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Decreased dendritic spine number

MedGen UID:
1814113
•Concept ID:
C5558378
•
Finding
HPO: HP:0034005

Definition

An abnormal reduction in the amount of spines on a given dendrite. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased dendritic spine number

Professional guidelines

PubMed

Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of Alzheimer's amyloidosis.
Maiti P, Bowers Z, Bourcier-Schultz A, Morse J, Dunbar GL
Alzheimers Res Ther 2021 Feb 8;13(1):37. doi: 10.1186/s13195-021-00769-9. PMID: 33557949Free PMC Article
PLA2G4E, a candidate gene for resilience in Alzheimer´s disease and a new target for dementia treatment.
Pérez-González M, Mendioroz M, Badesso S, Sucunza D, Roldan M, Espelosín M, Ursua S, Luján R, Cuadrado-Tejedor M, Garcia-Osta A
Prog Neurobiol 2020 Aug;191:101818. Epub 2020 May 5 doi: 10.1016/j.pneurobio.2020.101818. PMID: 32380223
Levodopa treatment and dendritic spine pathology.
Nishijima H, Ueno T, Funamizu Y, Ueno S, Tomiyama M
Mov Disord 2018 Jul;33(6):877-888. Epub 2017 Sep 7 doi: 10.1002/mds.27172. PMID: 28880414Free PMC Article

Recent clinical studies

Etiology

Electroacupuncture modulates glutamate neurotransmission to alleviate PTSD-like behaviors in a PTSD animal model.
Cai M, Park HR, Yang EJ
Transl Psychiatry 2023 Nov 22;13(1):357. doi: 10.1038/s41398-023-02663-4. PMID: 37993441Free PMC Article
The mechanism of Girdin in degenerative brain disease caused by high glucose stimulation.
Liu L, Zhang J, Han Y, Liu D
Front Endocrinol (Lausanne) 2022;13:892897. Epub 2022 Oct 3 doi: 10.3389/fendo.2022.892897. PMID: 36329890Free PMC Article
Stress induced neural reorganization: A conceptual framework linking depression and Alzheimer's disease.
Ross JA, Gliebus G, Van Bockstaele EJ
Prog Neuropsychopharmacol Biol Psychiatry 2018 Jul 13;85:136-151. Epub 2017 Aug 10 doi: 10.1016/j.pnpbp.2017.08.004. PMID: 28803923Free PMC Article
Autism spectrum disorder: neuropathology and animal models.
Varghese M, Keshav N, Jacot-Descombes S, Warda T, Wicinski B, Dickstein DL, Harony-Nicolas H, De Rubeis S, Drapeau E, Buxbaum JD, Hof PR
Acta Neuropathol 2017 Oct;134(4):537-566. Epub 2017 Jun 5 doi: 10.1007/s00401-017-1736-4. PMID: 28584888Free PMC Article
When cortical development goes wrong: schizophrenia as a neurodevelopmental disease of microcircuits.
Garey L
J Anat 2010 Oct;217(4):324-33. doi: 10.1111/j.1469-7580.2010.01231.x. PMID: 20408906Free PMC Article

Diagnosis

Decreased PD-1 expression on circulating CD4(+)T cell and PD-L1 expression on myeloid dendritic cell correlate with clinical manifestations in systemic juvenile idiopathic arthritis.
Cai L, Zhang C, Wu J, Zhou W, Chen T
Joint Bone Spine 2019 Jan;86(1):61-68. Epub 2018 Mar 30 doi: 10.1016/j.jbspin.2018.03.003. PMID: 29609005
Autism spectrum disorder: neuropathology and animal models.
Varghese M, Keshav N, Jacot-Descombes S, Warda T, Wicinski B, Dickstein DL, Harony-Nicolas H, De Rubeis S, Drapeau E, Buxbaum JD, Hof PR
Acta Neuropathol 2017 Oct;134(4):537-566. Epub 2017 Jun 5 doi: 10.1007/s00401-017-1736-4. PMID: 28584888Free PMC Article
When cortical development goes wrong: schizophrenia as a neurodevelopmental disease of microcircuits.
Garey L
J Anat 2010 Oct;217(4):324-33. doi: 10.1111/j.1469-7580.2010.01231.x. PMID: 20408906Free PMC Article
Development of rostral prefrontal cortex and cognitive and behavioural disorders.
Dumontheil I, Burgess PW, Blakemore SJ
Dev Med Child Neurol 2008 Mar;50(3):168-81. Epub 2008 Jan 11 doi: 10.1111/j.1469-8749.2008.02026.x. PMID: 18190537Free PMC Article
Neurons and their dendrites in frontotemporal dementia.
Ferrer I
Dement Geriatr Cogn Disord 1999;10 Suppl 1:55-60. doi: 10.1159/000051214. PMID: 10436342

