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Ovarian Dedifferentiated Carcinoma

MedGen UID:
1792061
•Concept ID:
C5555620
•
Neoplastic Process

Definition

An aggressive carcinoma arising from the ovary. Most patients present with advanced disease. Microscopically, it is characterized by the presence of an undifferentiated carcinomatous component and a second component of either endometrioid carcinoma or, rarely, serous carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian Dedifferentiated Carcinoma

Professional guidelines

PubMed

The value of SOX2 in the differential diagnosis of SMARCA4 (BRG1)-deficient uterine neoplasms.
Zheng L, Zhang L, Wang XI, Katz G, Tandon N, Zhao B, Lucci J, Ding J, Zhang S
Hum Pathol 2022 Jun;124:45-55. Epub 2022 Mar 22 doi: 10.1016/j.humpath.2022.03.009. PMID: 35331811

Recent clinical studies

Etiology

Trichorhinophalangeal Syndrome Type 1 Immunohistochemical Expression in Carcinomas of Gynecologic Origin.
Ruiz F, Tjendra Y, Millan N, Gomez-Fernandez C, Pinto A
Am J Surg Pathol 2024 May 1;48(5):546-550. Epub 2024 Feb 15 doi: 10.1097/PAS.0000000000002193. PMID: 38357982
Undifferentiated and dedifferentiated neoplasms of the female genital tract.
Bennett JA, Oliva E
Semin Diagn Pathol 2021 Nov;38(6):137-151. Epub 2020 Nov 27 doi: 10.1053/j.semdp.2020.11.002. PMID: 33323288
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172
Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications.
Kurman RJ, Shih IeM
Int J Gynecol Pathol 2008 Apr;27(2):151-60. doi: 10.1097/PGP.0b013e318161e4f5. PMID: 18317228Free PMC Article
Pteridines in the assessment of neoplasia.
Hausen A, Wachter H
J Clin Chem Clin Biochem 1982 Sep;20(9):593-602. doi: 10.1515/cclm.1982.20.9.593. PMID: 6754854

Diagnosis

Trichorhinophalangeal Syndrome Type 1 Immunohistochemical Expression in Carcinomas of Gynecologic Origin.
Ruiz F, Tjendra Y, Millan N, Gomez-Fernandez C, Pinto A
Am J Surg Pathol 2024 May 1;48(5):546-550. Epub 2024 Feb 15 doi: 10.1097/PAS.0000000000002193. PMID: 38357982
Undifferentiated and dedifferentiated neoplasms of the female genital tract.
Bennett JA, Oliva E
Semin Diagn Pathol 2021 Nov;38(6):137-151. Epub 2020 Nov 27 doi: 10.1053/j.semdp.2020.11.002. PMID: 33323288
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172
Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications.
Kurman RJ, Shih IeM
Int J Gynecol Pathol 2008 Apr;27(2):151-60. doi: 10.1097/PGP.0b013e318161e4f5. PMID: 18317228Free PMC Article
Pteridines in the assessment of neoplasia.
Hausen A, Wachter H
J Clin Chem Clin Biochem 1982 Sep;20(9):593-602. doi: 10.1515/cclm.1982.20.9.593. PMID: 6754854

Therapy

The epithelial-mesenchymal transition and the estrogen-signaling in ovarian cancer.
Gallo D, Ferlini C, Scambia G
Curr Drug Targets 2010 Apr;11(4):474-81. doi: 10.2174/138945010790980385. PMID: 20015012
Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications.
Kurman RJ, Shih IeM
Int J Gynecol Pathol 2008 Apr;27(2):151-60. doi: 10.1097/PGP.0b013e318161e4f5. PMID: 18317228Free PMC Article
Histologic and immunohistochemical analysis of tissue response to adenovirus-mediated herpes simplex thymidine kinase gene therapy of ovarian cancer.
Hasenburg A, Fischer DC, Tong XW, Rojas-Martinez A, Nyberg-Hoffman C, Orlowska-Volk M, Kohlberger P, Kaufman RH, Ramzy I, Aguilar-Cordova E, Kieback DG
Int J Gynecol Cancer 2002 Jan-Feb;12(1):66-73. doi: 10.1046/j.1525-1438.2002.01068.x. PMID: 11860538
Performance characteristics of the Indiana University Medical Center endometrial sampler (Tao Brush) in an outpatient office setting, first year's outcomes: recognizing histological patterns in cytology preparations of endometrial brushings.
Maksem JA
Diagn Cytopathol 2000 Mar;22(3):186-95. doi: 10.1002/(sici)1097-0339(20000301)22:3<186::aid-dc11>3.0.co;2-p. PMID: 10680001
Ovarian mucinous cystadenocarcinoma with sarcoma-appearing mural nodule of anaplastic carcinoma.
Tsuruchi N, Kaku T, Kinoshita H, Amada S, Saito T, Kamura T, Tsukamoto N, Nakano H
Gynecol Oncol 1993 Aug;50(2):259-63. doi: 10.1006/gyno.1993.1204. PMID: 8375741

