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Leukocyte migration defect

MedGen UID:
1788791
•Concept ID:
C5539816
•
Finding
Synonyms: Abnormal leukocyte migration; Defects of leukocyte migration
 
HPO: HP:0033797

Definition

Any abnormality of leukocyte motility in response to chemokines, which is required for the inflammatory response to infections, and for organ development, tissues homeostasis, and vascularization. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeukocyte migration defect

Professional guidelines

PubMed

The mechanistic impact of CD22 engagement with epratuzumab on B cell function: Implications for the treatment of systemic lupus erythematosus.
Dörner T, Shock A, Goldenberg DM, Lipsky PE
Autoimmun Rev 2015 Dec;14(12):1079-86. Epub 2015 Jul 23 doi: 10.1016/j.autrev.2015.07.013. PMID: 26212727
Allogeneic mesenchymal stem cell treatment alleviates experimental and clinical Sjögren syndrome.
Xu J, Wang D, Liu D, Fan Z, Zhang H, Liu O, Ding G, Gao R, Zhang C, Ding Y, Bromberg JS, Chen W, Sun L, Wang S
Blood 2012 Oct 11;120(15):3142-51. Epub 2012 Aug 27 doi: 10.1182/blood-2011-11-391144. PMID: 22927248Free PMC Article
The syndrome of asthma, recurrent viral infections and T-cell immunodeficiency: investigations and management.
Khan A
Ann Allergy 1979 Aug;43(2):69-72. PMID: 380414

Recent clinical studies

Etiology

Neutrophil-mediated innate immune resistance to bacterial pneumonia is dependent on Tet2 function.
Quin C, DeJong EN, Cook EK, Luo YZ, Vlasschaert C, Sadh S, McNaughton AJ, Buttigieg MM, Breznik JA, Kennedy AE, Zhao K, Mewburn J, Dunham-Snary KJ, Hindmarch CC, Bick AG, Archer SL, Rauh MJ, Bowdish DM
J Clin Invest 2024 Apr 4;134(11) doi: 10.1172/JCI171002. PMID: 38573824Free PMC Article
Clinical and functional spectrum of RAC2-related immunodeficiency.
Donkó Á, Sharapova SO, Kabat J, Ganesan S, Hauck FH, Bergerson JRE, Marois L, Abbott J, Moshous D, Williams KW, Campbell N, Martin PL, Lagresle-Peyrou C, Trojan T, Kuzmenko NB, Deordieva EA, Raykina EV, Abers MS, Abolhassani H, Barlogis V, Milla C, Hall G, Mousallem T, Church J, Kapoor N, Cros G, Chapdelaine H, Franco-Jarava C, Lopez-Lerma I, Miano M, Leiding JW, Klein C, Stasia MJ, Fischer A, Hsiao KC, Martelius T, Seppänen MRJ, Barmettler S, Walter J, Masmas TN, Mukhina AA, Falcone EL, Kracker S, Shcherbina A, Holland SM, Leto TL, Hsu AP
Blood 2024 Apr 11;143(15):1476-1487. doi: 10.1182/blood.2023022098. PMID: 38194689Free PMC Article
Adenoid lymphocyte heterogeneity in pediatric adenoid hypertrophy and obstructive sleep apnea.
Zhu Y, Wang S, Yang Y, Shen B, Wang A, Zhang X, Zhang X, Li N, Gao Z, Liu Y, Zhu J, Wei Z, Guan J, Su K, Liu F, Gu M, Yin S
Front Immunol 2023;14:1186258. Epub 2023 May 22 doi: 10.3389/fimmu.2023.1186258. PMID: 37283767Free PMC Article
Combined immunodeficiencies.
Aranda CS, Guimarães RR, de Gouveia-Pereira Pimentel M
J Pediatr (Rio J) 2021 Mar-Apr;97 Suppl 1(Suppl 1):S39-S48. Epub 2020 Dec 17 doi: 10.1016/j.jped.2020.10.014. PMID: 33340461Free PMC Article
Crohn's disease.
Baumgart DC, Sandborn WJ
Lancet 2012 Nov 3;380(9853):1590-605. Epub 2012 Aug 20 doi: 10.1016/S0140-6736(12)60026-9. PMID: 22914295

