U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hepatic or Biliary Problem

MedGen UID:
1723770
•Concept ID:
C5419397
•
Pathologic Function

Definition

A non-specific problem with the liver or biliary system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatic or Biliary Problem

Professional guidelines

PubMed

EASL Clinical Practice Guidelines on the management of hepatic encephalopathy.
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2022 Sep;77(3):807-824. Epub 2022 Jun 17 doi: 10.1016/j.jhep.2022.06.001. PMID: 35724930
Evidence-based clinical practice guidelines for Liver Cirrhosis 2020.
Yoshiji H, Nagoshi S, Akahane T, Asaoka Y, Ueno Y, Ogawa K, Kawaguchi T, Kurosaki M, Sakaida I, Shimizu M, Taniai M, Terai S, Nishikawa H, Hiasa Y, Hidaka H, Miwa H, Chayama K, Enomoto N, Shimosegawa T, Takehara T, Koike K
J Gastroenterol 2021 Jul;56(7):593-619. Epub 2021 Jul 7 doi: 10.1007/s00535-021-01788-x. PMID: 34231046Free PMC Article
A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement.
Eslam M, Newsome PN, Sarin SK, Anstee QM, Targher G, Romero-Gomez M, Zelber-Sagi S, Wai-Sun Wong V, Dufour JF, Schattenberg JM, Kawaguchi T, Arrese M, Valenti L, Shiha G, Tiribelli C, Yki-Järvinen H, Fan JG, Grønbæk H, Yilmaz Y, Cortez-Pinto H, Oliveira CP, Bedossa P, Adams LA, Zheng MH, Fouad Y, Chan WK, Mendez-Sanchez N, Ahn SH, Castera L, Bugianesi E, Ratziu V, George J
J Hepatol 2020 Jul;73(1):202-209. Epub 2020 Apr 8 doi: 10.1016/j.jhep.2020.03.039. PMID: 32278004

Recent clinical studies

Etiology

Biliary tract cancer.
Valle JW, Kelley RK, Nervi B, Oh DY, Zhu AX
Lancet 2021 Jan 30;397(10272):428-444. doi: 10.1016/S0140-6736(21)00153-7. PMID: 33516341
Feeding problems and gastrointestinal diseases in Down syndrome.
Ravel A, Mircher C, Rebillat AS, Cieuta-Walti C, Megarbane A
Arch Pediatr 2020 Jan;27(1):53-60. Epub 2019 Nov 26 doi: 10.1016/j.arcped.2019.11.008. PMID: 31784293
Pathophysiological consequences of obstructive jaundice and perioperative management.
Pavlidis ET, Pavlidis TE
Hepatobiliary Pancreat Dis Int 2018 Feb;17(1):17-21. Epub 2018 Jan 31 doi: 10.1016/j.hbpd.2018.01.008. PMID: 29428098
Pediatric Biliary Interventions.
Atchie B, Kalva S, Josephs S
Tech Vasc Interv Radiol 2015 Dec;18(4):276-84. Epub 2015 Jul 16 doi: 10.1053/j.tvir.2015.07.011. PMID: 26615168
Non-invasive diagnosis of advanced fibrosis and cirrhosis.
Sharma S, Khalili K, Nguyen GC
World J Gastroenterol 2014 Dec 7;20(45):16820-30. doi: 10.3748/wjg.v20.i45.16820. PMID: 25492996Free PMC Article

Diagnosis

Evidence-based approach to diagnosis and management of abdominal tuberculosis.
Jha DK, Pathiyil MM, Sharma V
Indian J Gastroenterol 2023 Feb;42(1):17-31. Epub 2023 Mar 11 doi: 10.1007/s12664-023-01343-x. PMID: 36899289Free PMC Article
Biliary tract cancer.
Valle JW, Kelley RK, Nervi B, Oh DY, Zhu AX
Lancet 2021 Jan 30;397(10272):428-444. doi: 10.1016/S0140-6736(21)00153-7. PMID: 33516341
Feeding problems and gastrointestinal diseases in Down syndrome.
Ravel A, Mircher C, Rebillat AS, Cieuta-Walti C, Megarbane A
Arch Pediatr 2020 Jan;27(1):53-60. Epub 2019 Nov 26 doi: 10.1016/j.arcped.2019.11.008. PMID: 31784293
Non-invasive diagnosis of advanced fibrosis and cirrhosis.
Sharma S, Khalili K, Nguyen GC
World J Gastroenterol 2014 Dec 7;20(45):16820-30. doi: 10.3748/wjg.v20.i45.16820. PMID: 25492996Free PMC Article
Biliary atresia.
Ohi R, Ibrahim M
Semin Pediatr Surg 1992 May;1(2):115-24. PMID: 1345477

