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Metastatic Medulloblastoma

MedGen UID:
1783727
•Concept ID:
C5447976
•
Neoplastic Process

Definition

Medulloblastoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Medulloblastoma

Professional guidelines

PubMed

Intrathecal delivery of nanoparticle PARP inhibitor to the cerebrospinal fluid for the treatment of metastatic medulloblastoma.
Khang M, Lee JH, Lee T, Suh HW, Lee S, Cavaliere A, Rushing A, Geraldo LH, Belitzky E, Rossano S, de Feyter HM, Shin K, Huttner A, Roussel MF, Thomas JL, Carson RE, Marquez-Nostra B, Bindra RS, Saltzman WM
Sci Transl Med 2023 Nov;15(720):eadi1617. Epub 2023 Nov 1 doi: 10.1126/scitranslmed.adi1617. PMID: 37910601Free PMC Article
Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma.
Donovan LK, Delaidelli A, Joseph SK, Bielamowicz K, Fousek K, Holgado BL, Manno A, Srikanthan D, Gad AZ, Van Ommeren R, Przelicki D, Richman C, Ramaswamy V, Daniels C, Pallota JG, Douglas T, Joynt ACM, Haapasalo J, Nor C, Vladoiu MC, Kuzan-Fischer CM, Garzia L, Mack SC, Varadharajan S, Baker ML, Hendrikse L, Ly M, Kharas K, Balin P, Wu X, Qin L, Huang N, Stucklin AG, Morrissy AS, Cavalli FMG, Luu B, Suarez R, De Antonellis P, Michealraj A, Rastan A, Hegde M, Komosa M, Sirbu O, Kumar SA, Abdullaev Z, Faria CC, Yip S, Hukin J, Tabori U, Hawkins C, Aldape K, Daugaard M, Maris JM, Sorensen PH, Ahmed N, Taylor MD
Nat Med 2020 May;26(5):720-731. Epub 2020 Apr 27 doi: 10.1038/s41591-020-0827-2. PMID: 32341580Free PMC Article
A four-hour topotecan infusion achieves cytotoxic exposure throughout the neuraxis in the nonhuman primate model: implications for treatment of children with metastatic medulloblastoma.
Zamboni WC, Gajjar AJ, Mandrell TD, Einhaus SL, Danks MK, Rogers WP, Heideman RL, Houghton PJ, Stewart CF
Clin Cancer Res 1998 Oct;4(10):2537-44. PMID: 9796988

Recent clinical studies

Etiology

Cerebrospinal fluid cytokines in metastatic group 3 and 4 medulloblastoma.
Low SYY, Bte Syed Sulaiman N, Tan EEK, Ng LP, Kuick CH, Chang KTE, Tang PH, Wong RX, Looi WS, Low DCY, Seow WT
BMC Cancer 2020 Jun 15;20(1):554. doi: 10.1186/s12885-020-07048-0. PMID: 32539808Free PMC Article
Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma.
Donovan LK, Delaidelli A, Joseph SK, Bielamowicz K, Fousek K, Holgado BL, Manno A, Srikanthan D, Gad AZ, Van Ommeren R, Przelicki D, Richman C, Ramaswamy V, Daniels C, Pallota JG, Douglas T, Joynt ACM, Haapasalo J, Nor C, Vladoiu MC, Kuzan-Fischer CM, Garzia L, Mack SC, Varadharajan S, Baker ML, Hendrikse L, Ly M, Kharas K, Balin P, Wu X, Qin L, Huang N, Stucklin AG, Morrissy AS, Cavalli FMG, Luu B, Suarez R, De Antonellis P, Michealraj A, Rastan A, Hegde M, Komosa M, Sirbu O, Kumar SA, Abdullaev Z, Faria CC, Yip S, Hukin J, Tabori U, Hawkins C, Aldape K, Daugaard M, Maris JM, Sorensen PH, Ahmed N, Taylor MD
Nat Med 2020 May;26(5):720-731. Epub 2020 Apr 27 doi: 10.1038/s41591-020-0827-2. PMID: 32341580Free PMC Article
Treatment of Children and Adolescents With Metastatic Medulloblastoma and Prognostic Relevance of Clinical and Biologic Parameters.
von Bueren AO, Kortmann RD, von Hoff K, Friedrich C, Mynarek M, Müller K, Goschzik T, Zur Mühlen A, Gerber N, Warmuth-Metz M, Soerensen N, Deinlein F, Benesch M, Zwiener I, Kwiecien R, Faldum A, Bode U, Fleischhack G, Hovestadt V, Kool M, Jones D, Northcott P, Kuehl J, Pfister S, Pietsch T, Rutkowski S
J Clin Oncol 2016 Dec;34(34):4151-4160. Epub 2016 Oct 31 doi: 10.1200/JCO.2016.67.2428. PMID: 27863192
Current treatment approaches to early childhood medulloblastoma.
Rutkowski S
Expert Rev Neurother 2006 Aug;6(8):1211-21. doi: 10.1586/14737175.6.8.1211. PMID: 16893348
Medulloblastoma in childhood.
Raimondi AJ, Tomita T
Acta Neurochir (Wien) 1979;50(1-2):127-38. doi: 10.1007/BF01813557. PMID: 517184

