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Elevated RV/TLC ratio

MedGen UID:
1780824
•Concept ID:
C5539448
•
Finding
Synonyms: Hyperinflation on pulmonary function test; Overinflation on pulmonary function test
 
HPO: HP:0033240

Definition

An increase in the ratio of residual volume (RV) to total lung capacity (TLC) on pulmonary function testing. RV is the amount of air remaining aftermaximal expiration and TLC is the total amount of air in theungs at full inspiration. These volumes cannot be determined by spirometry, but can be measured by inert gas dilution, nitrogen washout, and (3) body plethysmography. An elevated RV/TLC can be interpreted as a sign of air trapping and hyperinflation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated RV/TLC ratio

Recent clinical studies

Etiology

Calprotectin as a New Sensitive Marker of Neutrophilic Inflammation in Patients with Bronchiolitis Obliterans.
Jerkic SP, Michel F, Donath H, Herrmann E, Schubert R, Rosewich M, Zielen S
Mediators Inflamm 2020;2020:4641585. Epub 2020 May 1 doi: 10.1155/2020/4641585. PMID: 32410855Free PMC Article
Novel Pulmonary Function Parameter Shifts in High-Grade Upper Airway Stenoses.
Wiggenhauser PS, Adolph O, Hoffmann TK, Thierauf J, Veit JA
Ear Nose Throat J 2019 Aug;98(7):E104-E111. Epub 2019 May 9 doi: 10.1177/0145561319840870. PMID: 31072193
Pleuroparenchymal fibroelastosis diagnosed by multidisciplinary discussions in Japan.
Ishii H, Watanabe K, Kushima H, Baba T, Watanabe S, Yamada Y, Arai T, Tsushima K, Kondoh Y, Nakamura Y, Terasaki Y, Hebisawa A, Johkoh T, Sakai F, Takemura T, Kawabata Y, Ogura T; Tokyo Diffuse Lung Disease Study Group
Respir Med 2018 Aug;141:190-197. Epub 2018 Jun 27 doi: 10.1016/j.rmed.2018.06.022. PMID: 30053966
Correlation between hyperinflation defined as an elevated RV/TLC ratio and body composition and cytokine profile in patients with chronic obstructive pulmonary disease.
Rubinsztajn R, Przybyłowski T, Maskey-Warzęchowska M, Paplińska-Goryca M, Karwat K, Nejman-Gryz P, Chazan R
Pneumonol Alergol Pol 2015;83(2):120-5. doi: 10.5603/PiAP.2015.0019. PMID: 25754053
Respiratory and peripheral muscle function in cystic fibrosis.
Lands LC, Heigenhauser GJ, Jones NL
Am Rev Respir Dis 1993 Apr;147(4):865-9. doi: 10.1164/ajrccm/147.4.865. PMID: 8466121

Diagnosis

The usefulness of MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio for diagnosis and assessment of COPD severity.
Dimic-Janjic S, Hoda MA, Milenkovic B, Kotur-Stevuljevic J, Stjepanovic M, Gompelmann D, Jankovic J, Miljkovic M, Milin-Lazovic J, Djurdjevic N, Maric D, Milivojevic I, Popevic S
Eur J Med Res 2023 Mar 20;28(1):127. doi: 10.1186/s40001-023-01094-7. PMID: 36935521Free PMC Article
Calprotectin as a New Sensitive Marker of Neutrophilic Inflammation in Patients with Bronchiolitis Obliterans.
Jerkic SP, Michel F, Donath H, Herrmann E, Schubert R, Rosewich M, Zielen S
Mediators Inflamm 2020;2020:4641585. Epub 2020 May 1 doi: 10.1155/2020/4641585. PMID: 32410855Free PMC Article
Pleuroparenchymal fibroelastosis diagnosed by multidisciplinary discussions in Japan.
Ishii H, Watanabe K, Kushima H, Baba T, Watanabe S, Yamada Y, Arai T, Tsushima K, Kondoh Y, Nakamura Y, Terasaki Y, Hebisawa A, Johkoh T, Sakai F, Takemura T, Kawabata Y, Ogura T; Tokyo Diffuse Lung Disease Study Group
Respir Med 2018 Aug;141:190-197. Epub 2018 Jun 27 doi: 10.1016/j.rmed.2018.06.022. PMID: 30053966
Correlation between hyperinflation defined as an elevated RV/TLC ratio and body composition and cytokine profile in patients with chronic obstructive pulmonary disease.
Rubinsztajn R, Przybyłowski T, Maskey-Warzęchowska M, Paplińska-Goryca M, Karwat K, Nejman-Gryz P, Chazan R
Pneumonol Alergol Pol 2015;83(2):120-5. doi: 10.5603/PiAP.2015.0019. PMID: 25754053
Pulmonary findings in patients with primary Sjögren's syndrome.
Lahdensuo A, Korpela M
Chest 1995 Aug;108(2):316-9. doi: 10.1378/chest.108.2.316. PMID: 7634859

