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Salivary Gland Diffuse Large B-Cell Lymphoma

MedGen UID:
1730404
•Concept ID:
C2204355
•
Neoplastic Process
Synonym: Primary Salivary Gland Diffuse Large B-Cell Lymphoma

Definition

A diffuse large B-cell lymphoma that manifests initially in a salivary gland. It usually occurs in the parotid gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary Gland Diffuse Large B-Cell Lymphoma

Professional guidelines

PubMed

Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review.
Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999
Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.
Luk PP, Selinger CI, Cooper WA, Mahar A, Palme CE, O'Toole SA, Clark JR, Gupta R
Head Neck Pathol 2019 Sep;13(3):397-414. Epub 2018 Nov 22 doi: 10.1007/s12105-018-0988-1. PMID: 30467669Free PMC Article
Influence of differing radiotherapy strategies on treatment results in diffuse large-cell lymphoma: a review.
Nieder C, Licht T, Andratschke N, Peschel C, Molls M
Cancer Treat Rev 2003 Feb;29(1):11-9. doi: 10.1016/s0305-7372(02)00094-4. PMID: 12633576

Recent clinical studies

Etiology

Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review.
Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999
Lymphomas of the salivary glands: a systematic review.
Al-Khafaf AE, Al-Shahrestani F, Baysal Y, Rahbek Gjerdrum LM, Heegaard S, Pedersen LM, Homøe P
Acta Otolaryngol 2023 Jul-Aug;143(7):610-616. Epub 2023 Aug 12 doi: 10.1080/00016489.2023.2226689. PMID: 37572309
Clinical picture, outcome and predictive factors of lymphoma in primary Sjögren's syndrome: results from a harmonized dataset (1981-2021).
Chatzis LG, Stergiou IE, Goules AV, Pezoulas V, Tsourouflis G, Fotiadis D, Tzioufas AG, Voulgarelis M
Rheumatology (Oxford) 2022 Aug 30;61(9):3576-3585. doi: 10.1093/rheumatology/keab939. PMID: 34940812
Oral and maxillofacial cancer in pediatric patients: 30 years experience from a Brazilian reference center.
Arboleda LPA, Hoffmann IL, Cardinalli IA, Gallagher KPD, Santos-Silva AR, Mendonça RMH
Int J Pediatr Otorhinolaryngol 2020 Apr;131:109879. Epub 2020 Jan 10 doi: 10.1016/j.ijporl.2020.109879. PMID: 31951980
Long-term outcome in localized extranodal mucosa-associated lymphoid tissue lymphomas treated with radiotherapy.
Goda JS, Gospodarowicz M, Pintilie M, Wells W, Hodgson DC, Sun A, Crump M, Tsang RW
Cancer 2010 Aug 15;116(16):3815-24. doi: 10.1002/cncr.25226. PMID: 20564130

Diagnosis

Lymphomas affecting the submandibular glands.
Araújo GR, Morais-Perdigão AL, Lopez-de-Cáceres CV, Almeida OP, Vargas PA, Roman-Tager EM, Andrade BA, Soares CD, Ramos CC, Andrade MM, Sales AD, Pontes HA
Med Oral Patol Oral Cir Bucal 2024 Jan 1;29(1):e78-e86. doi: 10.4317/medoral.26065. PMID: 37471301Free PMC Article
Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review.
Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999
Clinical picture, outcome and predictive factors of lymphoma in primary Sjögren's syndrome: results from a harmonized dataset (1981-2021).
Chatzis LG, Stergiou IE, Goules AV, Pezoulas V, Tsourouflis G, Fotiadis D, Tzioufas AG, Voulgarelis M
Rheumatology (Oxford) 2022 Aug 30;61(9):3576-3585. doi: 10.1093/rheumatology/keab939. PMID: 34940812
Extranodal Lymphoproliferative Processes.
Zeppa P, Cozzolino I
Monogr Clin Cytol 2018;23:81-92. Epub 2017 Nov 13 doi: 10.1159/000478884. PMID: 29130993
Hodgkin and non-Hodgkin lymphoma of the head and neck: clinical, pathologic, and imaging evaluation.
Weber AL, Rahemtullah A, Ferry JA
Neuroimaging Clin N Am 2003 Aug;13(3):371-92. doi: 10.1016/s1052-5149(03)00039-x. PMID: 14631680

Therapy

Submandibular gland abscess in a kidney transplant recipient: a diagnostic and therapeutic enigma.
Viswam V, Puducherry Ravichandran S, George P, Karuvat Narayanan SL
BMJ Case Rep 2023 Oct 31;16(10) doi: 10.1136/bcr-2022-254154. PMID: 37907312Free PMC Article
Lymphoma-associated mutations in autoreactive memory B cells of patients with Sjögren's syndrome.
Bende RJ, Slot LM, Kwakkenbos MJ, Wormhoudt TA, Jongejan A, Verstappen GM, van Kampen AC, Guikema JE, Kroese FG, van Noesel CJ
J Pathol 2023 Mar;259(3):264-275. Epub 2023 Jan 12 doi: 10.1002/path.6039. PMID: 36426826Free PMC Article
Rheumatoid Factor and Disease Activity Are Independent Predictors of Lymphoma in Primary Sjögren's Syndrome.
Nocturne G, Virone A, Ng WF, Le Guern V, Hachulla E, Cornec D, Daien C, Vittecoq O, Bienvenu B, Marcelli C, Wendling D, Amoura Z, Dhote R, Lavigne C, Fior R, Gottenberg JE, Seror R, Mariette X
Arthritis Rheumatol 2016 Apr;68(4):977-85. doi: 10.1002/art.39518. PMID: 26606524
Influence of differing radiotherapy strategies on treatment results in diffuse large-cell lymphoma: a review.
Nieder C, Licht T, Andratschke N, Peschel C, Molls M
Cancer Treat Rev 2003 Feb;29(1):11-9. doi: 10.1016/s0305-7372(02)00094-4. PMID: 12633576
Unusual gingival presentation of post-transplantation lymphoproliferative disorder: a case report and review of the literature.
Raut A, Huryn J, Pollack A, Zlotolow I
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000 Oct;90(4):436-41. doi: 10.1067/moe.2000.107446. PMID: 11027379

