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Multisystem inflammatory syndrome in adults

MedGen UID:
1729457
Concept ID:
C5439527
Disease or Syndrome
Synonyms: Adult inflammatory multisystem syndrome temporally associated with COVID-19; MIS-A - multisystem inflammatory syndrome in adults; Multisystem Inflammatory Syndrome in Adults
SNOMED CT: Multisystem inflammatory syndrome in adults (1119306006); MIS-A - multisystem inflammatory syndrome in adults (1119306006); Adult inflammatory multisystem syndrome temporally associated with COVID-19 (1119306006)

Definition

A rare syndrome found in adults with positive test results for SARS-CoV-2 by polymerase chain reaction or antibody assays indicating recent infection that is marked by cardiovascular, gastrointestinal, dermatologic, and neurologic symptoms without severe respiratory illness. The most common signs and symptoms that have been reported to date include fever, low blood pressure, abdominal pain, vomiting, diarrhea, neck pain, rash, chest pain, and tiredness not attributable to other infections. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMultisystem inflammatory syndrome in adults

Professional guidelines

PubMed

Hookham L, Fisher C, Manson JJ, Morgan M, O'Hara G, Riley P, Tattersall RS, Goodman AL
Clin Med (Lond) 2022 May;22(3):266-270. doi: 10.7861/clinmed.2021-0700. PMID: 35584825Free PMC Article
Varadaraj G, Sangeetha B, Sandhu S, Santhiya G
J Assoc Physicians India 2021 Aug;69(8):11-12. PMID: 34472807
Carlotti APCP, de Carvalho WB, Johnston C, Gilio AE, de Sousa Marques HH, Ferranti JF, Rodriguez IS, Delgado AF
Clinics (Sao Paulo) 2020;75:e2353. Epub 2020 Nov 30 doi: 10.6061/clinics/2020/e2353. PMID: 33263635Free PMC Article

Recent clinical studies

Etiology

La Vecchia G, Del Buono MG, Bonaventura A, Vecchiè A, Moroni F, Cartella I, Saponara G, Campbell MJ, Dagna L, Ammirati E, Sanna T, Abbate A
J Am Heart Assoc 2024 Feb 20;13(4):e032143. Epub 2024 Feb 13 doi: 10.1161/JAHA.123.032143. PMID: 38348793Free PMC Article
Reyes J, Komarow L, Chen L, Ge L, Hanson BM, Cober E, Herc E, Alenazi T, Kaye KS, Garcia-Diaz J, Li L, Kanj SS, Liu Z, Oñate JM, Salata RA, Marimuthu K, Gao H, Zong Z, Valderrama-Beltrán SL, Yu Y, Tambyah P, Weston G, Salcedo S, Abbo LM, Xie Q, Ordoñez K, Wang M, Stryjewski ME, Munita JM, Paterson DL, Evans S, Hill C, Baum K, Bonomo RA, Kreiswirth BN, Villegas MV, Patel R, Arias CA, Chambers HF, Fowler VG Jr, Doi Y, van Duin D, Satlin MJ; Antibacterial Resistance Leadership Group and Multi-Drug Resistant Organism Network Investigators
Lancet Microbe 2023 Mar;4(3):e159-e170. Epub 2023 Feb 9 doi: 10.1016/S2666-5247(22)00329-9. PMID: 36774938Free PMC Article
Auger N, Bégin P, Kang H, Lo E, Brousseau É, Healy-Profitós J, Potter BJ
Respir Med 2023 Jan;206:107084. Epub 2022 Dec 9 doi: 10.1016/j.rmed.2022.107084. PMID: 36527990Free PMC Article
Serin I, Sari ND, Gunaltili M, Karakilic A, Gulesir B, Kal Kolik B, Cevik G, Sungurlu H, Keskin M, Baltik M, Cakmak O, Cinli TA
BMC Infect Dis 2022 Mar 28;22(1):300. doi: 10.1186/s12879-022-07303-8. PMID: 35346086Free PMC Article
Kunal S, Ish P, Sakthivel P, Malhotra N, Gupta K
Heart Lung 2022 Jul-Aug;54:7-18. Epub 2022 Mar 14 doi: 10.1016/j.hrtlng.2022.03.007. PMID: 35306376Free PMC Article

