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Metastatic Cutaneous Squamous Cell Carcinoma of the Head and Neck

MedGen UID:
1733748
Concept ID:
C5419185
Neoplastic Process

Definition

Cutaneous squamous cell carcinoma of the head and neck that has spread from the original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Cutaneous Squamous Cell Carcinoma of the Head and Neck

Professional guidelines

PubMed

O'Connell JE, Saeed A, Jones HB, Lloyd CJ
Br J Oral Maxillofac Surg 2021 Dec;59(10):1186-1191. Epub 2021 Jan 15 doi: 10.1016/j.bjoms.2021.01.003. PMID: 34674892
D'Souza J, Clark J
Curr Opin Otolaryngol Head Neck Surg 2011 Apr;19(2):99-105. doi: 10.1097/MOO.0b013e328343e811. PMID: 21297477
Oddone N, Morgan GJ, Palme CE, Perera L, Shannon J, Wong E, Gebski V, Veness MJ
Cancer 2009 May 1;115(9):1883-91. doi: 10.1002/cncr.24208. PMID: 19224549

Recent clinical studies

Etiology

Baggi A, Quaglino P, Rubatto M, Depenni R, Guida M, Ascierto PA, Trojaniello C, Queirolo P, Saponara M, Peris K, Spagnolo F, Bianchi L, De Galitiis F, Potenza MC, Proietti I, Marconcini R, Botticelli A, Barbieri V, Licitra L, Alfieri S, Ficorella C, Cortellini A, Fargnoli MC, Troiani T, Tondulli L, Bossi P
Eur J Cancer 2021 Nov;157:250-258. Epub 2021 Sep 15 doi: 10.1016/j.ejca.2021.08.018. PMID: 34536948
Sacco AG, Chen R, Worden FP, Wong DJL, Adkins D, Swiecicki P, Chai-Ho W, Oppelt P, Ghosh D, Bykowski J, Molinolo A, Pittman E, Estrada MV, Gold K, Daniels G, Lippman SM, Natsuhara A, Messer K, Cohen EEW
Lancet Oncol 2021 Jun;22(6):883-892. Epub 2021 May 11 doi: 10.1016/S1470-2045(21)00136-4. PMID: 33989559
Migden MR, Khushalani NI, Chang ALS, Lewis KD, Schmults CD, Hernandez-Aya L, Meier F, Schadendorf D, Guminski A, Hauschild A, Wong DJ, Daniels GA, Berking C, Jankovic V, Stankevich E, Booth J, Li S, Weinreich DM, Yancopoulos GD, Lowy I, Fury MG, Rischin D
Lancet Oncol 2020 Feb;21(2):294-305. Epub 2020 Jan 14 doi: 10.1016/S1470-2045(19)30728-4. PMID: 31952975Free PMC Article
Migden MR, Rischin D, Schmults CD, Guminski A, Hauschild A, Lewis KD, Chung CH, Hernandez-Aya L, Lim AM, Chang ALS, Rabinowits G, Thai AA, Dunn LA, Hughes BGM, Khushalani NI, Modi B, Schadendorf D, Gao B, Seebach F, Li S, Li J, Mathias M, Booth J, Mohan K, Stankevich E, Babiker HM, Brana I, Gil-Martin M, Homsi J, Johnson ML, Moreno V, Niu J, Owonikoko TK, Papadopoulos KP, Yancopoulos GD, Lowy I, Fury MG
N Engl J Med 2018 Jul 26;379(4):341-351. Epub 2018 Jun 4 doi: 10.1056/NEJMoa1805131. PMID: 29863979
Work Group; Invited Reviewers, Kim JYS, Kozlow JH, Mittal B, Moyer J, Olenecki T, Rodgers P
J Am Acad Dermatol 2018 Mar;78(3):560-578. Epub 2018 Jan 10 doi: 10.1016/j.jaad.2017.10.007. PMID: 29331386Free PMC Article