Therapy

Quantitative computed tomography detects peripheral airway disease in asthmatic children.
Jain N, Covar RA, Gleason MC, Newell JD Jr, Gelfand EW, Spahn JD
Pediatr Pulmonol 2005 Sep;40(3):211-8. doi: 10.1002/ppul.20215. PMID: 16015663
Methacholine inhalational challenge in the evaluation of chronic cough in children.
de Benedictis FM, Canny GJ, Levison H
J Asthma 1986;23(6):303-8. doi: 10.3109/02770908609073177. PMID: 3546254
Chest deformity, residual airways obstruction and hyperinflation, and growth in children with asthma. II. Significance of chronic chest deformity.
Gillam GL, McNicol KN, Williams HE
Arch Dis Child 1970 Dec;45(244):789-99. doi: 10.1136/adc.45.244.789. PMID: 5491883Free PMC Article

Prognosis

Novel Pulmonary Function Parameter Shifts in High-Grade Upper Airway Stenoses.
Wiggenhauser PS, Adolph O, Hoffmann TK, Thierauf J, Veit JA
Ear Nose Throat J 2019 Aug;98(7):E104-E111. Epub 2019 May 9 doi: 10.1177/0145561319840870. PMID: 31072193
Pleuroparenchymal fibroelastosis diagnosed by multidisciplinary discussions in Japan.
Ishii H, Watanabe K, Kushima H, Baba T, Watanabe S, Yamada Y, Arai T, Tsushima K, Kondoh Y, Nakamura Y, Terasaki Y, Hebisawa A, Johkoh T, Sakai F, Takemura T, Kawabata Y, Ogura T; Tokyo Diffuse Lung Disease Study Group
Respir Med 2018 Aug;141:190-197. Epub 2018 Jun 27 doi: 10.1016/j.rmed.2018.06.022. PMID: 30053966
Pulmonary Function Test Abnormalities in Pediatric Inflammatory Bowel Disease.
Furlano RI, Basek P, Müller P, Bieli C, Braegger CP, Barben J, Hammer J, Moeller A, Trachsel D
Respiration 2015;90(4):279-86. Epub 2015 Aug 18 doi: 10.1159/000435961. PMID: 26302766
Correlation between hyperinflation defined as an elevated RV/TLC ratio and body composition and cytokine profile in patients with chronic obstructive pulmonary disease.
Rubinsztajn R, Przybyłowski T, Maskey-Warzęchowska M, Paplińska-Goryca M, Karwat K, Nejman-Gryz P, Chazan R
Pneumonol Alergol Pol 2015;83(2):120-5. doi: 10.5603/PiAP.2015.0019. PMID: 25754053
Pulmonary findings in patients with primary Sjögren's syndrome.
Lahdensuo A, Korpela M
Chest 1995 Aug;108(2):316-9. doi: 10.1378/chest.108.2.316. PMID: 7634859

Clinical prediction guides

The usefulness of MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio for diagnosis and assessment of COPD severity.
Dimic-Janjic S, Hoda MA, Milenkovic B, Kotur-Stevuljevic J, Stjepanovic M, Gompelmann D, Jankovic J, Miljkovic M, Milin-Lazovic J, Djurdjevic N, Maric D, Milivojevic I, Popevic S
Eur J Med Res 2023 Mar 20;28(1):127. doi: 10.1186/s40001-023-01094-7. PMID: 36935521Free PMC Article
Novel Pulmonary Function Parameter Shifts in High-Grade Upper Airway Stenoses.
Wiggenhauser PS, Adolph O, Hoffmann TK, Thierauf J, Veit JA
Ear Nose Throat J 2019 Aug;98(7):E104-E111. Epub 2019 May 9 doi: 10.1177/0145561319840870. PMID: 31072193
Pleuroparenchymal fibroelastosis diagnosed by multidisciplinary discussions in Japan.
Ishii H, Watanabe K, Kushima H, Baba T, Watanabe S, Yamada Y, Arai T, Tsushima K, Kondoh Y, Nakamura Y, Terasaki Y, Hebisawa A, Johkoh T, Sakai F, Takemura T, Kawabata Y, Ogura T; Tokyo Diffuse Lung Disease Study Group
Respir Med 2018 Aug;141:190-197. Epub 2018 Jun 27 doi: 10.1016/j.rmed.2018.06.022. PMID: 30053966
Pulmonary Function Test Abnormalities in Pediatric Inflammatory Bowel Disease.
Furlano RI, Basek P, Müller P, Bieli C, Braegger CP, Barben J, Hammer J, Moeller A, Trachsel D
Respiration 2015;90(4):279-86. Epub 2015 Aug 18 doi: 10.1159/000435961. PMID: 26302766
Correlation between hyperinflation defined as an elevated RV/TLC ratio and body composition and cytokine profile in patients with chronic obstructive pulmonary disease.
Rubinsztajn R, Przybyłowski T, Maskey-Warzęchowska M, Paplińska-Goryca M, Karwat K, Nejman-Gryz P, Chazan R
Pneumonol Alergol Pol 2015;83(2):120-5. doi: 10.5603/PiAP.2015.0019. PMID: 25754053

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