Prognosis

Lymphomas of the salivary glands: a systematic review.
Al-Khafaf AE, Al-Shahrestani F, Baysal Y, Rahbek Gjerdrum LM, Heegaard S, Pedersen LM, Homøe P
Acta Otolaryngol 2023 Jul-Aug;143(7):610-616. Epub 2023 Aug 12 doi: 10.1080/00016489.2023.2226689. PMID: 37572309
EBV Association with Lymphomas and Carcinomas in the Oral Compartment.
Ward BJH, Schaal DL, Nkadi EH, Scott RS
Viruses 2022 Dec 1;14(12) doi: 10.3390/v14122700. PMID: 36560704Free PMC Article
Clinical picture, outcome and predictive factors of lymphoma in primary Sjögren's syndrome: results from a harmonized dataset (1981-2021).
Chatzis LG, Stergiou IE, Goules AV, Pezoulas V, Tsourouflis G, Fotiadis D, Tzioufas AG, Voulgarelis M
Rheumatology (Oxford) 2022 Aug 30;61(9):3576-3585. doi: 10.1093/rheumatology/keab939. PMID: 34940812
Oral and maxillofacial cancer in pediatric patients: 30 years experience from a Brazilian reference center.
Arboleda LPA, Hoffmann IL, Cardinalli IA, Gallagher KPD, Santos-Silva AR, Mendonça RMH
Int J Pediatr Otorhinolaryngol 2020 Apr;131:109879. Epub 2020 Jan 10 doi: 10.1016/j.ijporl.2020.109879. PMID: 31951980
The aetiology of B-cell lymphoid malignancies with a focus on chronic inflammation and infections.
Smedby KE, Ponzoni M
J Intern Med 2017 Nov;282(5):360-370. Epub 2017 Sep 27 doi: 10.1111/joim.12684. PMID: 28875507

Clinical prediction guides

Clinical diagnostic approach for oral lymphomas: a multi-institutional, observational study based on 107 cases.
de Oliveira EM, de Cáceres CVBL, Santos-Silva AR, Vargas PA, Lopes MA, Pontes HAR, Pontes FSC, Mesquita RA, de Sousa SF, Abreu LG, Xavier JCC Júnior,, de Andrade BAB, Lacerda JCT, Resende RG, Tomasi RA, Fonseca FP
Oral Surg Oral Med Oral Pathol Oral Radiol 2023 Oct;136(4):427-435. Epub 2023 Apr 7 doi: 10.1016/j.oooo.2023.03.011. PMID: 37150653
EBV Association with Lymphomas and Carcinomas in the Oral Compartment.
Ward BJH, Schaal DL, Nkadi EH, Scott RS
Viruses 2022 Dec 1;14(12) doi: 10.3390/v14122700. PMID: 36560704Free PMC Article
Clinical picture, outcome and predictive factors of lymphoma in primary Sjögren's syndrome: results from a harmonized dataset (1981-2021).
Chatzis LG, Stergiou IE, Goules AV, Pezoulas V, Tsourouflis G, Fotiadis D, Tzioufas AG, Voulgarelis M
Rheumatology (Oxford) 2022 Aug 30;61(9):3576-3585. doi: 10.1093/rheumatology/keab939. PMID: 34940812
Predictive markers of lymphomagenesis in Sjögren's syndrome: From clinical data to molecular stratification.
Kapsogeorgou EK, Voulgarelis M, Tzioufas AG
J Autoimmun 2019 Nov;104:102316. Epub 2019 Aug 17 doi: 10.1016/j.jaut.2019.102316. PMID: 31431317
Influence of differing radiotherapy strategies on treatment results in diffuse large-cell lymphoma: a review.
Nieder C, Licht T, Andratschke N, Peschel C, Molls M
Cancer Treat Rev 2003 Feb;29(1):11-9. doi: 10.1016/s0305-7372(02)00094-4. PMID: 12633576

Recent systematic reviews

Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review.
Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999
Lymphomas of the salivary glands: a systematic review.
Al-Khafaf AE, Al-Shahrestani F, Baysal Y, Rahbek Gjerdrum LM, Heegaard S, Pedersen LM, Homøe P
Acta Otolaryngol 2023 Jul-Aug;143(7):610-616. Epub 2023 Aug 12 doi: 10.1080/00016489.2023.2226689. PMID: 37572309

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