U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Orbit neoplasm

MedGen UID:
18190
•Concept ID:
C0029185
•
Neoplastic Process
Synonyms: Neoplasm, Orbital; Neoplasms, Orbital; Orbital Neoplasm; Orbital Neoplasms
SNOMED CT: Neoplasm of orbit proper (127003006); Neoplasm of orbit (127003006); Tumor of orbit (127003006)
 
Monarch Initiative: MONDO:0024611

Definition

A benign or malignant neoplasm that affects the orbit. [from NCI]

Professional guidelines

PubMed

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Sebaceous carcinoma: evidence-based clinical practice guidelines.
Owen JL, Kibbi N, Worley B, Kelm RC, Wang JV, Barker CA, Behshad R, Bichakjian CK, Bolotin D, Bordeaux JS, Bradshaw SH, Cartee TV, Chandra S, Cho NL, Choi JN, Council ML, Demirci H, Eisen DB, Esmaeli B, Golda N, Huang CC, Ibrahim SF, Jiang SB, Kim J, Kuzel TM, Lai SY, Lawrence N, Lee EH, Leitenberger JJ, Maher IA, Mann MW, Minkis K, Mittal BB, Nehal KS, Neuhaus IM, Ozog DM, Petersen B, Rotemberg V, Samant S, Samie FH, Servaes S, Shields CL, Shin TM, Sobanko JF, Somani AK, Stebbins WG, Thomas JR, Thomas VD, Tse DT, Waldman AH, Wong MK, Xu YG, Yu SS, Zeitouni NC, Ramsay T, Reynolds KA, Poon E, Alam M
Lancet Oncol 2019 Dec;20(12):e699-e714. doi: 10.1016/S1470-2045(19)30673-4. PMID: 31797796
Modern radiation therapy for extranodal lymphomas: field and dose guidelines from the International Lymphoma Radiation Oncology Group.
Yahalom J, Illidge T, Specht L, Hoppe RT, Li YX, Tsang R, Wirth A; International Lymphoma Radiation Oncology Group
Int J Radiat Oncol Biol Phys 2015 May 1;92(1):11-31. doi: 10.1016/j.ijrobp.2015.01.009. PMID: 25863750

Recent clinical studies

Etiology

Interventions for orbital lymphangioma.
Patel SR, Rosenberg JB, Barmettler A
Cochrane Database Syst Rev 2019 May 15;5(5):CD013000. doi: 10.1002/14651858.CD013000.pub2. PMID: 31094450Free PMC Article
Orbital Paraganglioma.
Zhu B, Yan J
J Craniofac Surg 2019 Sep;30(6):e503-e506. doi: 10.1097/SCS.0000000000005408. PMID: 30896513
Pediatric Orbital Primitive Neuroectodermal Tumors.
Afghani T, Mansoor H, Raza Hamdani SN
J Pediatr Ophthalmol Strabismus 2018 Mar 1;55(2):128-134. Epub 2017 Nov 14 doi: 10.3928/01913913-20170703-03. PMID: 29131914
Orbital peripheral nerve sheath tumors.
Sweeney AR, Gupta D, Keene CD, Cimino PJ, Chambers CB, Chang SH, Hanna E
Surv Ophthalmol 2017 Jan-Feb;62(1):43-57. Epub 2016 Aug 26 doi: 10.1016/j.survophthal.2016.08.002. PMID: 27570221
Orbital lymphaticovenous malformations: Current and future treatments.
Nassiri N, Rootman J, Rootman DB, Goldberg RA
Surv Ophthalmol 2015 Sep-Oct;60(5):383-405. Epub 2015 Mar 26 doi: 10.1016/j.survophthal.2015.03.001. PMID: 26077629

Diagnosis

Orbital dermoid cyst.
Bansal R, Honavar SG, Talloju SS, Mulay K
Indian J Ophthalmol 2022 Feb;70(2):709. doi: 10.4103/ijo.IJO_145_22. PMID: 35086291Free PMC Article
Rare Diseases of the Orbit.
Kisser U, Heichel J, Glien A
Laryngorhinootologie 2021 Apr;100(S 01):S1-S79. Epub 2021 Apr 30 doi: 10.1055/a-1384-4641. PMID: 34352903Free PMC Article
Orbital Tumors and Inflammatory Disorders: Diagnosis and Management.
Neems L, Echalier EL, Subramanian PS
Int Ophthalmol Clin 2018 Spring;58(2):181-195. doi: 10.1097/IIO.0000000000000217. PMID: 29517650
Lymphoproliferative Disease of the Orbit.
Li EY, Yuen HK, Cheuk W
Asia Pac J Ophthalmol (Phila) 2015 Mar-Apr;4(2):106-11. doi: 10.1097/APO.0000000000000102. PMID: 26065355
Cancer of the orbit and adnexa.
Schwarcz RM, Coupland SE, Finger PT
Am J Clin Oncol 2013 Apr;36(2):197-205. doi: 10.1097/COC.0b013e31820dbf28. PMID: 22157212