Diagnosis

La Vecchia G, Del Buono MG, Bonaventura A, Vecchiè A, Moroni F, Cartella I, Saponara G, Campbell MJ, Dagna L, Ammirati E, Sanna T, Abbate A
J Am Heart Assoc 2024 Feb 20;13(4):e032143. Epub 2024 Feb 13 doi: 10.1161/JAHA.123.032143. PMID: 38348793Free PMC Article
Lai CC, Hsu CK, Hsueh SC, Yen MY, Ko WC, Hsueh PR
J Med Virol 2023 Feb;95(2):e28426. doi: 10.1002/jmv.28426. PMID: 36571257
Sil A, Das A, Datta D
Clin Exp Dermatol 2022 Oct;47(10):1774-1780. Epub 2022 Jul 12 doi: 10.1111/ced.15271. PMID: 35603763Free PMC Article
Kunal S, Ish P, Sakthivel P, Malhotra N, Gupta K
Heart Lung 2022 Jul-Aug;54:7-18. Epub 2022 Mar 14 doi: 10.1016/j.hrtlng.2022.03.007. PMID: 35306376Free PMC Article
Patel P, DeCuir J, Abrams J, Campbell AP, Godfred-Cato S, Belay ED
JAMA Netw Open 2021 Sep 1;4(9):e2126456. doi: 10.1001/jamanetworkopen.2021.26456. PMID: 34550381Free PMC Article

Therapy

La Vecchia G, Del Buono MG, Bonaventura A, Vecchiè A, Moroni F, Cartella I, Saponara G, Campbell MJ, Dagna L, Ammirati E, Sanna T, Abbate A
J Am Heart Assoc 2024 Feb 20;13(4):e032143. Epub 2024 Feb 13 doi: 10.1161/JAHA.123.032143. PMID: 38348793Free PMC Article
Reyes J, Komarow L, Chen L, Ge L, Hanson BM, Cober E, Herc E, Alenazi T, Kaye KS, Garcia-Diaz J, Li L, Kanj SS, Liu Z, Oñate JM, Salata RA, Marimuthu K, Gao H, Zong Z, Valderrama-Beltrán SL, Yu Y, Tambyah P, Weston G, Salcedo S, Abbo LM, Xie Q, Ordoñez K, Wang M, Stryjewski ME, Munita JM, Paterson DL, Evans S, Hill C, Baum K, Bonomo RA, Kreiswirth BN, Villegas MV, Patel R, Arias CA, Chambers HF, Fowler VG Jr, Doi Y, van Duin D, Satlin MJ; Antibacterial Resistance Leadership Group and Multi-Drug Resistant Organism Network Investigators
Lancet Microbe 2023 Mar;4(3):e159-e170. Epub 2023 Feb 9 doi: 10.1016/S2666-5247(22)00329-9. PMID: 36774938Free PMC Article
Melgar M, Haston J, DeCuir J, Cheng Q, Arnold KE, Meng L, Murphy DJ, Overton E, Hollberg J, Tobin-D'Angelo M, Patel P, Campbell AP, Godfred-Cato S, Belay ED
Clin Infect Dis 2022 Nov 30;75(11):1903-1911. doi: 10.1093/cid/ciac303. PMID: 35442436Free PMC Article
Chung H, Seo H, Park S, Kim H, Jung J, Chong YP, Kim SH, Lee SO, Choi SH, Kim YS, Kim MJ
J Korean Med Sci 2021 Jun 28;36(25):e181. doi: 10.3346/jkms.2021.36.e181. PMID: 34184438Free PMC Article
Ahmad F, Ahmed A, Rajendraprasad SS, Loranger A, Gupta S, Velagapudi M, Vivekanandan R, Nahas JA, Plambeck R, Moore D
Int J Infect Dis 2021 Jul;108:209-211. Epub 2021 May 24 doi: 10.1016/j.ijid.2021.05.050. PMID: 34044140Free PMC Article

Prognosis

Yap RXL, Leung BPL, Howe HS, Loh ME, Young BE, Fan BE, Lim XR
Ann Acad Med Singap 2023 Feb;52(2):80-87. doi: 10.47102/annals-acadmedsg.2022290. PMID: 36880819
Serin I, Sari ND, Gunaltili M, Karakilic A, Gulesir B, Kal Kolik B, Cevik G, Sungurlu H, Keskin M, Baltik M, Cakmak O, Cinli TA
BMC Infect Dis 2022 Mar 28;22(1):300. doi: 10.1186/s12879-022-07303-8. PMID: 35346086Free PMC Article
Kunal S, Ish P, Sakthivel P, Malhotra N, Gupta K
Heart Lung 2022 Jul-Aug;54:7-18. Epub 2022 Mar 14 doi: 10.1016/j.hrtlng.2022.03.007. PMID: 35306376Free PMC Article
Huynh T, Sanchez-Flores X, Yau J, Huang JT
Am J Clin Dermatol 2022 May;23(3):277-286. Epub 2022 Mar 5 doi: 10.1007/s40257-022-00675-2. PMID: 35247198Free PMC Article
Ahmad F, Ahmed A, Rajendraprasad SS, Loranger A, Gupta S, Velagapudi M, Vivekanandan R, Nahas JA, Plambeck R, Moore D
Int J Infect Dis 2021 Jul;108:209-211. Epub 2021 May 24 doi: 10.1016/j.ijid.2021.05.050. PMID: 34044140Free PMC Article

