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Anti-Ki antibody positivity

MedGen UID:
1814319
•Concept ID:
C5676750
•
Finding
HPO: HP:0034154

Definition

The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ki. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-Ki antibody positivity

Professional guidelines

PubMed

Enhanced antitumor effect of YM872 and AG1296 combination treatment on human glioblastoma xenograft models.
Watanabe T, Ohtani T, Aihara M, Ishiuchi S
J Neurosurg 2013 Apr;118(4):838-45. Epub 2013 Jan 11 doi: 10.3171/2012.11.JNS12362. PMID: 23311938
Immunohistochemical assessment of Ki-67 in the differential diagnosis of adrenocortical tumors.
Terzolo M, Boccuzzi A, Bovio S, Cappia S, De Giuli P, Alì A, Paccotti P, Porpiglia F, Fontana D, Angeli A
Urology 2001 Jan;57(1):176-82. doi: 10.1016/s0090-4295(00)00852-9. PMID: 11164177

Recent clinical studies

Etiology

Ki-67 (30-9) scoring and differentiation of Luminal A- and Luminal B-like breast cancer subtypes.
Viale G, Hanlon Newell AE, Walker E, Harlow G, Bai I, Russo L, Dell'Orto P, Maisonneuve P
Breast Cancer Res Treat 2019 Nov;178(2):451-458. Epub 2019 Aug 17 doi: 10.1007/s10549-019-05402-w. PMID: 31422497Free PMC Article
Differential expression of cyclin D1, Ki‑67, pRb, and p53 in psoriatic skin lesions and normal skin.
Kim SA, Ryu YW, Kwon JI, Choe MS, Jung JW, Cho JW
Mol Med Rep 2018 Jan;17(1):735-742. Epub 2017 Nov 8 doi: 10.3892/mmr.2017.8015. PMID: 29115643Free PMC Article
Rare autoantibodies to cellular antigens in systemic lupus erythematosus.
Fredi M, Cavazzana I, Quinzanini M, Taraborelli M, Cartella S, Tincani A, Franceschini F
Lupus 2014 Jun;23(7):672-7. Epub 2014 Feb 20 doi: 10.1177/0961203314524850. PMID: 24557777
"Silent"corticotropinoma.
Pawlikowski M, Kunert-Radek J, Radek M
Neuro Endocrinol Lett 2008 Jun;29(3):347-50. PMID: 18580839
Clinical and serological features of 35 patients with anti-Ki autoantibodies.
Cavazzana I, Franceschini F, Vassalini C, Danieli E, Quinzanini M, Airò P, Cattaneo R
Lupus 2005;14(10):837-41. doi: 10.1191/0961203305lu2226oa. PMID: 16302679

Diagnosis

Anti-Ki/anti-PA28γ autoantibodies contribute to the HEp-2 indirect immunofluorescence nuclear speckled pattern.
Boon L, Belmondo T, Vulsteke JB, Wuyts G, Derua R, Hüe S, Bossuyt X
Clin Chem Lab Med 2023 Feb 23;61(3):435-441. Epub 2022 Nov 30 doi: 10.1515/cclm-2022-0858. PMID: 36445291
Ki-67 (30-9) scoring and differentiation of Luminal A- and Luminal B-like breast cancer subtypes.
Viale G, Hanlon Newell AE, Walker E, Harlow G, Bai I, Russo L, Dell'Orto P, Maisonneuve P
Breast Cancer Res Treat 2019 Nov;178(2):451-458. Epub 2019 Aug 17 doi: 10.1007/s10549-019-05402-w. PMID: 31422497Free PMC Article
Pathologic Findings and Clinical Course of Midline Paraventricular Gliomas Diagnosed Using a Neuroendoscope.
Fukami S, Nakajima N, Okada H, Akimoto J, Miki T, Fukuhara H, Shishido-Hara Y, Nagao T, Tsuda M, Kohno M
World Neurosurg 2018 Jun;114:e366-e377. Epub 2018 Mar 9 doi: 10.1016/j.wneu.2018.02.185. PMID: 29530692
Clinical and serological features of 35 patients with anti-Ki autoantibodies.
Cavazzana I, Franceschini F, Vassalini C, Danieli E, Quinzanini M, Airò P, Cattaneo R
Lupus 2005;14(10):837-41. doi: 10.1191/0961203305lu2226oa. PMID: 16302679
The Ki-67 protein: from the known and the unknown.
Scholzen T, Gerdes J
J Cell Physiol 2000 Mar;182(3):311-22. doi: 10.1002/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9. PMID: 10653597

