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Fungal hyphae in sputum

MedGen UID:
1826138
•Concept ID:
C5826374
•
Finding
HPO: HP:0034404

Definition

Presence of hyphae (long, branching, filamentous structures produced by fungi) in sputum. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFungal hyphae in sputum

Professional guidelines

PubMed

Treatment with rhDNase in patients with cystic fibrosis alters in-vitro CHIT-1 activity of isolated leucocytes.
Weckmann M, Schultheiss C, Hollaender A, Bobis I, Rupp J, Kopp MV
Clin Exp Immunol 2016 Sep;185(3):382-91. Epub 2016 Jul 28 doi: 10.1111/cei.12827. PMID: 27324468Free PMC Article

Recent clinical studies

Etiology

Detection of Aspergillus fumigatus hyphae in respiratory secretions by membrane filtration, fluorescent labelling and laser scanning.
De Vos MM, Sanders NN, Nelis HJ
J Microbiol Methods 2006 Mar;64(3):420-3. Epub 2005 Aug 8 doi: 10.1016/j.mimet.2005.07.004. PMID: 16091295
Significance of Aspergillus fumigatus isolation from respiratory specimens of nongranulocytopenic patients.
Uffredi ML, Mangiapan G, Cadranel J, Kac G
Eur J Clin Microbiol Infect Dis 2003 Aug;22(8):457-62. Epub 2003 Jul 25 doi: 10.1007/s10096-003-0970-y. PMID: 12898283
Acremonium strictum pulmonary infection in a leukemic patient successfully treated with posaconazole after failure of amphotericin B.
Herbrecht R, Letscher-Bru V, Fohrer C, Campos F, Natarajan-Ame S, Zamfir A, Waller J
Eur J Clin Microbiol Infect Dis 2002 Nov;21(11):814-7. Epub 2002 Oct 31 doi: 10.1007/s10096-002-0828-8. PMID: 12461592
Bronchocentric granulomatosis.
Koss MN, Robinson RG, Hochholzer L
Hum Pathol 1981 Jul;12(7):632-8. doi: 10.1016/s0046-8177(81)80047-0. PMID: 7275101
Aspergillosis and atopy in cystic fibrosis.
Nelson LA, Callerame ML, Schwartz RH
Am Rev Respir Dis 1979 Oct;120(4):863-73. doi: 10.1164/arrd.1979.120.4.863. PMID: 507513

Diagnosis

Aspergillus fumigatus Strain-Specific Conidia Lung Persistence Causes an Allergic Broncho-Pulmonary Aspergillosis-Like Disease Phenotype.
Jones JT, Liu KW, Wang X, Kowalski CH, Ross BS, Mills KAM, Kerkaert JD, Hohl TM, Lofgren LA, Stajich JE, Obar JJ, Cramer RA
mSphere 2021 Feb 17;6(1) doi: 10.1128/mSphere.01250-20. PMID: 33597172Free PMC Article
Allergic bronchopulmonary aspergillosis.
Patel G, Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):421-424. doi: 10.2500/aap.2019.40.4262. PMID: 31690385
Cavitary pulmonary coccidioidomycosis: pathologic and clinical correlates of disease.
Sobonya RE, Yanes J, Klotz SA
Hum Pathol 2014 Jan;45(1):153-9. doi: 10.1016/j.humpath.2013.08.014. PMID: 24321524
Chapter 18: Allergic bronchopulmonary aspergillosis.
Greenberger PA
Allergy Asthma Proc 2012 May-Jun;33 Suppl 1:61-63. doi: 10.2500/aap.2012.33.3551. PMID: 22794691
Disseminated pheohyphomycosis.
Shivaswamy KN, Pradhan P, Laxmisha C, Thappa DM, Jayanthi S
Int J Dermatol 2007 Mar;46(3):278-81. doi: 10.1111/j.1365-4632.2006.02960.x. PMID: 17343584

