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Upper extremity akinesia

MedGen UID:
1778147
•Concept ID:
C5539573
•
Finding
Synonym: Akinesia of the upper extremities
 
HPO: HP:0033412

Definition

Inability to initiate changes in activity or movement and to perform ordinary volitional movements rapidly and easily in the upper extremities. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUpper extremity akinesia

Recent clinical studies

Etiology

The Progressive Supranuclear Palsy Clinical Deficits Scale.
Piot I, Schweyer K, Respondek G, Stamelou M; DescribePSP study group; ProPSP study group; MDS-endorsed PSP study group, Sckopke P, Schenk T, Goetz CG, Stebbins GT, Höglinger GU
Mov Disord 2020 Apr;35(4):650-661. Epub 2020 Jan 17 doi: 10.1002/mds.27964. PMID: 31951049
Bradykinesia-akinesia incoordination test: validating an online keyboard test of upper limb function.
Noyce AJ, Nagy A, Acharya S, Hadavi S, Bestwick JP, Fearnley J, Lees AJ, Giovannoni G
PLoS One 2014;9(4):e96260. Epub 2014 Apr 29 doi: 10.1371/journal.pone.0096260. PMID: 24781810Free PMC Article
Single injection peribulbar anesthesia with a short needle combined with digital compression.
Riad W, Ahmed N
Anesth Analg 2008 Nov;107(5):1751-3. doi: 10.1213/ane.0b013e3181864d1c. PMID: 18931243
Sonographic diagnosis of fetal upper extremity dysmorphology: significance and outcome.
Zelop C, Benacerraf B
Ultrasound Obstet Gynecol 1996 Dec;8(6):391-6. doi: 10.1046/j.1469-0705.1997.08060391.x. PMID: 9014278
Movement related desynchronisation pattern preceding voluntary movement in untreated Parkinson's disease.
Defebvre L, Bourriez JL, Destée A, Guieu JD
J Neurol Neurosurg Psychiatry 1996 Mar;60(3):307-12. doi: 10.1136/jnnp.60.3.307. PMID: 8609509Free PMC Article

Diagnosis

The Progressive Supranuclear Palsy Clinical Deficits Scale.
Piot I, Schweyer K, Respondek G, Stamelou M; DescribePSP study group; ProPSP study group; MDS-endorsed PSP study group, Sckopke P, Schenk T, Goetz CG, Stebbins GT, Höglinger GU
Mov Disord 2020 Apr;35(4):650-661. Epub 2020 Jan 17 doi: 10.1002/mds.27964. PMID: 31951049
Bradykinesia-akinesia incoordination test: validating an online keyboard test of upper limb function.
Noyce AJ, Nagy A, Acharya S, Hadavi S, Bestwick JP, Fearnley J, Lees AJ, Giovannoni G
PLoS One 2014;9(4):e96260. Epub 2014 Apr 29 doi: 10.1371/journal.pone.0096260. PMID: 24781810Free PMC Article
MRI-negative frontal lobe epilepsy with ipsilateral akinesia and reflex activation.
Malone S, Miller I, Jakayar P, Resnick T, Bhatia S, Duchowny M
Epileptic Disord 2008 Dec;10(4):349-55. doi: 10.1684/epd.2008.0224. PMID: 19017579
Cortical motor activation in akinetic schizophrenic patients: a pilot functional MRI study.
Payoux P, Boulanouar K, Sarramon C, Fabre N, Descombes S, Galitsky M, Thalamas C, Brefel-Courbon C, Sabatini U, Manelfe C, Chollet F, Schmitt L, Rascol O
Mov Disord 2004 Jan;19(1):83-90. doi: 10.1002/mds.10598. PMID: 14743365
The palmomental reflex in Parkinson's disease. Comparisons with normal subjects and clinical relevance.
Maertens de Noordhout A, Delwaide PJ
Arch Neurol 1988 Apr;45(4):425-7. doi: 10.1001/archneur.1988.00520280075018. PMID: 3355398

