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Endometrial Mucinous Adenocarcinoma, Gastric-Type

MedGen UID:
1792891
•Concept ID:
C5556450
•
Neoplastic Process

Definition

A rare mucinous adenocarcinoma arising from gastric metaplasia of the endometrium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndometrial Mucinous Adenocarcinoma, Gastric-Type

Professional guidelines

PubMed

International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article

Recent clinical studies

Etiology

Mucinous Proliferations of the Uterine Corpus: Comprehensive Appraisal of an Evolving Spectrum of Neoplasms.
Fadare O
Adv Anat Pathol 2022 Sep 1;29(5):275-296. Epub 2022 May 3 doi: 10.1097/PAP.0000000000000348. PMID: 35499137
Endometrial Gastric (Gastrointestinal)-type Mucinous Lesions: Report of a Series Illustrating the Spectrum of Benign and Malignant Lesions.
Wong RW, Ralte A, Grondin K, Talia KL, McCluggage WG
Am J Surg Pathol 2020 Mar;44(3):406-419. doi: 10.1097/PAS.0000000000001381. PMID: 31567280
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Endocervical adenocarcinoma: selected diagnostic challenges.
Ronnett BM
Mod Pathol 2016 Jan;29 Suppl 1:S12-28. doi: 10.1038/modpathol.2015.131. PMID: 26715171
Cytologic features of gastric-type adenocarcinoma of the uterine cervix.
Kawakami F, Mikami Y, Sudo T, Fujiwara K, Hirose T, Itoh T
Diagn Cytopathol 2015 Oct;43(10):791-6. Epub 2015 Jul 14 doi: 10.1002/dc.23304. PMID: 26173165

Diagnosis

Primary endometrial gastric (gastro-intestinal)-type carcinoma: A practical approach.
Dridi M, Peoc'h M, Karpathiou G
Pathol Res Pract 2023 Jan;241:154271. Epub 2022 Dec 6 doi: 10.1016/j.prp.2022.154271. PMID: 36502736
Molecular characterization of gastric-type endocervical adenocarcinoma using next-generation sequencing.
Garg S, Nagaria TS, Clarke B, Freedman O, Khan Z, Schwock J, Bernardini MQ, Oza AM, Han K, Smith AC, Stockley TL, Rouzbahman M
Mod Pathol 2019 Dec;32(12):1823-1833. Epub 2019 Jul 15 doi: 10.1038/s41379-019-0305-x. PMID: 31308508
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Endocervical adenocarcinoma: selected diagnostic challenges.
Ronnett BM
Mod Pathol 2016 Jan;29 Suppl 1:S12-28. doi: 10.1038/modpathol.2015.131. PMID: 26715171
Cytologic features of gastric-type adenocarcinoma of the uterine cervix.
Kawakami F, Mikami Y, Sudo T, Fujiwara K, Hirose T, Itoh T
Diagn Cytopathol 2015 Oct;43(10):791-6. Epub 2015 Jul 14 doi: 10.1002/dc.23304. PMID: 26173165

Prognosis

Endometrial Gastric (Gastrointestinal)-type Mucinous Lesions: Report of a Series Illustrating the Spectrum of Benign and Malignant Lesions.
Wong RW, Ralte A, Grondin K, Talia KL, McCluggage WG
Am J Surg Pathol 2020 Mar;44(3):406-419. doi: 10.1097/PAS.0000000000001381. PMID: 31567280
Trefoil factor family 2 protein: a potential immunohistochemical marker for aiding diagnosis of lobular endocervical glandular hyperplasia and gastric-type adenocarcinoma of the uterine cervix.
Asaka S, Nakajima T, Momose M, Miyamoto T, Uehara T, Ota H
Virchows Arch 2019 Jan;474(1):79-86. Epub 2018 Oct 15 doi: 10.1007/s00428-018-2469-z. PMID: 30324235
Uncommon hereditary gynaecological tumour syndromes: pathological features in tumours that may predict risk for a germline mutation.
Garg K, Karnezis AN, Rabban JT
Pathology 2018 Feb;50(2):238-256. Epub 2018 Jan 17 doi: 10.1016/j.pathol.2017.10.009. PMID: 29373116
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Endocervical glandular lesions exhibiting gastric differentiation: an emerging spectrum of benign, premalignant, and malignant lesions.
Mikami Y, McCluggage WG
Adv Anat Pathol 2013 Jul;20(4):227-37. doi: 10.1097/PAP.0b013e31829c2d66. PMID: 23752085

Clinical prediction guides

Molecular characterization of gastric-type endocervical adenocarcinoma using next-generation sequencing.
Garg S, Nagaria TS, Clarke B, Freedman O, Khan Z, Schwock J, Bernardini MQ, Oza AM, Han K, Smith AC, Stockley TL, Rouzbahman M
Mod Pathol 2019 Dec;32(12):1823-1833. Epub 2019 Jul 15 doi: 10.1038/s41379-019-0305-x. PMID: 31308508
Trefoil factor family 2 protein: a potential immunohistochemical marker for aiding diagnosis of lobular endocervical glandular hyperplasia and gastric-type adenocarcinoma of the uterine cervix.
Asaka S, Nakajima T, Momose M, Miyamoto T, Uehara T, Ota H
Virchows Arch 2019 Jan;474(1):79-86. Epub 2018 Oct 15 doi: 10.1007/s00428-018-2469-z. PMID: 30324235
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Cytologic features of gastric-type adenocarcinoma of the uterine cervix.
Kawakami F, Mikami Y, Sudo T, Fujiwara K, Hirose T, Itoh T
Diagn Cytopathol 2015 Oct;43(10):791-6. Epub 2015 Jul 14 doi: 10.1002/dc.23304. PMID: 26173165
Endocervical glandular lesions exhibiting gastric differentiation: an emerging spectrum of benign, premalignant, and malignant lesions.
Mikami Y, McCluggage WG
Adv Anat Pathol 2013 Jul;20(4):227-37. doi: 10.1097/PAP.0b013e31829c2d66. PMID: 23752085

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