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Unresectable Primary Peritoneal Adenocarcinoma

MedGen UID:
1734723
•Concept ID:
C5418917
•
Neoplastic Process

Definition

Primary peritoneal adenocarcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Primary Peritoneal Adenocarcinoma

Professional guidelines

PubMed

Intraperitoneal chemotherapy in the management of pancreatic adenocarcinoma: A systematic review and meta-analysis.
Frassini S, Calabretto F, Granieri S, Fugazzola P, Viganò J, Fazzini N, Ansaloni L, Cobianchi L
Eur J Surg Oncol 2022 Sep;48(9):1911-1921. Epub 2022 Jun 2 doi: 10.1016/j.ejso.2022.05.030. PMID: 35688711
Clinicopathological features and treatment outcomes of metastatic or locally unresectable small bowel adenocarcinoma.
Li X, Ying H, Cheng Y, Zhao L, Zhao S, Bai C, Zhou J
J BUON 2019 Nov-Dec;24(6):2539-2545. PMID: 31983130
Multidisciplinary management of intrahepatic cholangiocarcinoma: Current approaches.
Guro H, Kim JW, Choi Y, Cho JY, Yoon YS, Han HS
Surg Oncol 2017 Jun;26(2):146-152. Epub 2017 Mar 7 doi: 10.1016/j.suronc.2017.03.001. PMID: 28577720

Recent clinical studies

Etiology

Intraperitoneal chemotherapy in the management of pancreatic adenocarcinoma: A systematic review and meta-analysis.
Frassini S, Calabretto F, Granieri S, Fugazzola P, Viganò J, Fazzini N, Ansaloni L, Cobianchi L
Eur J Surg Oncol 2022 Sep;48(9):1911-1921. Epub 2022 Jun 2 doi: 10.1016/j.ejso.2022.05.030. PMID: 35688711
Efficacy and safety of weekly paclitaxel with or without ramucirumab as second-line therapy for the treatment of advanced gastric or gastroesophageal junction adenocarcinoma (RAINBOW-Asia): a randomised, multicentre, double-blind, phase 3 trial.
Xu RH, Zhang Y, Pan H, Feng J, Zhang T, Liu T, Qin Y, Qin S, Yin X, Liu B, Ba Y, Yang N, Voon PJ, Tanasanvimon S, Zhou C, Zhang WL, Shen L
Lancet Gastroenterol Hepatol 2021 Dec;6(12):1015-1024. Epub 2021 Oct 7 doi: 10.1016/S2468-1253(21)00313-7. PMID: 34626550
Clinicopathological features and treatment outcomes of metastatic or locally unresectable small bowel adenocarcinoma.
Li X, Ying H, Cheng Y, Zhao L, Zhao S, Bai C, Zhou J
J BUON 2019 Nov-Dec;24(6):2539-2545. PMID: 31983130
Efficacy of palliative radiotherapy and chemo-radiotherapy for unresectable gastric cancer demonstrating bleeding and obstruction.
Hiramoto S, Kikuchi A, Tetsuso H, Yoshioka A, Kohigashi Y, Maeda I
Int J Clin Oncol 2018 Dec;23(6):1090-1094. Epub 2018 Jul 17 doi: 10.1007/s10147-018-1317-0. PMID: 30019177
Surgical resections of ulcerative colitis associated with dysplasia or carcinoma.
Sameshima S, Koketsu S, Takeshita E, Kubota Y, Okuyama T, Saito K, Ueda Y, Sawada T, Oya M
World J Surg Oncol 2015 Feb 21;13:70. doi: 10.1186/s12957-015-0499-4. PMID: 25884202Free PMC Article

Diagnosis

Is surgical resection justified for pancreatic ductal adenocarcinoma with distant abdominal organ metastasis? A position paper by experts in pancreatic surgery at the Joint Meeting of the International Association of Pancreatology (IAP) & the Japan Pancreas Society (JPS) 2022 in Kyoto.
Hashimoto D, Satoi S, Fujii T, Sho M, He J, Hackert T, Del Chiaro M, Jang JY, Gulla A, Yoon YS, Shan YS, Lou W, Valente R, Furuse J, Oba A, Nagai M, Terai T, Tanaka H, Sakai A, Yamamoto T, Yamaki S, Matsumoto I, Murakami Y, Takaori K, Takeyama Y
Pancreatology 2023 Sep;23(6):682-688. Epub 2023 Jul 20 doi: 10.1016/j.pan.2023.07.005. PMID: 37507301
Efficacy and safety of weekly paclitaxel with or without ramucirumab as second-line therapy for the treatment of advanced gastric or gastroesophageal junction adenocarcinoma (RAINBOW-Asia): a randomised, multicentre, double-blind, phase 3 trial.
Xu RH, Zhang Y, Pan H, Feng J, Zhang T, Liu T, Qin Y, Qin S, Yin X, Liu B, Ba Y, Yang N, Voon PJ, Tanasanvimon S, Zhou C, Zhang WL, Shen L
Lancet Gastroenterol Hepatol 2021 Dec;6(12):1015-1024. Epub 2021 Oct 7 doi: 10.1016/S2468-1253(21)00313-7. PMID: 34626550
Exploring the role of resection of extrahepatic metastases from hepatocellular carcinoma.
Chua TC, Morris DL
Surg Oncol 2012 Jun;21(2):95-101. Epub 2011 Mar 11 doi: 10.1016/j.suronc.2011.01.005. PMID: 21397495
Liver transplantation in primary hepatic carcinoid tumor: case report and literature review.
de Liguori Carino N, Manzia TM, Tariciotti L, Berlanda M, Orlando G, Tisone G
Transplant Proc 2009 May;41(4):1386-9. doi: 10.1016/j.transproceed.2009.03.011. PMID: 19460567
Pancreatic adenocarcinoma.
Howard TJ
Curr Probl Cancer 1996 Sep-Oct;20(5):281-328. doi: 10.1016/s0147-0272(96)80001-8. PMID: 8902402

