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NTRK Gene Rearrangement

MedGen UID:
1761023
•Concept ID:
C5418973
•
Cell or Molecular Dysfunction
Synonyms: NTRK Family Gene Rearrangement; NTRK Family Rearrangement; TRK Family Gene Rearrangement; TRK Receptor Family Gene Rearrangement

Definition

A molecular abnormality indicating cytogenetic rearrangement involving an NTRK family gene. [from NCI]

Professional guidelines

PubMed

Evaluation of NTRK immunohistochemistry as a screening method for NTRK gene fusion detection in non-small cell lung cancer.
Elfving H, Broström E, Moens LNJ, Almlöf J, Cerjan D, Lauter G, Nord H, Mattsson JSM, Ullenhag GJ, Strell C, Backman M, La Fleur L, Brunnström H, Botling J, Micke P
Lung Cancer 2021 Jan;151:53-59. Epub 2020 Nov 27 doi: 10.1016/j.lungcan.2020.11.023. PMID: 33310622
Evaluating entrectinib as a treatment option for non-small cell lung cancer.
Lee J, Park S, Jung HA, Sun JM, Lee SH, Ahn JS, Park K, Ahn MJ
Expert Opin Pharmacother 2020 Nov;21(16):1935-1942. Epub 2020 Jul 31 doi: 10.1080/14656566.2020.1798932. PMID: 32736487
Entrectinib for the treatment of metastatic NSCLC: safety and efficacy.
Sartore-Bianchi A, Pizzutilo EG, Marrapese G, Tosi F, Cerea G, Siena S
Expert Rev Anticancer Ther 2020 May;20(5):333-341. Epub 2020 Apr 8 doi: 10.1080/14737140.2020.1747439. PMID: 32223357

Recent clinical studies

Etiology

Fine-needle aspiration cytomorphology of papillary thyroid carcinoma with NTRK gene rearrangement from a case series with predominantly indeterminate cytology.
Abi-Raad R, Prasad ML, Adeniran AJ, Cai G
Cancer Cytopathol 2020 Nov;128(11):803-811. Epub 2020 Sep 15 doi: 10.1002/cncy.22353. PMID: 32931153

Diagnosis

NTRK-rearranged spindle cell sarcoma of the uterine cervix with a novel NUMA1::NTRK1 fusion.
Szalai L, Vereczkey I, Szemes M, Rókusz A, Csernák E, Tóth E, Melegh Z
Virchows Arch 2024 Mar;484(3):527-531. Epub 2023 Dec 28 doi: 10.1007/s00428-023-03724-1. PMID: 38151535Free PMC Article
MET kinase inhibitor reverses resistance to entrectinib induced by hepatocyte growth factor in tumors with NTRK1 or ROS1 rearrangements.
Takumi Y, Arai S, Suzuki C, Fukuda K, Nishiyama A, Takeuchi S, Sato H, Matsumoto K, Sugio K, Yano S
Cancer Med 2023 Mar;12(5):5809-5820. Epub 2022 Nov 23 doi: 10.1002/cam4.5342. PMID: 36416133Free PMC Article
Fine-needle aspiration cytomorphology of papillary thyroid carcinoma with NTRK gene rearrangement from a case series with predominantly indeterminate cytology.
Abi-Raad R, Prasad ML, Adeniran AJ, Cai G
Cancer Cytopathol 2020 Nov;128(11):803-811. Epub 2020 Sep 15 doi: 10.1002/cncy.22353. PMID: 32931153

Therapy

MET kinase inhibitor reverses resistance to entrectinib induced by hepatocyte growth factor in tumors with NTRK1 or ROS1 rearrangements.
Takumi Y, Arai S, Suzuki C, Fukuda K, Nishiyama A, Takeuchi S, Sato H, Matsumoto K, Sugio K, Yano S
Cancer Med 2023 Mar;12(5):5809-5820. Epub 2022 Nov 23 doi: 10.1002/cam4.5342. PMID: 36416133Free PMC Article

Prognosis

NTRK-rearranged spindle cell sarcoma of the uterine cervix with a novel NUMA1::NTRK1 fusion.
Szalai L, Vereczkey I, Szemes M, Rókusz A, Csernák E, Tóth E, Melegh Z
Virchows Arch 2024 Mar;484(3):527-531. Epub 2023 Dec 28 doi: 10.1007/s00428-023-03724-1. PMID: 38151535Free PMC Article
Fine-needle aspiration cytomorphology of papillary thyroid carcinoma with NTRK gene rearrangement from a case series with predominantly indeterminate cytology.
Abi-Raad R, Prasad ML, Adeniran AJ, Cai G
Cancer Cytopathol 2020 Nov;128(11):803-811. Epub 2020 Sep 15 doi: 10.1002/cncy.22353. PMID: 32931153

Clinical prediction guides

NTRK-rearranged spindle cell sarcoma of the uterine cervix with a novel NUMA1::NTRK1 fusion.
Szalai L, Vereczkey I, Szemes M, Rókusz A, Csernák E, Tóth E, Melegh Z
Virchows Arch 2024 Mar;484(3):527-531. Epub 2023 Dec 28 doi: 10.1007/s00428-023-03724-1. PMID: 38151535Free PMC Article
Fine-needle aspiration cytomorphology of papillary thyroid carcinoma with NTRK gene rearrangement from a case series with predominantly indeterminate cytology.
Abi-Raad R, Prasad ML, Adeniran AJ, Cai G
Cancer Cytopathol 2020 Nov;128(11):803-811. Epub 2020 Sep 15 doi: 10.1002/cncy.22353. PMID: 32931153

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