained throughout the seizure. [from HPO]

Professional guidelines

PubMed

Efficacy and safety of adjunctive perampanel treatment in pediatric patients with epilepsy aged 4-12 years: a real-world study.
Zeng Q, Xia X, Jiang L, Chen J, Liu Y, Hu Y
J Neurol 2024 Jul;271(7):4566-4576. Epub 2024 May 8 doi: 10.1007/s00415-024-12416-y. PMID: 38717610

Recent clinical studies

Etiology

Temporal encephalocele: a rare but treatable cause of temporal lobe epilepsy.
Jagtap SA, Kurwale N, Patil S, Bapat D, Joshi A, Chitnis S, Deshmukh Y, Nilegaonkar S
Epileptic Disord 2022 Dec 1;24(6):1073-1080. doi: 10.1684/epd.2022.1487. PMID: 36153932
The spectrum of epilepsy in children with 15q13.3 microdeletion syndrome.
Whitney R, Nair A, McCready E, Keller AE, Adil IS, Aziz AS, Borys O, Siu K, Shah C, Meaney BF, Jones K, RamachandranNair R
Seizure 2021 Nov;92:221-229. Epub 2021 Sep 26 doi: 10.1016/j.seizure.2021.09.016. PMID: 34601452
Electroclinical markers to differentiate between focal and generalized epilepsies.
Raga S, Rheims S, Specchio N, Wilmshurst JM
Epileptic Disord 2021 Jun 1;23(3):437-458. doi: 10.1684/epd.2021.1291. PMID: 34106053
Surgery in intractable epilepsy-physicians' recommendations and patients' decisions.
Davids R, Kowski AB, Meencke HJ, Oltmanns F, Dehnicke C, Schneider UC, Holtkamp M
Acta Neurol Scand 2021 Apr;143(4):421-429. Epub 2020 Dec 1 doi: 10.1111/ane.13377. PMID: 33210727
Acute seizure epidemiology in a neurological emergency department.
Valdes-Galvan RE, Gonzalez-Calderon G, Castro-Martinez E
Rev Neurol 2019 Apr 16;68(8):321-325. doi: 10.33588/rn.6808.2018218. PMID: 30963528

Diagnosis

Clinical characterization of non-ketotic hyperglycemia-related seizures: A systematic review and individual participant data meta-analysis.
Licchetta L, Ferri L, Morsillo F, Faustini-Fustini M, Toni F, Pondrelli F, Nonino F, Bisulli F, Tinuper P
Seizure 2023 Mar;106:50-57. Epub 2023 Jan 27 doi: 10.1016/j.seizure.2023.01.018. PMID: 36773573
The spectrum of epilepsy in children with 15q13.3 microdeletion syndrome.
Whitney R, Nair A, McCready E, Keller AE, Adil IS, Aziz AS, Borys O, Siu K, Shah C, Meaney BF, Jones K, RamachandranNair R
Seizure 2021 Nov;92:221-229. Epub 2021 Sep 26 doi: 10.1016/j.seizure.2021.09.016. PMID: 34601452
Electroclinical markers to differentiate between focal and generalized epilepsies.
Raga S, Rheims S, Specchio N, Wilmshurst JM
Epileptic Disord 2021 Jun 1;23(3):437-458. doi: 10.1684/epd.2021.1291. PMID: 34106053
Electroencephalography in neonatal epilepsies.
Okumura A
Pediatr Int 2020 Sep;62(9):1019-1028. doi: 10.1111/ped.14227. PMID: 32153072
The new classification of seizures: an overview for the general physician.
Liyanagedera S, Williams RP
J R Coll Physicians Edinb 2017 Dec;47(4):336-338. doi: 10.4997/JRCPE.2017.406. PMID: 29537403

Therapy

Efficacy and safety of adjunctive perampanel treatment in pediatric patients with epilepsy aged 4-12 years: a real-world study.
Zeng Q, Xia X, Jiang L, Chen J, Liu Y, Hu Y
J Neurol 2024 Jul;271(7):4566-4576. Epub 2024 May 8 doi: 10.1007/s00415-024-12416-y. PMID: 38717610
Predictive models for starting antiseizure medication withdrawal following epilepsy surgery in adults.
Ferreira-Atuesta C, de Tisi J, McEvoy AW, Miserocchi A, Khoury J, Yardi R, Vegh DT, Butler J, Lee HJ, Deli-Peri V, Yao Y, Wang FP, Zhang XB, Shakhatreh L, Siriratnam P, Neal A, Sen A, Tristram M, Varghese E, Biney W, Gray WP, Peralta AR, Rainha-Campos A, Gonçalves-Ferreira AJC, Pimentel J, Arias JF, Terman S, Terziev R, Lamberink HJ, Braun KPJ, Otte WM, Rugg-Gunn FJ, Gonzalez W, Bentes C, Hamandi K, O'Brien TJ, Perucca P, Yao C, Burman RJ, Jehi L, Duncan JS, Sander JW, Koepp M, Galovic M
Brain 2023 Jun 1;146(6):2389-2398. doi: 10.1093/brain/awac437. PMID: 36415957
Acute seizure epidemiology in a neurological emergency department.
Valdes-Galvan RE, Gonzalez-Calderon G, Castro-Martinez E
Rev Neurol 2019 Apr 16;68(8):321-325. doi: 10.33588/rn.6808.2018218. PMID: 30963528