Therapy

Tislelizumab plus chemotherapy versus placebo plus chemotherapy as first line treatment for advanced gastric or gastro-oesophageal junction adenocarcinoma: RATIONALE-305 randomised, double blind, phase 3 trial.
Qiu MZ, Oh DY, Kato K, Arkenau T, Tabernero J, Correa MC, Zimina AV, Bai Y, Shi J, Lee KW, Wang J, Poddubskaya E, Pan H, Rha SY, Zhang R, Hirano H, Spigel D, Yamaguchi K, Chao Y, Wyrwicz L, Disel U, Cid RP, Fornaro L, Evesque L, Wang H, Xu Y, Li J, Sheng T, Yang S, Li L, Moehler M, Xu RH; RATIONALE-305 Investigators
BMJ 2024 May 28;385:e078876. doi: 10.1136/bmj-2023-078876. PMID: 38806195
Intraperitoneal chemotherapy in the management of pancreatic adenocarcinoma: A systematic review and meta-analysis.
Frassini S, Calabretto F, Granieri S, Fugazzola P, Viganò J, Fazzini N, Ansaloni L, Cobianchi L
Eur J Surg Oncol 2022 Sep;48(9):1911-1921. Epub 2022 Jun 2 doi: 10.1016/j.ejso.2022.05.030. PMID: 35688711
Efficacy and safety of weekly paclitaxel with or without ramucirumab as second-line therapy for the treatment of advanced gastric or gastroesophageal junction adenocarcinoma (RAINBOW-Asia): a randomised, multicentre, double-blind, phase 3 trial.
Xu RH, Zhang Y, Pan H, Feng J, Zhang T, Liu T, Qin Y, Qin S, Yin X, Liu B, Ba Y, Yang N, Voon PJ, Tanasanvimon S, Zhou C, Zhang WL, Shen L
Lancet Gastroenterol Hepatol 2021 Dec;6(12):1015-1024. Epub 2021 Oct 7 doi: 10.1016/S2468-1253(21)00313-7. PMID: 34626550
Clinicopathological features and treatment outcomes of metastatic or locally unresectable small bowel adenocarcinoma.
Li X, Ying H, Cheng Y, Zhao L, Zhao S, Bai C, Zhou J
J BUON 2019 Nov-Dec;24(6):2539-2545. PMID: 31983130
Multidisciplinary management of intrahepatic cholangiocarcinoma: Current approaches.
Guro H, Kim JW, Choi Y, Cho JY, Yoon YS, Han HS
Surg Oncol 2017 Jun;26(2):146-152. Epub 2017 Mar 7 doi: 10.1016/j.suronc.2017.03.001. PMID: 28577720