Prognosis

The value of SOX2 in the differential diagnosis of SMARCA4 (BRG1)-deficient uterine neoplasms.
Zheng L, Zhang L, Wang XI, Katz G, Tandon N, Zhao B, Lucci J, Ding J, Zhang S
Hum Pathol 2022 Jun;124:45-55. Epub 2022 Mar 22 doi: 10.1016/j.humpath.2022.03.009. PMID: 35331811
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172
Decreased expression of BTG3 was linked to carcinogenesis, aggressiveness, and prognosis of ovarian carcinoma.
Deng B, Zhao Y, Gou W, Chen S, Mao X, Takano Y, Zheng H
Tumour Biol 2013 Oct;34(5):2617-24. Epub 2013 May 9 doi: 10.1007/s13277-013-0811-2. PMID: 23657964Free PMC Article
POLD2 and KSP37 (FGFBP2) correlate strongly with histology, stage and outcome in ovarian carcinomas.
Elgaaen BV, Haug KB, Wang J, Olstad OK, Fortunati D, Onsrud M, Staff AC, Sauer T, Gautvik KM
PLoS One 2010 Nov 4;5(11):e13837. doi: 10.1371/journal.pone.0013837. PMID: 21079801Free PMC Article
Pteridines in the assessment of neoplasia.
Hausen A, Wachter H
J Clin Chem Clin Biochem 1982 Sep;20(9):593-602. doi: 10.1515/cclm.1982.20.9.593. PMID: 6754854

Clinical prediction guides

Trichorhinophalangeal Syndrome Type 1 Immunohistochemical Expression in Carcinomas of Gynecologic Origin.
Ruiz F, Tjendra Y, Millan N, Gomez-Fernandez C, Pinto A
Am J Surg Pathol 2024 May 1;48(5):546-550. Epub 2024 Feb 15 doi: 10.1097/PAS.0000000000002193. PMID: 38357982
Mixed Endometrioid Adenocarcinoma and Müllerian Adenosarcoma of the Uterus and Ovary: Clinicopathologic Characterization With Emphasis on its Distinction From Carcinosarcoma.
El Hallani S, Arora R, Lin DI, Måsbäc A, Mateoiu C, McCluggage WG, Nucci MR, Otis CN, Parkash V, Parra-Herran C, Longacre TA
Am J Surg Pathol 2021 Mar 1;45(3):374-383. doi: 10.1097/PAS.0000000000001643. PMID: 33565764
Loss of ARID1B and SMARCB1 expression are specific for the diagnosis of dedifferentiated/undifferentiated carcinoma in tumours of the upper gynaecological tract and cervix.
Kang EY, Tessier-Cloutier B, Duggan MA, Stewart CJR, Lee CH, Köbel M
Histopathology 2021 Aug;79(2):160-167. Epub 2021 Jun 2 doi: 10.1111/his.14333. PMID: 33432679
Dedifferentiation into blastomere-like cancer stem cells via formation of polyploid giant cancer cells.
Niu N, Mercado-Uribe I, Liu J
Oncogene 2017 Aug 24;36(34):4887-4900. Epub 2017 Apr 24 doi: 10.1038/onc.2017.72. PMID: 28436947Free PMC Article
Ovarian endometrioid adenocarcinoma: incidence and clinical significance of the morphologic and immunohistochemical markers of mismatch repair protein defects and tumor microsatellite instability.
Aysal A, Karnezis A, Medhi I, Grenert JP, Zaloudek CJ, Rabban JT
Am J Surg Pathol 2012 Feb;36(2):163-72. doi: 10.1097/PAS.0b013e31823bc434. PMID: 22189970

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