Therapy

Ki-67 (30-9) scoring and differentiation of Luminal A- and Luminal B-like breast cancer subtypes.
Viale G, Hanlon Newell AE, Walker E, Harlow G, Bai I, Russo L, Dell'Orto P, Maisonneuve P
Breast Cancer Res Treat 2019 Nov;178(2):451-458. Epub 2019 Aug 17 doi: 10.1007/s10549-019-05402-w. PMID: 31422497Free PMC Article
Evaluation of drug mechanism and efficacy of a novel anti-angiogenic agent, TTAC-0001, using multi-modality bioimaging in a mouse breast cancer orthotopic model.
Kim J, Choi SH, Ham SJ, Cho YC, Lee SI, Kang J, Woo DC, Lee WS, Yoo JS, Kim KW, Choi Y
PLoS One 2018;13(1):e0187063. Epub 2018 Jan 25 doi: 10.1371/journal.pone.0187063. PMID: 29370209Free PMC Article
Ki-67 evaluation at the hottest spot predicts clinical outcome of patients with hormone receptor-positive/HER2-negative breast cancer treated with adjuvant tamoxifen monotherapy.
Honma N, Horii R, Iwase T, Saji S, Younes M, Ito Y, Akiyama F
Breast Cancer 2015 Jan;22(1):71-8. Epub 2013 Mar 12 doi: 10.1007/s12282-013-0455-5. PMID: 23479208
FTY720 and cyclosporin protect ovarian tissue grafted into rabbits.
Ying Y, Wang L, Chen Y, Jiang J, Ouyang Y, Huang H, Xu J
Eur J Obstet Gynecol Reprod Biol 2013 Nov;171(1):88-95. Epub 2013 Aug 26 doi: 10.1016/j.ejogrb.2013.08.033. PMID: 24035595
Enhanced antitumor effect of YM872 and AG1296 combination treatment on human glioblastoma xenograft models.
Watanabe T, Ohtani T, Aihara M, Ishiuchi S
J Neurosurg 2013 Apr;118(4):838-45. Epub 2013 Jan 11 doi: 10.3171/2012.11.JNS12362. PMID: 23311938

Prognosis

Pathological Significance of Kidney and Brain Expressed Protein (KIBRA) in Clear Cell Renal Cell Carcinoma.
Nagashima Y, Mitsunari K, Matsuo T, Nakamura Y, Miyata Y, Ohba K
Anticancer Res 2023 Jan;43(1):45-51. doi: 10.21873/anticanres.16132. PMID: 36585159
Ki-67 (30-9) scoring and differentiation of Luminal A- and Luminal B-like breast cancer subtypes.
Viale G, Hanlon Newell AE, Walker E, Harlow G, Bai I, Russo L, Dell'Orto P, Maisonneuve P
Breast Cancer Res Treat 2019 Nov;178(2):451-458. Epub 2019 Aug 17 doi: 10.1007/s10549-019-05402-w. PMID: 31422497Free PMC Article
Pathological significance and prognostic roles of densities of CD57+ cells, CD68+ cells, and mast cells, and their ratios in clear cell renal cell carcinoma.
Nakanishi H, Miyata Y, Mochizuki Y, Yasuda T, Nakamura Y, Araki K, Sagara Y, Matsuo T, Ohba K, Sakai H
Hum Pathol 2018 Sep;79:102-108. Epub 2018 May 19 doi: 10.1016/j.humpath.2018.05.007. PMID: 29787818
Pathologic Findings and Clinical Course of Midline Paraventricular Gliomas Diagnosed Using a Neuroendoscope.
Fukami S, Nakajima N, Okada H, Akimoto J, Miki T, Fukuhara H, Shishido-Hara Y, Nagao T, Tsuda M, Kohno M
World Neurosurg 2018 Jun;114:e366-e377. Epub 2018 Mar 9 doi: 10.1016/j.wneu.2018.02.185. PMID: 29530692
The Ki-67 protein: from the known and the unknown.
Scholzen T, Gerdes J
J Cell Physiol 2000 Mar;182(3):311-22. doi: 10.1002/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9. PMID: 10653597

Clinical prediction guides

The expression of c-MYC, Cyclin D1 and Ki-67/MIB-1 in benign and malignant thyroid tissues: is there any diagnostic value?
Forozidou E, Syrnioti A, Laskou S, Poutoglidis A, Sapalidis K, Koletsa T
Rom J Morphol Embryol 2024 Apr-Jun;65(2):267-271. doi: 10.47162/RJME.65.2.13. PMID: 39020541Free PMC Article
Pathological Significance of Kidney and Brain Expressed Protein (KIBRA) in Clear Cell Renal Cell Carcinoma.
Nagashima Y, Mitsunari K, Matsuo T, Nakamura Y, Miyata Y, Ohba K
Anticancer Res 2023 Jan;43(1):45-51. doi: 10.21873/anticanres.16132. PMID: 36585159
Syndecan-1 (CD138) and Ki-67 expression in odontogenic cystic lesions.
Nadalin MR, Fregnani ER, Silva-Sousa YT, Perez DE
Braz Dent J 2011;22(3):223-9. doi: 10.1590/s0103-64402011000300008. PMID: 21915520
"Silent"corticotropinoma.
Pawlikowski M, Kunert-Radek J, Radek M
Neuro Endocrinol Lett 2008 Jun;29(3):347-50. PMID: 18580839
Clinical and prognostic significance of Ki-67 and proliferating cell nuclear antigen expression in childhood primitive neuroectodermal brain tumors.
Bodey B, Bodey B Jr, Gröger AM, Siegel SE, Kaiser HE
Anticancer Res 1997 Jan-Feb;17(1A):189-96. PMID: 9066650

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