Prognosis

Does response to vagus nerve stimulation for drug-resistant epilepsy differ in patients with and without Lennox-Gastaut syndrome?
Dibué M, Greco T, Spoor JKH, Senft C, Kamp MA
Brain Behav 2023 Aug;13(8):e3025. Epub 2023 Jun 29 doi: 10.1002/brb3.3025. PMID: 37386739Free PMC Article
Predictive models for starting antiseizure medication withdrawal following epilepsy surgery in adults.
Ferreira-Atuesta C, de Tisi J, McEvoy AW, Miserocchi A, Khoury J, Yardi R, Vegh DT, Butler J, Lee HJ, Deli-Peri V, Yao Y, Wang FP, Zhang XB, Shakhatreh L, Siriratnam P, Neal A, Sen A, Tristram M, Varghese E, Biney W, Gray WP, Peralta AR, Rainha-Campos A, Gonçalves-Ferreira AJC, Pimentel J, Arias JF, Terman S, Terziev R, Lamberink HJ, Braun KPJ, Otte WM, Rugg-Gunn FJ, Gonzalez W, Bentes C, Hamandi K, O'Brien TJ, Perucca P, Yao C, Burman RJ, Jehi L, Duncan JS, Sander JW, Koepp M, Galovic M
Brain 2023 Jun 1;146(6):2389-2398. doi: 10.1093/brain/awac437. PMID: 36415957

Clinical prediction guides

Does response to vagus nerve stimulation for drug-resistant epilepsy differ in patients with and without Lennox-Gastaut syndrome?
Dibué M, Greco T, Spoor JKH, Senft C, Kamp MA
Brain Behav 2023 Aug;13(8):e3025. Epub 2023 Jun 29 doi: 10.1002/brb3.3025. PMID: 37386739Free PMC Article
Predictive models for starting antiseizure medication withdrawal following epilepsy surgery in adults.
Ferreira-Atuesta C, de Tisi J, McEvoy AW, Miserocchi A, Khoury J, Yardi R, Vegh DT, Butler J, Lee HJ, Deli-Peri V, Yao Y, Wang FP, Zhang XB, Shakhatreh L, Siriratnam P, Neal A, Sen A, Tristram M, Varghese E, Biney W, Gray WP, Peralta AR, Rainha-Campos A, Gonçalves-Ferreira AJC, Pimentel J, Arias JF, Terman S, Terziev R, Lamberink HJ, Braun KPJ, Otte WM, Rugg-Gunn FJ, Gonzalez W, Bentes C, Hamandi K, O'Brien TJ, Perucca P, Yao C, Burman RJ, Jehi L, Duncan JS, Sander JW, Koepp M, Galovic M
Brain 2023 Jun 1;146(6):2389-2398. doi: 10.1093/brain/awac437. PMID: 36415957
Temporal encephalocele: a rare but treatable cause of temporal lobe epilepsy.
Jagtap SA, Kurwale N, Patil S, Bapat D, Joshi A, Chitnis S, Deshmukh Y, Nilegaonkar S
Epileptic Disord 2022 Dec 1;24(6):1073-1080. doi: 10.1684/epd.2022.1487. PMID: 36153932
The spectrum of epilepsy in children with 15q13.3 microdeletion syndrome.
Whitney R, Nair A, McCready E, Keller AE, Adil IS, Aziz AS, Borys O, Siu K, Shah C, Meaney BF, Jones K, RamachandranNair R
Seizure 2021 Nov;92:221-229. Epub 2021 Sep 26 doi: 10.1016/j.seizure.2021.09.016. PMID: 34601452
Prevalence, Semiology, and Risk Factors of Epilepsy in Alzheimer's Disease: An Ambulatory EEG Study.
Horváth A, Szűcs A, Hidasi Z, Csukly G, Barcs G, Kamondi A
J Alzheimers Dis 2018;63(3):1045-1054. doi: 10.3233/JAD-170925. PMID: 29710705

Recent systematic reviews

Clinical characterization of non-ketotic hyperglycemia-related seizures: A systematic review and individual participant data meta-analysis.
Licchetta L, Ferri L, Morsillo F, Faustini-Fustini M, Toni F, Pondrelli F, Nonino F, Bisulli F, Tinuper P
Seizure 2023 Mar;106:50-57. Epub 2023 Jan 27 doi: 10.1016/j.seizure.2023.01.018. PMID: 36773573

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