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Bone marrow myeloid vacuolization

MedGen UID:
1841590
Concept ID:
C5826546
Finding
Synonyms: Bone marrow: myeloid vacuolization; Vacuolization of bone marrow myeloid precursors
 
HPO: HP:0034636

Definition

Formation of vacuoles (a space within a cell that is empty of cytoplasm, lined with a membrane, and filled with fluid) in the cytoplasm of myeloid precursors in the bone marrow. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBone marrow myeloid vacuolization

Professional guidelines

PubMed

Loeza-Uribe MP, Hinojosa-Azaola A, Sánchez-Hernández BE, Crispín JC, Apodaca-Chávez E, Ferrada MA, Martín-Nares E
Reumatol Clin (Engl Ed) 2024 Jan;20(1):47-56. Epub 2023 Dec 29 doi: 10.1016/j.reumae.2023.12.004. PMID: 38160120
Koster MJ, Lasho TL, Olteanu H, Reichard KK, Mangaonkar A, Warrington KJ, Patnaik MM
Am J Hematol 2024 Feb;99(2):284-299. Epub 2023 Nov 11 doi: 10.1002/ajh.27156. PMID: 37950858
Chabrun F, Lacombe V, Dieu X, Geneviève F, Urbanski G
Clin Chem Lab Med 2023 Jun 27;61(7):1275-1279. Epub 2023 Feb 2 doi: 10.1515/cclm-2022-1283. PMID: 36722042

Recent clinical studies

Etiology

Kunimoto H, Miura A, Maeda A, Tsuchida N, Uchiyama Y, Kunishita Y, Nakajima Y, Takase-Minegishi K, Yoshimi R, Miyazaki T, Hagihara M, Yamazaki E, Kirino Y, Matsumoto N, Nakajima H
Int J Hematol 2023 Oct;118(4):494-502. Epub 2023 Apr 17 doi: 10.1007/s12185-023-03598-8. PMID: 37062784
van der Made CI, Potjewijd J, Hoogstins A, Willems HPJ, Kwakernaak AJ, de Sevaux RGL, van Daele PLA, Simons A, Heijstek M, Beck DB, Netea MG, van Paassen P, Elizabeth Hak A, van der Veken LT, van Gijn ME, Hoischen A, van de Veerdonk FL, Leavis HL, Rutgers A
J Allergy Clin Immunol 2022 Jan;149(1):432-439.e4. Epub 2021 May 25 doi: 10.1016/j.jaci.2021.05.014. PMID: 34048852
Oganesyan A, Hakobyan Y, Terrier B, Georgin-Lavialle S, Mekinian A
Semin Hematol 2021 Oct;58(4):247-253. Epub 2021 Oct 9 doi: 10.1053/j.seminhematol.2021.10.003. PMID: 34802547
Zakine E, Schell B, Battistella M, Vignon-Pennamen MD, Chasset F, Mahévas T, Cordoliani F, Adès L, Sébert M, Delaleu J, Jachiet M, Lepelletier C, Lemaire P, Chauvel C, Dhouaieb B, Kim R, Cassius C, Georgin-Lavialle S, Mekinian A, Bagot M, Braun T, Rousset L, Begon E, de Masson A, Fenaux P, Clappier E, Bouaziz JD
JAMA Dermatol 2021 Nov 1;157(11):1349-1354. doi: 10.1001/jamadermatol.2021.3344. PMID: 34495287Free PMC Article
Obiorah IE, Patel BA, Groarke EM, Wang W, Trick M, Ombrello AK, Ferrada MA, Wu Z, Gutierrez-Rodrigues F, Lotter J, Wilson L, Hoffmann P, Cardona DO, Patel N, Dulau-Florea A, Kastner DL, Grayson PC, Beck DB, Young NS, Calvo KR
Blood Adv 2021 Aug 24;5(16):3203-3215. doi: 10.1182/bloodadvances.2021004976. PMID: 34427584Free PMC Article

Diagnosis

Loeza-Uribe MP, Hinojosa-Azaola A, Sánchez-Hernández BE, Crispín JC, Apodaca-Chávez E, Ferrada MA, Martín-Nares E
Reumatol Clin (Engl Ed) 2024 Jan;20(1):47-56. Epub 2023 Dec 29 doi: 10.1016/j.reumae.2023.12.004. PMID: 38160120
Koster MJ, Lasho TL, Olteanu H, Reichard KK, Mangaonkar A, Warrington KJ, Patnaik MM
Am J Hematol 2024 Feb;99(2):284-299. Epub 2023 Nov 11 doi: 10.1002/ajh.27156. PMID: 37950858
Yoshimi A, Ishikawa K, Niemeyer C, Grünert SC
Orphanet J Rare Dis 2022 Oct 17;17(1):379. doi: 10.1186/s13023-022-02538-9. PMID: 36253820Free PMC Article
Zakine E, Schell B, Battistella M, Vignon-Pennamen MD, Chasset F, Mahévas T, Cordoliani F, Adès L, Sébert M, Delaleu J, Jachiet M, Lepelletier C, Lemaire P, Chauvel C, Dhouaieb B, Kim R, Cassius C, Georgin-Lavialle S, Mekinian A, Bagot M, Braun T, Rousset L, Begon E, de Masson A, Fenaux P, Clappier E, Bouaziz JD
JAMA Dermatol 2021 Nov 1;157(11):1349-1354. doi: 10.1001/jamadermatol.2021.3344. PMID: 34495287Free PMC Article
Gurnari C, Pagliuca S, Durkin L, Terkawi L, Awada H, Kongkiatkamon S, Zawit M, Hsi ED, Carraway HE, Rogers HJ, Visconte V, Maciejewski JP
Blood 2021 Jul 1;137(26):3685-3689. doi: 10.1182/blood.2021010811. PMID: 33690844Free PMC Article

