U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Transplant-Associated Thrombotic Microangiopathy

MedGen UID:
1758357
Concept ID:
C5417748
Disease or Syndrome

Definition

Thrombotic microangiopathy that presents in some patients undergoing hematopoietic stem cell transplantation (HSCT). Though similar in presentation to thrombotic thrombocytopenic purpura (TTP) and atypical hemolytic uremic syndrome (aHUS), transplant-associated thrombotic microangiopathy (TA-TMA) is a distinct disorder. Several risk factors may be associated with TA-TMA, including high-dose chemotherapy, radiation therapy, HLA mismatch, use of calcineurin inhibitors, acute graft-versus-host disease (GVHD), and infections. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTransplant-Associated Thrombotic Microangiopathy

Professional guidelines

PubMed

McEwan A, Greenwood M, Ward C, Ritchie D, Szer J, Gardiner E, Colic A, Sipavicius J, Panek-Hudson Y, Kerridge I
Intern Med J 2023 Dec;53(12):2162-2174. Epub 2023 Aug 1 doi: 10.1111/imj.16188. PMID: 37528613
Yang LP, Zhao P, Wu YJ, Fu HX, He Y, Mo XD, Lv M, Wang FR, Yan CH, Chen YH, Chang YJ, Xu LP, Liu KY, Huang XJ, Zhang XH
Bone Marrow Transplant 2022 Apr;57(4):554-561. Epub 2022 Jan 25 doi: 10.1038/s41409-022-01581-1. PMID: 35079139
Elemary M, Sabry W, Seghatchian J, Goubran H
Transfus Apher Sci 2019 Jun;58(3):347-350. Epub 2019 May 1 doi: 10.1016/j.transci.2019.04.022. PMID: 31097308

Recent clinical studies

Etiology

Jodele S, Dandoy CE, Aguayo-Hiraldo P, Lane A, Teusink-Cross A, Sabulski A, Mizuno K, Laskin BL, Freedman J, Davies SM
Blood 2024 Mar 21;143(12):1112-1123. doi: 10.1182/blood.2023022526. PMID: 37946262Free PMC Article
Lazana I
Int J Mol Sci 2023 Jan 6;24(2) doi: 10.3390/ijms24021159. PMID: 36674666Free PMC Article
Schoettler ML, Saldana BD, Berkenkamp L, Chonat S, Watkins B, Rotz SJ, Simons D, Graf E, Rossi C, Cheng J, Hammers YA, Rytting H, Williams KM
Transplant Cell Ther 2023 Jan;29(1):45.e1-45.e8. Epub 2022 Oct 4 doi: 10.1016/j.jtct.2022.09.026. PMID: 36202334Free PMC Article
Neidemire-Colley L, Robert J, Ackaoui A, Dorrance AM, Guimond M, Ranganathan P
Front Immunol 2022;13:1033490. Epub 2022 Nov 23 doi: 10.3389/fimmu.2022.1033490. PMID: 36505438Free PMC Article
Jodele S, Dandoy CE, Lane A, Laskin BL, Teusink-Cross A, Myers KC, Wallace G, Nelson A, Bleesing J, Chima RS, Hirsch R, Ryan TD, Benoit S, Mizuno K, Warren M, Davies SM
Blood 2020 Mar 26;135(13):1049-1057. doi: 10.1182/blood.2019004218. PMID: 31932840Free PMC Article

Diagnosis

Lazana I
Int J Mol Sci 2023 Jan 6;24(2) doi: 10.3390/ijms24021159. PMID: 36674666Free PMC Article
Schoettler ML, Saldana BD, Berkenkamp L, Chonat S, Watkins B, Rotz SJ, Simons D, Graf E, Rossi C, Cheng J, Hammers YA, Rytting H, Williams KM
Transplant Cell Ther 2023 Jan;29(1):45.e1-45.e8. Epub 2022 Oct 4 doi: 10.1016/j.jtct.2022.09.026. PMID: 36202334Free PMC Article
Young JA, Pallas CR, Knovich MA
Bone Marrow Transplant 2021 Aug;56(8):1805-1817. Epub 2021 Apr 19 doi: 10.1038/s41409-021-01283-0. PMID: 33875812Free PMC Article
Hildebrandt GC, Chao N
Br J Haematol 2020 Aug;190(4):508-519. Epub 2020 Apr 21 doi: 10.1111/bjh.16621. PMID: 32319084Free PMC Article
Jodele S, Dandoy CE, Lane A, Laskin BL, Teusink-Cross A, Myers KC, Wallace G, Nelson A, Bleesing J, Chima RS, Hirsch R, Ryan TD, Benoit S, Mizuno K, Warren M, Davies SM
Blood 2020 Mar 26;135(13):1049-1057. doi: 10.1182/blood.2019004218. PMID: 31932840Free PMC Article