Therapy

PET/CT and PET/MRI in ophthalmic oncology (Review).
Kalemaki MS, Karantanas AH, Exarchos D, Detorakis ET, Zoras O, Marias K, Millo C, Bagci U, Pallikaris I, Stratis A, Karatzanis I, Perisinakis K, Koutentakis P, Kontadakis GA, Spandidos DA, Tsatsakis A, Papadakis GZ
Int J Oncol 2020 Feb;56(2):417-429. Epub 2020 Jan 3 doi: 10.3892/ijo.2020.4955. PMID: 31939615Free PMC Article
Update on orbital lymphatic malformations.
Lally SE
Curr Opin Ophthalmol 2016 Sep;27(5):413-5. doi: 10.1097/ICU.0000000000000291. PMID: 27219273
Lymphoproliferative Disease of the Orbit.
Li EY, Yuen HK, Cheuk W
Asia Pac J Ophthalmol (Phila) 2015 Mar-Apr;4(2):106-11. doi: 10.1097/APO.0000000000000102. PMID: 26065355
Green bone.
Boulos PR, Knoepp SM, Rubin PA
Arch Ophthalmol 2007 Mar;125(3):380-6. doi: 10.1001/archopht.125.3.380. PMID: 17353410
Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic disease.
Crist WM, Anderson JR, Meza JL, Fryer C, Raney RB, Ruymann FB, Breneman J, Qualman SJ, Wiener E, Wharam M, Lobe T, Webber B, Maurer HM, Donaldson SS
J Clin Oncol 2001 Jun 15;19(12):3091-102. doi: 10.1200/JCO.2001.19.12.3091. PMID: 11408506

Prognosis

Rare Diseases of the Orbit.
Kisser U, Heichel J, Glien A
Laryngorhinootologie 2021 Apr;100(S 01):S1-S79. Epub 2021 Apr 30 doi: 10.1055/a-1384-4641. PMID: 34352903Free PMC Article
Diagnosis of orbital mass lesions: clinical, radiological, and pathological recommendations.
Mombaerts I, Ramberg I, Coupland SE, Heegaard S
Surv Ophthalmol 2019 Nov-Dec;64(6):741-756. Epub 2019 Jul 2 doi: 10.1016/j.survophthal.2019.06.006. PMID: 31276737
Orbital lymphoma.
Olsen TG, Heegaard S
Surv Ophthalmol 2019 Jan-Feb;64(1):45-66. Epub 2018 Aug 23 doi: 10.1016/j.survophthal.2018.08.002. PMID: 30144455
Life expectancy following orbital exenteration.
Wong JC, Thampy R, Cook A
Br J Ophthalmol 2015 Jan;99(1):1-4. Epub 2014 May 30 doi: 10.1136/bjophthalmol-2013-304436. PMID: 24879806
Metastatic orbital tumors.
Günalp I, Gündüz K
Jpn J Ophthalmol 1995;39(1):65-70. PMID: 7643486

Clinical prediction guides

Inferolateral Transorbital Endoscopic Approach for Spheno-Orbital Meningiomas.
Colombo G, Ferreli F, Baram A, Mercante G, Riva M, Di Maria A, Pessina F
J Craniofac Surg 2022 May 1;33(3):e260-e265. Epub 2021 Jul 30 doi: 10.1097/SCS.0000000000008062. PMID: 34334747
Surgical Treatment of Intraorbital Lesions.
Aftahy AK, Krauss P, Barz M, Wagner A, Meyer B, Negwer C, Gempt J
World Neurosurg 2021 Nov;155:e805-e813. Epub 2021 Sep 9 doi: 10.1016/j.wneu.2021.09.011. PMID: 34509678
Interventions for orbital lymphangioma.
Patel SR, Rosenberg JB, Barmettler A
Cochrane Database Syst Rev 2019 May 15;5(5):CD013000. doi: 10.1002/14651858.CD013000.pub2. PMID: 31094450Free PMC Article
Orbital Paraganglioma.
Zhu B, Yan J
J Craniofac Surg 2019 Sep;30(6):e503-e506. doi: 10.1097/SCS.0000000000005408. PMID: 30896513
Orbital Metastases: When to Suspect? When to biopsy?
Allen RC
Middle East Afr J Ophthalmol 2018 Apr-Jun;25(2):60-64. doi: 10.4103/meajo.MEAJO_93_18. PMID: 30122850Free PMC Article

Recent systematic reviews

Endoscopic Transorbital Approach for the Management of Spheno-Orbital Meningiomas: Literature Review and Preliminary Experience.
Di Somma A, De Rosa A, Ferrés A, Mosteiro A, Guizzardi G, Fassi JM, Topczewski TE, Reyes L, Roldán P, Torné R, Alobid I, Enseñat J
World Neurosurg 2023 Aug;176:43-59. Epub 2023 Apr 5 doi: 10.1016/j.wneu.2023.03.126. PMID: 37024084
Exclusively endoscopic endonasal resection of benign orbital tumors: a systematic review and meta-analysis.
Jafari A, von Sneidern M, Lehmann AE, Shen SA, Shishido S, Freitag SK, Bleier BS
Int Forum Allergy Rhinol 2021 May;11(5):924-934. Epub 2020 Dec 22 doi: 10.1002/alr.22745. PMID: 33350602
Interventions for orbital lymphangioma.
Patel SR, Rosenberg JB, Barmettler A
Cochrane Database Syst Rev 2019 May 15;5(5):CD013000. doi: 10.1002/14651858.CD013000.pub2. PMID: 31094450Free PMC Article
The epidemiology and clinical manifestations of mucormycosis: a systematic review and meta-analysis of case reports.
Jeong W, Keighley C, Wolfe R, Lee WL, Slavin MA, Kong DCM, Chen SC
Clin Microbiol Infect 2019 Jan;25(1):26-34. Epub 2018 Jul 21 doi: 10.1016/j.cmi.2018.07.011. PMID: 30036666
Prognostic Value of the Staging System for Eyelid Tumors in the 7th Edition of the American Joint Committee on Cancer Staging Manual.
Ford J, Thakar S, Thuro B, Esmaeli B
Ophthalmic Plast Reconstr Surg 2017 Sep/Oct;33(5):317-324. doi: 10.1097/IOP.0000000000000901. PMID: 28350693

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...