Diagnosis

Cerebrospinal fluid cytokines in metastatic group 3 and 4 medulloblastoma.
Low SYY, Bte Syed Sulaiman N, Tan EEK, Ng LP, Kuick CH, Chang KTE, Tang PH, Wong RX, Looi WS, Low DCY, Seow WT
BMC Cancer 2020 Jun 15;20(1):554. doi: 10.1186/s12885-020-07048-0. PMID: 32539808Free PMC Article
Treatment of Children and Adolescents With Metastatic Medulloblastoma and Prognostic Relevance of Clinical and Biologic Parameters.
von Bueren AO, Kortmann RD, von Hoff K, Friedrich C, Mynarek M, Müller K, Goschzik T, Zur Mühlen A, Gerber N, Warmuth-Metz M, Soerensen N, Deinlein F, Benesch M, Zwiener I, Kwiecien R, Faldum A, Bode U, Fleischhack G, Hovestadt V, Kool M, Jones D, Northcott P, Kuehl J, Pfister S, Pietsch T, Rutkowski S
J Clin Oncol 2016 Dec;34(34):4151-4160. Epub 2016 Oct 31 doi: 10.1200/JCO.2016.67.2428. PMID: 27863192
Metastatic medulloblastoma at diagnosis.
Gupta S, Pant MC, Husain N, Sundar S
J Cancer Res Ther 2011 Apr-Jun;7(2):203-4. doi: 10.4103/0973-1482.82929. PMID: 21768715
Establishment and characterization of the human medulloblastoma cell line and transplantable xenograft D283 Med.
Friedman HS, Burger PC, Bigner SH, Trojanowski JQ, Wikstrand CJ, Halperin EC, Bigner DD
J Neuropathol Exp Neurol 1985 Nov;44(6):592-605. doi: 10.1097/00005072-198511000-00005. PMID: 4056828
Medulloblastoma in childhood.
Raimondi AJ, Tomita T
Acta Neurochir (Wien) 1979;50(1-2):127-38. doi: 10.1007/BF01813557. PMID: 517184