Therapy

De Santis M, Tonutti A, Motta F, Todisco G, Manes N, Milanesi C, Caselli R, Albertazzi S, Bonometti A, Selmi C, Della Porta MG
Ann Hematol 2024 Nov;103(11):4789-4791. Epub 2024 Aug 23 doi: 10.1007/s00277-024-05863-0. PMID: 39177793
Sharma K, Keri VC, Kumar TP, Sethi P, Dass J, Mishra RK
Trop Doct 2023 Apr;53(2):315-316. Epub 2023 Mar 8 doi: 10.1177/00494755231159292. PMID: 36890727
Arai J, Wakiguchi H, Hisakawa H, Kubota H, Kurashige T
Pediatr Hematol Oncol 2000 Mar;17(2):171-6. doi: 10.1080/088800100276532. PMID: 10734660
Oberling F, Lang JM, Juif JG, Luckel JC
Scand J Haematol 1976 Aug;17(2):105-10. PMID: 968442
Goh KO
South Med J 1971 Jul;64(7):815-9. doi: 10.1097/00007611-197107000-00008. PMID: 5282895

Prognosis

Loeza-Uribe MP, Hinojosa-Azaola A, Sánchez-Hernández BE, Crispín JC, Apodaca-Chávez E, Ferrada MA, Martín-Nares E
Reumatol Clin (Engl Ed) 2024 Jan;20(1):47-56. Epub 2023 Dec 29 doi: 10.1016/j.reumae.2023.12.004. PMID: 38160120
Kunimoto H, Miura A, Maeda A, Tsuchida N, Uchiyama Y, Kunishita Y, Nakajima Y, Takase-Minegishi K, Yoshimi R, Miyazaki T, Hagihara M, Yamazaki E, Kirino Y, Matsumoto N, Nakajima H
Int J Hematol 2023 Oct;118(4):494-502. Epub 2023 Apr 17 doi: 10.1007/s12185-023-03598-8. PMID: 37062784
Yoshimi A, Ishikawa K, Niemeyer C, Grünert SC
Orphanet J Rare Dis 2022 Oct 17;17(1):379. doi: 10.1186/s13023-022-02538-9. PMID: 36253820Free PMC Article
van der Made CI, Potjewijd J, Hoogstins A, Willems HPJ, Kwakernaak AJ, de Sevaux RGL, van Daele PLA, Simons A, Heijstek M, Beck DB, Netea MG, van Paassen P, Elizabeth Hak A, van der Veken LT, van Gijn ME, Hoischen A, van de Veerdonk FL, Leavis HL, Rutgers A
J Allergy Clin Immunol 2022 Jan;149(1):432-439.e4. Epub 2021 May 25 doi: 10.1016/j.jaci.2021.05.014. PMID: 34048852
Obiorah IE, Patel BA, Groarke EM, Wang W, Trick M, Ombrello AK, Ferrada MA, Wu Z, Gutierrez-Rodrigues F, Lotter J, Wilson L, Hoffmann P, Cardona DO, Patel N, Dulau-Florea A, Kastner DL, Grayson PC, Beck DB, Young NS, Calvo KR
Blood Adv 2021 Aug 24;5(16):3203-3215. doi: 10.1182/bloodadvances.2021004976. PMID: 34427584Free PMC Article

Clinical prediction guides

Lacombe V, Hadjadj J, Georgin-Lavialle S, Lavigne C, Geneviève F, Kosmider O
Lancet Haematol 2024 Feb;11(2):e160-e167. doi: 10.1016/S2352-3026(23)00375-7. PMID: 38302223
Nishimura A, Hirabayashi S, Hasegawa D, Yoshida K, Shiraishi Y, Ashiarai M, Hosoya Y, Fujiwara T, Harigae H, Miyano S, Ogawa S, Manabe A
Pediatr Blood Cancer 2021 Feb;68(2):e28799. Epub 2020 Nov 16 doi: 10.1002/pbc.28799. PMID: 33200495
Ahluwalia J, Kumar V, Trehan A, Marwaha RK, Garewal G
Pediatr Hematol Oncol 2004 Apr-May;21(3):199-202. doi: 10.1080/08880010490276881. PMID: 15202158
Imashuku S, Hibi S, Sako M, Lin YW, Ikuta K, Nakata Y, Mori T, Iizuka S, Horibe K, Tsunematsu Y
Cancer 2000 Apr 15;88(8):1970-5. PMID: 10760776
Akashi K, Shibuya T, Harada M, Oogami A, Teshima T, Takamatsu Y, Kikuchi M, Niho Y
Br J Haematol 1992 Feb;80(2):172-7. doi: 10.1111/j.1365-2141.1992.tb08896.x. PMID: 1550772

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