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Inflammatory Bowel Disease-Associated Colorectal Adenocarcinoma

MedGen UID:
1753872
•Concept ID:
C5419800
•
Neoplastic Process

Definition

A colorectal adenocarcinoma that develops in patients with a history of inflammatory bowel disease. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInflammatory Bowel Disease-Associated Colorectal Adenocarcinoma

Recent clinical studies

Etiology

Prognostic and tumor immunity implication of inflammatory bowel disease-associated genes in colorectal cancer.
Wang D, Xie B
Eur J Med Res 2022 Jun 13;27(1):91. doi: 10.1186/s40001-022-00720-0. PMID: 35698180Free PMC Article
Loss of SATB2 Expression Is a Biomarker of Inflammatory Bowel Disease-associated Colorectal Dysplasia and Adenocarcinoma.
Ma C, Henn P, Miller C, Herbst C, Hartman DJ, Pai RK
Am J Surg Pathol 2019 Oct;43(10):1314-1322. doi: 10.1097/PAS.0000000000001330. PMID: 31318711
Dynamics of Genome Alterations in Crohn's Disease-Associated Colorectal Carcinogenesis.
Hirsch D, Wangsa D, Zhu YJ, Hu Y, Edelman DC, Meltzer PS, Heselmeyer-Haddad K, Ott C, Kienle P, Galata C, Horisberger K, Ried T, Gaiser T
Clin Cancer Res 2018 Oct 15;24(20):4997-5011. Epub 2018 Jul 2 doi: 10.1158/1078-0432.CCR-18-0630. PMID: 29967250Free PMC Article
Genomic Profiling of Small-Bowel Adenocarcinoma.
Schrock AB, Devoe CE, McWilliams R, Sun J, Aparicio T, Stephens PJ, Ross JS, Wilson R, Miller VA, Ali SM, Overman MJ
JAMA Oncol 2017 Nov 1;3(11):1546-1553. doi: 10.1001/jamaoncol.2017.1051. PMID: 28617917Free PMC Article
Review article: what are the important endoscopic lesions for detection of dysplasia in inflammatory bowel disease?
Geboes K
Aliment Pharmacol Ther 2006 Oct;24 Suppl 3:50-5. doi: 10.1111/j.1365-2036.2006.03061.x. PMID: 16961746

Diagnosis

Prognostic and tumor immunity implication of inflammatory bowel disease-associated genes in colorectal cancer.
Wang D, Xie B
Eur J Med Res 2022 Jun 13;27(1):91. doi: 10.1186/s40001-022-00720-0. PMID: 35698180Free PMC Article
Crohn's disease associated adenocarcinoma of ileocaecal region: a miscalculated approach.
Dsouza R, Varghese G, Korula DR, Dutta AK
BMJ Case Rep 2020 Apr 16;13(4) doi: 10.1136/bcr-2020-234512. PMID: 32303529Free PMC Article
Loss of SATB2 Expression Is a Biomarker of Inflammatory Bowel Disease-associated Colorectal Dysplasia and Adenocarcinoma.
Ma C, Henn P, Miller C, Herbst C, Hartman DJ, Pai RK
Am J Surg Pathol 2019 Oct;43(10):1314-1322. doi: 10.1097/PAS.0000000000001330. PMID: 31318711
Genomic Profiling of Small-Bowel Adenocarcinoma.
Schrock AB, Devoe CE, McWilliams R, Sun J, Aparicio T, Stephens PJ, Ross JS, Wilson R, Miller VA, Ali SM, Overman MJ
JAMA Oncol 2017 Nov 1;3(11):1546-1553. doi: 10.1001/jamaoncol.2017.1051. PMID: 28617917Free PMC Article
Expression of MACC1 and MET in inflammatory bowel disease-associated colonic neoplasia.
Harpaz N, Taboada S, Ko HM, Yu J, Yang Q, Xu H, Cao W
Inflamm Bowel Dis 2014 Apr;20(4):703-11. doi: 10.1097/01.MIB.0000442679.39804.48. PMID: 24518605

Therapy

Review article: what are the important endoscopic lesions for detection of dysplasia in inflammatory bowel disease?
Geboes K
Aliment Pharmacol Ther 2006 Oct;24 Suppl 3:50-5. doi: 10.1111/j.1365-2036.2006.03061.x. PMID: 16961746

