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Decreased dendritic spine number

MedGen UID:
1814113
•Concept ID:
C5558378
•
Finding
HPO: HP:0034005

Definition

An abnormal reduction in the amount of spines on a given dendrite. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased dendritic spine number

Professional guidelines

PubMed

Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of Alzheimer's amyloidosis.
Maiti P, Bowers Z, Bourcier-Schultz A, Morse J, Dunbar GL
Alzheimers Res Ther 2021 Feb 8;13(1):37. doi: 10.1186/s13195-021-00769-9. PMID: 33557949Free PMC Article
PLA2G4E, a candidate gene for resilience in Alzheimer´s disease and a new target for dementia treatment.
Pérez-González M, Mendioroz M, Badesso S, Sucunza D, Roldan M, Espelosín M, Ursua S, Luján R, Cuadrado-Tejedor M, Garcia-Osta A
Prog Neurobiol 2020 Aug;191:101818. Epub 2020 May 5 doi: 10.1016/j.pneurobio.2020.101818. PMID: 32380223
Levodopa treatment and dendritic spine pathology.
Nishijima H, Ueno T, Funamizu Y, Ueno S, Tomiyama M
Mov Disord 2018 Jul;33(6):877-888. Epub 2017 Sep 7 doi: 10.1002/mds.27172. PMID: 28880414Free PMC Article

Recent clinical studies

Therapy

Psilocybin facilitates fear extinction in mice by promoting hippocampal neuroplasticity.
Du Y, Li Y, Zhao X, Yao Y, Wang B, Zhang L, Wang G
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Impact of Pharmacological and Non-Pharmacological Modulators on Dendritic Spines Structure and Functions in Brain.
Mahalakshmi AM, Ray B, Tuladhar S, Hediyal TA, Raj P, Rathipriya AG, Qoronfleh MW, Essa MM, Chidambaram SB
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Hum Mol Genet 2018 Jul 15;27(14):2502-2516. doi: 10.1093/hmg/ddy154. PMID: 29701781Free PMC Article
Levodopa treatment and dendritic spine pathology.
Nishijima H, Ueno T, Funamizu Y, Ueno S, Tomiyama M
Mov Disord 2018 Jul;33(6):877-888. Epub 2017 Sep 7 doi: 10.1002/mds.27172. PMID: 28880414Free PMC Article
Stress induced neural reorganization: A conceptual framework linking depression and Alzheimer's disease.
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Prognosis

Intramyocardial injection of human adipose-derived stem cells ameliorates cognitive deficit by regulating oxidative stress-mediated hippocampal damage after myocardial infarction.
Lee TM, Lee CC, Harn HJ, Chiou TW, Chuang MH, Chen CH, Chuang CH, Lin PC, Lin SZ
J Mol Med (Berl) 2021 Dec;99(12):1815-1827. Epub 2021 Oct 11 doi: 10.1007/s00109-021-02135-6. PMID: 34633469Free PMC Article
Excess Neuronal Branching Allows for Local Innervation of Specific Dendritic Compartments in Mature Cortex.
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Stress induced neural reorganization: A conceptual framework linking depression and Alzheimer's disease.
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Prog Neuropsychopharmacol Biol Psychiatry 2018 Jul 13;85:136-151. Epub 2017 Aug 10 doi: 10.1016/j.pnpbp.2017.08.004. PMID: 28803923Free PMC Article
Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: relationship with the progression of Alzheimer's disease.
Akram A, Christoffel D, Rocher AB, Bouras C, Kövari E, Perl DP, Morrison JH, Herrmann FR, Haroutunian V, Giannakopoulos P, Hof PR
Neurobiol Aging 2008 Sep;29(9):1296-307. Epub 2007 Apr 8 doi: 10.1016/j.neurobiolaging.2007.03.007. PMID: 17420070Free PMC Article
Different dendrite and dendritic spine alterations in basal and apical arbors in mutant human amyloid precursor protein transgenic mice.
Alpár A, Ueberham U, Brückner MK, Seeger G, Arendt T, Gärtner U
Brain Res 2006 Jul 12;1099(1):189-98. Epub 2006 Jun 15 doi: 10.1016/j.brainres.2006.04.109. PMID: 16781686

Clinical prediction guides

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Recent systematic reviews

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Use of human amniotic epithelial cells in mouse models of bleomycin-induced lung fibrosis: A systematic review and meta-analysis.
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