Therapy

Effects of Repetitive Transcranial Magnetic Stimulation on Motor Symptoms in Parkinson's Disease: A Meta-Analysis.
Li R, He Y, Qin W, Zhang Z, Su J, Guan Q, Chen Y, Jin L
Neurorehabil Neural Repair 2022 Jul;36(7):395-404. Epub 2022 May 26 doi: 10.1177/15459683221095034. PMID: 35616427
The Progressive Supranuclear Palsy Clinical Deficits Scale.
Piot I, Schweyer K, Respondek G, Stamelou M; DescribePSP study group; ProPSP study group; MDS-endorsed PSP study group, Sckopke P, Schenk T, Goetz CG, Stebbins GT, Höglinger GU
Mov Disord 2020 Apr;35(4):650-661. Epub 2020 Jan 17 doi: 10.1002/mds.27964. PMID: 31951049
Single injection peribulbar anesthesia with a short needle combined with digital compression.
Riad W, Ahmed N
Anesth Analg 2008 Nov;107(5):1751-3. doi: 10.1213/ane.0b013e3181864d1c. PMID: 18931243
Subthalamic nucleus stimulation for Parkinson's disease preferentially improves akinesia of proximal arm movements compared to finger movements.
Wenzelburger R, Kopper F, Zhang BR, Witt K, Hamel W, Weinert D, Kuhtz-Buschbeck J, Gölge M, Illert M, Deuschl G, Krack P
Mov Disord 2003 Oct;18(10):1162-9. doi: 10.1002/mds.10501. PMID: 14534921
Fetal akinesia deformation sequence (Pena-Shokeir phenotype) associated with acquired intrauterine brain damage.
Lavi E, Montone KT, Rorke LB, Kliman HJ
Neurology 1991 Sep;41(9):1467-8. doi: 10.1212/wnl.41.9.1467. PMID: 1891100

Prognosis

Developing and assessing a new web-based tapping test for measuring distal movement in Parkinson's disease: a Distal Finger Tapping test.
Akram N, Li H, Ben-Joseph A, Budu C, Gallagher DA, Bestwick JP, Schrag A, Noyce AJ, Simonet C
Sci Rep 2022 Jan 10;12(1):386. doi: 10.1038/s41598-021-03563-7. PMID: 35013372Free PMC Article
A system-level mathematical model of Basal Ganglia motor-circuit for kinematic planning of arm movements.
Salimi-Badr A, Ebadzadeh MM, Darlot C
Comput Biol Med 2018 Jan 1;92:78-89. Epub 2017 Nov 10 doi: 10.1016/j.compbiomed.2017.11.004. PMID: 29156412
Bradykinesia-akinesia incoordination test: validating an online keyboard test of upper limb function.
Noyce AJ, Nagy A, Acharya S, Hadavi S, Bestwick JP, Fearnley J, Lees AJ, Giovannoni G
PLoS One 2014;9(4):e96260. Epub 2014 Apr 29 doi: 10.1371/journal.pone.0096260. PMID: 24781810Free PMC Article
Sonographic diagnosis of fetal upper extremity dysmorphology: significance and outcome.
Zelop C, Benacerraf B
Ultrasound Obstet Gynecol 1996 Dec;8(6):391-6. doi: 10.1046/j.1469-0705.1997.08060391.x. PMID: 9014278

Clinical prediction guides

The Progressive Supranuclear Palsy Clinical Deficits Scale.
Piot I, Schweyer K, Respondek G, Stamelou M; DescribePSP study group; ProPSP study group; MDS-endorsed PSP study group, Sckopke P, Schenk T, Goetz CG, Stebbins GT, Höglinger GU
Mov Disord 2020 Apr;35(4):650-661. Epub 2020 Jan 17 doi: 10.1002/mds.27964. PMID: 31951049
A system-level mathematical model of Basal Ganglia motor-circuit for kinematic planning of arm movements.
Salimi-Badr A, Ebadzadeh MM, Darlot C
Comput Biol Med 2018 Jan 1;92:78-89. Epub 2017 Nov 10 doi: 10.1016/j.compbiomed.2017.11.004. PMID: 29156412
Tests of manual dexterity and speed in Parkinson's disease: Not all measure the same.
Růžička E, Krupička R, Zárubová K, Rusz J, Jech R, Szabó Z
Parkinsonism Relat Disord 2016 Jul;28:118-23. Epub 2016 May 7 doi: 10.1016/j.parkreldis.2016.05.009. PMID: 27185294
Bradykinesia-akinesia incoordination test: validating an online keyboard test of upper limb function.
Noyce AJ, Nagy A, Acharya S, Hadavi S, Bestwick JP, Fearnley J, Lees AJ, Giovannoni G
PLoS One 2014;9(4):e96260. Epub 2014 Apr 29 doi: 10.1371/journal.pone.0096260. PMID: 24781810Free PMC Article
Differential effects of cortical lesions in humans.
Freund HJ
Ciba Found Symp 1987;132:269-81. doi: 10.1002/9780470513545.ch16. PMID: 3322719

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