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Abnormal chorion morphology

MedGen UID:
1766088
•Concept ID:
C5421568
•
Anatomical Abnormality
HPO: HP:0033042

Definition

Any structural anomaly of the fetal part of the placenta, which is known as the chorion. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal chorion morphology

Professional guidelines

PubMed

Advances in diagnostics and management of gestational trophoblastic disease.
Lukinovic N, Malovrh EP, Takac I, Sobocan M, Knez J
Radiol Oncol 2022 Dec 1;56(4):430-439. Epub 2022 Oct 27 doi: 10.2478/raon-2022-0038. PMID: 36286620Free PMC Article
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
Mid-trimester preterm premature rupture of membranes (PPROM): etiology, diagnosis, classification, international recommendations of treatment options and outcome.
Tchirikov M, Schlabritz-Loutsevitch N, Maher J, Buchmann J, Naberezhnev Y, Winarno AS, Seliger G
J Perinat Med 2018 Jul 26;46(5):465-488. doi: 10.1515/jpm-2017-0027. PMID: 28710882

Recent clinical studies

Etiology

Whole-exome sequencing in the evaluation of fetal structural anomalies: a prospective cohort study.
Petrovski S, Aggarwal V, Giordano JL, Stosic M, Wou K, Bier L, Spiegel E, Brennan K, Stong N, Jobanputra V, Ren Z, Zhu X, Mebane C, Nahum O, Wang Q, Kamalakaran S, Malone C, Anyane-Yeboa K, Miller R, Levy B, Goldstein DB, Wapner RJ
Lancet 2019 Feb 23;393(10173):758-767. Epub 2019 Jan 31 doi: 10.1016/S0140-6736(18)32042-7. PMID: 30712878
Chronic inflammation of the placenta: definition, classification, pathogenesis, and clinical significance.
Kim CJ, Romero R, Chaemsaithong P, Kim JS
Am J Obstet Gynecol 2015 Oct;213(4 Suppl):S53-69. doi: 10.1016/j.ajog.2015.08.041. PMID: 26428503Free PMC Article
Brachydactyly.
Temtamy SA, Aglan MS
Orphanet J Rare Dis 2008 Jun 13;3:15. doi: 10.1186/1750-1172-3-15. PMID: 18554391Free PMC Article
Leopard syndrome.
Sarkozy A, Digilio MC, Dallapiccola B
Orphanet J Rare Dis 2008 May 27;3:13. doi: 10.1186/1750-1172-3-13. PMID: 18505544Free PMC Article
Monosomy 18p.
Turleau C
Orphanet J Rare Dis 2008 Feb 19;3:4. doi: 10.1186/1750-1172-3-4. PMID: 18284672Free PMC Article

Diagnosis

Whole-exome sequencing in the evaluation of fetal structural anomalies: a prospective cohort study.
Petrovski S, Aggarwal V, Giordano JL, Stosic M, Wou K, Bier L, Spiegel E, Brennan K, Stong N, Jobanputra V, Ren Z, Zhu X, Mebane C, Nahum O, Wang Q, Kamalakaran S, Malone C, Anyane-Yeboa K, Miller R, Levy B, Goldstein DB, Wapner RJ
Lancet 2019 Feb 23;393(10173):758-767. Epub 2019 Jan 31 doi: 10.1016/S0140-6736(18)32042-7. PMID: 30712878
Brachydactyly.
Temtamy SA, Aglan MS
Orphanet J Rare Dis 2008 Jun 13;3:15. doi: 10.1186/1750-1172-3-15. PMID: 18554391Free PMC Article
Leopard syndrome.
Sarkozy A, Digilio MC, Dallapiccola B
Orphanet J Rare Dis 2008 May 27;3:13. doi: 10.1186/1750-1172-3-13. PMID: 18505544Free PMC Article
Monosomy 18p.
Turleau C
Orphanet J Rare Dis 2008 Feb 19;3:4. doi: 10.1186/1750-1172-3-4. PMID: 18284672Free PMC Article
Therapeutic hysteroscopic procedures.
Siegler AM, Valle RF
Fertil Steril 1988 Nov;50(5):685-701. doi: 10.1016/s0015-0282(16)60300-x. PMID: 3053254

Therapy

Radial Ray Malformation.
Society for Maternal-Fetal Medicine (SMFM), Gandhi M, Rac MWF, McKinney J
Am J Obstet Gynecol 2019 Dec;221(6):B16-B18. doi: 10.1016/j.ajog.2019.09.024. PMID: 31787159
Mid-trimester preterm premature rupture of membranes (PPROM): etiology, diagnosis, classification, international recommendations of treatment options and outcome.
Tchirikov M, Schlabritz-Loutsevitch N, Maher J, Buchmann J, Naberezhnev Y, Winarno AS, Seliger G
J Perinat Med 2018 Jul 26;46(5):465-488. doi: 10.1515/jpm-2017-0027. PMID: 28710882
Cryptorchidism.
Rabinowitz R, Hulbert WC Jr
Pediatr Rev 1994 Jul;15(7):272-4. doi: 10.1542/pir.15-7-272. PMID: 7916154
Therapeutic hysteroscopic procedures.
Siegler AM, Valle RF
Fertil Steril 1988 Nov;50(5):685-701. doi: 10.1016/s0015-0282(16)60300-x. PMID: 3053254
Polycystic ovarian disease.
Raj SG, Talbert LM
Obstet Gynecol Annu 1984;13:261-73. PMID: 6232474