Therapy

Intrathecal delivery of nanoparticle PARP inhibitor to the cerebrospinal fluid for the treatment of metastatic medulloblastoma.
Khang M, Lee JH, Lee T, Suh HW, Lee S, Cavaliere A, Rushing A, Geraldo LH, Belitzky E, Rossano S, de Feyter HM, Shin K, Huttner A, Roussel MF, Thomas JL, Carson RE, Marquez-Nostra B, Bindra RS, Saltzman WM
Sci Transl Med 2023 Nov;15(720):eadi1617. Epub 2023 Nov 1 doi: 10.1126/scitranslmed.adi1617. PMID: 37910601Free PMC Article
Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma.
Donovan LK, Delaidelli A, Joseph SK, Bielamowicz K, Fousek K, Holgado BL, Manno A, Srikanthan D, Gad AZ, Van Ommeren R, Przelicki D, Richman C, Ramaswamy V, Daniels C, Pallota JG, Douglas T, Joynt ACM, Haapasalo J, Nor C, Vladoiu MC, Kuzan-Fischer CM, Garzia L, Mack SC, Varadharajan S, Baker ML, Hendrikse L, Ly M, Kharas K, Balin P, Wu X, Qin L, Huang N, Stucklin AG, Morrissy AS, Cavalli FMG, Luu B, Suarez R, De Antonellis P, Michealraj A, Rastan A, Hegde M, Komosa M, Sirbu O, Kumar SA, Abdullaev Z, Faria CC, Yip S, Hukin J, Tabori U, Hawkins C, Aldape K, Daugaard M, Maris JM, Sorensen PH, Ahmed N, Taylor MD
Nat Med 2020 May;26(5):720-731. Epub 2020 Apr 27 doi: 10.1038/s41591-020-0827-2. PMID: 32341580Free PMC Article
Risk-adapted therapy for young children with medulloblastoma (SJYC07): therapeutic and molecular outcomes from a multicentre, phase 2 trial.
Robinson GW, Rudneva VA, Buchhalter I, Billups CA, Waszak SM, Smith KS, Bowers DC, Bendel A, Fisher PG, Partap S, Crawford JR, Hassall T, Indelicato DJ, Boop F, Klimo P, Sabin ND, Patay Z, Merchant TE, Stewart CF, Orr BA, Korbel JO, Jones DTW, Sharma T, Lichter P, Kool M, Korshunov A, Pfister SM, Gilbertson RJ, Sanders RP, Onar-Thomas A, Ellison DW, Gajjar A, Northcott PA
Lancet Oncol 2018 Jun;19(6):768-784. Epub 2018 May 16 doi: 10.1016/S1470-2045(18)30204-3. PMID: 29778738Free PMC Article
Treatment of Children and Adolescents With Metastatic Medulloblastoma and Prognostic Relevance of Clinical and Biologic Parameters.
von Bueren AO, Kortmann RD, von Hoff K, Friedrich C, Mynarek M, Müller K, Goschzik T, Zur Mühlen A, Gerber N, Warmuth-Metz M, Soerensen N, Deinlein F, Benesch M, Zwiener I, Kwiecien R, Faldum A, Bode U, Fleischhack G, Hovestadt V, Kool M, Jones D, Northcott P, Kuehl J, Pfister S, Pietsch T, Rutkowski S
J Clin Oncol 2016 Dec;34(34):4151-4160. Epub 2016 Oct 31 doi: 10.1200/JCO.2016.67.2428. PMID: 27863192
Calbindin-d(28k): a marker of recurrence for medulloblastomas.
Pelc K, Vincent S, Ruchoux MM, Kiss R, Pochet R, Sariban E, Decaestecker C, Heizmann CW
Cancer 2002 Jul 15;95(2):410-9. doi: 10.1002/cncr.10666. PMID: 12124842