Prognosis

Prognostic and tumor immunity implication of inflammatory bowel disease-associated genes in colorectal cancer.
Wang D, Xie B
Eur J Med Res 2022 Jun 13;27(1):91. doi: 10.1186/s40001-022-00720-0. PMID: 35698180Free PMC Article
Crohn's disease associated adenocarcinoma of ileocaecal region: a miscalculated approach.
Dsouza R, Varghese G, Korula DR, Dutta AK
BMJ Case Rep 2020 Apr 16;13(4) doi: 10.1136/bcr-2020-234512. PMID: 32303529Free PMC Article
Dynamics of Genome Alterations in Crohn's Disease-Associated Colorectal Carcinogenesis.
Hirsch D, Wangsa D, Zhu YJ, Hu Y, Edelman DC, Meltzer PS, Heselmeyer-Haddad K, Ott C, Kienle P, Galata C, Horisberger K, Ried T, Gaiser T
Clin Cancer Res 2018 Oct 15;24(20):4997-5011. Epub 2018 Jul 2 doi: 10.1158/1078-0432.CCR-18-0630. PMID: 29967250Free PMC Article
Genomic Profiling of Small-Bowel Adenocarcinoma.
Schrock AB, Devoe CE, McWilliams R, Sun J, Aparicio T, Stephens PJ, Ross JS, Wilson R, Miller VA, Ali SM, Overman MJ
JAMA Oncol 2017 Nov 1;3(11):1546-1553. doi: 10.1001/jamaoncol.2017.1051. PMID: 28617917Free PMC Article
Shift from pStat6 to pStat3 predominance is associated with inflammatory bowel disease-associated dysplasia.
Wick EC, LeBlanc RE, Ortega G, Robinson C, Platz E, Pardoll DM, Iacobuzio-Donahue C, Sears CL
Inflamm Bowel Dis 2012 Jul;18(7):1267-74. Epub 2011 Oct 21 doi: 10.1002/ibd.21908. PMID: 22021169Free PMC Article

Clinical prediction guides

Dynamics of Genome Alterations in Crohn's Disease-Associated Colorectal Carcinogenesis.
Hirsch D, Wangsa D, Zhu YJ, Hu Y, Edelman DC, Meltzer PS, Heselmeyer-Haddad K, Ott C, Kienle P, Galata C, Horisberger K, Ried T, Gaiser T
Clin Cancer Res 2018 Oct 15;24(20):4997-5011. Epub 2018 Jul 2 doi: 10.1158/1078-0432.CCR-18-0630. PMID: 29967250Free PMC Article
Distinct Histopathologic and Molecular Alterations in Inflammatory Bowel Disease-Associated Intestinal Adenocarcinoma: c-MYC Amplification is Common and Associated with Mucinous/Signet Ring Cell Differentiation.
Hartman DJ, Binion DG, Regueiro MD, Miller C, Herbst C, Pai RK
Inflamm Bowel Dis 2018 Jul 12;24(8):1780-1790. doi: 10.1093/ibd/izy057. PMID: 29788391
Genomic Profiling of Small-Bowel Adenocarcinoma.
Schrock AB, Devoe CE, McWilliams R, Sun J, Aparicio T, Stephens PJ, Ross JS, Wilson R, Miller VA, Ali SM, Overman MJ
JAMA Oncol 2017 Nov 1;3(11):1546-1553. doi: 10.1001/jamaoncol.2017.1051. PMID: 28617917Free PMC Article
Expression of MACC1 and MET in inflammatory bowel disease-associated colonic neoplasia.
Harpaz N, Taboada S, Ko HM, Yu J, Yang Q, Xu H, Cao W
Inflamm Bowel Dis 2014 Apr;20(4):703-11. doi: 10.1097/01.MIB.0000442679.39804.48. PMID: 24518605
Diagnostic utility of TP53 and cytokeratin 7 immunohistochemistry in idiopathic inflammatory bowel disease-associated neoplasia.
Xie H, Xiao SY, Pai R, Jiang W, Shadrach B, Carver P, Wang Y, Shen B, Zhou W, Liu X
Mod Pathol 2014 Feb;27(2):303-13. Epub 2013 Jul 26 doi: 10.1038/modpathol.2013.133. PMID: 23887291

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