Therapy

Adenosine Triphosphate Citrate Lyase and Fatty Acid Synthesis Inhibition: A Narrative Review.
Duarte Lau F, Giugliano RP
JAMA Cardiol 2023 Sep 1;8(9):879-887. doi: 10.1001/jamacardio.2023.2402. PMID: 37585218
Metastatic uveal melanoma: The final frontier.
Rantala ES, Hernberg MM, Piperno-Neumann S, Grossniklaus HE, Kivelä TT
Prog Retin Eye Res 2022 Sep;90:101041. Epub 2022 Jan 6 doi: 10.1016/j.preteyeres.2022.101041. PMID: 34999237
Current Options and Future Directions for NAFLD and NASH Treatment.
Zhang C, Yang M
Int J Mol Sci 2021 Jul 15;22(14) doi: 10.3390/ijms22147571. PMID: 34299189Free PMC Article
Clinical Pharmacokinetics of Oral Semaglutide: Analyses of Data from Clinical Pharmacology Trials.
Overgaard RV, Navarria A, Ingwersen SH, Bækdal TA, Kildemoes RJ
Clin Pharmacokinet 2021 Oct;60(10):1335-1348. Epub 2021 May 10 doi: 10.1007/s40262-021-01025-x. PMID: 33969456Free PMC Article
Pathobiology of liver fibrosis: a translational success story.
Lee YA, Wallace MC, Friedman SL
Gut 2015 May;64(5):830-41. Epub 2015 Feb 13 doi: 10.1136/gutjnl-2014-306842. PMID: 25681399Free PMC Article

Prognosis

Epidemiology of Hepatic Encephalopathy.
Elsaid MI, Rustgi VK
Clin Liver Dis 2020 May;24(2):157-174. Epub 2020 Mar 2 doi: 10.1016/j.cld.2020.01.001. PMID: 32245524
Hepatic encephalopathy in acute-on-chronic liver failure.
Lee GH
Hepatol Int 2015 Oct;9(4):520-6. Epub 2015 May 28 doi: 10.1007/s12072-015-9626-0. PMID: 26016460
Pre-eclampsia/eclampsia and hepatic rupture.
Vigil-De Gracia P, Ortega-Paz L
Int J Gynaecol Obstet 2012 Sep;118(3):186-9. Epub 2012 Jun 19 doi: 10.1016/j.ijgo.2012.03.042. PMID: 22717416
Alagille syndrome.
Hadchouel M
Indian J Pediatr 2002 Sep;69(9):815-8. doi: 10.1007/BF02723697. PMID: 12420916
Acute liver failure.
Kelly DA
Indian J Pediatr 1999;66(1 Suppl):S104-9. PMID: 11132456

Clinical prediction guides

Non-invasive diagnosis of advanced fibrosis and cirrhosis.
Sharma S, Khalili K, Nguyen GC
World J Gastroenterol 2014 Dec 7;20(45):16820-30. doi: 10.3748/wjg.v20.i45.16820. PMID: 25492996Free PMC Article
Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.
Takahashi Y, Fukusato T
World J Gastroenterol 2014 Nov 14;20(42):15539-48. doi: 10.3748/wjg.v20.i42.15539. PMID: 25400438Free PMC Article
Design and validation of a histological scoring system for nonalcoholic fatty liver disease.
Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, Ferrell LD, Liu YC, Torbenson MS, Unalp-Arida A, Yeh M, McCullough AJ, Sanyal AJ; Nonalcoholic Steatohepatitis Clinical Research Network
Hepatology 2005 Jun;41(6):1313-21. doi: 10.1002/hep.20701. PMID: 15915461
A risk score to predict need for treatment for upper-gastrointestinal haemorrhage.
Blatchford O, Murray WR, Blatchford M
Lancet 2000 Oct 14;356(9238):1318-21. doi: 10.1016/S0140-6736(00)02816-6. PMID: 11073021
Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases.
Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH
Ann Surg 1999 Sep;230(3):309-18; discussion 318-21. doi: 10.1097/00000658-199909000-00004. PMID: 10493478Free PMC Article

Recent systematic reviews

Intermittent fasting improves hepatic end points in nonalcoholic fatty liver disease: A systematic review and meta-analysis.
Lange M, Nadkarni D, Martin L, Newberry C, Kumar S, Kushner T
Hepatol Commun 2023 Aug 1;7(8) Epub 2023 Aug 3 doi: 10.1097/HC9.0000000000000212. PMID: 37534936Free PMC Article
Rifaximin for prevention and treatment of hepatic encephalopathy in people with cirrhosis.
Zacharias HD, Kamel F, Tan J, Kimer N, Gluud LL, Morgan MY
Cochrane Database Syst Rev 2023 Jul 19;7(7):CD011585. doi: 10.1002/14651858.CD011585.pub2. PMID: 37467180Free PMC Article
Linezolid pharmacokinetics: a systematic review for the best clinical practice.
Heidari S, Khalili H
Eur J Clin Pharmacol 2023 Feb;79(2):195-206. Epub 2022 Dec 24 doi: 10.1007/s00228-022-03446-4. PMID: 36565357
Combination therapy with rifaximin and lactulose in hepatic encephalopathy: A systematic review and meta-analysis.
Fu J, Gao Y, Shi L
PLoS One 2022;17(4):e0267647. Epub 2022 Apr 26 doi: 10.1371/journal.pone.0267647. PMID: 35471992Free PMC Article
Polyethylene glycol versus lactulose in the treatment of hepatic encephalopathy: a systematic review and meta-analysis.
Hoilat GJ, Ayas MF, Hoilat JN, Abu-Zaid A, Durer C, Durer S, Adhami T, John S
BMJ Open Gastroenterol 2021 May;8(1) doi: 10.1136/bmjgast-2021-000648. PMID: 34006606Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...