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Focal non-convulsive status epilepticus without coma

MedGen UID:
1718145
•Concept ID:
C5397686
•
Disease or Syndrome
HPO: HP:0032673

Definition

Focal non-convulsive status epilepticus without coma is a type of status epilepticus without prominent motor signs, which is electrographically focal. It is a prolonged focal non-motor seizure. [from HPO]

Professional guidelines

PubMed

Principles of Management of Central Nervous System Infections.
Singhi S, Angurana SK
Indian J Pediatr 2019 Jan;86(1):52-59. Epub 2018 Jan 15 doi: 10.1007/s12098-017-2583-y. PMID: 29333566
Treatment of Refractory and Super-refractory Status Epilepticus.
Rai S, Drislane FW
Neurotherapeutics 2018 Jul;15(3):697-712. doi: 10.1007/s13311-018-0640-5. PMID: 29922905Free PMC Article
Management of refractory status epilepticus in adults: still more questions than answers.
Rossetti AO, Lowenstein DH
Lancet Neurol 2011 Oct;10(10):922-30. doi: 10.1016/S1474-4422(11)70187-9. PMID: 21939901Free PMC Article

Recent clinical studies

Etiology

Clinical Characteristics, Imaging Findings, and Outcomes of Cerebral Air Embolism.
Brown AE, Rabinstein AA, Braksick SA
Neurocrit Care 2023 Feb;38(1):158-164. Epub 2023 Jan 10 doi: 10.1007/s12028-022-01664-3. PMID: 36627433
Nonconvulsive status epilepticus in the elderly.
Dupont S, Kinugawa K
Rev Neurol (Paris) 2020 Nov;176(9):701-709. Epub 2020 Mar 10 doi: 10.1016/j.neurol.2019.12.007. PMID: 32169326
Non convulsive status epilepticus in the elderly.
Dupont S
Geriatr Psychol Neuropsychiatr Vieil 2019 Mar 1;17(S1):25-30. doi: 10.1684/pnv.2019.0782. PMID: 30916648
Treatment of Refractory and Super-refractory Status Epilepticus.
Rai S, Drislane FW
Neurotherapeutics 2018 Jul;15(3):697-712. doi: 10.1007/s13311-018-0640-5. PMID: 29922905Free PMC Article
Cefepime-induced neurotoxicity: a systematic review.
Payne LE, Gagnon DJ, Riker RR, Seder DB, Glisic EK, Morris JG, Fraser GL
Crit Care 2017 Nov 14;21(1):276. doi: 10.1186/s13054-017-1856-1. PMID: 29137682Free PMC Article

Diagnosis

Non convulsive status epilepticus in the elderly.
Dupont S
Geriatr Psychol Neuropsychiatr Vieil 2019 Mar 1;17(S1):25-30. doi: 10.1684/pnv.2019.0782. PMID: 30916648
Electroencephalography in Pediatric Epilepsy.
Kaushik JS, Farmania R
Indian Pediatr 2018 Oct 15;55(10):893-901. PMID: 30426956
Treatment of Refractory and Super-refractory Status Epilepticus.
Rai S, Drislane FW
Neurotherapeutics 2018 Jul;15(3):697-712. doi: 10.1007/s13311-018-0640-5. PMID: 29922905Free PMC Article
Cefepime-induced neurotoxicity: a systematic review.
Payne LE, Gagnon DJ, Riker RR, Seder DB, Glisic EK, Morris JG, Fraser GL
Crit Care 2017 Nov 14;21(1):276. doi: 10.1186/s13054-017-1856-1. PMID: 29137682Free PMC Article
Is it status?
Brenner RP
Epilepsia 2002;43 Suppl 3:103-13. doi: 10.1046/j.1528-1157.43.s.3.9.x. PMID: 12060012