Prognosis

Is surgical resection justified for pancreatic ductal adenocarcinoma with distant abdominal organ metastasis? A position paper by experts in pancreatic surgery at the Joint Meeting of the International Association of Pancreatology (IAP) & the Japan Pancreas Society (JPS) 2022 in Kyoto.
Hashimoto D, Satoi S, Fujii T, Sho M, He J, Hackert T, Del Chiaro M, Jang JY, Gulla A, Yoon YS, Shan YS, Lou W, Valente R, Furuse J, Oba A, Nagai M, Terai T, Tanaka H, Sakai A, Yamamoto T, Yamaki S, Matsumoto I, Murakami Y, Takaori K, Takeyama Y
Pancreatology 2023 Sep;23(6):682-688. Epub 2023 Jul 20 doi: 10.1016/j.pan.2023.07.005. PMID: 37507301
Clinicopathological features and treatment outcomes of metastatic or locally unresectable small bowel adenocarcinoma.
Li X, Ying H, Cheng Y, Zhao L, Zhao S, Bai C, Zhou J
J BUON 2019 Nov-Dec;24(6):2539-2545. PMID: 31983130
Efficacy of palliative radiotherapy and chemo-radiotherapy for unresectable gastric cancer demonstrating bleeding and obstruction.
Hiramoto S, Kikuchi A, Tetsuso H, Yoshioka A, Kohigashi Y, Maeda I
Int J Clin Oncol 2018 Dec;23(6):1090-1094. Epub 2018 Jul 17 doi: 10.1007/s10147-018-1317-0. PMID: 30019177
Multidisciplinary management of intrahepatic cholangiocarcinoma: Current approaches.
Guro H, Kim JW, Choi Y, Cho JY, Yoon YS, Han HS
Surg Oncol 2017 Jun;26(2):146-152. Epub 2017 Mar 7 doi: 10.1016/j.suronc.2017.03.001. PMID: 28577720
Surgical resections of ulcerative colitis associated with dysplasia or carcinoma.
Sameshima S, Koketsu S, Takeshita E, Kubota Y, Okuyama T, Saito K, Ueda Y, Sawada T, Oya M
World J Surg Oncol 2015 Feb 21;13:70. doi: 10.1186/s12957-015-0499-4. PMID: 25884202Free PMC Article

Clinical prediction guides

Tislelizumab plus chemotherapy versus placebo plus chemotherapy as first line treatment for advanced gastric or gastro-oesophageal junction adenocarcinoma: RATIONALE-305 randomised, double blind, phase 3 trial.
Qiu MZ, Oh DY, Kato K, Arkenau T, Tabernero J, Correa MC, Zimina AV, Bai Y, Shi J, Lee KW, Wang J, Poddubskaya E, Pan H, Rha SY, Zhang R, Hirano H, Spigel D, Yamaguchi K, Chao Y, Wyrwicz L, Disel U, Cid RP, Fornaro L, Evesque L, Wang H, Xu Y, Li J, Sheng T, Yang S, Li L, Moehler M, Xu RH; RATIONALE-305 Investigators
BMJ 2024 May 28;385:e078876. doi: 10.1136/bmj-2023-078876. PMID: 38806195
Conversion Surgery After Atezolizumab Plus Bevacizumab for Primary and Peritoneal Metastasis After Hepatocellular Carcinoma Rupture.
Miyata T, Sugi K, Horino T, Ono A, Tagayasu Y, Nomoto D, Inoue M, Mizumoto T, Kubota T, Yanagida E, Murayama T, Miyanari N, Baba H
Anticancer Res 2023 Feb;43(2):943-947. doi: 10.21873/anticanres.16239. PMID: 36697062
Intraperitoneal chemotherapy in the management of pancreatic adenocarcinoma: A systematic review and meta-analysis.
Frassini S, Calabretto F, Granieri S, Fugazzola P, Viganò J, Fazzini N, Ansaloni L, Cobianchi L
Eur J Surg Oncol 2022 Sep;48(9):1911-1921. Epub 2022 Jun 2 doi: 10.1016/j.ejso.2022.05.030. PMID: 35688711
Clinical impact of primary tumor sidedness and sex on unresectable post-recurrence survival in resected pathological stage II-III colorectal cancers: a nationwide multicenter retrospective study.
Abe S, Kawai K, Nozawa H, Sasaki K, Murono K, Emoto S, Ozawa T, Yokoyama Y, Nagai Y, Anzai H, Sonoda H, Yamauchi S, Sugihara K, Ishihara S
BMC Cancer 2022 May 2;22(1):486. doi: 10.1186/s12885-022-09615-z. PMID: 35501727Free PMC Article
Pancreatic adenocarcinoma.
Howard TJ
Curr Probl Cancer 1996 Sep-Oct;20(5):281-328. doi: 10.1016/s0147-0272(96)80001-8. PMID: 8902402

Recent systematic reviews

Intraperitoneal chemotherapy in the management of pancreatic adenocarcinoma: A systematic review and meta-analysis.
Frassini S, Calabretto F, Granieri S, Fugazzola P, Viganò J, Fazzini N, Ansaloni L, Cobianchi L
Eur J Surg Oncol 2022 Sep;48(9):1911-1921. Epub 2022 Jun 2 doi: 10.1016/j.ejso.2022.05.030. PMID: 35688711
Diagnostic accuracy of staging laparoscopy for detecting metastasized or locally advanced perihilar cholangiocarcinoma: a systematic review and meta-analysis.
Coelen RJ, Ruys AT, Besselink MG, Busch OR, van Gulik TM
Surg Endosc 2016 Oct;30(10):4163-73. Epub 2016 Feb 19 doi: 10.1007/s00464-016-4788-y. PMID: 26895909Free PMC Article
Systematic review of prognostic factors related to overall survival in patients with stage IV colorectal cancer and unresectable metastases.
Stillwell AP, Ho YH, Veitch C
World J Surg 2011 Mar;35(3):684-92. doi: 10.1007/s00268-010-0891-8. PMID: 21181473

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