Diagnosis

Innovative breakthroughs facilitated by single-cell multi-omics: manipulating natural killer cell functionality correlates with a novel subcategory of melanoma cells.
Zhao Z, Ding Y, Tran LJ, Chai G, Lin L
Front Immunol 2023;14:1196892. Epub 2023 Jun 26 doi: 10.3389/fimmu.2023.1196892. PMID: 37435067Free PMC Article
Combined immunodeficiencies.
Aranda CS, Guimarães RR, de Gouveia-Pereira Pimentel M
J Pediatr (Rio J) 2021 Mar-Apr;97 Suppl 1(Suppl 1):S39-S48. Epub 2020 Dec 17 doi: 10.1016/j.jped.2020.10.014. PMID: 33340461Free PMC Article
Disorders of neutrophil function: an overview.
Dinauer MC
Methods Mol Biol 2014;1124:501-15. doi: 10.1007/978-1-62703-845-4_30. PMID: 24504971
Leukocyte adhesion deficiencies.
van de Vijver E, van den Berg TK, Kuijpers TW
Hematol Oncol Clin North Am 2013 Feb;27(1):101-16, viii. Epub 2012 Nov 13 doi: 10.1016/j.hoc.2012.10.001. PMID: 23351991
Crohn's disease.
Baumgart DC, Sandborn WJ
Lancet 2012 Nov 3;380(9853):1590-605. Epub 2012 Aug 20 doi: 10.1016/S0140-6736(12)60026-9. PMID: 22914295

Therapy

Histidine-rich glycoprotein modulates neutrophils and thrombolysis-associated hemorrhagic transformation.
Jiang W, Zhao Y, Liu R, Zhang B, Xie Y, Gao B, Shi K, Zou M, Jia D, Ding J, Hu X, Duan Y, Han R, Huang D, Van Kaer L, Shi FD
EMBO Mol Med 2024 Sep;16(9):2146-2169. Epub 2024 Aug 15 doi: 10.1038/s44321-024-00117-y. PMID: 39148004Free PMC Article
Clinical and functional spectrum of RAC2-related immunodeficiency.
Donkó Á, Sharapova SO, Kabat J, Ganesan S, Hauck FH, Bergerson JRE, Marois L, Abbott J, Moshous D, Williams KW, Campbell N, Martin PL, Lagresle-Peyrou C, Trojan T, Kuzmenko NB, Deordieva EA, Raykina EV, Abers MS, Abolhassani H, Barlogis V, Milla C, Hall G, Mousallem T, Church J, Kapoor N, Cros G, Chapdelaine H, Franco-Jarava C, Lopez-Lerma I, Miano M, Leiding JW, Klein C, Stasia MJ, Fischer A, Hsiao KC, Martelius T, Seppänen MRJ, Barmettler S, Walter J, Masmas TN, Mukhina AA, Falcone EL, Kracker S, Shcherbina A, Holland SM, Leto TL, Hsu AP
Blood 2024 Apr 11;143(15):1476-1487. doi: 10.1182/blood.2023022098. PMID: 38194689Free PMC Article
Lenalidomide enhances CD23.CAR T cell therapy in chronic lymphocytic leukemia.
Tettamanti S, Rotiroti MC, Giordano Attianese GMP, Arcangeli S, Zhang R, Banerjee P, Galletti G, McManus S, Mazza M, Nicolini F, Martinelli G, Ivan C, Veliz Rodriguez T, Barbaglio F, Scarfò L, Ponzoni M, Wierda W, Gandhi V, Keating M, Biondi A, Caligaris-Cappio F, Biagi E, Ghia P, Bertilaccio MTS
Leuk Lymphoma 2022 Jul;63(7):1566-1579. Epub 2022 Mar 8 doi: 10.1080/10428194.2022.2043299. PMID: 35259043Free PMC Article
Vitiligo Pathogenesis and Emerging Treatments.
Rashighi M, Harris JE
Dermatol Clin 2017 Apr;35(2):257-265. doi: 10.1016/j.det.2016.11.014. PMID: 28317534Free PMC Article
Lazy leukocyte syndrome.
Patrone F, Dallegri F, Rebora A, Sacchetti C
Blut 1979 Oct;39(4):265-9. doi: 10.1007/BF01013219. PMID: 497407