Therapy

Psilocybin facilitates fear extinction in mice by promoting hippocampal neuroplasticity.
Du Y, Li Y, Zhao X, Yao Y, Wang B, Zhang L, Wang G
Chin Med J (Engl) 2023 Dec 20;136(24):2983-2992. Epub 2023 Mar 30 doi: 10.1097/CM9.0000000000002647. PMID: 37000971Free PMC Article
Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease.
Reddy PH, Yin X, Manczak M, Kumar S, Pradeepkiran JA, Vijayan M, Reddy AP
Hum Mol Genet 2018 Jul 15;27(14):2502-2516. doi: 10.1093/hmg/ddy154. PMID: 29701781Free PMC Article
Levodopa treatment and dendritic spine pathology.
Nishijima H, Ueno T, Funamizu Y, Ueno S, Tomiyama M
Mov Disord 2018 Jul;33(6):877-888. Epub 2017 Sep 7 doi: 10.1002/mds.27172. PMID: 28880414Free PMC Article
Stress induced neural reorganization: A conceptual framework linking depression and Alzheimer's disease.
Ross JA, Gliebus G, Van Bockstaele EJ
Prog Neuropsychopharmacol Biol Psychiatry 2018 Jul 13;85:136-151. Epub 2017 Aug 10 doi: 10.1016/j.pnpbp.2017.08.004. PMID: 28803923Free PMC Article
The flavonoid baicalein rescues synaptic plasticity and memory deficits in a mouse model of Alzheimer's disease.
Gu XH, Xu LJ, Liu ZQ, Wei B, Yang YJ, Xu GG, Yin XP, Wang W
Behav Brain Res 2016 Sep 15;311:309-321. Epub 2016 May 24 doi: 10.1016/j.bbr.2016.05.052. PMID: 27233830

Prognosis

Intramyocardial injection of human adipose-derived stem cells ameliorates cognitive deficit by regulating oxidative stress-mediated hippocampal damage after myocardial infarction.
Lee TM, Lee CC, Harn HJ, Chiou TW, Chuang MH, Chen CH, Chuang CH, Lin PC, Lin SZ
J Mol Med (Berl) 2021 Dec;99(12):1815-1827. Epub 2021 Oct 11 doi: 10.1007/s00109-021-02135-6. PMID: 34633469Free PMC Article
Excess Neuronal Branching Allows for Local Innervation of Specific Dendritic Compartments in Mature Cortex.
Bird AD, Deters LH, Cuntz H
Cereb Cortex 2021 Jan 5;31(2):1008-1031. doi: 10.1093/cercor/bhaa271. PMID: 33078188
Stress induced neural reorganization: A conceptual framework linking depression and Alzheimer's disease.
Ross JA, Gliebus G, Van Bockstaele EJ
Prog Neuropsychopharmacol Biol Psychiatry 2018 Jul 13;85:136-151. Epub 2017 Aug 10 doi: 10.1016/j.pnpbp.2017.08.004. PMID: 28803923Free PMC Article
The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders.
Chang H, Hoshina N, Zhang C, Ma Y, Cao H, Wang Y, Wu DD, Bergen SE, Landén M, Hultman CM, Preisig M, Kutalik Z, Castelao E, Grigoroiu-Serbanescu M, Forstner AJ, Strohmaier J, Hecker J, Schulze TG, Müller-Myhsok B, Reif A, Mitchell PB, Martin NG, Schofield PR, Cichon S, Nöthen MM; Swedish Bipolar Study Group; MooDS Bipolar Consortium, Walter H, Erk S, Heinz A, Amin N, van Duijn CM, Meyer-Lindenberg A, Tost H, Xiao X, Yamamoto T, Rietschel M, Li M
Mol Psychiatry 2018 Feb;23(2):400-412. Epub 2017 Jan 10 doi: 10.1038/mp.2016.231. PMID: 28070120Free PMC Article
Molecular profiles of pyramidal neurons in the superior temporal cortex in schizophrenia.
Pietersen CY, Mauney SA, Kim SS, Lim MP, Rooney RJ, Goldstein JM, Petryshen TL, Seidman LJ, Shenton ME, McCarley RW, Sonntag KC, Woo TU
J Neurogenet 2014 Mar-Jun;28(1-2):53-69. Epub 2014 Apr 10 doi: 10.3109/01677063.2014.882918. PMID: 24702465Free PMC Article