Clinical prediction guides

Agarwal A, Jakhar R, Sharma A, Sharma A, Agarwal A, Kumari A
J Assoc Physicians India 2023 Aug;71(8):11-12. doi: 10.59556/japi.71.0314. PMID: 37651238
Reyes J, Komarow L, Chen L, Ge L, Hanson BM, Cober E, Herc E, Alenazi T, Kaye KS, Garcia-Diaz J, Li L, Kanj SS, Liu Z, Oñate JM, Salata RA, Marimuthu K, Gao H, Zong Z, Valderrama-Beltrán SL, Yu Y, Tambyah P, Weston G, Salcedo S, Abbo LM, Xie Q, Ordoñez K, Wang M, Stryjewski ME, Munita JM, Paterson DL, Evans S, Hill C, Baum K, Bonomo RA, Kreiswirth BN, Villegas MV, Patel R, Arias CA, Chambers HF, Fowler VG Jr, Doi Y, van Duin D, Satlin MJ; Antibacterial Resistance Leadership Group and Multi-Drug Resistant Organism Network Investigators
Lancet Microbe 2023 Mar;4(3):e159-e170. Epub 2023 Feb 9 doi: 10.1016/S2666-5247(22)00329-9. PMID: 36774938Free PMC Article
Lai CC, Hsu CK, Hsueh SC, Yen MY, Ko WC, Hsueh PR
J Med Virol 2023 Feb;95(2):e28426. doi: 10.1002/jmv.28426. PMID: 36571257
Serin I, Sari ND, Gunaltili M, Karakilic A, Gulesir B, Kal Kolik B, Cevik G, Sungurlu H, Keskin M, Baltik M, Cakmak O, Cinli TA
BMC Infect Dis 2022 Mar 28;22(1):300. doi: 10.1186/s12879-022-07303-8. PMID: 35346086Free PMC Article
Ozsurekci Y, Gürlevik S, Kesici S, Akca UK, Oygar PD, Aykac K, Karacanoglu D, Sarıtas Nakip O, Ilbay S, Katlan B, Ertugrul İ, Cengiz AB, Basaran O, Cura Yayla BC, Karakaya J, Bilginer Y, Bayrakci B, Ceyhan M, Ozen S
Clin Rheumatol 2021 Aug;40(8):3227-3237. Epub 2021 Feb 12 doi: 10.1007/s10067-021-05631-9. PMID: 33576926Free PMC Article

Recent systematic reviews

Meshref M, Shaheen N, Swed S, Ibrahim M, Mostafa MR, Algazar MO, Dobs M, Elsayed SI, Amro Y, Afsa A, Morra ME
Medicine (Baltimore) 2022 Dec 9;101(49):e32023. doi: 10.1097/MD.0000000000032023. PMID: 36626529Free PMC Article
Melgar M, Haston J, DeCuir J, Cheng Q, Arnold KE, Meng L, Murphy DJ, Overton E, Hollberg J, Tobin-D'Angelo M, Patel P, Campbell AP, Godfred-Cato S, Belay ED
Clin Infect Dis 2022 Nov 30;75(11):1903-1911. doi: 10.1093/cid/ciac303. PMID: 35442436Free PMC Article
Kunal S, Ish P, Sakthivel P, Malhotra N, Gupta K
Heart Lung 2022 Jul-Aug;54:7-18. Epub 2022 Mar 14 doi: 10.1016/j.hrtlng.2022.03.007. PMID: 35306376Free PMC Article
Patel P, DeCuir J, Abrams J, Campbell AP, Godfred-Cato S, Belay ED
JAMA Netw Open 2021 Sep 1;4(9):e2126456. doi: 10.1001/jamanetworkopen.2021.26456. PMID: 34550381Free PMC Article

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