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Acute Myeloid Leukemia Arising from Previous Myelodysplastic/Myeloproliferative Neoplasm

MedGen UID:
1760542
Concept ID:
C5419465
Neoplastic Process

Definition

An acute myeloid leukemia developing in patients with a prior history of myelodysplastic/myeloproliferative neoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute Myeloid Leukemia Arising from Previous Myelodysplastic/Myeloproliferative Neoplasm

Recent clinical studies

Etiology

Brunner AM, Blonquist TM, DeAngelo DJ, McMasters M, Fell G, Hermance NM, Winer ES, Lindsley RC, Hobbs GS, Amrein PC, Hock HR, Steensma DP, Garcia JS, Luskin MR, Stone RM, Ballen KK, Rosenblatt J, Avigan D, Nahas MR, Mendez LM, McAfee SL, Moran JA, Bergeron M, Foster J, Bertoli C, Manning AL, McGregor KL, Fishman KM, Kuo FC, Baltay MT, Macrae M, Burke M, Behnan T, Wey MC, Som TT, Ramos AY, Rae J, Lombardi Story J, Nelson N, Logan E, Connolly C, Neuberg DS, Chen YB, Graubert TA, Fathi AT
Lancet Haematol 2020 Feb;7(2):e122-e133. Epub 2019 Dec 11 doi: 10.1016/S2352-3026(19)30203-0. PMID: 31837959Free PMC Article
Szotkowski T, Rohon P, Zapletalova L, Sicova K, Hubacek J, Indrak K
Neoplasma 2010;57(2):170-8. doi: 10.4149/neo_2010_02_170. PMID: 20099982

Diagnosis

Pich A, Beggiato E, Godio L, Riera L, Francia di Celle P, Lanzarone G, Benevolo G
Expert Rev Hematol 2021 Sep;14(9):841-850. Epub 2021 Aug 20 doi: 10.1080/17474086.2021.1967138. PMID: 34384330
Szotkowski T, Rohon P, Zapletalova L, Sicova K, Hubacek J, Indrak K
Neoplasma 2010;57(2):170-8. doi: 10.4149/neo_2010_02_170. PMID: 20099982
Wang SA, Galili N, Cerny J, Sechman E, Chen SS, Loew J, Liu Q, Fadare O, Hasserjian R, Jones D, Qawi H, Woda B, Raza A
Am J Clin Pathol 2006 Nov;126(5):789-97. doi: 10.1309/FU04-P779-U310-R3EE. PMID: 17050076

Therapy

Brunner AM, Blonquist TM, DeAngelo DJ, McMasters M, Fell G, Hermance NM, Winer ES, Lindsley RC, Hobbs GS, Amrein PC, Hock HR, Steensma DP, Garcia JS, Luskin MR, Stone RM, Ballen KK, Rosenblatt J, Avigan D, Nahas MR, Mendez LM, McAfee SL, Moran JA, Bergeron M, Foster J, Bertoli C, Manning AL, McGregor KL, Fishman KM, Kuo FC, Baltay MT, Macrae M, Burke M, Behnan T, Wey MC, Som TT, Ramos AY, Rae J, Lombardi Story J, Nelson N, Logan E, Connolly C, Neuberg DS, Chen YB, Graubert TA, Fathi AT
Lancet Haematol 2020 Feb;7(2):e122-e133. Epub 2019 Dec 11 doi: 10.1016/S2352-3026(19)30203-0. PMID: 31837959Free PMC Article
Szotkowski T, Rohon P, Zapletalova L, Sicova K, Hubacek J, Indrak K
Neoplasma 2010;57(2):170-8. doi: 10.4149/neo_2010_02_170. PMID: 20099982

Prognosis

Brunner AM, Blonquist TM, DeAngelo DJ, McMasters M, Fell G, Hermance NM, Winer ES, Lindsley RC, Hobbs GS, Amrein PC, Hock HR, Steensma DP, Garcia JS, Luskin MR, Stone RM, Ballen KK, Rosenblatt J, Avigan D, Nahas MR, Mendez LM, McAfee SL, Moran JA, Bergeron M, Foster J, Bertoli C, Manning AL, McGregor KL, Fishman KM, Kuo FC, Baltay MT, Macrae M, Burke M, Behnan T, Wey MC, Som TT, Ramos AY, Rae J, Lombardi Story J, Nelson N, Logan E, Connolly C, Neuberg DS, Chen YB, Graubert TA, Fathi AT
Lancet Haematol 2020 Feb;7(2):e122-e133. Epub 2019 Dec 11 doi: 10.1016/S2352-3026(19)30203-0. PMID: 31837959Free PMC Article
Szotkowski T, Rohon P, Zapletalova L, Sicova K, Hubacek J, Indrak K
Neoplasma 2010;57(2):170-8. doi: 10.4149/neo_2010_02_170. PMID: 20099982

Clinical prediction guides

Brunner AM, Blonquist TM, DeAngelo DJ, McMasters M, Fell G, Hermance NM, Winer ES, Lindsley RC, Hobbs GS, Amrein PC, Hock HR, Steensma DP, Garcia JS, Luskin MR, Stone RM, Ballen KK, Rosenblatt J, Avigan D, Nahas MR, Mendez LM, McAfee SL, Moran JA, Bergeron M, Foster J, Bertoli C, Manning AL, McGregor KL, Fishman KM, Kuo FC, Baltay MT, Macrae M, Burke M, Behnan T, Wey MC, Som TT, Ramos AY, Rae J, Lombardi Story J, Nelson N, Logan E, Connolly C, Neuberg DS, Chen YB, Graubert TA, Fathi AT
Lancet Haematol 2020 Feb;7(2):e122-e133. Epub 2019 Dec 11 doi: 10.1016/S2352-3026(19)30203-0. PMID: 31837959Free PMC Article

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