Clinical prediction guides

Functional Evaluation of a Novel GRIN2B Missense Variant Associated with Epilepsy and Intellectual Disability.
Wang X, Mei D, Gou L, Zhao S, Gao C, Guo J, Luo S, Guo B, Yang Z, Wang Q, Tan T, Zhang Y
Neuroscience 2023 Aug 21;526:107-120. Epub 2023 Jun 28 doi: 10.1016/j.neuroscience.2023.06.018. PMID: 37385334
MKRN3 inhibits puberty onset via interaction with IGF2BP1 and regulation of hypothalamic plasticity.
Naulé L, Mancini A, Pereira SA, Gassaway BM, Lydeard JR, Magnotto JC, Kim HK, Liang J, Matos C, Gygi SP, Merkle FT, Carroll RS, Abreu AP, Kaiser UB
JCI Insight 2023 Apr 24;8(8) doi: 10.1172/jci.insight.164178. PMID: 37092553Free PMC Article
Placental transfer of NMDAR antibodies causes reversible alterations in mice.
García-Serra A, Radosevic M, Pupak A, Brito V, Ríos J, Aguilar E, Maudes E, Ariño H, Spatola M, Mannara F, Pedreño M, Joubert B, Ginés S, Planagumà J, Dalmau J
Neurol Neuroimmunol Neuroinflamm 2021 Jan;8(1) Epub 2020 Nov 10 doi: 10.1212/NXI.0000000000000915. PMID: 33172961Free PMC Article
Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease.
Reddy PH, Yin X, Manczak M, Kumar S, Pradeepkiran JA, Vijayan M, Reddy AP
Hum Mol Genet 2018 Jul 15;27(14):2502-2516. doi: 10.1093/hmg/ddy154. PMID: 29701781Free PMC Article
Nutrition and Alzheimer's disease: pre-clinical concepts.
Kamphuis PJ, Wurtman RJ
Eur J Neurol 2009 Sep;16 Suppl 1:12-8. doi: 10.1111/j.1468-1331.2009.02737.x. PMID: 19703215

Recent systematic reviews

Synapse Pathology in Schizophrenia: A Meta-analysis of Postsynaptic Elements in Postmortem Brain Studies.
Berdenis van Berlekom A, Muflihah CH, Snijders GJLJ, MacGillavry HD, Middeldorp J, Hol EM, Kahn RS, de Witte LD
Schizophr Bull 2020 Feb 26;46(2):374-386. doi: 10.1093/schbul/sbz060. PMID: 31192350Free PMC Article
Use of human amniotic epithelial cells in mouse models of bleomycin-induced lung fibrosis: A systematic review and meta-analysis.
He F, Zhou A, Feng S
PLoS One 2018;13(5):e0197658. Epub 2018 May 17 doi: 10.1371/journal.pone.0197658. PMID: 29772024Free PMC Article

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