Prognosis

Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
Mid-trimester preterm premature rupture of membranes (PPROM): etiology, diagnosis, classification, international recommendations of treatment options and outcome.
Tchirikov M, Schlabritz-Loutsevitch N, Maher J, Buchmann J, Naberezhnev Y, Winarno AS, Seliger G
J Perinat Med 2018 Jul 26;46(5):465-488. doi: 10.1515/jpm-2017-0027. PMID: 28710882
Glucose-6-phosphatase deficiency.
Froissart R, Piraud M, Boudjemline AM, Vianey-Saban C, Petit F, Hubert-Buron A, Eberschweiler PT, Gajdos V, Labrune P
Orphanet J Rare Dis 2011 May 20;6:27. doi: 10.1186/1750-1172-6-27. PMID: 21599942Free PMC Article
A review of trisomy X (47,XXX).
Tartaglia NR, Howell S, Sutherland A, Wilson R, Wilson L
Orphanet J Rare Dis 2010 May 11;5:8. doi: 10.1186/1750-1172-5-8. PMID: 20459843Free PMC Article
Leopard syndrome.
Sarkozy A, Digilio MC, Dallapiccola B
Orphanet J Rare Dis 2008 May 27;3:13. doi: 10.1186/1750-1172-3-13. PMID: 18505544Free PMC Article

Clinical prediction guides

Clinical and ultrasonographic characteristics of pregnancy-related enhanced myometrial vascularity: prospective cohort study.
Xholli A, Scovazzi U, Londero AP, Paudice M, Vacca I, Schiaffino MG, Kratochwila C, Cavalli E, Perugi I, Cagnacci A; Collaborators
Ultrasound Obstet Gynecol 2024 May;63(5):672-682. Epub 2024 Apr 5 doi: 10.1002/uog.27537. PMID: 37984401
Abnormal expression of SLIT3 induces intravillous vascularization dysplasia in ectopic pregnancy.
Zhu Q, Zhao X, Zhang D, Xia W, Zhang J
PeerJ 2023;11:e14850. Epub 2023 Feb 10 doi: 10.7717/peerj.14850. PMID: 36793891Free PMC Article
Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk.
Wang XH, Xu S, Zhou XY, Zhao R, Lin Y, Cao J, Zang WD, Tao H, Xu W, Li MQ, Zhao SM, Jin LP, Zhao JY
Nat Commun 2021 Jun 8;12(1):3428. doi: 10.1038/s41467-021-23827-0. PMID: 34103526Free PMC Article
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
Hyperglycosylated hCG.
Cole LA
Placenta 2007 Oct;28(10):977-86. Epub 2007 Mar 7 doi: 10.1016/j.placenta.2007.01.011. PMID: 17346790

Recent systematic reviews

Cesarean Scar Pregnancies: A Systematic Review of Treatment Options.
Maheux-Lacroix S, Li F, Bujold E, Nesbitt-Hawes E, Deans R, Abbott J
J Minim Invasive Gynecol 2017 Sep-Oct;24(6):915-925. Epub 2017 Jul 18 doi: 10.1016/j.jmig.2017.05.019. PMID: 28599886
Prenatal diagnosis and management of vasa previa in twin pregnancies: a case series and systematic review.
Jauniaux E, Melcer Y, Maymon R
Am J Obstet Gynecol 2017 Jun;216(6):568-575. Epub 2017 Jan 30 doi: 10.1016/j.ajog.2017.01.029. PMID: 28153653
Pseudomonoamniotic Pregnancy: Case Report and Review of Etiologic Considerations.
Patil AS, Martin J, Tsukahara K, Skljarevski A, Miller K, Towns R, Schubert FP
Fetal Pediatr Pathol 2015;34(6):413-21. Epub 2015 Sep 11 doi: 10.3109/15513815.2015.1075633. PMID: 26359803
Karyotype versus genomic hybridization for the prenatal diagnosis of chromosomal abnormalities: a metaanalysis.
Saldarriaga W, García-Perdomo HA, Arango-Pineda J, Fonseca J
Am J Obstet Gynecol 2015 Mar;212(3):330.e1-10. Epub 2014 Oct 18 doi: 10.1016/j.ajog.2014.10.011. PMID: 25305409
Systematic review of sonographic findings of placental mesenchymal dysplasia and subsequent pregnancy outcome.
Nayeri UA, West AB, Grossetta Nardini HK, Copel JA, Sfakianaki AK
Ultrasound Obstet Gynecol 2013 Apr;41(4):366-74. doi: 10.1002/uog.12359. PMID: 23239538

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