Therapy

Nonconvulsive status epilepticus in the elderly.
Dupont S, Kinugawa K
Rev Neurol (Paris) 2020 Nov;176(9):701-709. Epub 2020 Mar 10 doi: 10.1016/j.neurol.2019.12.007. PMID: 32169326
Non convulsive status epilepticus in the elderly.
Dupont S
Geriatr Psychol Neuropsychiatr Vieil 2019 Mar 1;17(S1):25-30. doi: 10.1684/pnv.2019.0782. PMID: 30916648
Principles of Management of Central Nervous System Infections.
Singhi S, Angurana SK
Indian J Pediatr 2019 Jan;86(1):52-59. Epub 2018 Jan 15 doi: 10.1007/s12098-017-2583-y. PMID: 29333566
Cefepime-induced neurotoxicity: a systematic review.
Payne LE, Gagnon DJ, Riker RR, Seder DB, Glisic EK, Morris JG, Fraser GL
Crit Care 2017 Nov 14;21(1):276. doi: 10.1186/s13054-017-1856-1. PMID: 29137682Free PMC Article
Viral encephalitis in the ICU.
Kramer AH
Crit Care Clin 2013 Jul;29(3):621-49. doi: 10.1016/j.ccc.2013.03.011. PMID: 23830656

Prognosis

Nonconvulsive status epilepticus in the elderly.
Dupont S, Kinugawa K
Rev Neurol (Paris) 2020 Nov;176(9):701-709. Epub 2020 Mar 10 doi: 10.1016/j.neurol.2019.12.007. PMID: 32169326
Non convulsive status epilepticus in the elderly.
Dupont S
Geriatr Psychol Neuropsychiatr Vieil 2019 Mar 1;17(S1):25-30. doi: 10.1684/pnv.2019.0782. PMID: 30916648
Treatment of Refractory and Super-refractory Status Epilepticus.
Rai S, Drislane FW
Neurotherapeutics 2018 Jul;15(3):697-712. doi: 10.1007/s13311-018-0640-5. PMID: 29922905Free PMC Article
Cefepime-induced neurotoxicity: a systematic review.
Payne LE, Gagnon DJ, Riker RR, Seder DB, Glisic EK, Morris JG, Fraser GL
Crit Care 2017 Nov 14;21(1):276. doi: 10.1186/s13054-017-1856-1. PMID: 29137682Free PMC Article
Is it status?
Brenner RP
Epilepsia 2002;43 Suppl 3:103-13. doi: 10.1046/j.1528-1157.43.s.3.9.x. PMID: 12060012

Clinical prediction guides

Long-term outcome of status epilepticus-related to systemic lupus erythematosus: An observational study and a systematic review.
Mikdashi J, Krumholz A
Semin Arthritis Rheum 2023 Dec;63:152250. Epub 2023 Aug 10 doi: 10.1016/j.semarthrit.2023.152250. PMID: 37595509
Clinical Characteristics, Imaging Findings, and Outcomes of Cerebral Air Embolism.
Brown AE, Rabinstein AA, Braksick SA
Neurocrit Care 2023 Feb;38(1):158-164. Epub 2023 Jan 10 doi: 10.1007/s12028-022-01664-3. PMID: 36627433
Prediction of Long-term Survival After Status Epilepticus Using the ACD Score.
Roberg LE, Monsson O, Kristensen SB, Dahl SM, Ulvin LB, Heuser K, Taubøll E, Strzelczyk A, Knake S, Bechert L, Rosenow F, Beier D, Beniczky S, Krøigård T, Beier CP
JAMA Neurol 2022 Jun 1;79(6):604-613. doi: 10.1001/jamaneurol.2022.0609. PMID: 35404392Free PMC Article
Elderly patients with nonconvulsive status epilepticus: Clinical-EEG data, hospital mortality, STESS and EMSE.
Tedrus GM, Nogueira E Junior, Vidal MA
Seizure 2022 Jan;94:18-22. Epub 2021 Nov 11 doi: 10.1016/j.seizure.2021.11.004. PMID: 34808547
Management of refractory status epilepticus in adults: still more questions than answers.
Rossetti AO, Lowenstein DH
Lancet Neurol 2011 Oct;10(10):922-30. doi: 10.1016/S1474-4422(11)70187-9. PMID: 21939901Free PMC Article

Recent systematic reviews

Long-term outcome of status epilepticus-related to systemic lupus erythematosus: An observational study and a systematic review.
Mikdashi J, Krumholz A
Semin Arthritis Rheum 2023 Dec;63:152250. Epub 2023 Aug 10 doi: 10.1016/j.semarthrit.2023.152250. PMID: 37595509
Cefepime-induced neurotoxicity: a systematic review.
Payne LE, Gagnon DJ, Riker RR, Seder DB, Glisic EK, Morris JG, Fraser GL
Crit Care 2017 Nov 14;21(1):276. doi: 10.1186/s13054-017-1856-1. PMID: 29137682Free PMC Article

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