Therapy

Jodele S, Dandoy CE, Aguayo-Hiraldo P, Lane A, Teusink-Cross A, Sabulski A, Mizuno K, Laskin BL, Freedman J, Davies SM
Blood 2024 Mar 21;143(12):1112-1123. doi: 10.1182/blood.2023022526. PMID: 37946262Free PMC Article
Lazana I
Int J Mol Sci 2023 Jan 6;24(2) doi: 10.3390/ijms24021159. PMID: 36674666Free PMC Article
Gavriilaki E, Papakonstantinou A, Agrios KA
Int J Mol Sci 2022 Jun 29;23(13) doi: 10.3390/ijms23137216. PMID: 35806224Free PMC Article
Young JA, Pallas CR, Knovich MA
Bone Marrow Transplant 2021 Aug;56(8):1805-1817. Epub 2021 Apr 19 doi: 10.1038/s41409-021-01283-0. PMID: 33875812Free PMC Article
Jodele S, Dandoy CE, Lane A, Laskin BL, Teusink-Cross A, Myers KC, Wallace G, Nelson A, Bleesing J, Chima RS, Hirsch R, Ryan TD, Benoit S, Mizuno K, Warren M, Davies SM
Blood 2020 Mar 26;135(13):1049-1057. doi: 10.1182/blood.2019004218. PMID: 31932840Free PMC Article

Prognosis

Lazana I
Int J Mol Sci 2023 Jan 6;24(2) doi: 10.3390/ijms24021159. PMID: 36674666Free PMC Article
Zhang R, Zhou M, Qi J, Miao W, Zhang Z, Wu D, Han Y
Front Immunol 2020;11:564647. Epub 2021 Jan 20 doi: 10.3389/fimmu.2020.564647. PMID: 33552043Free PMC Article
Jodele S, Dandoy CE, Lane A, Laskin BL, Teusink-Cross A, Myers KC, Wallace G, Nelson A, Bleesing J, Chima RS, Hirsch R, Ryan TD, Benoit S, Mizuno K, Warren M, Davies SM
Blood 2020 Mar 26;135(13):1049-1057. doi: 10.1182/blood.2019004218. PMID: 31932840Free PMC Article
Gavriilaki E, Sakellari I, Anagnostopoulos A, Brodsky RA
Bone Marrow Transplant 2017 Oct;52(10):1355-1360. Epub 2017 Mar 13 doi: 10.1038/bmt.2017.39. PMID: 28287636
Dhakal P, Giri S, Pathak R, Bhatt VR
Clin Appl Thromb Hemost 2017 Mar;23(2):175-180. Epub 2016 Jul 10 doi: 10.1177/1076029615599439. PMID: 26259912

Clinical prediction guides

Schoettler ML, Lehmann L, Kao PC, Chen N, Jodele S, Chonat S, Williams KM, London WB, Duncan C, Dandoy C
Blood Adv 2024 Mar 12;8(5):1220-1233. doi: 10.1182/bloodadvances.2023011078. PMID: 38154068Free PMC Article
Lazana I
Int J Mol Sci 2023 Jan 6;24(2) doi: 10.3390/ijms24021159. PMID: 36674666Free PMC Article
Sabulski A, Arcuri G, Szabo S, Care MM, Dandoy CE, Davies SM, Jodele S
Blood Adv 2022 Jul 26;6(14):4310-4319. doi: 10.1182/bloodadvances.2022007453. PMID: 35877136Free PMC Article
Zhang R, Zhou M, Qi J, Miao W, Zhang Z, Wu D, Han Y
Front Immunol 2020;11:564647. Epub 2021 Jan 20 doi: 10.3389/fimmu.2020.564647. PMID: 33552043Free PMC Article
Jodele S, Medvedovic M, Luebbering N, Chen J, Dandoy CE, Laskin BL, Davies SM
Blood Adv 2020 Mar 24;4(6):1166-1177. doi: 10.1182/bloodadvances.2020001515. PMID: 32208488Free PMC Article

Recent systematic reviews

Guo M, Qi J, Hou Q, Li X, Han Y
Expert Rev Hematol 2023 Mar;16(3):191-203. Epub 2023 Jan 2 doi: 10.1080/17474086.2023.2162501. PMID: 36588482
Kashyap R, Anwer F, Iqbal MA, Khalid F, Khan A, Ali MA, Anwar MY, Chaudhary A, Jaan A
Hematol Oncol Stem Cell Ther 2023 Jan 17;16(2):93-101. doi: 10.1016/j.hemonc.2021.09.002. PMID: 34655527
Schoettler ML, Bhatt H, Vasu S
Front Immunol 2022;13:1064203. Epub 2023 Feb 2 doi: 10.3389/fimmu.2022.1064203. PMID: 36818475Free PMC Article
Zhang R, Zhou M, Qi J, Miao W, Zhang Z, Wu D, Han Y
Front Immunol 2020;11:564647. Epub 2021 Jan 20 doi: 10.3389/fimmu.2020.564647. PMID: 33552043Free PMC Article
Warren M, Jodele S, Dandoy C, Myers KC, Wallace G, Nelson A, El-Bietar J
Arch Pathol Lab Med 2017 Nov;141(11):1558-1566. Epub 2017 Aug 10 doi: 10.5858/arpa.2016-0599-RA. PMID: 28795840

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...