Therapy

Severe influenza A virus pneumonia complicated with Curvularia lunata infection: Case Report.
Zhang Y, Li H, Chen L, Feng F, Liu L, Guo Q
Front Cell Infect Microbiol 2023;13:1289235. Epub 2023 Dec 15 doi: 10.3389/fcimb.2023.1289235. PMID: 38162579Free PMC Article
Acute mediastinitis associated with tracheobronchial tuberculosis and aspergillosis: a case report and literature review.
Liang CN, Zhao HW, Kang J, Hou G, Yin Y
J Int Med Res 2020 May;48(5):300060520918469. doi: 10.1177/0300060520918469. PMID: 32431185Free PMC Article
Septate hyphae (Rhizoctonia sp) in sputum cytology.
Martínez-Girón R, Martínez-Torre C
Cytopathology 2020 Sep;31(5):475-476. Epub 2020 Jun 24 doi: 10.1111/cyt.12849. PMID: 32379906
Disseminated pheohyphomycosis.
Shivaswamy KN, Pradhan P, Laxmisha C, Thappa DM, Jayanthi S
Int J Dermatol 2007 Mar;46(3):278-81. doi: 10.1111/j.1365-4632.2006.02960.x. PMID: 17343584
Infection of the pleura by Aspergillus fumigatus.
Krakówka P, Rowińska E, Halweg H
Thorax 1970 Mar;25(2):245-53. doi: 10.1136/thx.25.2.245. PMID: 5441996Free PMC Article

Prognosis

Acute mediastinitis associated with tracheobronchial tuberculosis and aspergillosis: a case report and literature review.
Liang CN, Zhao HW, Kang J, Hou G, Yin Y
J Int Med Res 2020 May;48(5):300060520918469. doi: 10.1177/0300060520918469. PMID: 32431185Free PMC Article
Allergic bronchopulmonary aspergillosis.
Patel G, Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):421-424. doi: 10.2500/aap.2019.40.4262. PMID: 31690385
Chapter 18: Allergic bronchopulmonary aspergillosis.
Greenberger PA
Allergy Asthma Proc 2012 May-Jun;33 Suppl 1:61-63. doi: 10.2500/aap.2012.33.3551. PMID: 22794691
Bronchocentric granulomatosis.
Koss MN, Robinson RG, Hochholzer L
Hum Pathol 1981 Jul;12(7):632-8. doi: 10.1016/s0046-8177(81)80047-0. PMID: 7275101
Aspergillosis and atopy in cystic fibrosis.
Nelson LA, Callerame ML, Schwartz RH
Am Rev Respir Dis 1979 Oct;120(4):863-73. doi: 10.1164/arrd.1979.120.4.863. PMID: 507513

Clinical prediction guides

Exposure to the Pseudomonas aeruginosa secretome alters the proteome and secondary metabolite production of Aspergillus fumigatus.
Margalit A, Sheehan D, Carolan JC, Kavanagh K
Microbiology (Reading) 2022 Mar;168(3) doi: 10.1099/mic.0.001164. PMID: 35333152Free PMC Article
Aspergillus fumigatus Strain-Specific Conidia Lung Persistence Causes an Allergic Broncho-Pulmonary Aspergillosis-Like Disease Phenotype.
Jones JT, Liu KW, Wang X, Kowalski CH, Ross BS, Mills KAM, Kerkaert JD, Hohl TM, Lofgren LA, Stajich JE, Obar JJ, Cramer RA
mSphere 2021 Feb 17;6(1) doi: 10.1128/mSphere.01250-20. PMID: 33597172Free PMC Article
Pulmonary infection caused by Talaromyces purpurogenus in a patient with multiple myeloma.
Atalay A, Koc AN, Akyol G, Cakir N, Kaynar L, Ulu-Kilic A
Infez Med 2016 Jun 1;24(2):153-7. PMID: 27367328
Invasive pulmonary aspergillosis in a patient presenting with idiopathic systemic capillary leak syndrome.
Hayama M, Shime N, Mio T
BMJ Case Rep 2014 May 23;2014 doi: 10.1136/bcr-2014-203764. PMID: 24859554Free PMC Article
Disseminated infection due to Chrysosporium zonatum in a patient with chronic granulomatous disease and review of non-Aspergillus fungal infections in patients with this disease.
Roilides E, Sigler L, Bibashi E, Katsifa H, Flaris N, Panteliadis C
J Clin Microbiol 1999 Jan;37(1):18-25. doi: 10.1128/JCM.37.1.18-25.1999. PMID: 9854057Free PMC Article

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