Prognosis

Reconstitution of the Multiple Myeloma Microenvironment Following Lymphodepletion with BCMA CAR-T Therapy.
Yang Y, Qin S, Yang M, Wang T, Feng R, Zhang C, Zheng E, Li Q, Xiang P, Ning S, Xu X, Zuo X, Zhang S, Yun X, Zhou X, Wang Y, He L, Shang Y, Sun L, Liu H
Clin Cancer Res 2024 Sep 13;30(18):4201-4214. doi: 10.1158/1078-0432.CCR-24-0352. PMID: 39024031Free PMC Article
Innovative breakthroughs facilitated by single-cell multi-omics: manipulating natural killer cell functionality correlates with a novel subcategory of melanoma cells.
Zhao Z, Ding Y, Tran LJ, Chai G, Lin L
Front Immunol 2023;14:1196892. Epub 2023 Jun 26 doi: 10.3389/fimmu.2023.1196892. PMID: 37435067Free PMC Article
Combined immunodeficiencies.
Aranda CS, Guimarães RR, de Gouveia-Pereira Pimentel M
J Pediatr (Rio J) 2021 Mar-Apr;97 Suppl 1(Suppl 1):S39-S48. Epub 2020 Dec 17 doi: 10.1016/j.jped.2020.10.014. PMID: 33340461Free PMC Article
Leukocyte adhesion deficiencies.
van de Vijver E, van den Berg TK, Kuijpers TW
Hematol Oncol Clin North Am 2013 Feb;27(1):101-16, viii. Epub 2012 Nov 13 doi: 10.1016/j.hoc.2012.10.001. PMID: 23351991
Impaired collateral vessel development in diabetes: potential cellular mechanisms and therapeutic implications.
Waltenberger J
Cardiovasc Res 2001 Feb 16;49(3):554-60. doi: 10.1016/s0008-6363(00)00228-5. PMID: 11166268

Clinical prediction guides

Reconstitution of the Multiple Myeloma Microenvironment Following Lymphodepletion with BCMA CAR-T Therapy.
Yang Y, Qin S, Yang M, Wang T, Feng R, Zhang C, Zheng E, Li Q, Xiang P, Ning S, Xu X, Zuo X, Zhang S, Yun X, Zhou X, Wang Y, He L, Shang Y, Sun L, Liu H
Clin Cancer Res 2024 Sep 13;30(18):4201-4214. doi: 10.1158/1078-0432.CCR-24-0352. PMID: 39024031Free PMC Article
Self-extinguishing relay waves enable homeostatic control of human neutrophil swarming.
Strickland E, Pan D, Godfrey C, Kim JS, Hopke A, Ji W, Degrange M, Villavicencio B, Mansour MK, Zerbe CS, Irimia D, Amir A, Weiner OD
Dev Cell 2024 Oct 7;59(19):2659-2671.e4. Epub 2024 Jul 5 doi: 10.1016/j.devcel.2024.06.003. PMID: 38971157Free PMC Article
Clinical and functional spectrum of RAC2-related immunodeficiency.
Donkó Á, Sharapova SO, Kabat J, Ganesan S, Hauck FH, Bergerson JRE, Marois L, Abbott J, Moshous D, Williams KW, Campbell N, Martin PL, Lagresle-Peyrou C, Trojan T, Kuzmenko NB, Deordieva EA, Raykina EV, Abers MS, Abolhassani H, Barlogis V, Milla C, Hall G, Mousallem T, Church J, Kapoor N, Cros G, Chapdelaine H, Franco-Jarava C, Lopez-Lerma I, Miano M, Leiding JW, Klein C, Stasia MJ, Fischer A, Hsiao KC, Martelius T, Seppänen MRJ, Barmettler S, Walter J, Masmas TN, Mukhina AA, Falcone EL, Kracker S, Shcherbina A, Holland SM, Leto TL, Hsu AP
Blood 2024 Apr 11;143(15):1476-1487. doi: 10.1182/blood.2023022098. PMID: 38194689Free PMC Article
Lenalidomide enhances CD23.CAR T cell therapy in chronic lymphocytic leukemia.
Tettamanti S, Rotiroti MC, Giordano Attianese GMP, Arcangeli S, Zhang R, Banerjee P, Galletti G, McManus S, Mazza M, Nicolini F, Martinelli G, Ivan C, Veliz Rodriguez T, Barbaglio F, Scarfò L, Ponzoni M, Wierda W, Gandhi V, Keating M, Biondi A, Caligaris-Cappio F, Biagi E, Ghia P, Bertilaccio MTS
Leuk Lymphoma 2022 Jul;63(7):1566-1579. Epub 2022 Mar 8 doi: 10.1080/10428194.2022.2043299. PMID: 35259043Free PMC Article
Natural killer cell-mediated immunosurveillance of human cancer.
Malmberg KJ, Carlsten M, Björklund A, Sohlberg E, Bryceson YT, Ljunggren HG
Semin Immunol 2017 Jun;31:20-29. Epub 2017 Sep 6 doi: 10.1016/j.smim.2017.08.002. PMID: 28888619

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