Diagnosis

Desai N, Divatia MK, Jadhav A, Wagh A
Curr Oncol 2023 Jul 11;30(7):6634-6647. doi: 10.3390/curroncol30070487. PMID: 37504347Free PMC Article
Ferrarotto R, Amit M, Nagarajan P, Rubin ML, Yuan Y, Bell D, El-Naggar AK, Johnson JM, Morrison WH, Rosenthal DI, Glisson BS, Johnson FM, Lu C, Mott FE, Esmaeli B, Diaz EM Jr, Gidley PW, Goepfert RP, Lewis CM, Weber RS, Wargo JA, Basu S, Duan F, Yadav SS, Sharma P, Allison JP, Myers JN, Gross ND
Clin Cancer Res 2021 Aug 15;27(16):4557-4565. Epub 2021 Jun 29 doi: 10.1158/1078-0432.CCR-21-0585. PMID: 34187851Free PMC Article
Jaros J, Hunt S, Mose E, Lai O, Tsoukas M
Clin Dermatol 2020 Mar-Apr;38(2):216-222. Epub 2019 Oct 25 doi: 10.1016/j.clindermatol.2019.10.004. PMID: 32513401
Work Group; Invited Reviewers, Kim JYS, Kozlow JH, Mittal B, Moyer J, Olenecki T, Rodgers P
J Am Acad Dermatol 2018 Mar;78(3):560-578. Epub 2018 Jan 10 doi: 10.1016/j.jaad.2017.10.007. PMID: 29331386Free PMC Article
Maroldi R, Farina D, Borghesi A, Marconi A, Gatti E
Neuroimaging Clin N Am 2008 May;18(2):413-29, xi. doi: 10.1016/j.nic.2008.01.001. PMID: 18466839

Therapy

Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Kaufman HL, Seebach F, Lowy I, Yoo SY, Mathias M, Fenech K, Han H, Fury MG, Rischin D
N Engl J Med 2022 Oct 27;387(17):1557-1568. Epub 2022 Sep 12 doi: 10.1056/NEJMoa2209813. PMID: 36094839Free PMC Article
Ferrarotto R, Amit M, Nagarajan P, Rubin ML, Yuan Y, Bell D, El-Naggar AK, Johnson JM, Morrison WH, Rosenthal DI, Glisson BS, Johnson FM, Lu C, Mott FE, Esmaeli B, Diaz EM Jr, Gidley PW, Goepfert RP, Lewis CM, Weber RS, Wargo JA, Basu S, Duan F, Yadav SS, Sharma P, Allison JP, Myers JN, Gross ND
Clin Cancer Res 2021 Aug 15;27(16):4557-4565. Epub 2021 Jun 29 doi: 10.1158/1078-0432.CCR-21-0585. PMID: 34187851Free PMC Article
Migden MR, Khushalani NI, Chang ALS, Lewis KD, Schmults CD, Hernandez-Aya L, Meier F, Schadendorf D, Guminski A, Hauschild A, Wong DJ, Daniels GA, Berking C, Jankovic V, Stankevich E, Booth J, Li S, Weinreich DM, Yancopoulos GD, Lowy I, Fury MG, Rischin D
Lancet Oncol 2020 Feb;21(2):294-305. Epub 2020 Jan 14 doi: 10.1016/S1470-2045(19)30728-4. PMID: 31952975Free PMC Article
Migden MR, Rischin D, Schmults CD, Guminski A, Hauschild A, Lewis KD, Chung CH, Hernandez-Aya L, Lim AM, Chang ALS, Rabinowits G, Thai AA, Dunn LA, Hughes BGM, Khushalani NI, Modi B, Schadendorf D, Gao B, Seebach F, Li S, Li J, Mathias M, Booth J, Mohan K, Stankevich E, Babiker HM, Brana I, Gil-Martin M, Homsi J, Johnson ML, Moreno V, Niu J, Owonikoko TK, Papadopoulos KP, Yancopoulos GD, Lowy I, Fury MG
N Engl J Med 2018 Jul 26;379(4):341-351. Epub 2018 Jun 4 doi: 10.1056/NEJMoa1805131. PMID: 29863979
Work Group; Invited Reviewers, Kim JYS, Kozlow JH, Mittal B, Moyer J, Olenecki T, Rodgers P
J Am Acad Dermatol 2018 Mar;78(3):560-578. Epub 2018 Jan 10 doi: 10.1016/j.jaad.2017.10.007. PMID: 29331386Free PMC Article

Prognosis

Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Yoo SY, Mathias M, Han H, Seebach F, Lowy I, Fury MG, Rischin D
Lancet Oncol 2023 Nov;24(11):1196-1205. Epub 2023 Oct 21 doi: 10.1016/S1470-2045(23)00459-X. PMID: 37875144
Desai N, Divatia MK, Jadhav A, Wagh A
Curr Oncol 2023 Jul 11;30(7):6634-6647. doi: 10.3390/curroncol30070487. PMID: 37504347Free PMC Article
Migden MR, Khushalani NI, Chang ALS, Lewis KD, Schmults CD, Hernandez-Aya L, Meier F, Schadendorf D, Guminski A, Hauschild A, Wong DJ, Daniels GA, Berking C, Jankovic V, Stankevich E, Booth J, Li S, Weinreich DM, Yancopoulos GD, Lowy I, Fury MG, Rischin D
Lancet Oncol 2020 Feb;21(2):294-305. Epub 2020 Jan 14 doi: 10.1016/S1470-2045(19)30728-4. PMID: 31952975Free PMC Article
Hughley BB, Schmalbach CE
Clin Geriatr Med 2018 May;34(2):245-258. Epub 2018 Feb 17 doi: 10.1016/j.cger.2018.01.004. PMID: 29661336
Maroldi R, Farina D, Borghesi A, Marconi A, Gatti E
Neuroimaging Clin N Am 2008 May;18(2):413-29, xi. doi: 10.1016/j.nic.2008.01.001. PMID: 18466839