Prognosis

Cerebrospinal fluid cytokines in metastatic group 3 and 4 medulloblastoma.
Low SYY, Bte Syed Sulaiman N, Tan EEK, Ng LP, Kuick CH, Chang KTE, Tang PH, Wong RX, Looi WS, Low DCY, Seow WT
BMC Cancer 2020 Jun 15;20(1):554. doi: 10.1186/s12885-020-07048-0. PMID: 32539808Free PMC Article
Telomere elongation via alternative lengthening of telomeres (ALT) and telomerase activation in primary metastatic medulloblastoma of childhood.
Minasi S, Baldi C, Pietsch T, Donofrio V, Pollo B, Antonelli M, Massimino M, Giangaspero F, Buttarelli FR
J Neurooncol 2019 May;142(3):435-444. Epub 2019 Mar 4 doi: 10.1007/s11060-019-03127-w. PMID: 30830680
Treatment of Children and Adolescents With Metastatic Medulloblastoma and Prognostic Relevance of Clinical and Biologic Parameters.
von Bueren AO, Kortmann RD, von Hoff K, Friedrich C, Mynarek M, Müller K, Goschzik T, Zur Mühlen A, Gerber N, Warmuth-Metz M, Soerensen N, Deinlein F, Benesch M, Zwiener I, Kwiecien R, Faldum A, Bode U, Fleischhack G, Hovestadt V, Kool M, Jones D, Northcott P, Kuehl J, Pfister S, Pietsch T, Rutkowski S
J Clin Oncol 2016 Dec;34(34):4151-4160. Epub 2016 Oct 31 doi: 10.1200/JCO.2016.67.2428. PMID: 27863192
Current treatment approaches to early childhood medulloblastoma.
Rutkowski S
Expert Rev Neurother 2006 Aug;6(8):1211-21. doi: 10.1586/14737175.6.8.1211. PMID: 16893348
Medulloblastoma in childhood.
Raimondi AJ, Tomita T
Acta Neurochir (Wien) 1979;50(1-2):127-38. doi: 10.1007/BF01813557. PMID: 517184

Clinical prediction guides

Cerebrospinal fluid cytokines in metastatic group 3 and 4 medulloblastoma.
Low SYY, Bte Syed Sulaiman N, Tan EEK, Ng LP, Kuick CH, Chang KTE, Tang PH, Wong RX, Looi WS, Low DCY, Seow WT
BMC Cancer 2020 Jun 15;20(1):554. doi: 10.1186/s12885-020-07048-0. PMID: 32539808Free PMC Article
Hand1 overexpression inhibits medulloblastoma metastasis.
Asuthkar S, Guda MR, Martin SE, Antony R, Fernandez K, Lin J, Tsung AJ, Velpula KK
Biochem Biophys Res Commun 2016 Aug 19;477(2):215-21. Epub 2016 Jun 11 doi: 10.1016/j.bbrc.2016.06.045. PMID: 27297109
Biomarker-driven stratification of disease-risk in non-metastatic medulloblastoma: Results from the multi-center HIT-SIOP-PNET4 clinical trial.
Clifford SC, Lannering B, Schwalbe EC, Hicks D, O'Toole K, Nicholson SL, Goschzik T, Zur Mühlen A, Figarella-Branger D, Doz F, Rutkowski S, Gustafsson G, Pietsch T; SIOP-Europe PNET Group
Oncotarget 2015 Nov 17;6(36):38827-39. doi: 10.18632/oncotarget.5149. PMID: 26420814Free PMC Article
Medulloblastoma subgroups remain stable across primary and metastatic compartments.
Wang X, Dubuc AM, Ramaswamy V, Mack S, Gendoo DM, Remke M, Wu X, Garzia L, Luu B, Cavalli F, Peacock J, López B, Skowron P, Zagzag D, Lyden D, Hoffman C, Cho YJ, Eberhart C, MacDonald T, Li XN, Van Meter T, Northcott PA, Haibe-Kains B, Hawkins C, Rutka JT, Bouffet E, Pfister SM, Korshunov A, Taylor MD
Acta Neuropathol 2015 Mar;129(3):449-57. Epub 2015 Jan 21 doi: 10.1007/s00401-015-1389-0. PMID: 25689980Free PMC Article
Calbindin-d(28k): a marker of recurrence for medulloblastomas.
Pelc K, Vincent S, Ruchoux MM, Kiss R, Pochet R, Sariban E, Decaestecker C, Heizmann CW
Cancer 2002 Jul 15;95(2):410-9. doi: 10.1002/cncr.10666. PMID: 12124842

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