Clinical prediction guides

Gross ND, Miller DM, Khushalani NI, Divi V, Ruiz ES, Lipson EJ, Meier F, Su YB, Swiecicki PL, Atlas J, Geiger JL, Hauschild A, Choe JH, Hughes BGM, Schadendorf D, Patel VA, Homsi J, Taube JM, Lim AM, Ferrarotto R, Kaufman HL, Seebach F, Lowy I, Yoo SY, Mathias M, Fenech K, Han H, Fury MG, Rischin D
N Engl J Med 2022 Oct 27;387(17):1557-1568. Epub 2022 Sep 12 doi: 10.1056/NEJMoa2209813. PMID: 36094839Free PMC Article
Baggi A, Quaglino P, Rubatto M, Depenni R, Guida M, Ascierto PA, Trojaniello C, Queirolo P, Saponara M, Peris K, Spagnolo F, Bianchi L, De Galitiis F, Potenza MC, Proietti I, Marconcini R, Botticelli A, Barbieri V, Licitra L, Alfieri S, Ficorella C, Cortellini A, Fargnoli MC, Troiani T, Tondulli L, Bossi P
Eur J Cancer 2021 Nov;157:250-258. Epub 2021 Sep 15 doi: 10.1016/j.ejca.2021.08.018. PMID: 34536948
Migden MR, Khushalani NI, Chang ALS, Lewis KD, Schmults CD, Hernandez-Aya L, Meier F, Schadendorf D, Guminski A, Hauschild A, Wong DJ, Daniels GA, Berking C, Jankovic V, Stankevich E, Booth J, Li S, Weinreich DM, Yancopoulos GD, Lowy I, Fury MG, Rischin D
Lancet Oncol 2020 Feb;21(2):294-305. Epub 2020 Jan 14 doi: 10.1016/S1470-2045(19)30728-4. PMID: 31952975Free PMC Article
Migden MR, Rischin D, Schmults CD, Guminski A, Hauschild A, Lewis KD, Chung CH, Hernandez-Aya L, Lim AM, Chang ALS, Rabinowits G, Thai AA, Dunn LA, Hughes BGM, Khushalani NI, Modi B, Schadendorf D, Gao B, Seebach F, Li S, Li J, Mathias M, Booth J, Mohan K, Stankevich E, Babiker HM, Brana I, Gil-Martin M, Homsi J, Johnson ML, Moreno V, Niu J, Owonikoko TK, Papadopoulos KP, Yancopoulos GD, Lowy I, Fury MG
N Engl J Med 2018 Jul 26;379(4):341-351. Epub 2018 Jun 4 doi: 10.1056/NEJMoa1805131. PMID: 29863979
D'Souza J, Clark J
Curr Opin Otolaryngol Head Neck Surg 2011 Apr;19(2):99-105. doi: 10.1097/MOO.0b013e328343e811. PMID: 21297477

Recent systematic reviews

Leong WS, Gowda S, Jackson R, Chabrillac E, Edafe O
J Laryngol Otol 2023 Jun;137(6):592-598. Epub 2022 Aug 1 doi: 10.1017/S0022215122001724. PMID: 35912693
Lubov J, Labbé M, Sioufi K, Morand GB, Hier MP, Khanna M, Sultanem K, Mlynarek AM
J Otolaryngol Head Neck Surg 2021 Sep 7;50(1):54. doi: 10.1186/s40463-021-00529-7. PMID: 34493343Free PMC Article
Rotman A, Kerr SJ, Giddings CEB
Head Neck 2019 Apr;41(4):1131-1139. Epub 2018 Dec 7 doi: 10.1002/hed.25561. PMID: 30536662
Trodello C, Pepper JP, Wong M, Wysong A
Dermatol Surg 2017 Jan;43(1):40-49. doi: 10.1097/DSS.0000000000000799. PMID: 27618393
Ahmed MM, Moore BA, Schmalbach CE
Otolaryngol Head Neck Surg 2014 Feb;150(2):180-7. Epub 2013 Nov 7 doi: 10.1177/0194599813511949. PMID: 24201060

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